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Protein

Histone acetyltransferase GCN5

Gene

GCN5

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, with a lower preference histone H4 to form H4K8ac and H4K16ac, and contributes to H2A.Z acetylation. Acetylation of histones gives a specific tag for epigenetic transcription activation (By similarity).By similarity

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei200Proton donor/acceptorBy similarity1
Sitei200Important for catalytic activityBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Acyltransferase, Chromatin regulator, Transferase
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase GCN5 (EC:2.3.1.48)
Gene namesi
Name:GCN5
Ordered Locus Names:YALI0E02772g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi
  • UP000001300 Componenti: Chromosome E

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002112001 – 464Histone acetyltransferase GCN5Add BLAST464

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi4952.XP_503473.1.

Structurei

3D structure databases

ProteinModelPortaliQ8WZM0.
SMRiQ8WZM0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini127 – 282N-acetyltransferasePROSITE-ProRule annotationAdd BLAST156
Domaini369 – 439BromoPROSITE-ProRule annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni204 – 206Acetyl-CoA bindingBy similarity3
Regioni211 – 217Acetyl-CoA bindingBy similarity7
Regioni243 – 246Acetyl-CoA bindingBy similarity4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi31 – 128Glu-richAdd BLAST98

Sequence similaritiesi

Keywords - Domaini

Bromodomain

Phylogenomic databases

HOGENOMiHOG000192257.
InParanoidiQ8WZM0.
KOiK06062.
OMAiGTIMQCS.
OrthoDBiEOG092C0SVC.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
InterProiView protein in InterPro
IPR016181. Acyl_CoA_acyltransferase.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR000182. GNAT_dom.
PfamiView protein in Pfam
PF00583. Acetyltransf_1. 1 hit.
PF00439. Bromodomain. 1 hit.
PRINTSiPR00503. BROMODOMAIN.
SMARTiView protein in SMART
SM00297. BROMO. 1 hit.
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF55729. SSF55729. 1 hit.
PROSITEiView protein in PROSITE
PS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51186. GNAT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8WZM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSDTESVKR RKSSGSESES SVRDPKRTKI EDEDFQENGI DDEDEEEEEE
60 70 80 90 100
EAKDEGDEDD EEKGEDDEED DEEKEGEDGE GEEEDEEEDE EKKREEEEKY
110 120 130 140 150
VTSFNFDGVE YKYKERPAVI EEREGKIEFR VVNNDNSKEN LMILTGLKNI
160 170 180 190 200
FQKQLPKMPR EYIARLVYDR SHVSMAVVRK PLTVVGGITF RPFDTRKFAE
210 220 230 240 250
IVFCAISSTE QVRGYGAHLM NHLKDYVKAT SPVMYFLTYA DNYAIGYFKK
260 270 280 290 300
QGFSKEISLD RSVWMGYIKD YEGGTLMQCS MLPRIRYLDV NKILLLQKAL
310 320 330 340 350
IHKKIRAISK SHVVRKGLDH FRDSTTPVDP MTIPGLKEAG WTPEMDELAR
360 370 380 390 400
RPKRGPHFAV MQHVLSELQN HASAWPFAQA VNRDEVPDYY EVIKEPMDLS
410 420 430 440 450
TMEQRLEADS YKTMEEFVYD ARLVFNNCRA YNNETTTYYK NANKLEKFMV
460
AKIKEIPEYS HLVE
Length:464
Mass (Da):54,096
Last modified:March 1, 2002 - v1
Checksum:iA7F3FC0C3B6D2CC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ237940 Genomic DNA. Translation: CAC80210.1.
CR382131 Genomic DNA. Translation: CAG79052.1.
RefSeqiXP_503473.1. XM_503473.1.

Genome annotation databases

EnsemblFungiiCAG79052; CAG79052; YALI0_E02772g.
GeneIDi2912645.
KEGGiyli:YALI0E02772g.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGCN5_YARLI
AccessioniPrimary (citable) accession number: Q8WZM0
Secondary accession number(s): Q6C789
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: March 1, 2002
Last modified: July 5, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families