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Reviewed, UniProtKB/Swiss-Prot Q8X6C5 (XDHB_ECO57)

Last modified June 16, 2009. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Xanthine dehydrogenase FAD-binding subunit
    EC=1.17.1.4
Gene names
Name: xdhB
Ordered Locus Names: Z4206, ECs3740
OrganismEscherichia coli O157:H7 [Complete proteome] [HAMAP]
Taxonomic identifier83334 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) By similarity.

Catalytic activity

Xanthine + NAD+ + H2O = urate + NADH.

Hypoxanthine + NAD+ + H2O = xanthine + NADH.

Cofactor

FAD By similarity.

Pathway

Purine metabolism; hypoxanthine degradation; uric acid from hypoxanthine: step 1/2.

Purine metabolism; hypoxanthine degradation; uric acid from hypoxanthine: step 2/2.

Subunit structure

Heterotrimer of xdhA, xdhB and xdhC Probable.

Sequence similarities

Contains 1 FAD-binding PCMH-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 292292Xanthine dehydrogenase FAD-binding subunit
PRO_0000166093

Regions

Domain1 – 176176FAD-binding PCMH-type

Sequences

Sequence LengthMass (Da)Tools
Q8X6C5-1 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: FEC44F9990BF9BC1

FASTA29231,561
        10         20         30         40         50         60 
MFDFASYHRA ATLADAINLL ADNPQAKLLA GGTDVLIQLH HHNDRYRHIV DIHNLAELRG 

        70         80         90        100        110        120 
ITLAEDGSLR IGSATTFTQL IEDSITQRHL PALCAAASSI AGPQIRNVAT YGGNICNGAT 

       130        140        150        160        170        180 
SADSATPTLI YDAKLEIHSP RGVRFVPING FHTGPGKVSL EHDEILVAFH FPPQPKEHVG 

       190        200        210        220        230        240 
SAHFKYAMRD AMDISTIGCA AHCRLDNGNF SELRLAFGVA APTPIRCQHA EQTAQNAPLN 

       250        260        270        280        290 
LQTLEAISES VLQDVAPRSS WRASKEFRLH LIQTMTKKVI SEAVAAAGGK LQ 

« Hide

References

Cross-references

Sequence databases

AE005174 Genomic DNA. Translation: AAG57996.2.
BA000007 Genomic DNA. Translation: BAB37163.1.
PIRD91096.
H85941.
RefSeqNP_289437.2.
NP_311767.1.

3D structure databases

HSSPHSSP built from PDB template 1FFV based on UniProtKB P19914.
ModBaseSearch...

Genome annotation databases

GeneID916440.
958358.
GenomeReviewsGene locus Z4206 in contig AE005174_GR.
Gene locus ECs3740 in contig BA000007_GR.
KEGGece:Z4206.
ecs:ECs3740.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ8X6C5.

Enzyme and pathway databases

BioCycECOL83334:ECS3740-MON.

Family and domain databases

InterProIPR005107. CO_DH_flav_C.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR002346. Mopterin_DH_FAD-bd.
[Graphical view]
Gene3DG3DSA:3.30.390.50. CO_DH_flav_C. 1 hit.
G3DSA:3.30.465.10. CO_DH_flavoprot_FAD-bd_sub2. 1 hit.
G3DSA:3.30.43.10. FAD-binding_2_sub1. 1 hit.
PfamPF03450. CO_deh_flav_C. 1 hit.
PF00941. FAD_binding_5. 1 hit.
[Graphical view]
PROSITEPS51387. FAD_PCMH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameXDHB_ECO57
AccessionPrimary (citable) accession number: Q8X6C5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: March 1, 2002
Last modified: June 16, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents