Q8X5J9 (ACDH_ECO57) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 70.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Acetaldehyde dehydrogenase EC=1.2.1.10 Alternative name(s): Acetaldehyde dehydrogenase [acetylating] | ||||
| Gene names |
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| Organism | Escherichia coli O157:H7 [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 83334 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia |
Protein attributes
| Sequence length | 316 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP MF_01657 |
| Catalytic activity | Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP MF_01657 |
| Pathway | Aromatic compound metabolism; 3-phenylpropanoate degradation. HAMAP MF_01657 |
| Subunit structure | Interacts with MhpE By similarity. HAMAP MF_01657 |
| Sequence similarities | Belongs to the acetaldehyde dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Aromatic hydrocarbons catabolism |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | aromatic compound catabolic process Inferred from electronic annotation. Source: UniProtKB-KW cellular amino acid metabolic processInferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: InterPro |
| Molecular function | NAD binding Inferred from electronic annotation. Source: InterPro acetaldehyde dehydrogenase (acetylating) activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 316 | 316 | Acetaldehyde dehydrogenase HAMAP MF_01657 | PRO_0000337980 | |||||
Regions | |||||||||
| Nucleotide binding | 11 – 14 | 4 | NAD By similarity | ||||||
| Nucleotide binding | 162 – 170 | 9 | NAD By similarity | ||||||
Sites | |||||||||
| Binding site | 289 | 1 | NAD By similarity | ||||||
Sequences
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References
| [1] | "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7." Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J., Davis N.W. Blattner F.R.Nature 409:529-533(2001) [PubMed: 11206551] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC. |
| [2] | "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12." Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T. Shinagawa H.DNA Res. 8:11-22(2001) [PubMed: 11258796] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE005174 Genomic DNA. Translation: AAG54702.1. BA000007 Genomic DNA. Translation: BAB33829.1. |
| PIR | B85530. F90679. |
| RefSeq | NP_286094.1. NC_002655.2. NP_308433.1. NC_002695.1. |
3D structure databases | |
| ProteinModelPortal | Q8X5J9. |
| SMR | Q8X5J9. Positions 3-308. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBESCT00000027905; EBESCP00000026798; EBESCG00000026957. EBESCT00000057207; EBESCP00000055035; EBESCG00000056255. |
| GeneID | 914508. 957291. |
| GenomeReviews | Gene locus Z0450 in contig AE005174_GR. Gene locus ECs0406 in contig BA000007_GR. |
| KEGG | ece:Z0450. ecs:ECs0406. |
| PATRIC | 18349759. VBIEscCol44059_0400. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| GeneTree | EBGT00050000011515. |
| HOGENOM | HBG300125. |
| OMA | HVKNDAF. |
| ProtClustDB | PRK08300. |
Enzyme and pathway databases | |
| BioCyc | ECOL83334:ECS0406-MONOMER. |
Family and domain databases | |
| HAMAP | MF_01657. Ac_ald_DH_ac. [Tree] |
| InterPro | IPR003361. Acetaldehyde_dehydrogenase. IPR015426. Acetylaldehyde_DH_C. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| KO | K04073. |
| PANTHER | PTHR21123. Acetylald_dh. 1 hit. |
| Pfam | PF09290. AcetDehyd-dimer. 1 hit. PF01118. Semialdhyde_dh. 1 hit. [Graphical view] |
| PIRSF | PIRSF015689. Actaldh_dh_actl. 1 hit. |
| SMART | SM00859. Semialdhyde_dh. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR03215. Ac_ald_DH_ac. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | ACDH_ECO57 | ||||||||
| Accession | Primary (citable) accession number: Q8X5J9 Secondary accession number(s): Q7AH50 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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