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Q8X092

- ALG11_NEUCR

UniProt

Q8X092 - ALG11_NEUCR

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Protein

GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

Gene

alg-11

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum By similarity.By similarity

Catalytic activityi

2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol.

Pathwayi

GO - Molecular functioni

  1. GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Names & Taxonomyi

Protein namesi
Recommended name:
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (EC:2.4.1.131)
Alternative name(s):
Alpha-1,2-mannosyltransferase alg-11
Asparagine-linked glycosylation protein 11
Glycolipid 2-alpha-mannosyltransferase
Gene namesi
Name:alg-11
ORF Names:B14D6.360, NCU06779
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 6, Linkage Group II

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferasePRO_0000080277Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi81 – 811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi297 – 2971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi314 – 3141N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5141.NCU06779.1.

Structurei

3D structure databases

ProteinModelPortaliQ8X092.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77CytoplasmicSequence Analysis
Topological domaini29 – 556528LumenalSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0438.
HOGENOMiHOG000209670.
InParanoidiQ8X092.
KOiK03844.
OMAiSEDSYAA.
OrthoDBiEOG7673KQ.

Family and domain databases

InterProiIPR001296. Glyco_trans_1.
[Graphical view]
PfamiPF00534. Glycos_transf_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8X092-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANGLFTYVA ISLFTIGPLL ALFIPFVWRL VGSSLGWYLR RKTDGRRCHI
60 70 80 90 100
LEVVEADERK YRDSKSAKGR KAEKEDRDTF NNTEATGTSD GKVYDKDWDG
110 120 130 140 150
IVGFFHPFCN AGGGGERVLW AAIRATQKRW PKAKCVVYTG DHDVSKEAIL
160 170 180 190 200
SRVEQRFNIH LHPPTVNFLY LSTRRWVLAS TWPYFTLAGQ SFGSLIMAWD
210 220 230 240 250
AFSLLVPDIF VDTMGYAFAL GFSRFLFRDV PTAAYVHYPT ISTDMLESLD
260 270 280 290 300
PASAVGSQGV NAGKGTGAKG RAKKIYWQLF ARLYSLMGAS VDVVMTNSTW
310 320 330 340 350
TQAHIEKLWG PVRNLTGAVP GIKSKVNPIA VVYPPVAVEE LEQEVEVSPE
360 370 380 390 400
SEKRRENVLL YIAQFRPEKN HQLIVQAFAE FLKSGSEAAR DAKLVLVGSV
410 420 430 440 450
RDDYDSKRVY KLRLLVNELH IKDRVEFHLD ASWPDILEWL RRASVGVNGM
460 470 480 490 500
WNEHFGIGVV EYQAAGLISV VHDSGGPKLD IVVEVDGEPT GFHATTSKEF
510 520 530 540 550
AEGFEKALSL PNPYAVRLRA RKSAKRFTEE EFARRWIEQL EKCVAIKAVE

KPKSRQ
Length:556
Mass (Da):62,533
Last modified:March 1, 2002 - v1
Checksum:i3D59DA2B140B287A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL356173 Genomic DNA. Translation: CAB91745.2.
CM002237 Genomic DNA. Translation: EAA34384.1.
RefSeqiXP_963620.1. XM_958527.2.
UniGeneiNcr.23849.

Genome annotation databases

EnsemblFungiiEFNCRT00000006888; EFNCRP00000006879; EFNCRG00000006876.
GeneIDi3879830.
KEGGincr:NCU06779.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL356173 Genomic DNA. Translation: CAB91745.2 .
CM002237 Genomic DNA. Translation: EAA34384.1 .
RefSeqi XP_963620.1. XM_958527.2.
UniGenei Ncr.23849.

3D structure databases

ProteinModelPortali Q8X092.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5141.NCU06779.1.

Protein family/group databases

CAZyi GT4. Glycosyltransferase Family 4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000006888 ; EFNCRP00000006879 ; EFNCRG00000006876 .
GeneIDi 3879830.
KEGGi ncr:NCU06779.

Phylogenomic databases

eggNOGi COG0438.
HOGENOMi HOG000209670.
InParanoidi Q8X092.
KOi K03844.
OMAi SEDSYAA.
OrthoDBi EOG7673KQ.

Enzyme and pathway databases

UniPathwayi UPA00378 .

Family and domain databases

InterProi IPR001296. Glyco_trans_1.
[Graphical view ]
Pfami PF00534. Glycos_transf_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
    Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
    Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
  2. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiALG11_NEUCR
AccessioniPrimary (citable) accession number: Q8X092
Secondary accession number(s): Q1K8Z1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3