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Protein

GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

Gene

alg-11

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man5GlcNAc2-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum (By similarity).By similarity

Catalytic activityi

2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378

Protein family/group databases

CAZyiGT4 Glycosyltransferase Family 4

Names & Taxonomyi

Protein namesi
Recommended name:
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (EC:2.4.1.131)
Alternative name(s):
Alpha-1,2-mannosyltransferase alg-11
Asparagine-linked glycosylation protein 11
Glycolipid 2-alpha-mannosyltransferase
Gene namesi
Name:alg-11
ORF Names:B14D6.360, NCU06779
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 6, Linkage Group II

Organism-specific databases

EuPathDBiFungiDB:NCU06779

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 28Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini29 – 556LumenalSequence analysisAdd BLAST528

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000802771 – 556GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferaseAdd BLAST556

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi81N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi297N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi314N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ8X092
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000209670
InParanoidiQ8X092
KOiK03844
OMAiYTGDHEV
OrthoDBiEOG092C21XK

Family and domain databases

CDDicd03806 GT1_ALG11_like, 1 hit
InterProiView protein in InterPro
IPR038013 ALG11
IPR031814 ALG11_N
IPR001296 Glyco_trans_1
PfamiView protein in Pfam
PF15924 ALG11_N, 1 hit
PF00534 Glycos_transf_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q8X092-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANGLFTYVA ISLFTIGPLL ALFIPFVWRL VGSSLGWYLR RKTDGRRCHI
60 70 80 90 100
LEVVEADERK YRDSKSAKGR KAEKEDRDTF NNTEATGTSD GKVYDKDWDG
110 120 130 140 150
IVGFFHPFCN AGGGGERVLW AAIRATQKRW PKAKCVVYTG DHDVSKEAIL
160 170 180 190 200
SRVEQRFNIH LHPPTVNFLY LSTRRWVLAS TWPYFTLAGQ SFGSLIMAWD
210 220 230 240 250
AFSLLVPDIF VDTMGYAFAL GFSRFLFRDV PTAAYVHYPT ISTDMLESLD
260 270 280 290 300
PASAVGSQGV NAGKGTGAKG RAKKIYWQLF ARLYSLMGAS VDVVMTNSTW
310 320 330 340 350
TQAHIEKLWG PVRNLTGAVP GIKSKVNPIA VVYPPVAVEE LEQEVEVSPE
360 370 380 390 400
SEKRRENVLL YIAQFRPEKN HQLIVQAFAE FLKSGSEAAR DAKLVLVGSV
410 420 430 440 450
RDDYDSKRVY KLRLLVNELH IKDRVEFHLD ASWPDILEWL RRASVGVNGM
460 470 480 490 500
WNEHFGIGVV EYQAAGLISV VHDSGGPKLD IVVEVDGEPT GFHATTSKEF
510 520 530 540 550
AEGFEKALSL PNPYAVRLRA RKSAKRFTEE EFARRWIEQL EKCVAIKAVE

KPKSRQ
Length:556
Mass (Da):62,533
Last modified:March 1, 2002 - v1
Checksum:i3D59DA2B140B287A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356173 Genomic DNA Translation: CAB91745.2
CM002237 Genomic DNA Translation: EAA34384.1
RefSeqiXP_963620.1, XM_958527.3

Genome annotation databases

EnsemblFungiiEAA34384; EAA34384; NCU06779
GeneIDi3879830
KEGGincr:NCU06779

Similar proteinsi

Entry informationi

Entry nameiALG11_NEUCR
AccessioniPrimary (citable) accession number: Q8X092
Secondary accession number(s): Q1K8Z1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health