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Protein

Enoyl-[acyl-carrier-protein] reductase [NADPH, B-specific] 2, mitochondrial

Gene

ETR2

Organism
Candida tropicalis (Yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for respiration and the maintenance of the mitochondrial compartment. Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis.1 Publication

Catalytic activityi

An acyl-[acyl-carrier protein] + NADP+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH.1 Publication
Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei172NADP1 Publication1
Binding sitei381NADP1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi199 – 202NADP1 Publication4
Nucleotide bindingi222 – 224NADP1 Publication3
Nucleotide bindingi296 – 299NADP1 Publication4
Nucleotide bindingi321 – 323NADP1 Publication3

GO - Molecular functioni

GO - Biological processi

  • fatty acid biosynthetic process Source: UniProtKB-KW
  • fatty acid metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Enoyl-[acyl-carrier-protein] reductase [NADPH, B-specific] 2, mitochondrial (EC:1.3.1.10)
Alternative name(s):
Trans-2-enoyl-CoA reductase 2 (EC:1.3.1.38)
Gene namesi
Name:ETR2
OrganismiCandida tropicalis (Yeast)
Taxonomic identifieri5482 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 22MitochondrionSequence analysisAdd BLAST22
ChainiPRO_000000089923 – 386Enoyl-[acyl-carrier-protein] reductase [NADPH, B-specific] 2, mitochondrialAdd BLAST364

Expressioni

Inductioni

Up-regulated by growth on oleic acid.1 Publication

Interactioni

Subunit structurei

Homodimer and heterodimer with ETR1.1 Publication

Protein-protein interaction databases

IntActiQ8WZM4. 1 interactor.

Structurei

Secondary structure

1386
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi24 – 33Combined sources10
Helixi37 – 40Combined sources4
Beta strandi42 – 48Combined sources7
Beta strandi57 – 67Combined sources11
Helixi69 – 76Combined sources8
Beta strandi95 – 97Combined sources3
Beta strandi103 – 109Combined sources7
Beta strandi121 – 127Combined sources7
Beta strandi132 – 139Combined sources8
Helixi140 – 142Combined sources3
Beta strandi143 – 146Combined sources4
Helixi149 – 154Combined sources6
Helixi163 – 167Combined sources5
Beta strandi169 – 171Combined sources3
Helixi172 – 181Combined sources10
Beta strandi182 – 184Combined sources3
Turni188 – 190Combined sources3
Beta strandi192 – 196Combined sources5
Helixi201 – 213Combined sources13
Beta strandi216 – 221Combined sources6
Helixi227 – 237Combined sources11
Beta strandi240 – 244Combined sources5
Helixi245 – 249Combined sources5
Turni251 – 253Combined sources3
Helixi254 – 264Combined sources11
Beta strandi268 – 275Combined sources8
Helixi277 – 285Combined sources9
Beta strandi292 – 295Combined sources4
Helixi299 – 301Combined sources3
Beta strandi304 – 306Combined sources3
Helixi308 – 313Combined sources6
Beta strandi317 – 320Combined sources4
Helixi323 – 326Combined sources4
Turni327 – 329Combined sources3
Helixi331 – 346Combined sources16
Beta strandi356 – 359Combined sources4
Beta strandi362 – 364Combined sources3
Helixi366 – 375Combined sources10
Helixi377 – 379Combined sources3
Beta strandi382 – 385Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H0KX-ray2.11A/B23-386[»]
1N9GX-ray1.98A/C/F1-386[»]
ProteinModelPortaliQ8WZM4.
SMRiQ8WZM4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WZM4.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WZM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSVLKQSIR PRLLATHNQF RTMITAQAVL YTQHGEPKDV LFTQSFEIDD
60 70 80 90 100
DNLAPNEVIV KTLGSPINPS DINQIQGVYP SKPAKTTGFG TAEPAAPCGN
110 120 130 140 150
EGLFEVIKVG SNVSSLEAGD WVIPSHVNFG TWRTHALGND DDFIKLPNPA
160 170 180 190 200
QSKANGKPNG LTINQGATIS VNPLTAYLML THYVKLTPGK DWFIQNGGTS
210 220 230 240 250
AVGKYASQIG KLLNFNSISV IRDRPNLDEV VASLKELGAT QVITEDQNNS
260 270 280 290 300
KEFGPTIKEW IKQSGGEAKL ALNCVGGKSS TGIARKLNNN GLMLTYGGMS
310 320 330 340 350
FQPVTIPTSL YIFKNFTSAG FWVTELLKNN KELKTSTLNQ IIAWYEEGKL
360 370 380
TDAKSIETLY DGTKPLHELY QDGVANSKDG KQLITY
Length:386
Mass (Da):42,117
Last modified:March 1, 2002 - v1
Checksum:i91ABE00831F0C2E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94996 Genomic DNA. Translation: AAL55471.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94996 Genomic DNA. Translation: AAL55471.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H0KX-ray2.11A/B23-386[»]
1N9GX-ray1.98A/C/F1-386[»]
ProteinModelPortaliQ8WZM4.
SMRiQ8WZM4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8WZM4. 1 interactor.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WZM4.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiETR2_CANTR
AccessioniPrimary (citable) accession number: Q8WZM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.