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Protein

Superoxide dismutase [Cu-Zn]

Gene

Z3312

Organism
Escherichia coli O157:H7
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Cu cationUniRule annotationNote: Binds 1 copper ion per subunit.UniRule annotation
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

CopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

BioCyciECOO157:Z3312-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Z3312Imported
OrganismiEscherichia coli O157:H7Imported
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000002519 Componenti: Chromosome

PTM / Processingi

Proteomic databases

PRIDEiQ8X6B6.

Interactioni

Protein-protein interaction databases

STRINGi155864.Z3312.

Structurei

3D structure databases

ProteinModelPortaliQ8X6B6.
SMRiQ8X6B6. Positions 178-328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000263449.
OMAiCSPARQT.
OrthoDBiEOG6K13RS.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8X6B6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFADVMVRVT GFAFVTSTPS PVSAPEDSKP SGGVCSCSPA RQTAVTPCIT
60 70 80 90 100
GLPSVSVSGV LFTRILCSPF TGPSIGPSPI ASITLIICVD LRLSFASRGV
110 120 130 140 150
CALPPPLPIM FLSIGIINRS DRILHSYCAI SSERCLLPCN QQAQSVNGIN
160 170 180 190 200
EGFMKCKIIA AIAMLTAASC GYAAEQEVPM NLVSADGKEV SIGKITIQET
210 220 230 240 250
PYGLLFTPAL HSLSEGIHGF HVHEKGNCAP ALKDGKPVAA LSAGGHFDPK
260 270 280 290 300
NTGKHLGPWS PDGHLGDLPA LFVTHDGKAN YPVLAPRLNS LKEIKGRSLM
310 320
LHAGGDNHHD HPEPLGGGGA RMACGIIQ
Length:328
Mass (Da):34,218
Last modified:March 1, 2002 - v1
Checksum:iE9DE6E85C988E5A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG57201.1.
PIRiE85842.
E90877.

Genome annotation databases

EnsemblBacteriaiAAG57201; AAG57201; Z3312.
PATRICi18355278. VBIEscCol44059_2841.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG57201.1.
PIRiE85842.
E90877.

3D structure databases

ProteinModelPortaliQ8X6B6.
SMRiQ8X6B6. Positions 178-328.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi155864.Z3312.

Proteomic databases

PRIDEiQ8X6B6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG57201; AAG57201; Z3312.
PATRICi18355278. VBIEscCol44059_2841.

Phylogenomic databases

HOGENOMiHOG000263449.
OMAiCSPARQT.
OrthoDBiEOG6K13RS.

Enzyme and pathway databases

BioCyciECOO157:Z3312-MONOMER.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHECImported.

Entry informationi

Entry nameiQ8X6B6_ECO57
AccessioniPrimary (citable) accession number: Q8X6B6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: July 22, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.