Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8X251

- DCD_PYRFU

UniProt

Q8X251 - DCD_PYRFU

Protein

Probable deoxycytidine triphosphate deaminase

Gene

dcd

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    dCTP + H2O = dUTP + NH3.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. dCTP deaminase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dUMP biosynthetic process Source: UniProtKB-UniPathway
    2. dUTP biosynthetic process Source: InterPro
    3. pyrimidine ribonucleotide biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00610; UER00665.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable deoxycytidine triphosphate deaminaseUniRule annotation (EC:3.5.4.13UniRule annotation)
    Short name:
    dCTP deaminaseUniRule annotation
    Gene namesi
    Name:dcdUniRule annotation
    Ordered Locus Names:PF1996
    OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
    Taxonomic identifieri186497 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000001013: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 156156Probable deoxycytidine triphosphate deaminasePRO_0000156036Add
    BLAST

    Proteomic databases

    PRIDEiQ8X251.

    Interactioni

    Protein-protein interaction databases

    STRINGi186497.PF1996.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8X251.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the dCTP deaminase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0717.
    HOGENOMiHOG000228601.
    KOiK01494.
    OMAiGSFAWVD.

    Family and domain databases

    Gene3Di2.70.40.10. 1 hit.
    HAMAPiMF_00146. dCTP_deaminase.
    InterProiIPR011962. dCTP_deam.
    IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    [Graphical view]
    PfamiPF00692. dUTPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 1 hit.
    TIGRFAMsiTIGR02274. dCTP_deam. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8X251-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLPDWKIRK EILIEPFSEE SLQPAGYDLR VGREAFVKGK LIDVEKEGKV    50
    VIPPREYALI LTLERIKLPD DVMGDMKIRS SLAREGVIGS FAWVDPGWDG 100
    NLTLMLYNAS NEPVELRYGE RFVQIAFIRL EGPARNPYRG NYQGSTRLAF 150
    SKRKKL 156
    Length:156
    Mass (Da):17,869
    Last modified:March 1, 2002 - v1
    Checksum:i00D57A5A0207B451
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY066005 Genomic DNA. Translation: AAL47572.1.
    AE009950 Genomic DNA. Translation: AAL82120.1.
    RefSeqiNP_579725.1. NC_003413.1.
    WP_011013140.1. NC_003413.1.

    Genome annotation databases

    EnsemblBacteriaiAAL82120; AAL82120; PF1996.
    GeneIDi1469880.
    KEGGipfu:PF1996.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY066005 Genomic DNA. Translation: AAL47572.1 .
    AE009950 Genomic DNA. Translation: AAL82120.1 .
    RefSeqi NP_579725.1. NC_003413.1.
    WP_011013140.1. NC_003413.1.

    3D structure databases

    ProteinModelPortali Q8X251.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 186497.PF1996.

    Proteomic databases

    PRIDEi Q8X251.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL82120 ; AAL82120 ; PF1996 .
    GeneIDi 1469880.
    KEGGi pfu:PF1996.

    Phylogenomic databases

    eggNOGi COG0717.
    HOGENOMi HOG000228601.
    KOi K01494.
    OMAi GSFAWVD.

    Enzyme and pathway databases

    UniPathwayi UPA00610 ; UER00665 .

    Family and domain databases

    Gene3Di 2.70.40.10. 1 hit.
    HAMAPi MF_00146. dCTP_deaminase.
    InterProi IPR011962. dCTP_deam.
    IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    [Graphical view ]
    Pfami PF00692. dUTPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 1 hit.
    TIGRFAMsi TIGR02274. dCTP_deam. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Archaeal dUTPase enhances PCR amplifications with archaeal DNA polymerases by preventing dUTP incorporation."
      Hogrefe H.H., Hansen C.J., Scott B.R., Nielson K.B.
      Proc. Natl. Acad. Sci. U.S.A. 99:596-601(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
      Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
      Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.

    Entry informationi

    Entry nameiDCD_PYRFU
    AccessioniPrimary (citable) accession number: Q8X251
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3