Reviewed,
UniProtKB/Swiss-Prot Q8WZM0 (GCN5_YARLI)
Last modified
February 9, 2010.
Version 51.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Histone acetyltransferase GCN5 EC=2.3.1.48 | ||||
| Gene names |
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| Organism | Yarrowia lipolytica (Candida lipolytica) [Complete proteome] | ||||
| Taxonomic identifier | 4952 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Dipodascaceae › Yarrowia |
Protein attributes
| Sequence length | 464 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, with a lower preference histone H4 to form H4K8ac and H4K16ac, and contributes to H2A.Z acetylation. Acetylation of histones gives a specific tag for epigenetic transcription activation By similarity. |
| Catalytic activity | Acetyl-CoA + [histone] = CoA + acetyl-[histone]. |
| Subcellular location | Nucleus By similarity. |
| Sequence similarities | Belongs to the GCN5 family. Contains 1 bromo domain. Contains 1 N-acetyltransferase domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Nucleus |
| Domain | Bromodomain |
| Molecular function | Activator Acyltransferase Chromatin regulator Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcriptionInferred from electronic annotation. Source: UniProtKB-KW transcriptionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | histone acetyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 464 | 464 | Histone acetyltransferase GCN5 | PRO_0000211200 | |||||
Regions | |||||||||
| Domain | 127 – 282 | 156 | N-acetyltransferase | ||||||
| Domain | 369 – 439 | 71 | Bromo | ||||||
| Compositional bias | 31 – 128 | 98 | Glu-rich | ||||||
Sites | |||||||||
| Site | 200 | 1 | Important for catalytic activity By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Isolation and characterization of the GCN5 gene of Yarrowia lipolytica." Gonzalez-Prieto J., Dominguez-Olavarri A., Ruiz-Herrera J. Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: INAG 35668. |
| [2] | "Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. Souciet J.-L.Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CLIB 122 / E 150. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AJ237940 Genomic DNA. Translation: CAC80210.1. CR382131 Genomic DNA. Translation: CAG79052.1. |
| RefSeq | XP_503473.1. |
3D structure databases | |
| SMR | Q8WZM0. Positions 126-289, 354-463. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q8WZM0. |
Genome annotation databases | |
| GeneID | 2912645. |
| GenomeReviews | Gene locus YALI0E02772g in contig CR382131_GR. |
| KEGG | yli:YALI0E02772g. |
Phylogenomic databases | |
| eggNOG | fuNOG05844. |
| HOGENOM | HBG749648. |
| OMA | GLKNIFQ. |
| OrthoDB | EOG9BP2TZ. |
| PhylomeDB | Q8WZM0. |
Enzyme and pathway databases | |
| BRENDA | 2.3.1.48. 3602. |
Family and domain databases | |
| InterPro | IPR016181. Acyl_CoA_acyltransferase. IPR001487. Bromodomain. IPR018359. Bromodomain_CS. IPR000182. GCN5-rel_AcTrfase. [Graphical view] |
| Gene3D | G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit. G3DSA:1.20.920.10. Bromodomain. 1 hit. |
| Pfam | PF00583. Acetyltransf_1. 1 hit. PF00439. Bromodomain. 1 hit. [Graphical view] |
| PRINTS | PR00503. BROMODOMAIN. |
| SMART | SM00297. BROMO. 1 hit. [Graphical view] |
| PROSITE | PS00633. BROMODOMAIN_1. 1 hit. PS50014. BROMODOMAIN_2. 1 hit. PS51186. GNAT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GCN5_YARLI | ||||||||
| Accession | Primary (citable) accession number: Q8WZM0 Secondary accession number(s): Q6C789 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||

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