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Q8X178

- PP2A2_BLUGH

UniProt

Q8X178 - PP2A2_BLUGH

Protein

Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

Gene

PP2A-2

Organism
Blumeria graminis f. sp. hordei (Barley powdery mildew) (Oidium monilioides f. sp. hordei)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi76 – 761Manganese 1By similarity
    Metal bindingi78 – 781Manganese 1By similarity
    Metal bindingi104 – 1041Manganese 1By similarity
    Metal bindingi104 – 1041Manganese 2By similarity
    Metal bindingi136 – 1361Manganese 2By similarity
    Active sitei137 – 1371Proton donorBy similarity
    Metal bindingi186 – 1861Manganese 2By similarity
    Metal bindingi260 – 2601Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase PP2A-2 catalytic subunit (EC:3.1.3.16)
    Gene namesi
    Name:PP2A-2
    OrganismiBlumeria graminis f. sp. hordei (Barley powdery mildew) (Oidium monilioides f. sp. hordei)
    Taxonomic identifieri62688 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesErysiphalesErysiphaceaeBlumeria

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 328328Serine/threonine-protein phosphatase PP2A-2 catalytic subunitPRO_0000058869Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei328 – 3281Leucine methyl esterBy similarity

    Keywords - PTMi

    Methylation

    Proteomic databases

    PRIDEiQ8X178.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8X178.
    SMRiQ8X178. Positions 29-328.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8X178-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDTKMEDVGK TPEPIRFQTT TEPASISTLD GWIENLMACK QLPEVDVLRL    50
    CEKAREVLHS ESNVQPVKCP VTVCGDIHGQ FHDLMELFRI GGPNPDTNYL 100
    FMGDYVDRGY YSVETVTLLV ALKIRYPQRI TILRGNHESR QITQVYGFYD 150
    ECLRKYGNAN VWKYFTNLFD FLPLTALIEN QIFCLHGGLS PSIDTLDNIK 200
    SLDRIQEVPH EGPMCDLLWS DPDDRCGWGI SPRGAGYTFG QDISEAFNHN 250
    NGLTLVARAH QLVMEGYNWS QDRNVVTIFS APNYCYRCGN QAAIMEIDEH 300
    LKYTFLQFDP CPRAGEPMVT RRTPDYFL 328
    Length:328
    Mass (Da):37,486
    Last modified:March 1, 2002 - v1
    Checksum:iC5339E5D238618AE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF462042 Genomic DNA. Translation: AAL69898.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF462042 Genomic DNA. Translation: AAL69898.1 .

    3D structure databases

    ProteinModelPortali Q8X178.
    SMRi Q8X178. Positions 29-328.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q8X178.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Zhang Z., Scott P., Gurr S.J.
      Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiPP2A2_BLUGH
    AccessioniPrimary (citable) accession number: Q8X178
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 11, 2003
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3