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Q8X5L9

- GUN_ECO57

UniProt

Q8X5L9 - GUN_ECO57

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Protein

Endoglucanase

Gene
bcsZ, Z4946, ECs4411
Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Hydrolyzes carboxymethylcellulose By similarity.

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei55 – 551Proton donor By similarity
Active sitei116 – 1161Nucleophile Reviewed prediction

GO - Molecular functioni

  1. cellulase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

BioCyciECOL386585:GJFA-4378-MONOMER.
UniPathwayiUPA00694.

Protein family/group databases

CAZyiGH8. Glycoside Hydrolase Family 8.

Names & Taxonomyi

Protein namesi
Recommended name:
Endoglucanase (EC:3.2.1.4)
Alternative name(s):
Carboxymethylcellulase
Short name:
CMCase
Cellulase
Endo-1,4-beta-glucanase
Gene namesi
Name:bcsZ
Ordered Locus Names:Z4946, ECs4411
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Chaini22 – 368347EndoglucanasePRO_0000007939Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi155864.Z4946.

Structurei

3D structure databases

ProteinModelPortaliQ8X5L9.
SMRiQ8X5L9. Positions 26-347.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3405.
HOGENOMiHOG000259088.
KOiK01179.
OMAiDLWIAYT.
OrthoDBiEOG6DG2PM.

Family and domain databases

Gene3Di1.50.10.10. 1 hit.
InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR012341. 6hp_glycosidase.
IPR002037. Glyco_hydro_8.
IPR019834. Glyco_hydro_8_CS.
[Graphical view]
PfamiPF01270. Glyco_hydro_8. 1 hit.
[Graphical view]
PRINTSiPR00735. GLHYDRLASE8.
SUPFAMiSSF48208. SSF48208. 1 hit.
PROSITEiPS00812. GLYCOSYL_HYDROL_F8. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8X5L9-1 [UniParc]FASTAAdd to Basket

« Hide

MNVLRSGLVT MLLLAAFSVQ AACTWPAWEQ FKKDYISQEG RVIDPSDARK    50
ITTSEGQSYG MFFALAANDR AAFDNILDWT QNNLAQGSLK ERLPAWLWGK 100
KENSKWEVLD SNSASDGDVW MAWSLLEAGR LWKEQRYTDI GSALLKRIAR 150
EEVVTVPGLG SMLLPGKVGF AEDNSWRFNP SYLPPTLAQY FTRFGAPWTT 200
LRETNQRLLL ETAPKGFSPD WVRYEKDKGW QLKAEKTLIS SYDAIRVYMW 250
VGMMPDSDPQ KARMLNRFKP MATFTEKNGY PPEKVDVATG KAQGKGPVGF 300
SAAMLPFLQN RDAQAVQRQR VADNFPGSDA YYNYVLTLFG QGWDQHRFRF 350
STKGELLPDW GQECANSH 368
Length:368
Mass (Da):41,760
Last modified:March 1, 2002 - v1
Checksum:iECFD4234AD5113D2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG58673.1.
BA000007 Genomic DNA. Translation: BAB37834.1.
PIRiC91180.
E86026.
RefSeqiNP_290111.1. NC_002655.2.
NP_312438.1. NC_002695.1.

Genome annotation databases

EnsemblBacteriaiAAG58673; AAG58673; Z4946.
BAB37834; BAB37834; BAB37834.
GeneIDi915724.
961090.
KEGGiece:Z4946.
ecs:ECs4411.
PATRICi18358405. VBIEscCol44059_4369.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG58673.1 .
BA000007 Genomic DNA. Translation: BAB37834.1 .
PIRi C91180.
E86026.
RefSeqi NP_290111.1. NC_002655.2.
NP_312438.1. NC_002695.1.

3D structure databases

ProteinModelPortali Q8X5L9.
SMRi Q8X5L9. Positions 26-347.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 155864.Z4946.

Protein family/group databases

CAZyi GH8. Glycoside Hydrolase Family 8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG58673 ; AAG58673 ; Z4946 .
BAB37834 ; BAB37834 ; BAB37834 .
GeneIDi 915724.
961090.
KEGGi ece:Z4946.
ecs:ECs4411.
PATRICi 18358405. VBIEscCol44059_4369.

Phylogenomic databases

eggNOGi COG3405.
HOGENOMi HOG000259088.
KOi K01179.
OMAi DLWIAYT.
OrthoDBi EOG6DG2PM.

Enzyme and pathway databases

UniPathwayi UPA00694 .
BioCyci ECOL386585:GJFA-4378-MONOMER.

Family and domain databases

Gene3Di 1.50.10.10. 1 hit.
InterProi IPR008928. 6-hairpin_glycosidase-like.
IPR012341. 6hp_glycosidase.
IPR002037. Glyco_hydro_8.
IPR019834. Glyco_hydro_8_CS.
[Graphical view ]
Pfami PF01270. Glyco_hydro_8. 1 hit.
[Graphical view ]
PRINTSi PR00735. GLHYDRLASE8.
SUPFAMi SSF48208. SSF48208. 1 hit.
PROSITEi PS00812. GLYCOSYL_HYDROL_F8. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
  2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Entry informationi

Entry nameiGUN_ECO57
AccessioniPrimary (citable) accession number: Q8X5L9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: March 1, 2002
Last modified: May 14, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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