Q8X178 (PP2A2_ERYGR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit
EC=3.1.3.16

Gene names

Name:

PP2A-2

Organism

Erysiphe graminis subsp. hordei (Grass mildew) (Blumeria graminis subsp. hordei)

Taxonomic identifier

62688 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › sordariomyceta › Leotiomycetes › Erysiphales › Erysiphaceae › Blumeria › Blumeria graminis

Protein attributes

Sequence length	328 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Cofactor	Binds 1 iron ion per subunit By similarity. Binds 1 manganese ion per subunit By similarity.
Sequence similarities	Belongs to the PPP phosphatase family. PP-2A subfamily.

Ontologies

Keywords
Ligand	Iron Manganese Metal-binding
Molecular function	Hydrolase Protein phosphatase
PTM	Methylation
Gene Ontology (GO)
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoprotein phosphatase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 328	328	Serine/threonine-protein phosphatase PP2A-2 catalytic subunit		PRO_0000058869
Sites
	Active site	137	1	Proton donor By similarity
	Metal binding	76	1	Iron By similarity
	Metal binding	78	1	Iron By similarity
	Metal binding	104	1	Iron By similarity
	Metal binding	104	1	Manganese By similarity
	Metal binding	136	1	Manganese By similarity
	Metal binding	186	1	Manganese By similarity
	Metal binding	260	1	Manganese By similarity
Amino acid modifications
	Modified residue	328	1	Leucine methyl ester By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8X178 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: C5339E5D238618AE	FASTA	328	37,486
	10 20 30 40 50 60 MDTKMEDVGK TPEPIRFQTT TEPASISTLD GWIENLMACK QLPEVDVLRL CEKAREVLHS 70 80 90 100 110 120 ESNVQPVKCP VTVCGDIHGQ FHDLMELFRI GGPNPDTNYL FMGDYVDRGY YSVETVTLLV 130 140 150 160 170 180 ALKIRYPQRI TILRGNHESR QITQVYGFYD ECLRKYGNAN VWKYFTNLFD FLPLTALIEN 190 200 210 220 230 240 QIFCLHGGLS PSIDTLDNIK SLDRIQEVPH EGPMCDLLWS DPDDRCGWGI SPRGAGYTFG 250 260 270 280 290 300 QDISEAFNHN NGLTLVARAH QLVMEGYNWS QDRNVVTIFS APNYCYRCGN QAAIMEIDEH 310 320 LKYTFLQFDP CPRAGEPMVT RRTPDYFL

References

[1]	Zhang Z., Scott P., Gurr S.J. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF462042 Genomic DNA. Translation: AAL69898.1.
3D structure databases
ProteinModelPortal	Q8X178.
SMR	Q8X178. Positions 29-328.
ModBase	Search...
Proteomic databases
PRIDE	Q8X178.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR004843. Metallo_PEstase_dom. IPR006186. Ser/Thr-sp_prot-phosphatase. [Graphical view]
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PRINTS	PR00114. STPHPHTASE.
SMART	SM00156. PP2Ac. 1 hit. [Graphical view]
PROSITE	PS00125. SER_THR_PHOSPHATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PP2A2_ERYGR

Accession

Primary (citable) accession number: Q8X178

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 11, 2003
Last sequence update:	March 1, 2002
Last modified:	November 28, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program