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Q8X6C5

- XDHB_ECO57

UniProt

Q8X6C5 - XDHB_ECO57

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Protein

Xanthine dehydrogenase FAD-binding subunit

Gene

xdhB

Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) (By similarity).By similarity

Catalytic activityi

Xanthine + NAD+ + H2O = urate + NADH.
Hypoxanthine + NAD+ + H2O = xanthine + NADH.

Cofactori

FADBy similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei165 – 1651FAD; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei184 – 1841FADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi27 – 348FADBy similarity
Nucleotide bindingi109 – 1135FADBy similarity

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. UDP-N-acetylmuramate dehydrogenase activity Source: InterPro
  3. xanthine dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. hypoxanthine catabolic process Source: UniProtKB-UniPathway
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Purine metabolism, Purine salvage

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciECOL386585:GJFA-3707-MONOMER.
UniPathwayiUPA00604; UER00661.
UPA00604; UER00662.

Names & Taxonomyi

Protein namesi
Recommended name:
Xanthine dehydrogenase FAD-binding subunit (EC:1.17.1.4)
Gene namesi
Name:xdhB
Ordered Locus Names:Z4206, ECs3740
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Xanthine dehydrogenase FAD-binding subunitPRO_0000166093Add
BLAST

Interactioni

Subunit structurei

Heterotrimer of XdhA, XdhB and XdhC.Curated

Protein-protein interaction databases

STRINGi155864.Z4206.

Structurei

3D structure databases

ProteinModelPortaliQ8X6C5.
SMRiQ8X6C5. Positions 1-287.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 176176FAD-binding PCMH-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 FAD-binding PCMH-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1319.
HOGENOMiHOG000244729.
KOiK13479.
OMAiEICHVAP.
OrthoDBiEOG6ZSP3F.

Family and domain databases

Gene3Di3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
InterProiIPR005107. CO_DH_flav_C.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR002346. Mopterin_DH_FAD-bd.
[Graphical view]
PfamiPF03450. CO_deh_flav_C. 1 hit.
PF00941. FAD_binding_5. 1 hit.
[Graphical view]
SMARTiSM01092. CO_deh_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF55447. SSF55447. 1 hit.
SSF56176. SSF56176. 1 hit.
PROSITEiPS51387. FAD_PCMH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8X6C5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFDFASYHRA ATLADAINLL ADNPQAKLLA GGTDVLIQLH HHNDRYRHIV
60 70 80 90 100
DIHNLAELRG ITLAEDGSLR IGSATTFTQL IEDSITQRHL PALCAAASSI
110 120 130 140 150
AGPQIRNVAT YGGNICNGAT SADSATPTLI YDAKLEIHSP RGVRFVPING
160 170 180 190 200
FHTGPGKVSL EHDEILVAFH FPPQPKEHVG SAHFKYAMRD AMDISTIGCA
210 220 230 240 250
AHCRLDNGNF SELRLAFGVA APTPIRCQHA EQTAQNAPLN LQTLEAISES
260 270 280 290
VLQDVAPRSS WRASKEFRLH LIQTMTKKVI SEAVAAAGGK LQ
Length:292
Mass (Da):31,561
Last modified:March 1, 2002 - v1
Checksum:iFEC44F9990BF9BC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG57996.2.
BA000007 Genomic DNA. Translation: BAB37163.1.
PIRiD91096.
H85941.
RefSeqiNP_289437.2. NC_002655.2.
NP_311767.1. NC_002695.1.

Genome annotation databases

EnsemblBacteriaiAAG57996; AAG57996; Z4206.
BAB37163; BAB37163; BAB37163.
GeneIDi916440.
958358.
KEGGiece:Z4206.
ecs:ECs3740.
PATRICi18356961. VBIEscCol44059_3659.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG57996.2 .
BA000007 Genomic DNA. Translation: BAB37163.1 .
PIRi D91096.
H85941.
RefSeqi NP_289437.2. NC_002655.2.
NP_311767.1. NC_002695.1.

3D structure databases

ProteinModelPortali Q8X6C5.
SMRi Q8X6C5. Positions 1-287.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 155864.Z4206.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG57996 ; AAG57996 ; Z4206 .
BAB37163 ; BAB37163 ; BAB37163 .
GeneIDi 916440.
958358.
KEGGi ece:Z4206.
ecs:ECs3740.
PATRICi 18356961. VBIEscCol44059_3659.

Phylogenomic databases

eggNOGi COG1319.
HOGENOMi HOG000244729.
KOi K13479.
OMAi EICHVAP.
OrthoDBi EOG6ZSP3F.

Enzyme and pathway databases

UniPathwayi UPA00604 ; UER00661 .
UPA00604 ; UER00662 .
BioCyci ECOL386585:GJFA-3707-MONOMER.

Family and domain databases

Gene3Di 3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
InterProi IPR005107. CO_DH_flav_C.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR002346. Mopterin_DH_FAD-bd.
[Graphical view ]
Pfami PF03450. CO_deh_flav_C. 1 hit.
PF00941. FAD_binding_5. 1 hit.
[Graphical view ]
SMARTi SM01092. CO_deh_flav_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55447. SSF55447. 1 hit.
SSF56176. SSF56176. 1 hit.
PROSITEi PS51387. FAD_PCMH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
  2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Entry informationi

Entry nameiXDHB_ECO57
AccessioniPrimary (citable) accession number: Q8X6C5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: March 1, 2002
Last modified: November 26, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3