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Protein

dCTP deaminase

Gene

dcd

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the deamination of dCTP to dUTP.UniRule annotation

Catalytic activityi

dCTP + H2O = dUTP + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP (dUTP route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. dCTP deaminase (dcd)
  2. no protein annotated in this organism
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei95dCTPUniRule annotation1
Binding sitei124dCTPUniRule annotation1
Binding sitei138dCTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi79 – 84dCTP bindingUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandNucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00610; UER00665

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP deaminaseUniRule annotation (EC:3.5.4.13UniRule annotation)
Alternative name(s):
Deoxycytidine triphosphate deaminaseUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Ordered Locus Names:PF1996
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001560361 – 156dCTP deaminaseAdd BLAST156

Proteomic databases

PRIDEiQ8X251

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi186497.PF1996

Structurei

3D structure databases

ProteinModelPortaliQ8X251
SMRiQ8X251
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04048 Archaea
COG0717 LUCA
HOGENOMiHOG000228601
KOiK01494
OMAiRTSWIRK
OrthoDBiPOG093Z0C6C

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
HAMAPiMF_00146 dCTP_deaminase, 1 hit
InterProiView protein in InterPro
IPR011962 dCTP_deaminase
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR033704 dUTPase_trimeric
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit
TIGRFAMsiTIGR02274 dCTP_deam, 1 hit

Sequencei

Sequence statusi: Complete.

Q8X251-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLPDWKIRK EILIEPFSEE SLQPAGYDLR VGREAFVKGK LIDVEKEGKV
60 70 80 90 100
VIPPREYALI LTLERIKLPD DVMGDMKIRS SLAREGVIGS FAWVDPGWDG
110 120 130 140 150
NLTLMLYNAS NEPVELRYGE RFVQIAFIRL EGPARNPYRG NYQGSTRLAF

SKRKKL
Length:156
Mass (Da):17,869
Last modified:March 1, 2002 - v1
Checksum:i00D57A5A0207B451
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY066005 Genomic DNA Translation: AAL47572.1
AE009950 Genomic DNA Translation: AAL82120.1
RefSeqiWP_011013140.1, NC_003413.1

Genome annotation databases

EnsemblBacteriaiAAL82120; AAL82120; PF1996
GeneIDi1469880
KEGGipfu:PF1996
PATRICifig|186497.12.peg.2072

Similar proteinsi

Entry informationi

Entry nameiDCD_PYRFU
AccessioniPrimary (citable) accession number: Q8X251
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: March 1, 2002
Last modified: April 25, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health