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Protein

Endoglucanase

Gene

bcsZ

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Hydrolyzes carboxymethylcellulose.By similarity

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Pathwayi: bacterial cellulose biosynthesis

This protein is involved in the pathway bacterial cellulose biosynthesis, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway bacterial cellulose biosynthesis and in Glycan metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei55Proton donorBy similarity1
Active sitei116NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00694

Protein family/group databases

CAZyiGH8 Glycoside Hydrolase Family 8

Names & Taxonomyi

Protein namesi
Recommended name:
Endoglucanase (EC:3.2.1.4)
Alternative name(s):
Carboxymethylcellulase
Short name:
CMCase
Cellulase
Endo-1,4-beta-glucanase
Gene namesi
Name:bcsZ
Ordered Locus Names:Z4946, ECs4411
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000000793922 – 368EndoglucanaseAdd BLAST347

Interactioni

Protein-protein interaction databases

STRINGi155864.Z4946

Structurei

3D structure databases

ProteinModelPortaliQ8X5L9
SMRiQ8X5L9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105K2Z Bacteria
COG3405 LUCA
HOGENOMiHOG000259088
KOiK20542
OMAiIRVYLWV

Family and domain databases

Gene3Di1.50.10.10, 1 hit
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR002037 Glyco_hydro_8
IPR019834 Glyco_hydro_8_CS
PfamiView protein in Pfam
PF01270 Glyco_hydro_8, 1 hit
PRINTSiPR00735 GLHYDRLASE8
SUPFAMiSSF48208 SSF48208, 1 hit
PROSITEiView protein in PROSITE
PS00812 GLYCOSYL_HYDROL_F8, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8X5L9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVLRSGLVT MLLLAAFSVQ AACTWPAWEQ FKKDYISQEG RVIDPSDARK
60 70 80 90 100
ITTSEGQSYG MFFALAANDR AAFDNILDWT QNNLAQGSLK ERLPAWLWGK
110 120 130 140 150
KENSKWEVLD SNSASDGDVW MAWSLLEAGR LWKEQRYTDI GSALLKRIAR
160 170 180 190 200
EEVVTVPGLG SMLLPGKVGF AEDNSWRFNP SYLPPTLAQY FTRFGAPWTT
210 220 230 240 250
LRETNQRLLL ETAPKGFSPD WVRYEKDKGW QLKAEKTLIS SYDAIRVYMW
260 270 280 290 300
VGMMPDSDPQ KARMLNRFKP MATFTEKNGY PPEKVDVATG KAQGKGPVGF
310 320 330 340 350
SAAMLPFLQN RDAQAVQRQR VADNFPGSDA YYNYVLTLFG QGWDQHRFRF
360
STKGELLPDW GQECANSH
Length:368
Mass (Da):41,760
Last modified:March 1, 2002 - v1
Checksum:iECFD4234AD5113D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG58673.1
BA000007 Genomic DNA Translation: BAB37834.1
PIRiC91180
E86026
RefSeqiNP_312438.1, NC_002695.1
WP_001302749.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG58673; AAG58673; Z4946
BAB37834; BAB37834; BAB37834
GeneIDi915724
KEGGiece:Z4946
ecs:ECs4411
PATRICifig|386585.9.peg.4612

Similar proteinsi

Entry informationi

Entry nameiGUN_ECO57
AccessioniPrimary (citable) accession number: Q8X5L9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: March 1, 2002
Last modified: April 25, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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