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Q8X0Z1

- LCPS_GIBFU

UniProt

Q8X0Z1 - LCPS_GIBFU

Protein

Bifunctional lycopene cyclase/phytoene synthase

Gene

carRA

Organism
Gibberella fujikuroi (Bakanae and foot rot disease fungus) (Fusarium fujikuroi)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene and from lycopene to beta-carotene via the intermediate gamma-carotene. Gamma-carotene is further processed to the acidic carotenoid neurosporaxanthin.1 Publication

    Catalytic activityi

    Carotenoid psi-end group = carotenoid beta-end group.
    2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

    Pathwayi

    GO - Molecular functioni

    1. geranylgeranyl-diphosphate geranylgeranyltransferase activity Source: UniProtKB
    2. intramolecular lyase activity Source: InterPro
    3. lycopene beta cyclase activity Source: UniProtKB
    4. phytoene synthase activity Source: UniProtKB

    GO - Biological processi

    1. carotene biosynthetic process Source: UniProtKB
    2. carotenoid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase, Transferase

    Keywords - Biological processi

    Carotenoid biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00799; UER00773.
    UPA00802.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional lycopene cyclase/phytoene synthase
    Including the following 2 domains:
    Lycopene beta-cyclase (EC:5.5.1.19)
    Alternative name(s):
    Carotene cyclase
    Lycopene cyclase
    Phytoene synthase (EC:2.5.1.32)
    Gene namesi
    Name:carRA
    OrganismiGibberella fujikuroi (Bakanae and foot rot disease fungus) (Fusarium fujikuroi)
    Taxonomic identifieri5127 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusariumFusarium fujikuroi species complex

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 612612Bifunctional lycopene cyclase/phytoene synthasePRO_0000409236Add
    BLAST

    Expressioni

    Inductioni

    Induced by light.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ8X0Z1.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei3 – 2321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei31 – 5121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei112 – 13019HelicalSequence AnalysisAdd
    BLAST
    Transmembranei148 – 16821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei171 – 19121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei203 – 22321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei246 – 26621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 268268Lycopene beta-cyclaseAdd
    BLAST
    Regioni275 – 612338Phytoene synthaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the lycopene beta-cyclase family.Curated
    In the C-terminal section; belongs to the phytoene/squalene synthase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.10.600.10. 1 hit.
    InterProiIPR017825. Lycopene_cyclase_dom.
    IPR002060. Squ/phyt_synthse.
    IPR019845. Squalene/phytoene_synthase_CS.
    IPR008949. Terpenoid_synth.
    [Graphical view]
    PfamiPF00494. SQS_PSY. 1 hit.
    [Graphical view]
    SUPFAMiSSF48576. SSF48576. 1 hit.
    TIGRFAMsiTIGR03462. CarR_dom_SF. 2 hits.
    PROSITEiPS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8X0Z1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGWEYAQVHL KYTIPFGVVL AAVYRPLMSR LDVFKLVFLI TVSFFWVVKG    50
    LEANSCRLLL FLPCMLILRG VLLRLTNADS PWDSYLIKNR IWTYPPGVVV 100
    GLTAWDIPAE ELFFFVIQTF NTSLLYMILS KPTFHPIYLS KKTGWGKIAG 150
    QILFASAIIF GLVSVSSGGE GMYMGLILIW ACPFLLFLWS ISYQFIVNLP 200
    WTNTALPIAL PTLYLWVVDT FALRRGTWSI TSGTKYGVVL WDGLEIEEAV 250
    FFLLTNTLIV FGLIACDNNL AILDTFPEHF PRTKGVPSLL TIIRTLILPK 300
    EKYDEERIQG LVSAVALLRK KSRSFYLASG TFEGRLRIDL IRLYAFCRAA 350
    DDLVDEAPSV DDSRASIEKL RKFLDLAYEE NQEEPSQRLR EYVTSSIPEM 400
    FHMALLQLPT YYLPKQPLDD LLKGFDTDLL FDRKSGAFPI ETTEDLDIYG 450
    SRVAGTVAEL CNHLILYHTP EAVPEDIQRE VVASGQEMGI ALQYVNIARD 500
    IKTDAEIDRV YLPLSWLKEA QLTPEDVIQQ PHGPTIEALR HKLLDRAFEK 550
    YNMAKGAIDK LPSEGKGPIR VAVESYMEIG RVLREKGPTM KKGRATVPKM 600
    RRIRVAWSAL NK 612
    Length:612
    Mass (Da):69,458
    Last modified:March 1, 2002 - v1
    Checksum:i14F7D731B993AB65
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ426417 Genomic DNA. Translation: CAD19988.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ426417 Genomic DNA. Translation: CAD19988.1 .

    3D structure databases

    ProteinModelPortali Q8X0Z1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00799 ; UER00773 .
    UPA00802 .

    Family and domain databases

    Gene3Di 1.10.600.10. 1 hit.
    InterProi IPR017825. Lycopene_cyclase_dom.
    IPR002060. Squ/phyt_synthse.
    IPR019845. Squalene/phytoene_synthase_CS.
    IPR008949. Terpenoid_synth.
    [Graphical view ]
    Pfami PF00494. SQS_PSY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48576. SSF48576. 1 hit.
    TIGRFAMsi TIGR03462. CarR_dom_SF. 2 hits.
    PROSITEi PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A carotenoid biosynthesis gene cluster in Fusarium fujikuroi: the genes carB and carRA."
      Linnemannstons P., Prado M.M., Fernandez-Martin R., Tudzynski B., Avalos J.
      Mol. Genet. Genomics 267:593-602(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION.

    Entry informationi

    Entry nameiLCPS_GIBFU
    AccessioniPrimary (citable) accession number: Q8X0Z1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 31, 2011
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3