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Q8X0Z1

- LCPS_GIBFU

UniProt

Q8X0Z1 - LCPS_GIBFU

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Protein

Bifunctional lycopene cyclase/phytoene synthase

Gene

carRA

Organism
Gibberella fujikuroi (Bakanae and foot rot disease fungus) (Fusarium fujikuroi)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene and from lycopene to beta-carotene via the intermediate gamma-carotene. Gamma-carotene is further processed to the acidic carotenoid neurosporaxanthin.1 Publication

Catalytic activityi

Carotenoid psi-end group = carotenoid beta-end group.
2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

Pathwayi

GO - Molecular functioni

  1. geranylgeranyl-diphosphate geranylgeranyltransferase activity Source: UniProtKB
  2. intramolecular lyase activity Source: InterPro
  3. lycopene beta cyclase activity Source: UniProtKB
  4. phytoene synthase activity Source: UniProtKB

GO - Biological processi

  1. carotene biosynthetic process Source: UniProtKB
  2. carotenoid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Transferase

Keywords - Biological processi

Carotenoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00799; UER00773.
UPA00802.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional lycopene cyclase/phytoene synthase
Including the following 2 domains:
Lycopene beta-cyclase (EC:5.5.1.19)
Alternative name(s):
Carotene cyclase
Lycopene cyclase
Phytoene synthase (EC:2.5.1.32)
Gene namesi
Name:carRA
OrganismiGibberella fujikuroi (Bakanae and foot rot disease fungus) (Fusarium fujikuroi)
Taxonomic identifieri5127 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusariumFusarium fujikuroi species complex

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321HelicalSequence AnalysisAdd
BLAST
Transmembranei31 – 5121HelicalSequence AnalysisAdd
BLAST
Transmembranei112 – 13019HelicalSequence AnalysisAdd
BLAST
Transmembranei148 – 16821HelicalSequence AnalysisAdd
BLAST
Transmembranei171 – 19121HelicalSequence AnalysisAdd
BLAST
Transmembranei203 – 22321HelicalSequence AnalysisAdd
BLAST
Transmembranei246 – 26621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 612612Bifunctional lycopene cyclase/phytoene synthasePRO_0000409236Add
BLAST

Expressioni

Inductioni

Induced by light.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ8X0Z1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 268268Lycopene beta-cyclaseAdd
BLAST
Regioni275 – 612338Phytoene synthaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the lycopene beta-cyclase family.Curated
In the C-terminal section; belongs to the phytoene/squalene synthase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamiPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
TIGRFAMsiTIGR03462. CarR_dom_SF. 2 hits.
PROSITEiPS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8X0Z1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGWEYAQVHL KYTIPFGVVL AAVYRPLMSR LDVFKLVFLI TVSFFWVVKG
60 70 80 90 100
LEANSCRLLL FLPCMLILRG VLLRLTNADS PWDSYLIKNR IWTYPPGVVV
110 120 130 140 150
GLTAWDIPAE ELFFFVIQTF NTSLLYMILS KPTFHPIYLS KKTGWGKIAG
160 170 180 190 200
QILFASAIIF GLVSVSSGGE GMYMGLILIW ACPFLLFLWS ISYQFIVNLP
210 220 230 240 250
WTNTALPIAL PTLYLWVVDT FALRRGTWSI TSGTKYGVVL WDGLEIEEAV
260 270 280 290 300
FFLLTNTLIV FGLIACDNNL AILDTFPEHF PRTKGVPSLL TIIRTLILPK
310 320 330 340 350
EKYDEERIQG LVSAVALLRK KSRSFYLASG TFEGRLRIDL IRLYAFCRAA
360 370 380 390 400
DDLVDEAPSV DDSRASIEKL RKFLDLAYEE NQEEPSQRLR EYVTSSIPEM
410 420 430 440 450
FHMALLQLPT YYLPKQPLDD LLKGFDTDLL FDRKSGAFPI ETTEDLDIYG
460 470 480 490 500
SRVAGTVAEL CNHLILYHTP EAVPEDIQRE VVASGQEMGI ALQYVNIARD
510 520 530 540 550
IKTDAEIDRV YLPLSWLKEA QLTPEDVIQQ PHGPTIEALR HKLLDRAFEK
560 570 580 590 600
YNMAKGAIDK LPSEGKGPIR VAVESYMEIG RVLREKGPTM KKGRATVPKM
610
RRIRVAWSAL NK
Length:612
Mass (Da):69,458
Last modified:March 1, 2002 - v1
Checksum:i14F7D731B993AB65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ426417 Genomic DNA. Translation: CAD19988.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ426417 Genomic DNA. Translation: CAD19988.1 .

3D structure databases

ProteinModelPortali Q8X0Z1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00799 ; UER00773 .
UPA00802 .

Family and domain databases

Gene3Di 1.10.600.10. 1 hit.
InterProi IPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view ]
Pfami PF00494. SQS_PSY. 1 hit.
[Graphical view ]
SUPFAMi SSF48576. SSF48576. 1 hit.
TIGRFAMsi TIGR03462. CarR_dom_SF. 2 hits.
PROSITEi PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A carotenoid biosynthesis gene cluster in Fusarium fujikuroi: the genes carB and carRA."
    Linnemannstons P., Prado M.M., Fernandez-Martin R., Tudzynski B., Avalos J.
    Mol. Genet. Genomics 267:593-602(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION.

Entry informationi

Entry nameiLCPS_GIBFU
AccessioniPrimary (citable) accession number: Q8X0Z1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: March 1, 2002
Last modified: October 1, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3