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Protein

Vitamin B12 import system permease protein BtuC

Gene

btuC

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Vitamin B12 import system permease protein BtuC
Gene namesi
Name:btuC
Ordered Locus Names:Z2740, ECs2418
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicBy similarity10
Transmembranei11 – 35Helical; Name=1By similarityAdd BLAST25
Topological domaini36 – 56PeriplasmicBy similarityAdd BLAST21
Transmembranei57 – 81Helical; Name=2By similarityAdd BLAST25
Topological domaini82 – 92CytoplasmicBy similarityAdd BLAST11
Transmembranei93 – 107Helical; Name=3By similarityAdd BLAST15
Topological domaini108 – 113PeriplasmicBy similarity6
Transmembranei114 – 138Helical; Name=4By similarityAdd BLAST25
Topological domaini139 – 141CytoplasmicBy similarity3
Transmembranei142 – 166Helical; Name=5By similarityAdd BLAST25
Topological domaini167 – 190PeriplasmicBy similarityAdd BLAST24
Transmembranei191 – 206Helical; Name=6By similarityAdd BLAST16
Topological domaini207 – 228CytoplasmicBy similarityAdd BLAST22
Transmembranei229 – 249Helical; Name=7By similarityAdd BLAST21
Topological domaini250 – 257PeriplasmicBy similarity8
Transmembranei258 – 267Helical; Name=8By similarity10
Topological domaini268 – 274CytoplasmicBy similarity7
Transmembranei275 – 296Helical; Name=9By similarityAdd BLAST22
Topological domaini297 – 304PeriplasmicBy similarity8
Transmembranei305 – 324Helical; Name=10By similarityAdd BLAST20
Topological domaini325 – 326CytoplasmicBy similarity2

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000599701 – 326Vitamin B12 import system permease protein BtuCAdd BLAST326

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (BtuD), two transmembrane proteins (BtuC) and a solute-binding protein (BtuF).By similarity

Protein-protein interaction databases

STRINGi155864.Z2740.

Structurei

3D structure databases

ProteinModelPortaliQ8X4L7.
SMRiQ8X4L7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108ESU. Bacteria.
COG4139. LUCA.
HOGENOMiHOG000045407.
KOiK06073.
OMAiHSINESA.

Family and domain databases

Gene3Di1.10.3470.10. 1 hit.
HAMAPiMF_01004. BtuC. 1 hit.
InterProiView protein in InterPro
IPR029022. ABC_BtuC-like.
IPR023691. ABC_transptr_BtuC.
IPR000522. ABC_transptr_FecCD.
PANTHERiPTHR30472. PTHR30472. 1 hit.
PfamiView protein in Pfam
PF01032. FecCD. 1 hit.
SUPFAMiSSF81345. SSF81345. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8X4L7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTLARQQQR QNIRWLLCLS VLMLLALLLS LCAGEQWISP GDWFSPRGEL
60 70 80 90 100
FVWQIRLPRT LAVLLVGAAL AISGAVMQAL FENPLAEPGL LGVSNGAGVG
110 120 130 140 150
LIAAVLLGQG QLPNWALGLC AIAGALIITL ILLRFARRHL STSRLLLAGV
160 170 180 190 200
ALGIICSALM TWAIYFSTSV DLRQLMYWMM GGFGGVDWRQ SWLMLALIPM
210 220 230 240 250
LLWICCQSRP MNMLALGEIS ARQLGLPLWF WRNVLVAATG WMVGVSVALA
260 270 280 290 300
GAIGFIGLVI PHILRLCGLT DHRALLPGCA LAGASALLLA DIVARLALAA
310 320
AELPIGVVTA TLGAPVFIWL LLKAGR
Length:326
Mass (Da):34,939
Last modified:March 5, 2002 - v1
Checksum:iBE09441DA21566C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG56698.1.
BA000007 Genomic DNA. Translation: BAB35841.1.
PIRiB90931.
F85779.
RefSeqiNP_310445.1. NC_002695.1.
WP_000956513.1. NZ_LPWC02000002.1.

Genome annotation databases

EnsemblBacteriaiAAG56698; AAG56698; Z2740.
BAB35841; BAB35841; BAB35841.
GeneIDi912333.
KEGGiece:Z2740.
ecs:ECs2418.
PATRICi18354180. VBIEscCol44059_2301.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG56698.1.
BA000007 Genomic DNA. Translation: BAB35841.1.
PIRiB90931.
F85779.
RefSeqiNP_310445.1. NC_002695.1.
WP_000956513.1. NZ_LPWC02000002.1.

3D structure databases

ProteinModelPortaliQ8X4L7.
SMRiQ8X4L7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi155864.Z2740.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG56698; AAG56698; Z2740.
BAB35841; BAB35841; BAB35841.
GeneIDi912333.
KEGGiece:Z2740.
ecs:ECs2418.
PATRICi18354180. VBIEscCol44059_2301.

Phylogenomic databases

eggNOGiENOG4108ESU. Bacteria.
COG4139. LUCA.
HOGENOMiHOG000045407.
KOiK06073.
OMAiHSINESA.

Family and domain databases

Gene3Di1.10.3470.10. 1 hit.
HAMAPiMF_01004. BtuC. 1 hit.
InterProiView protein in InterPro
IPR029022. ABC_BtuC-like.
IPR023691. ABC_transptr_BtuC.
IPR000522. ABC_transptr_FecCD.
PANTHERiPTHR30472. PTHR30472. 1 hit.
PfamiView protein in Pfam
PF01032. FecCD. 1 hit.
SUPFAMiSSF81345. SSF81345. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBTUC_ECO57
AccessioniPrimary (citable) accession number: Q8X4L7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: March 5, 2002
Last modified: February 15, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.