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Q8X693

- PRPD_ECO57

UniProt

Q8X693 - PRPD_ECO57

Protein

2-methylcitrate dehydratase

Gene

prpD

Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the dehydration of 2-methylcitrate to 2-methyl-cis-aconitate.By similarity

    Catalytic activityi

    (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H2O.

    Cofactori

    Binds 1 2Fe-2S cluster.By similarity

    Pathwayi

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
    2. 2-methylcitrate dehydratase activity Source: UniProtKB-EC
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. propionate catabolic process, 2-methylcitrate cycle Source: InterPro

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    2Fe-2S, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    BioCyciECOL386585:GJFA-381-MONOMER.
    ECOO157:PRPD-MONOMER.
    UniPathwayiUPA00946.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-methylcitrate dehydratase (EC:4.2.1.79)
    Gene namesi
    Name:prpD
    Ordered Locus Names:Z0429, ECs0387
    OrganismiEscherichia coli O157:H7
    Taxonomic identifieri83334 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 4834822-methylcitrate dehydratasePRO_0000215024Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi155864.Z0429.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8X693.
    SMRiQ8X693. Positions 11-483.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PrpD family.Curated

    Phylogenomic databases

    eggNOGiCOG2079.
    HOGENOMiHOG000159916.
    KOiK01720.
    OMAiTAPQWGF.
    OrthoDBiEOG6RC3K5.

    Family and domain databases

    InterProiIPR012705. 2Me_IsoCit_deHydtase_PrpD.
    IPR005656. MmgE_PrpD.
    [Graphical view]
    PANTHERiPTHR16943. PTHR16943. 1 hit.
    PfamiPF03972. MmgE_PrpD. 1 hit.
    [Graphical view]
    SUPFAMiSSF103378. SSF103378. 1 hit.
    TIGRFAMsiTIGR02330. prpD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8X693-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAQINNIRP EFDREIVDIV DYVMNYEISS KVAYDTAHYC LLDTLGCGLE    50
    ALEYPACKKL LGPIVPGTVV PNGVRVPGTQ FQLDPVQAAF NIGAMIRWLD 100
    FNDTWLAAEW GHPSDNLGGI LATADWLSRN AVASGKAPLT MKQVLTGMIK 150
    AHEIQGCIAL ENSFNRVGLD HVLLVKVAST AVVAEMLGLT REEILNAVSL 200
    AWVDGQSLRT YRHAPNTGTR KSWAAGDATS RAVRLALMAK TGEMGYPSAL 250
    TAPVWGFYDV SFKGESFRFQ RPYGSYVMEN VLFKISFPAE FHSQTAVEAA 300
    MTLYEQMQAA GKTAADIEKV SIRTHEACIR IIDKKGPLNN PADRDHCIQY 350
    MVAIPLLFGR LTAADYEDNV AQDKRIDALR EKINCFEDPV FTADYHDPEK 400
    RAIANAITLE FTDGTRFEEV VVEYPIGHAR RRQDGIPKLV DKFKINLARQ 450
    FPTRQQQRIL EVSLDRARLE QMPVNEYLDL YVI 483
    Length:483
    Mass (Da):53,952
    Last modified:January 23, 2007 - v3
    Checksum:i288942C490E56F86
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG54682.1.
    BA000007 Genomic DNA. Translation: BAB33810.1.
    PIRiC90677.
    F85527.
    RefSeqiNP_286074.1. NC_002655.2.
    NP_308414.1. NC_002695.1.

    Genome annotation databases

    EnsemblBacteriaiAAG54682; AAG54682; Z0429.
    BAB33810; BAB33810; BAB33810.
    GeneIDi914489.
    957258.
    KEGGiece:Z0429.
    ecs:ECs0387.
    PATRICi18349721. VBIEscCol44059_0381.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG54682.1 .
    BA000007 Genomic DNA. Translation: BAB33810.1 .
    PIRi C90677.
    F85527.
    RefSeqi NP_286074.1. NC_002655.2.
    NP_308414.1. NC_002695.1.

    3D structure databases

    ProteinModelPortali Q8X693.
    SMRi Q8X693. Positions 11-483.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 155864.Z0429.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG54682 ; AAG54682 ; Z0429 .
    BAB33810 ; BAB33810 ; BAB33810 .
    GeneIDi 914489.
    957258.
    KEGGi ece:Z0429.
    ecs:ECs0387.
    PATRICi 18349721. VBIEscCol44059_0381.

    Phylogenomic databases

    eggNOGi COG2079.
    HOGENOMi HOG000159916.
    KOi K01720.
    OMAi TAPQWGF.
    OrthoDBi EOG6RC3K5.

    Enzyme and pathway databases

    UniPathwayi UPA00946 .
    BioCyci ECOL386585:GJFA-381-MONOMER.
    ECOO157:PRPD-MONOMER.

    Family and domain databases

    InterProi IPR012705. 2Me_IsoCit_deHydtase_PrpD.
    IPR005656. MmgE_PrpD.
    [Graphical view ]
    PANTHERi PTHR16943. PTHR16943. 1 hit.
    Pfami PF03972. MmgE_PrpD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103378. SSF103378. 1 hit.
    TIGRFAMsi TIGR02330. prpD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
    2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
      Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
      , Kuhara S., Shiba T., Hattori M., Shinagawa H.
      DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

    Entry informationi

    Entry nameiPRPD_ECO57
    AccessioniPrimary (citable) accession number: Q8X693
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2002
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 75 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3