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Q8X6C5

- XDHB_ECO57

UniProt

Q8X6C5 - XDHB_ECO57

Protein

Xanthine dehydrogenase FAD-binding subunit

Gene

xdhB

Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) By similarity.By similarity

    Catalytic activityi

    Xanthine + NAD+ + H2O = urate + NADH.
    Hypoxanthine + NAD+ + H2O = xanthine + NADH.

    Cofactori

    FAD.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei165 – 1651FAD; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei184 – 1841FADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi27 – 348FADBy similarity
    Nucleotide bindingi109 – 1135FADBy similarity

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: InterPro
    2. UDP-N-acetylmuramate dehydrogenase activity Source: InterPro
    3. xanthine dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. hypoxanthine catabolic process Source: UniProtKB-UniPathway
    2. purine ribonucleoside salvage Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Purine metabolism, Purine salvage

    Keywords - Ligandi

    FAD, Flavoprotein, NAD

    Enzyme and pathway databases

    BioCyciECOL386585:GJFA-3707-MONOMER.
    UniPathwayiUPA00604; UER00661.
    UPA00604; UER00662.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Xanthine dehydrogenase FAD-binding subunit (EC:1.17.1.4)
    Gene namesi
    Name:xdhB
    Ordered Locus Names:Z4206, ECs3740
    OrganismiEscherichia coli O157:H7
    Taxonomic identifieri83334 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 292292Xanthine dehydrogenase FAD-binding subunitPRO_0000166093Add
    BLAST

    Interactioni

    Subunit structurei

    Heterotrimer of XdhA, XdhB and XdhC.Curated

    Protein-protein interaction databases

    STRINGi155864.Z4206.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8X6C5.
    SMRiQ8X6C5. Positions 1-287.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 176176FAD-binding PCMH-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 FAD-binding PCMH-type domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1319.
    HOGENOMiHOG000244729.
    KOiK13479.
    OMAiEICHVAP.
    OrthoDBiEOG6ZSP3F.

    Family and domain databases

    Gene3Di3.30.43.10. 1 hit.
    3.30.465.10. 1 hit.
    InterProiIPR005107. CO_DH_flav_C.
    IPR016169. CO_DH_flavot_FAD-bd_sub2.
    IPR016166. FAD-bd_2.
    IPR016167. FAD-bd_2_sub1.
    IPR002346. Mopterin_DH_FAD-bd.
    [Graphical view]
    PfamiPF03450. CO_deh_flav_C. 1 hit.
    PF00941. FAD_binding_5. 1 hit.
    [Graphical view]
    SMARTiSM01092. CO_deh_flav_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55447. SSF55447. 1 hit.
    SSF56176. SSF56176. 1 hit.
    PROSITEiPS51387. FAD_PCMH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8X6C5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFDFASYHRA ATLADAINLL ADNPQAKLLA GGTDVLIQLH HHNDRYRHIV    50
    DIHNLAELRG ITLAEDGSLR IGSATTFTQL IEDSITQRHL PALCAAASSI 100
    AGPQIRNVAT YGGNICNGAT SADSATPTLI YDAKLEIHSP RGVRFVPING 150
    FHTGPGKVSL EHDEILVAFH FPPQPKEHVG SAHFKYAMRD AMDISTIGCA 200
    AHCRLDNGNF SELRLAFGVA APTPIRCQHA EQTAQNAPLN LQTLEAISES 250
    VLQDVAPRSS WRASKEFRLH LIQTMTKKVI SEAVAAAGGK LQ 292
    Length:292
    Mass (Da):31,561
    Last modified:March 1, 2002 - v1
    Checksum:iFEC44F9990BF9BC1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG57996.2.
    BA000007 Genomic DNA. Translation: BAB37163.1.
    PIRiD91096.
    H85941.
    RefSeqiNP_289437.2. NC_002655.2.
    NP_311767.1. NC_002695.1.

    Genome annotation databases

    EnsemblBacteriaiAAG57996; AAG57996; Z4206.
    BAB37163; BAB37163; BAB37163.
    GeneIDi916440.
    958358.
    KEGGiece:Z4206.
    ecs:ECs3740.
    PATRICi18356961. VBIEscCol44059_3659.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG57996.2 .
    BA000007 Genomic DNA. Translation: BAB37163.1 .
    PIRi D91096.
    H85941.
    RefSeqi NP_289437.2. NC_002655.2.
    NP_311767.1. NC_002695.1.

    3D structure databases

    ProteinModelPortali Q8X6C5.
    SMRi Q8X6C5. Positions 1-287.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 155864.Z4206.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG57996 ; AAG57996 ; Z4206 .
    BAB37163 ; BAB37163 ; BAB37163 .
    GeneIDi 916440.
    958358.
    KEGGi ece:Z4206.
    ecs:ECs3740.
    PATRICi 18356961. VBIEscCol44059_3659.

    Phylogenomic databases

    eggNOGi COG1319.
    HOGENOMi HOG000244729.
    KOi K13479.
    OMAi EICHVAP.
    OrthoDBi EOG6ZSP3F.

    Enzyme and pathway databases

    UniPathwayi UPA00604 ; UER00661 .
    UPA00604 ; UER00662 .
    BioCyci ECOL386585:GJFA-3707-MONOMER.

    Family and domain databases

    Gene3Di 3.30.43.10. 1 hit.
    3.30.465.10. 1 hit.
    InterProi IPR005107. CO_DH_flav_C.
    IPR016169. CO_DH_flavot_FAD-bd_sub2.
    IPR016166. FAD-bd_2.
    IPR016167. FAD-bd_2_sub1.
    IPR002346. Mopterin_DH_FAD-bd.
    [Graphical view ]
    Pfami PF03450. CO_deh_flav_C. 1 hit.
    PF00941. FAD_binding_5. 1 hit.
    [Graphical view ]
    SMARTi SM01092. CO_deh_flav_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55447. SSF55447. 1 hit.
    SSF56176. SSF56176. 1 hit.
    PROSITEi PS51387. FAD_PCMH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
    2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
      Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
      , Kuhara S., Shiba T., Hattori M., Shinagawa H.
      DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

    Entry informationi

    Entry nameiXDHB_ECO57
    AccessioniPrimary (citable) accession number: Q8X6C5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3