Reviewed, UniProtKB/Swiss-Prot Q8WZM0 (GCN5_YARLI)

Names and origin

Protein names

Recommended name:
    Histone acetyltransferase GCN5
    EC=2.3.1.48

Gene names

Name:	GCN5
Ordered Locus Names:	YALI0E02772g

Organism

Yarrowia lipolytica (Candida lipolytica) [Complete proteome]

Taxonomic identifier

4952 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Dipodascaceae › Yarrowia

Protein attributes

Sequence length	464 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, with a lower preference histone H4 to form H4K8ac and H4K16ac, and contributes to H2A.Z acetylation. Acetylation of histones gives a specific tag for epigenetic transcription activation By similarity.
Catalytic activity	Acetyl-CoA + [histone] = CoA + acetyl-[histone].
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the GCN5 family. Contains 1 bromo domain. Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Bromodomain
Molecular function	Activator Acyltransferase Chromatin regulator Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	histone acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 464	464	Histone acetyltransferase GCN5		PRO_0000211200
Regions
	Domain	127 – 282	156	N-acetyltransferase
	Domain	369 – 439	71	Bromo
	Compositional bias	31 – 128	98	Glu-rich
Sites
	Site	200	1	Important for catalytic activity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8WZM0-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: A7F3FC0C3B6D2CC4	FASTA	464	54,096
	10 20 30 40 50 60 MDSDTESVKR RKSSGSESES SVRDPKRTKI EDEDFQENGI DDEDEEEEEE EAKDEGDEDD 70 80 90 100 110 120 EEKGEDDEED DEEKEGEDGE GEEEDEEEDE EKKREEEEKY VTSFNFDGVE YKYKERPAVI 130 140 150 160 170 180 EEREGKIEFR VVNNDNSKEN LMILTGLKNI FQKQLPKMPR EYIARLVYDR SHVSMAVVRK 190 200 210 220 230 240 PLTVVGGITF RPFDTRKFAE IVFCAISSTE QVRGYGAHLM NHLKDYVKAT SPVMYFLTYA 250 260 270 280 290 300 DNYAIGYFKK QGFSKEISLD RSVWMGYIKD YEGGTLMQCS MLPRIRYLDV NKILLLQKAL 310 320 330 340 350 360 IHKKIRAISK SHVVRKGLDH FRDSTTPVDP MTIPGLKEAG WTPEMDELAR RPKRGPHFAV 370 380 390 400 410 420 MQHVLSELQN HASAWPFAQA VNRDEVPDYY EVIKEPMDLS TMEQRLEADS YKTMEEFVYD 430 440 450 460 ARLVFNNCRA YNNETTTYYK NANKLEKFMV AKIKEIPEYS HLVE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of the GCN5 gene of Yarrowia lipolytica." Gonzalez-Prieto J., Dominguez-Olavarri A., Ruiz-Herrera J. Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: INAG 35668.
[2]	"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CLIB 122 / E 150.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ237940 Genomic DNA. Translation: CAC80210.1. CR382131 Genomic DNA. Translation: CAG79052.1.
RefSeq	XP_503473.1.
3D structure databases
SMR	Q8WZM0. Positions 126-289, 354-463.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8WZM0.
Genome annotation databases
GeneID	2912645.
GenomeReviews	Gene locus YALI0E02772g in contig CR382131_GR.
KEGG	yli:YALI0E02772g.
Phylogenomic databases
eggNOG	fuNOG05844.
HOGENOM	HBG749648.
OMA	GLKNIFQ.
OrthoDB	EOG9BP2TZ.
PhylomeDB	Q8WZM0.
Enzyme and pathway databases
BRENDA	2.3.1.48. 3602.
Family and domain databases
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR001487. Bromodomain. IPR018359. Bromodomain_CS. IPR000182. GCN5-rel_AcTrfase. [Graphical view]
Gene3D	G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit. G3DSA:1.20.920.10. Bromodomain. 1 hit.
Pfam	PF00583. Acetyltransf_1. 1 hit. PF00439. Bromodomain. 1 hit. [Graphical view]
PRINTS	PR00503. BROMODOMAIN.
SMART	SM00297. BROMO. 1 hit. [Graphical view]
PROSITE	PS00633. BROMODOMAIN_1. 1 hit. PS50014. BROMODOMAIN_2. 1 hit. PS51186. GNAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCN5_YARLI

Accession

Primary (citable) accession number: Q8WZM0
Secondary accession number(s): Q6C789

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	March 1, 2002
Last modified:	February 9, 2010
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)