Q8WZM0 (GCN5_YARLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone acetyltransferase GCN5
EC=2.3.1.48

Gene names

Name:	GCN5
Ordered Locus Names:	YALI0E02772g

Organism

Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) [Reference proteome]

Taxonomic identifier

284591 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Dipodascaceae › Yarrowia › Yarrowia lipolytica

Protein attributes

Sequence length	464 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, with a lower preference histone H4 to form H4K8ac and H4K16ac, and contributes to H2A.Z acetylation. Acetylation of histones gives a specific tag for epigenetic transcription activation By similarity.
Catalytic activity	Acetyl-CoA + [histone] = CoA + acetyl-[histone].
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the GCN5 family. Contains 1 bromo domain. Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Bromodomain
Molecular function	Activator Acyltransferase Chromatin regulator Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	histone acetylation Inferred from electronic annotation. Source: GOC regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	histone acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 464	464	Histone acetyltransferase GCN5		PRO_0000211200
Regions
	Domain	127 – 282	156	N-acetyltransferase
	Domain	369 – 439	71	Bromo
	Compositional bias	31 – 128	98	Glu-rich
Sites
	Site	200	1	Important for catalytic activity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8WZM0 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: A7F3FC0C3B6D2CC4	FASTA	464	54,096
	10 20 30 40 50 60 MDSDTESVKR RKSSGSESES SVRDPKRTKI EDEDFQENGI DDEDEEEEEE EAKDEGDEDD 70 80 90 100 110 120 EEKGEDDEED DEEKEGEDGE GEEEDEEEDE EKKREEEEKY VTSFNFDGVE YKYKERPAVI 130 140 150 160 170 180 EEREGKIEFR VVNNDNSKEN LMILTGLKNI FQKQLPKMPR EYIARLVYDR SHVSMAVVRK 190 200 210 220 230 240 PLTVVGGITF RPFDTRKFAE IVFCAISSTE QVRGYGAHLM NHLKDYVKAT SPVMYFLTYA 250 260 270 280 290 300 DNYAIGYFKK QGFSKEISLD RSVWMGYIKD YEGGTLMQCS MLPRIRYLDV NKILLLQKAL 310 320 330 340 350 360 IHKKIRAISK SHVVRKGLDH FRDSTTPVDP MTIPGLKEAG WTPEMDELAR RPKRGPHFAV 370 380 390 400 410 420 MQHVLSELQN HASAWPFAQA VNRDEVPDYY EVIKEPMDLS TMEQRLEADS YKTMEEFVYD 430 440 450 460 ARLVFNNCRA YNNETTTYYK NANKLEKFMV AKIKEIPEYS HLVE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of the GCN5 gene of Yarrowia lipolytica." Gonzalez-Prieto J., Dominguez-Olavarri A., Ruiz-Herrera J. Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: INAG 35668.
[2]	"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CLIB 122 / E 150.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ237940 Genomic DNA. Translation: CAC80210.1. CR382131 Genomic DNA. Translation: CAG79052.1.
RefSeq	XP_503473.1. XM_503473.1.
3D structure databases
ProteinModelPortal	Q8WZM0.
SMR	Q8WZM0. Positions 126-289, 354-463.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2912645.
KEGG	yli:YALI0E02772g.
Phylogenomic databases
eggNOG	COG5076.
HOGENOM	HOG000192257.
KO	K06062.
OMA	SVWMGYI.
OrthoDB	EOG412QF2.
Family and domain databases
Gene3D	1.20.920.10. 1 hit. 3.40.630.30. 1 hit.
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR001487. Bromodomain. IPR018359. Bromodomain_CS. IPR000182. GNAT_dom. [Graphical view]
Pfam	PF00583. Acetyltransf_1. 1 hit. PF00439. Bromodomain. 1 hit. [Graphical view]
PRINTS	PR00503. BROMODOMAIN.
SMART	SM00297. BROMO. 1 hit. [Graphical view]
SUPFAM	SSF55729. Acyl_CoA_acyltransferase. 1 hit. SSF47370. Bromodomain. 1 hit.
PROSITE	PS00633. BROMODOMAIN_1. 1 hit. PS50014. BROMODOMAIN_2. 1 hit. PS51186. GNAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCN5_YARLI

Accession

Primary (citable) accession number: Q8WZM0
Secondary accession number(s): Q6C789

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program