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Q8X167

- XKS1_ASPNG

UniProt

Q8X167 - XKS1_ASPNG

Protein

D-xylulose kinase A

Gene

xkiA

Organism
Aspergillus niger
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.1 Publication

    Catalytic activityi

    ATP + D-xylulose = ADP + D-xylulose 5-phosphate.

    Kineticsi

    1. KM=0.76 mM for D-xylulose1 Publication
    2. KM=0.061 mM for ATP1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei95 – 951SubstrateBy similarity
    Binding sitei166 – 1661SubstrateBy similarity
    Binding sitei282 – 2821SubstrateBy similarity
    Binding sitei283 – 2831SubstrateBy similarity
    Binding sitei364 – 3641ATPBy similarity
    Binding sitei473 – 4731ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi469 – 4702ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. xylulokinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. D-xylose metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism, Xylose metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-13191.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    D-xylulose kinase A (EC:2.7.1.17)
    Short name:
    Xylulokinase A
    Gene namesi
    Name:xkiA
    OrganismiAspergillus niger
    Taxonomic identifieri5061 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 570570D-xylulose kinase APRO_0000393521Add
    BLAST

    Expressioni

    Inductioni

    By D-xylose, L-arabinose or L-arabitol.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ8X167.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FGGY kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG1070.

    Family and domain databases

    InterProiIPR018485. Carb_kinase_FGGY_C.
    IPR018484. Carb_kinase_FGGY_N.
    [Graphical view]
    PfamiPF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8X167-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQGPLYIGFD LSTQQLKGLV VNSDLKVVYV SKFDFDADSR GFPIKKGVLT    50
    NEAEHEVFAP VALWLQALDG VLEGLRKQGM DFSQIKGISG AGQQHGSVYW 100
    GENAEKLLKE LDASKTLEEQ LDGAFSHPFS PNWQDSSTQK ECDEFDAALG 150
    GQSELAFATG SKAHHRFTGP QIMRFQRKYP DVYKKTSRIS LVSSFIASLF 200
    LGHIAPMDIS DVCGMNLWNI KKGAYDEKLL QLCAGSSGVD DLKRKLGDVP 250
    EDGGIHLGPI DRYYVERYGF SPDCTIIPAT GDNPATILAL PLRASDAMVS 300
    LGTSTTFLMS TPSYKPDPAT HFFNHPTTAG LYMFMLCYKN GGLARELVRD 350
    AVNEKLGEKP STSWANFDKV TLETPPMGQK ADSDPMKLGL FFPRPEIVPN 400
    LRSGQWRFDY NPKDGSLQPS NGGWDEPFDE ARAIVESQML SLRLRSRGLT 450
    QSPGEGIPAQ PRRVYLVGGG SKNKAIAKVA GEILGGSEGV YKLEIGDNAC 500
    ALGAAYKAVW AMERAEGQTF EDLIGKRWHE EEFIEKIADG YQPGVFERYG 550
    QAVEGFEKME LEVLRQEGKH 570
    Length:570
    Mass (Da):62,809
    Last modified:March 1, 2002 - v1
    Checksum:iDB28E6CC2728EE86
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ305311 Genomic DNA. Translation: CAC83746.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ305311 Genomic DNA. Translation: CAC83746.1 .

    3D structure databases

    ProteinModelPortali Q8X167.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG1070.

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-13191.

    Family and domain databases

    InterProi IPR018485. Carb_kinase_FGGY_C.
    IPR018484. Carb_kinase_FGGY_N.
    [Graphical view ]
    Pfami PF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Aspergillus niger D-xylulose kinase gene is co-expressed with genes encoding arabinan degrading enzymes, and is essential for growth on D-xylose and L-arabinose."
      vanKuyk P.A., de Groot M.J., Ruijter G.J., de Vries R.P., Visser J.
      Eur. J. Biochem. 268:5414-5423(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION, FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
      Strain: ATCC 9029 / NRRL 3 / CBS 120.49 / DSM 2466 / N400.

    Entry informationi

    Entry nameiXKS1_ASPNG
    AccessioniPrimary (citable) accession number: Q8X167
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 20, 2010
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3