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Q8WZM0 (GCN5_YARLI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone acetyltransferase GCN5

EC=2.3.1.48
Gene names
Name:GCN5
Ordered Locus Names:YALI0E02772g
OrganismYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) [Reference proteome]
Taxonomic identifier284591 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia

Protein attributes

Sequence length464 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, with a lower preference histone H4 to form H4K8ac and H4K16ac, and contributes to H2A.Z acetylation. Acetylation of histones gives a specific tag for epigenetic transcription activation By similarity.

Catalytic activity

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the acetyltransferase family. GCN5 subfamily.

Contains 1 bromo domain.

Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainBromodomain
   Molecular functionActivator
Acyltransferase
Chromatin regulator
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionhistone acetyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 464464Histone acetyltransferase GCN5
PRO_0000211200

Regions

Domain127 – 282156N-acetyltransferase
Domain369 – 43971Bromo
Compositional bias31 – 12898Glu-rich

Sites

Site2001Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8WZM0 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: A7F3FC0C3B6D2CC4

FASTA46454,096
        10         20         30         40         50         60 
MDSDTESVKR RKSSGSESES SVRDPKRTKI EDEDFQENGI DDEDEEEEEE EAKDEGDEDD 

        70         80         90        100        110        120 
EEKGEDDEED DEEKEGEDGE GEEEDEEEDE EKKREEEEKY VTSFNFDGVE YKYKERPAVI 

       130        140        150        160        170        180 
EEREGKIEFR VVNNDNSKEN LMILTGLKNI FQKQLPKMPR EYIARLVYDR SHVSMAVVRK 

       190        200        210        220        230        240 
PLTVVGGITF RPFDTRKFAE IVFCAISSTE QVRGYGAHLM NHLKDYVKAT SPVMYFLTYA 

       250        260        270        280        290        300 
DNYAIGYFKK QGFSKEISLD RSVWMGYIKD YEGGTLMQCS MLPRIRYLDV NKILLLQKAL 

       310        320        330        340        350        360 
IHKKIRAISK SHVVRKGLDH FRDSTTPVDP MTIPGLKEAG WTPEMDELAR RPKRGPHFAV 

       370        380        390        400        410        420 
MQHVLSELQN HASAWPFAQA VNRDEVPDYY EVIKEPMDLS TMEQRLEADS YKTMEEFVYD 

       430        440        450        460 
ARLVFNNCRA YNNETTTYYK NANKLEKFMV AKIKEIPEYS HLVE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ237940 Genomic DNA. Translation: CAC80210.1.
CR382131 Genomic DNA. Translation: CAG79052.1.
RefSeqXP_503473.1. XM_503473.1.

3D structure databases

ProteinModelPortalQ8WZM0.
SMRQ8WZM0. Positions 126-289, 354-463.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCAG79052; CAG79052; YALI0_E02772g.
GeneID2912645.
KEGGyli:YALI0E02772g.

Phylogenomic databases

eggNOGCOG5076.
HOGENOMHOG000192257.
KOK06062.
OMADNCRKYN.
OrthoDBEOG7XM37B.

Family and domain databases

Gene3D1.20.920.10. 1 hit.
3.40.630.30. 1 hit.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR000182. GNAT_dom.
[Graphical view]
PfamPF00583. Acetyltransf_1. 1 hit.
PF00439. Bromodomain. 1 hit.
[Graphical view]
PRINTSPR00503. BROMODOMAIN.
SMARTSM00297. BROMO. 1 hit.
[Graphical view]
SUPFAMSSF47370. SSF47370. 1 hit.
SSF55729. SSF55729. 1 hit.
PROSITEPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCN5_YARLI
AccessionPrimary (citable) accession number: Q8WZM0
Secondary accession number(s): Q6C789
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: March 1, 2002
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families