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Protein

Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

Gene

PP2A-2

Organism
Blumeria graminis f. sp. hordei (Barley powdery mildew) (Oidium monilioides f. sp. hordei)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi76Manganese 1By similarity1
Metal bindingi78Manganese 1By similarity1
Metal bindingi104Manganese 1By similarity1
Metal bindingi104Manganese 2By similarity1
Metal bindingi136Manganese 2By similarity1
Active sitei137Proton donorBy similarity1
Metal bindingi186Manganese 2By similarity1
Metal bindingi260Manganese 2By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit (EC:3.1.3.16)
Gene namesi
Name:PP2A-2
OrganismiBlumeria graminis f. sp. hordei (Barley powdery mildew) (Oidium monilioides f. sp. hordei)
Taxonomic identifieri62688 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesErysiphalesErysiphaceaeBlumeria

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588691 – 328Serine/threonine-protein phosphatase PP2A-2 catalytic subunitAdd BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei328Leucine methyl esterBy similarity1

Keywords - PTMi

Methylation

Structurei

3D structure databases

ProteinModelPortaliQ8X178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8X178-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTKMEDVGK TPEPIRFQTT TEPASISTLD GWIENLMACK QLPEVDVLRL
60 70 80 90 100
CEKAREVLHS ESNVQPVKCP VTVCGDIHGQ FHDLMELFRI GGPNPDTNYL
110 120 130 140 150
FMGDYVDRGY YSVETVTLLV ALKIRYPQRI TILRGNHESR QITQVYGFYD
160 170 180 190 200
ECLRKYGNAN VWKYFTNLFD FLPLTALIEN QIFCLHGGLS PSIDTLDNIK
210 220 230 240 250
SLDRIQEVPH EGPMCDLLWS DPDDRCGWGI SPRGAGYTFG QDISEAFNHN
260 270 280 290 300
NGLTLVARAH QLVMEGYNWS QDRNVVTIFS APNYCYRCGN QAAIMEIDEH
310 320
LKYTFLQFDP CPRAGEPMVT RRTPDYFL
Length:328
Mass (Da):37,486
Last modified:March 1, 2002 - v1
Checksum:iC5339E5D238618AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF462042 Genomic DNA. Translation: AAL69898.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF462042 Genomic DNA. Translation: AAL69898.1.

3D structure databases

ProteinModelPortaliQ8X178.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPP2A2_BLUGH
AccessioniPrimary (citable) accession number: Q8X178
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.