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Protein

Probable proteasome subunit alpha type-2

Gene

pca-2

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Protein family/group databases

MEROPSiT01.A11.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable proteasome subunit alpha type-2 (EC:3.4.25.1)
Gene namesi
Name:pca-2
ORF Names:B14D6.510, NCU06764
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 6, Linkage Group II

Organism-specific databases

EuPathDBiFungiDB:NCU06764.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001240881 – 249Probable proteasome subunit alpha type-2Add BLAST249

Proteomic databases

PRIDEiQ8X077.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8X077.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000091085.
InParanoidiQ8X077.
KOiK02726.
OrthoDBiEOG092C47D8.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTiSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8X077-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADRYSFSLT TFSPSGKLVQ IEYALNAVNQ GVTALGIKAT NGIVLATEKK
60 70 80 90 100
SSSPLADPSS LSKISLITPN IGMVYSGMGP DYRVLVDRAR KVSHTGYKRI
110 120 130 140 150
YNEYPPTRIL VQDVARVMQE ATQSGGVRPY GVSLLIAGWD EGGPMLYQVD
160 170 180 190 200
PSGSYFPWKA TAIGKNATTA KTFLEKRYTE GLELEDAVHI ALLTLKETIE
210 220 230 240
GEMNGDTIEI GIVGPPADHL LGVEGVEGAK GPRFRKLSPQ EIEDYLTNL
Length:249
Mass (Da):26,998
Last modified:March 1, 2002 - v1
Checksum:iA08206326F2E9654
GO

Sequence cautioni

The sequence EAA34300 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356173 Genomic DNA. Translation: CAB91760.2.
CM002237 Genomic DNA. Translation: EAA34300.2. Sequence problems.
RefSeqiXP_963536.2. XM_958443.2.

Genome annotation databases

EnsemblFungiiEAA34300; EAA34300; NCU06764.
GeneIDi3879660.
KEGGincr:NCU06764.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356173 Genomic DNA. Translation: CAB91760.2.
CM002237 Genomic DNA. Translation: EAA34300.2. Sequence problems.
RefSeqiXP_963536.2. XM_958443.2.

3D structure databases

ProteinModelPortaliQ8X077.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiT01.A11.

Proteomic databases

PRIDEiQ8X077.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAA34300; EAA34300; NCU06764.
GeneIDi3879660.
KEGGincr:NCU06764.

Organism-specific databases

EuPathDBiFungiDB:NCU06764.

Phylogenomic databases

HOGENOMiHOG000091085.
InParanoidiQ8X077.
KOiK02726.
OrthoDBiEOG092C47D8.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTiSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSA2_NEUCR
AccessioniPrimary (citable) accession number: Q8X077
Secondary accession number(s): Q7SCC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.