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Q8WZM0

- GCN5_YARLI

UniProt

Q8WZM0 - GCN5_YARLI

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Protein

Histone acetyltransferase GCN5

Gene

GCN5

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, with a lower preference histone H4 to form H4K8ac and H4K16ac, and contributes to H2A.Z acetylation. Acetylation of histones gives a specific tag for epigenetic transcription activation (By similarity).By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei200 – 2001Proton donor/acceptorBy similarity
Sitei200 – 2001Important for catalytic activityBy similarity

GO - Molecular functioni

  1. histone acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase GCN5 (EC:2.3.1.48)
Gene namesi
Name:GCN5
Ordered Locus Names:YALI0E02772g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Chromosome E

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 464464Histone acetyltransferase GCN5PRO_0000211200Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ8WZM0.
SMRiQ8WZM0. Positions 126-289, 354-463.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini127 – 282156N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST
Domaini369 – 43971BromoPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni204 – 2063Acetyl-CoA bindingBy similarity
Regioni211 – 2177Acetyl-CoA bindingBy similarity
Regioni243 – 2464Acetyl-CoA bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi31 – 12898Glu-richAdd
BLAST

Sequence similaritiesi

Contains 1 bromo domain.PROSITE-ProRule annotation
Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Keywords - Domaini

Bromodomain

Phylogenomic databases

eggNOGiCOG5076.
HOGENOMiHOG000192257.
InParanoidiQ8WZM0.
KOiK06062.
OMAiDNCRKYN.
OrthoDBiEOG7XM37B.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
PF00439. Bromodomain. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF55729. SSF55729. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WZM0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSDTESVKR RKSSGSESES SVRDPKRTKI EDEDFQENGI DDEDEEEEEE
60 70 80 90 100
EAKDEGDEDD EEKGEDDEED DEEKEGEDGE GEEEDEEEDE EKKREEEEKY
110 120 130 140 150
VTSFNFDGVE YKYKERPAVI EEREGKIEFR VVNNDNSKEN LMILTGLKNI
160 170 180 190 200
FQKQLPKMPR EYIARLVYDR SHVSMAVVRK PLTVVGGITF RPFDTRKFAE
210 220 230 240 250
IVFCAISSTE QVRGYGAHLM NHLKDYVKAT SPVMYFLTYA DNYAIGYFKK
260 270 280 290 300
QGFSKEISLD RSVWMGYIKD YEGGTLMQCS MLPRIRYLDV NKILLLQKAL
310 320 330 340 350
IHKKIRAISK SHVVRKGLDH FRDSTTPVDP MTIPGLKEAG WTPEMDELAR
360 370 380 390 400
RPKRGPHFAV MQHVLSELQN HASAWPFAQA VNRDEVPDYY EVIKEPMDLS
410 420 430 440 450
TMEQRLEADS YKTMEEFVYD ARLVFNNCRA YNNETTTYYK NANKLEKFMV
460
AKIKEIPEYS HLVE
Length:464
Mass (Da):54,096
Last modified:March 1, 2002 - v1
Checksum:iA7F3FC0C3B6D2CC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ237940 Genomic DNA. Translation: CAC80210.1.
CR382131 Genomic DNA. Translation: CAG79052.1.
RefSeqiXP_503473.1. XM_503473.1.

Genome annotation databases

EnsemblFungiiCAG79052; CAG79052; YALI0_E02772g.
GeneIDi2912645.
KEGGiyli:YALI0E02772g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ237940 Genomic DNA. Translation: CAC80210.1 .
CR382131 Genomic DNA. Translation: CAG79052.1 .
RefSeqi XP_503473.1. XM_503473.1.

3D structure databases

ProteinModelPortali Q8WZM0.
SMRi Q8WZM0. Positions 126-289, 354-463.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAG79052 ; CAG79052 ; YALI0_E02772g .
GeneIDi 2912645.
KEGGi yli:YALI0E02772g.

Phylogenomic databases

eggNOGi COG5076.
HOGENOMi HOG000192257.
InParanoidi Q8WZM0.
KOi K06062.
OMAi DNCRKYN.
OrthoDBi EOG7XM37B.

Family and domain databases

Gene3Di 1.20.920.10. 1 hit.
3.40.630.30. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR000182. GNAT_dom.
[Graphical view ]
Pfami PF00583. Acetyltransf_1. 1 hit.
PF00439. Bromodomain. 1 hit.
[Graphical view ]
PRINTSi PR00503. BROMODOMAIN.
SMARTi SM00297. BROMO. 1 hit.
[Graphical view ]
SUPFAMi SSF47370. SSF47370. 1 hit.
SSF55729. SSF55729. 1 hit.
PROSITEi PS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of the GCN5 gene of Yarrowia lipolytica."
    Gonzalez-Prieto J., Dominguez-Olavarri A., Ruiz-Herrera J.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: INAG 35668.
  2. "Genome evolution in yeasts."
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CLIB 122 / E 150.

Entry informationi

Entry nameiGCN5_YARLI
AccessioniPrimary (citable) accession number: Q8WZM0
Secondary accession number(s): Q6C789
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3