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Protein

RuvB-like helicase 1

Gene

hel-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi71 – 78ATPBy similarity8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Chromatin regulator, Helicase, Hydrolase
Biological processDNA damage, DNA repair, Transcription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RuvB-like helicase 1 (EC:3.6.4.12)
Gene namesi
Name:hel-1
Synonyms:rvb1
ORF Names:B8L21.150, NCU03482
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 6, Linkage Group II

Organism-specific databases

EuPathDBiFungiDB:NCU03482

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001656571 – 458RuvB-like helicase 1Add BLAST458

Interactioni

Subunit structurei

May form heterododecamers with hel-2/rvb2. Component of the SWR1 chromatin remodeling complex, the INO80 chromatin remodeling complex, and of the R2TP complex (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8WZS3
SMRiQ8WZS3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvB family.Curated

Phylogenomic databases

HOGENOMiHOG000190885
InParanoidiQ8WZS3
KOiK04499
OMAiDVHKRKE
OrthoDBiEOG092C2Z17

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR027417 P-loop_NTPase
IPR027238 RuvB-like
IPR037938 RUVBL1
IPR010339 TIP49_C
PANTHERiPTHR11093 PTHR11093, 1 hit
PTHR11093:SF6 PTHR11093:SF6, 1 hit
PfamiView protein in Pfam
PF06068 TIP49, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits

Sequencei

Sequence statusi: Complete.

Q8WZS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQISEVKGN SRDNRTAAHT HIKGLGLNSQ GIAEKQASGF VGQTTAREAC
60 70 80 90 100
GVVVDLIKAH KMAGRGVLLA GGPGTGKTAL ALAISQELGT KIPFCPITGS
110 120 130 140 150
EIYSTEVKKT EVLMENFRRA IGLKVRETKE VYEGEVTELT PEEAENPLGG
160 170 180 190 200
YGKTITTLLI GLKSAKGQKK LRLDPSIYEA IQKERVTVGD VIYIEANTGA
210 220 230 240 250
CKRVGRSDAY ATEFDLEAEE YVPIPKGEVH KKKEIVQDVS LHDLDVANAR
260 270 280 290 300
PQGGQDIMSM MGQLMKPKMT EITDKLRSEI NKVVSKYIDQ GVAELVPGVL
310 320 330 340 350
FIDEAHMLDV ECFTYLNKAL ESPISPIVVL ASNRGMTGIR GAEDLVAAHG
360 370 380 390 400
IPPDFLSRLL IIPTTAYDPE EIKRIVKIRS TTEGVKITEA AIDKIAEHGV
410 420 430 440 450
RISLRYCLQL LTPASILAKV NGRNEIDVQD VAECEDLFLD ARRSAALLSS

EQGQEFIC
Length:458
Mass (Da):49,811
Last modified:March 1, 2002 - v1
Checksum:i74F74EA256BEE7BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL669989 Genomic DNA Translation: CAD21100.1
CM002237 Genomic DNA Translation: EAA26533.1
RefSeqiXP_955769.1, XM_950676.2

Genome annotation databases

EnsemblFungiiEAA26533; EAA26533; NCU03482
GeneIDi3871916
KEGGincr:NCU03482

Similar proteinsi

Entry informationi

Entry nameiRUVB1_NEUCR
AccessioniPrimary (citable) accession number: Q8WZS3
Secondary accession number(s): Q1K4L8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health