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Q8WZM0

- GCN5_YARLI

UniProt

Q8WZM0 - GCN5_YARLI

Protein

Histone acetyltransferase GCN5

Gene

GCN5

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, with a lower preference histone H4 to form H4K8ac and H4K16ac, and contributes to H2A.Z acetylation. Acetylation of histones gives a specific tag for epigenetic transcription activation By similarity.By similarity

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei200 – 2001Important for catalytic activityBy similarity

    GO - Molecular functioni

    1. histone acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Acyltransferase, Chromatin regulator, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone acetyltransferase GCN5 (EC:2.3.1.48)
    Gene namesi
    Name:GCN5
    Ordered Locus Names:YALI0E02772g
    OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
    Taxonomic identifieri284591 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
    ProteomesiUP000001300: Chromosome E

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 464464Histone acetyltransferase GCN5PRO_0000211200Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WZM0.
    SMRiQ8WZM0. Positions 126-289, 354-463.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini127 – 282156N-acetyltransferasePROSITE-ProRule annotationAdd
    BLAST
    Domaini369 – 43971BromoPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi31 – 12898Glu-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 bromo domain.PROSITE-ProRule annotation
    Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Bromodomain

    Phylogenomic databases

    eggNOGiCOG5076.
    HOGENOMiHOG000192257.
    KOiK06062.
    OMAiDNCRKYN.
    OrthoDBiEOG7XM37B.

    Family and domain databases

    Gene3Di1.20.920.10. 1 hit.
    3.40.630.30. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR001487. Bromodomain.
    IPR018359. Bromodomain_CS.
    IPR000182. GNAT_dom.
    [Graphical view]
    PfamiPF00583. Acetyltransf_1. 1 hit.
    PF00439. Bromodomain. 1 hit.
    [Graphical view]
    PRINTSiPR00503. BROMODOMAIN.
    SMARTiSM00297. BROMO. 1 hit.
    [Graphical view]
    SUPFAMiSSF47370. SSF47370. 1 hit.
    SSF55729. SSF55729. 1 hit.
    PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
    PS50014. BROMODOMAIN_2. 1 hit.
    PS51186. GNAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8WZM0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSDTESVKR RKSSGSESES SVRDPKRTKI EDEDFQENGI DDEDEEEEEE    50
    EAKDEGDEDD EEKGEDDEED DEEKEGEDGE GEEEDEEEDE EKKREEEEKY 100
    VTSFNFDGVE YKYKERPAVI EEREGKIEFR VVNNDNSKEN LMILTGLKNI 150
    FQKQLPKMPR EYIARLVYDR SHVSMAVVRK PLTVVGGITF RPFDTRKFAE 200
    IVFCAISSTE QVRGYGAHLM NHLKDYVKAT SPVMYFLTYA DNYAIGYFKK 250
    QGFSKEISLD RSVWMGYIKD YEGGTLMQCS MLPRIRYLDV NKILLLQKAL 300
    IHKKIRAISK SHVVRKGLDH FRDSTTPVDP MTIPGLKEAG WTPEMDELAR 350
    RPKRGPHFAV MQHVLSELQN HASAWPFAQA VNRDEVPDYY EVIKEPMDLS 400
    TMEQRLEADS YKTMEEFVYD ARLVFNNCRA YNNETTTYYK NANKLEKFMV 450
    AKIKEIPEYS HLVE 464
    Length:464
    Mass (Da):54,096
    Last modified:March 1, 2002 - v1
    Checksum:iA7F3FC0C3B6D2CC4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ237940 Genomic DNA. Translation: CAC80210.1.
    CR382131 Genomic DNA. Translation: CAG79052.1.
    RefSeqiXP_503473.1. XM_503473.1.

    Genome annotation databases

    EnsemblFungiiCAG79052; CAG79052; YALI0_E02772g.
    GeneIDi2912645.
    KEGGiyli:YALI0E02772g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ237940 Genomic DNA. Translation: CAC80210.1 .
    CR382131 Genomic DNA. Translation: CAG79052.1 .
    RefSeqi XP_503473.1. XM_503473.1.

    3D structure databases

    ProteinModelPortali Q8WZM0.
    SMRi Q8WZM0. Positions 126-289, 354-463.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CAG79052 ; CAG79052 ; YALI0_E02772g .
    GeneIDi 2912645.
    KEGGi yli:YALI0E02772g.

    Phylogenomic databases

    eggNOGi COG5076.
    HOGENOMi HOG000192257.
    KOi K06062.
    OMAi DNCRKYN.
    OrthoDBi EOG7XM37B.

    Family and domain databases

    Gene3Di 1.20.920.10. 1 hit.
    3.40.630.30. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR001487. Bromodomain.
    IPR018359. Bromodomain_CS.
    IPR000182. GNAT_dom.
    [Graphical view ]
    Pfami PF00583. Acetyltransf_1. 1 hit.
    PF00439. Bromodomain. 1 hit.
    [Graphical view ]
    PRINTSi PR00503. BROMODOMAIN.
    SMARTi SM00297. BROMO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47370. SSF47370. 1 hit.
    SSF55729. SSF55729. 1 hit.
    PROSITEi PS00633. BROMODOMAIN_1. 1 hit.
    PS50014. BROMODOMAIN_2. 1 hit.
    PS51186. GNAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of the GCN5 gene of Yarrowia lipolytica."
      Gonzalez-Prieto J., Dominguez-Olavarri A., Ruiz-Herrera J.
      Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: INAG 35668.
    2. "Genome evolution in yeasts."
      Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
      , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
      Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CLIB 122 / E 150.

    Entry informationi

    Entry nameiGCN5_YARLI
    AccessioniPrimary (citable) accession number: Q8WZM0
    Secondary accession number(s): Q6C789
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3