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Q8X5L9

- GUN_ECO57

UniProt

Q8X5L9 - GUN_ECO57

Protein

Endoglucanase

Gene

bcsZ

Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Hydrolyzes carboxymethylcellulose.By similarity

    Catalytic activityi

    Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei55 – 551Proton donorBy similarity
    Active sitei116 – 1161NucleophilePROSITE-ProRule annotation

    GO - Molecular functioni

    1. cellulase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellulose catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

    Enzyme and pathway databases

    BioCyciECOL386585:GJFA-4378-MONOMER.
    UniPathwayiUPA00694.

    Protein family/group databases

    CAZyiGH8. Glycoside Hydrolase Family 8.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endoglucanase (EC:3.2.1.4)
    Alternative name(s):
    Carboxymethylcellulase
    Short name:
    CMCase
    Cellulase
    Endo-1,4-beta-glucanase
    Gene namesi
    Name:bcsZ
    Ordered Locus Names:Z4946, ECs4411
    OrganismiEscherichia coli O157:H7
    Taxonomic identifieri83334 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 368347EndoglucanasePRO_0000007939Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi155864.Z4946.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8X5L9.
    SMRiQ8X5L9. Positions 26-347.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3405.
    HOGENOMiHOG000259088.
    KOiK01179.
    OMAiDLWIAYT.
    OrthoDBiEOG6DG2PM.

    Family and domain databases

    Gene3Di1.50.10.10. 1 hit.
    InterProiIPR008928. 6-hairpin_glycosidase-like.
    IPR012341. 6hp_glycosidase.
    IPR002037. Glyco_hydro_8.
    IPR019834. Glyco_hydro_8_CS.
    [Graphical view]
    PfamiPF01270. Glyco_hydro_8. 1 hit.
    [Graphical view]
    PRINTSiPR00735. GLHYDRLASE8.
    SUPFAMiSSF48208. SSF48208. 1 hit.
    PROSITEiPS00812. GLYCOSYL_HYDROL_F8. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8X5L9-1 [UniParc]FASTAAdd to Basket

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    MNVLRSGLVT MLLLAAFSVQ AACTWPAWEQ FKKDYISQEG RVIDPSDARK    50
    ITTSEGQSYG MFFALAANDR AAFDNILDWT QNNLAQGSLK ERLPAWLWGK 100
    KENSKWEVLD SNSASDGDVW MAWSLLEAGR LWKEQRYTDI GSALLKRIAR 150
    EEVVTVPGLG SMLLPGKVGF AEDNSWRFNP SYLPPTLAQY FTRFGAPWTT 200
    LRETNQRLLL ETAPKGFSPD WVRYEKDKGW QLKAEKTLIS SYDAIRVYMW 250
    VGMMPDSDPQ KARMLNRFKP MATFTEKNGY PPEKVDVATG KAQGKGPVGF 300
    SAAMLPFLQN RDAQAVQRQR VADNFPGSDA YYNYVLTLFG QGWDQHRFRF 350
    STKGELLPDW GQECANSH 368
    Length:368
    Mass (Da):41,760
    Last modified:March 1, 2002 - v1
    Checksum:iECFD4234AD5113D2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG58673.1.
    BA000007 Genomic DNA. Translation: BAB37834.1.
    PIRiC91180.
    E86026.
    RefSeqiNP_290111.1. NC_002655.2.
    NP_312438.1. NC_002695.1.

    Genome annotation databases

    EnsemblBacteriaiAAG58673; AAG58673; Z4946.
    BAB37834; BAB37834; BAB37834.
    GeneIDi915724.
    961090.
    KEGGiece:Z4946.
    ecs:ECs4411.
    PATRICi18358405. VBIEscCol44059_4369.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG58673.1 .
    BA000007 Genomic DNA. Translation: BAB37834.1 .
    PIRi C91180.
    E86026.
    RefSeqi NP_290111.1. NC_002655.2.
    NP_312438.1. NC_002695.1.

    3D structure databases

    ProteinModelPortali Q8X5L9.
    SMRi Q8X5L9. Positions 26-347.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 155864.Z4946.

    Protein family/group databases

    CAZyi GH8. Glycoside Hydrolase Family 8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG58673 ; AAG58673 ; Z4946 .
    BAB37834 ; BAB37834 ; BAB37834 .
    GeneIDi 915724.
    961090.
    KEGGi ece:Z4946.
    ecs:ECs4411.
    PATRICi 18358405. VBIEscCol44059_4369.

    Phylogenomic databases

    eggNOGi COG3405.
    HOGENOMi HOG000259088.
    KOi K01179.
    OMAi DLWIAYT.
    OrthoDBi EOG6DG2PM.

    Enzyme and pathway databases

    UniPathwayi UPA00694 .
    BioCyci ECOL386585:GJFA-4378-MONOMER.

    Family and domain databases

    Gene3Di 1.50.10.10. 1 hit.
    InterProi IPR008928. 6-hairpin_glycosidase-like.
    IPR012341. 6hp_glycosidase.
    IPR002037. Glyco_hydro_8.
    IPR019834. Glyco_hydro_8_CS.
    [Graphical view ]
    Pfami PF01270. Glyco_hydro_8. 1 hit.
    [Graphical view ]
    PRINTSi PR00735. GLHYDRLASE8.
    SUPFAMi SSF48208. SSF48208. 1 hit.
    PROSITEi PS00812. GLYCOSYL_HYDROL_F8. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
    2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
      Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
      , Kuhara S., Shiba T., Hattori M., Shinagawa H.
      DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

    Entry informationi

    Entry nameiGUN_ECO57
    AccessioniPrimary (citable) accession number: Q8X5L9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 26, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3