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Protein

Glutamine synthetase

Gene

GLN1

Organism
Amanita muscaria (Fly agaric)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase (EC:6.3.1.2)
Short name:
GS
Alternative name(s):
Glutamate--ammonia ligase
Gene namesi
Name:GLN1
OrganismiAmanita muscaria (Fly agaric)
Taxonomic identifieri41956 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesAmanitaceaeAmanita

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Glutamine synthetasePRO_0000153150Add
BLAST

Proteomic databases

PRIDEiQ8X169.

Interactioni

Subunit structurei

Homooctamer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8X169.
SMRiQ8X169. Positions 17-354.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Family and domain databases

Gene3Di3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8X169-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANQYHNDLL APYLALDQGG KFHAEYVWID GDGGLRSKTT TVDQKVTDIS
60 70 80 90 100
QLRVWDFDGS STNQAPSGNS DVYLRPSAIF KDPFRGGENI LVLSETYNND
110 120 130 140 150
GTPNRTNHRH HTAKVMELAK DEIPWFGIEQ EYTLFDADGS PYGWPKGGFP
160 170 180 190 200
GPQGPYYCGA GTGKVFARDL IEAHYRACLY AGVNISGINA EVMPSQWEFQ
210 220 230 240 250
VGPCEGISMG DHLWMARYLL IRVAEQWGVK VSFHPKPLQG DWNGAGAHTN
260 270 280 290 300
YSTLAMREPG GMKYIEAAIE KLAKRHDEHI AVYGEDNEMR LTGRHETGHI
310 320 330 340 350
GTFSSGVANR GASIRVPRHV ANKGYGYLED RRPASNIDPY RVTGIIIETT

ILDK
Length:354
Mass (Da):39,337
Last modified:April 13, 2004 - v2
Checksum:i10C9AC87BCF5257E
GO

Sequence cautioni

The sequence CAD22045.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ428992 mRNA. Translation: CAD22045.1. Different initiation.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ428992 mRNA. Translation: CAD22045.1. Different initiation.

3D structure databases

ProteinModelPortaliQ8X169.
SMRiQ8X169. Positions 17-354.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ8X169.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Glutamine synthetase in Amanita muscaria."
    Nehls U., Kleber R., Hampp R.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiGLNA_AMAMU
AccessioniPrimary (citable) accession number: Q8X169
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: January 7, 2015
This is version 45 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.