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Q8X167

- XKS1_ASPNG

UniProt

Q8X167 - XKS1_ASPNG

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Protein

D-xylulose kinase A

Gene
xkiA
Organism
Aspergillus niger
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.1 Publication

Catalytic activityi

ATP + D-xylulose = ADP + D-xylulose 5-phosphate.

Kineticsi

  1. KM=0.76 mM for D-xylulose1 Publication
  2. KM=0.061 mM for ATP

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei95 – 951Substrate By similarity
Binding sitei166 – 1661Substrate By similarity
Binding sitei282 – 2821Substrate By similarity
Binding sitei283 – 2831Substrate By similarity
Binding sitei364 – 3641ATP By similarity
Binding sitei473 – 4731ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi469 – 4702ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. xylulokinase activity Source: UniProtKB-EC

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism, Xylose metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13191.

Names & Taxonomyi

Protein namesi
Recommended name:
D-xylulose kinase A (EC:2.7.1.17)
Short name:
Xylulokinase A
Gene namesi
Name:xkiA
OrganismiAspergillus niger
Taxonomic identifieri5061 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570D-xylulose kinase APRO_0000393521Add
BLAST

Expressioni

Inductioni

By D-xylose, L-arabinose or L-arabitol.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ8X167.

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.

Phylogenomic databases

eggNOGiCOG1070.

Family and domain databases

InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8X167-1 [UniParc]FASTAAdd to Basket

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MQGPLYIGFD LSTQQLKGLV VNSDLKVVYV SKFDFDADSR GFPIKKGVLT    50
NEAEHEVFAP VALWLQALDG VLEGLRKQGM DFSQIKGISG AGQQHGSVYW 100
GENAEKLLKE LDASKTLEEQ LDGAFSHPFS PNWQDSSTQK ECDEFDAALG 150
GQSELAFATG SKAHHRFTGP QIMRFQRKYP DVYKKTSRIS LVSSFIASLF 200
LGHIAPMDIS DVCGMNLWNI KKGAYDEKLL QLCAGSSGVD DLKRKLGDVP 250
EDGGIHLGPI DRYYVERYGF SPDCTIIPAT GDNPATILAL PLRASDAMVS 300
LGTSTTFLMS TPSYKPDPAT HFFNHPTTAG LYMFMLCYKN GGLARELVRD 350
AVNEKLGEKP STSWANFDKV TLETPPMGQK ADSDPMKLGL FFPRPEIVPN 400
LRSGQWRFDY NPKDGSLQPS NGGWDEPFDE ARAIVESQML SLRLRSRGLT 450
QSPGEGIPAQ PRRVYLVGGG SKNKAIAKVA GEILGGSEGV YKLEIGDNAC 500
ALGAAYKAVW AMERAEGQTF EDLIGKRWHE EEFIEKIADG YQPGVFERYG 550
QAVEGFEKME LEVLRQEGKH 570
Length:570
Mass (Da):62,809
Last modified:March 1, 2002 - v1
Checksum:iDB28E6CC2728EE86
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ305311 Genomic DNA. Translation: CAC83746.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ305311 Genomic DNA. Translation: CAC83746.1 .

3D structure databases

ProteinModelPortali Q8X167.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG1070.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-13191.

Family and domain databases

InterProi IPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view ]
Pfami PF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The Aspergillus niger D-xylulose kinase gene is co-expressed with genes encoding arabinan degrading enzymes, and is essential for growth on D-xylose and L-arabinose."
    vanKuyk P.A., de Groot M.J., Ruijter G.J., de Vries R.P., Visser J.
    Eur. J. Biochem. 268:5414-5423(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION, FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
    Strain: ATCC 9029 / NRRL 3 / CBS 120.49 / DSM 2466 / N400.

Entry informationi

Entry nameiXKS1_ASPNG
AccessioniPrimary (citable) accession number: Q8X167
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: March 1, 2002
Last modified: April 16, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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