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Q8X178 (PP2A2_BLUGH) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

EC=3.1.3.16
Gene names
Name:PP2A-2
OrganismBlumeria graminis f. sp. hordei (Barley powdery mildew) (Oidium monilioides f. sp. hordei)
Taxonomic identifier62688 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesErysiphalesErysiphaceaeBlumeria

Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 manganese ions per subunit By similarity.

Sequence similarities

Belongs to the PPP phosphatase family. PP-2A subfamily.

Ontologies

Keywords
   LigandManganese
Metal-binding
   Molecular functionHydrolase
Protein phosphatase
   PTMMethylation
Gene Ontology (GO)
   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoprotein phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 328328Serine/threonine-protein phosphatase PP2A-2 catalytic subunit
PRO_0000058869

Sites

Active site1371Proton donor By similarity
Metal binding761Manganese 1 By similarity
Metal binding781Manganese 1 By similarity
Metal binding1041Manganese 1 By similarity
Metal binding1041Manganese 2 By similarity
Metal binding1361Manganese 2 By similarity
Metal binding1861Manganese 2 By similarity
Metal binding2601Manganese 2 By similarity

Amino acid modifications

Modified residue3281Leucine methyl ester By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8X178 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: C5339E5D238618AE

FASTA32837,486
        10         20         30         40         50         60 
MDTKMEDVGK TPEPIRFQTT TEPASISTLD GWIENLMACK QLPEVDVLRL CEKAREVLHS 

        70         80         90        100        110        120 
ESNVQPVKCP VTVCGDIHGQ FHDLMELFRI GGPNPDTNYL FMGDYVDRGY YSVETVTLLV 

       130        140        150        160        170        180 
ALKIRYPQRI TILRGNHESR QITQVYGFYD ECLRKYGNAN VWKYFTNLFD FLPLTALIEN 

       190        200        210        220        230        240 
QIFCLHGGLS PSIDTLDNIK SLDRIQEVPH EGPMCDLLWS DPDDRCGWGI SPRGAGYTFG 

       250        260        270        280        290        300 
QDISEAFNHN NGLTLVARAH QLVMEGYNWS QDRNVVTIFS APNYCYRCGN QAAIMEIDEH 

       310        320 
LKYTFLQFDP CPRAGEPMVT RRTPDYFL 

« Hide

References

[1]Zhang Z., Scott P., Gurr S.J.
Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF462042 Genomic DNA. Translation: AAL69898.1.

3D structure databases

ProteinModelPortalQ8X178.
SMRQ8X178. Positions 29-328.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ8X178.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.60.21.10. 1 hit.
InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSPR00114. STPHPHTASE.
SMARTSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMSSF56300. SSF56300. 1 hit.
PROSITEPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePP2A2_BLUGH
AccessionPrimary (citable) accession number: Q8X178
Entry history
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: March 1, 2002
Last modified: June 11, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families