Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histone acetyltransferase GCN5

Gene

GCN5

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, with a lower preference histone H4 to form H4K8ac and H4K16ac, and contributes to H2A.Z acetylation. Acetylation of histones gives a specific tag for epigenetic transcription activation (By similarity).By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei200 – 2001Proton donor/acceptorBy similarity
Sitei200 – 2001Important for catalytic activityBy similarity

GO - Molecular functioni

  1. H3 histone acetyltransferase activity Source: EnsemblFungi

GO - Biological processi

  1. chromatin organization involved in regulation of transcription Source: EnsemblFungi
  2. chromatin remodeling Source: EnsemblFungi
  3. negative regulation of leucine import Source: EnsemblFungi
  4. negative regulation of transcription from RNA polymerase II promoter Source: EnsemblFungi
  5. positive regulation of transcription elongation from RNA polymerase II promoter Source: EnsemblFungi
  6. reciprocal meiotic recombination Source: EnsemblFungi
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase GCN5 (EC:2.3.1.48)
Gene namesi
Name:GCN5
Ordered Locus Names:YALI0E02772g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300 Componenti: Chromosome E

Subcellular locationi

  1. Nucleus By similarity

GO - Cellular componenti

  1. Ada2/Gcn5/Ada3 transcription activator complex Source: EnsemblFungi
  2. chromosome, centromeric region Source: EnsemblFungi
  3. cytosol Source: EnsemblFungi
  4. SAGA complex Source: EnsemblFungi
  5. SLIK (SAGA-like) complex Source: EnsemblFungi
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 464464Histone acetyltransferase GCN5PRO_0000211200Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ8WZM0.
SMRiQ8WZM0. Positions 126-289, 354-463.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini127 – 282156N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST
Domaini369 – 43971BromoPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni204 – 2063Acetyl-CoA bindingBy similarity
Regioni211 – 2177Acetyl-CoA bindingBy similarity
Regioni243 – 2464Acetyl-CoA bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi31 – 12898Glu-richAdd
BLAST

Sequence similaritiesi

Contains 1 bromo domain.PROSITE-ProRule annotation
Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Keywords - Domaini

Bromodomain

Phylogenomic databases

eggNOGiCOG5076.
HOGENOMiHOG000192257.
InParanoidiQ8WZM0.
KOiK06062.
OMAiLLKQKEC.
OrthoDBiEOG7XM37B.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
PF00439. Bromodomain. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF55729. SSF55729. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WZM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSDTESVKR RKSSGSESES SVRDPKRTKI EDEDFQENGI DDEDEEEEEE
60 70 80 90 100
EAKDEGDEDD EEKGEDDEED DEEKEGEDGE GEEEDEEEDE EKKREEEEKY
110 120 130 140 150
VTSFNFDGVE YKYKERPAVI EEREGKIEFR VVNNDNSKEN LMILTGLKNI
160 170 180 190 200
FQKQLPKMPR EYIARLVYDR SHVSMAVVRK PLTVVGGITF RPFDTRKFAE
210 220 230 240 250
IVFCAISSTE QVRGYGAHLM NHLKDYVKAT SPVMYFLTYA DNYAIGYFKK
260 270 280 290 300
QGFSKEISLD RSVWMGYIKD YEGGTLMQCS MLPRIRYLDV NKILLLQKAL
310 320 330 340 350
IHKKIRAISK SHVVRKGLDH FRDSTTPVDP MTIPGLKEAG WTPEMDELAR
360 370 380 390 400
RPKRGPHFAV MQHVLSELQN HASAWPFAQA VNRDEVPDYY EVIKEPMDLS
410 420 430 440 450
TMEQRLEADS YKTMEEFVYD ARLVFNNCRA YNNETTTYYK NANKLEKFMV
460
AKIKEIPEYS HLVE
Length:464
Mass (Da):54,096
Last modified:March 1, 2002 - v1
Checksum:iA7F3FC0C3B6D2CC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ237940 Genomic DNA. Translation: CAC80210.1.
CR382131 Genomic DNA. Translation: CAG79052.1.
RefSeqiXP_503473.1. XM_503473.1.

Genome annotation databases

EnsemblFungiiCAG79052; CAG79052; YALI0_E02772g.
GeneIDi2912645.
KEGGiyli:YALI0E02772g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ237940 Genomic DNA. Translation: CAC80210.1.
CR382131 Genomic DNA. Translation: CAG79052.1.
RefSeqiXP_503473.1. XM_503473.1.

3D structure databases

ProteinModelPortaliQ8WZM0.
SMRiQ8WZM0. Positions 126-289, 354-463.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG79052; CAG79052; YALI0_E02772g.
GeneIDi2912645.
KEGGiyli:YALI0E02772g.

Phylogenomic databases

eggNOGiCOG5076.
HOGENOMiHOG000192257.
InParanoidiQ8WZM0.
KOiK06062.
OMAiLLKQKEC.
OrthoDBiEOG7XM37B.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
PF00439. Bromodomain. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF55729. SSF55729. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of the GCN5 gene of Yarrowia lipolytica."
    Gonzalez-Prieto J., Dominguez-Olavarri A., Ruiz-Herrera J.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: INAG 35668.
  2. "Genome evolution in yeasts."
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CLIB 122 / E 150.

Entry informationi

Entry nameiGCN5_YARLI
AccessioniPrimary (citable) accession number: Q8WZM0
Secondary accession number(s): Q6C789
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: March 1, 2002
Last modified: April 1, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.