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Q8X178

- PP2A2_BLUGH

UniProt

Q8X178 - PP2A2_BLUGH

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Protein

Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

Gene

PP2A-2

Organism
Blumeria graminis f. sp. hordei (Barley powdery mildew) (Oidium monilioides f. sp. hordei)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi76 – 761Manganese 1By similarity
Metal bindingi78 – 781Manganese 1By similarity
Metal bindingi104 – 1041Manganese 1By similarity
Metal bindingi104 – 1041Manganese 2By similarity
Metal bindingi136 – 1361Manganese 2By similarity
Active sitei137 – 1371Proton donorBy similarity
Metal bindingi186 – 1861Manganese 2By similarity
Metal bindingi260 – 2601Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit (EC:3.1.3.16)
Gene namesi
Name:PP2A-2
OrganismiBlumeria graminis f. sp. hordei (Barley powdery mildew) (Oidium monilioides f. sp. hordei)
Taxonomic identifieri62688 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesErysiphalesErysiphaceaeBlumeria

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Serine/threonine-protein phosphatase PP2A-2 catalytic subunitPRO_0000058869Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei328 – 3281Leucine methyl esterBy similarity

Keywords - PTMi

Methylation

Proteomic databases

PRIDEiQ8X178.

Structurei

3D structure databases

ProteinModelPortaliQ8X178.
SMRiQ8X178. Positions 29-328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8X178-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDTKMEDVGK TPEPIRFQTT TEPASISTLD GWIENLMACK QLPEVDVLRL
60 70 80 90 100
CEKAREVLHS ESNVQPVKCP VTVCGDIHGQ FHDLMELFRI GGPNPDTNYL
110 120 130 140 150
FMGDYVDRGY YSVETVTLLV ALKIRYPQRI TILRGNHESR QITQVYGFYD
160 170 180 190 200
ECLRKYGNAN VWKYFTNLFD FLPLTALIEN QIFCLHGGLS PSIDTLDNIK
210 220 230 240 250
SLDRIQEVPH EGPMCDLLWS DPDDRCGWGI SPRGAGYTFG QDISEAFNHN
260 270 280 290 300
NGLTLVARAH QLVMEGYNWS QDRNVVTIFS APNYCYRCGN QAAIMEIDEH
310 320
LKYTFLQFDP CPRAGEPMVT RRTPDYFL
Length:328
Mass (Da):37,486
Last modified:March 1, 2002 - v1
Checksum:iC5339E5D238618AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF462042 Genomic DNA. Translation: AAL69898.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF462042 Genomic DNA. Translation: AAL69898.1 .

3D structure databases

ProteinModelPortali Q8X178.
SMRi Q8X178. Positions 29-328.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q8X178.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Zhang Z., Scott P., Gurr S.J.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiPP2A2_BLUGH
AccessioniPrimary (citable) accession number: Q8X178
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: March 1, 2002
Last modified: November 26, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3