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Protein

Dual specificity phosphatase ibp1

Gene

ibp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in DNA replication checkpoint via regulation of hsk1 or may act downstream of hsk1 in an S phase regulatory pathway.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei70 – 701Phosphocysteine intermediateBy similarity

GO - Molecular functioni

  • phosphoprotein phosphatase activity Source: PomBase
  • protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • mitotic nuclear division Source: UniProtKB-KW
  • protein dephosphorylation Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity phosphatase ibp1 (EC:3.1.3.48)
Alternative name(s):
Cdc25-like phosphatase ibp1
Itsy bitsy phosphatase 1
Gene namesi
Name:ibp1
ORF Names:SPBC839.07
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC839.07.
PomBaseiSPBC839.07. ibp1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi70 – 701C → S: No catalytic activity. 1 Publication
Mutagenesisi73 – 731S → A: No catalytic activity. 1 Publication
Mutagenesisi76 – 761R → A: No catalytic activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 138138Dual specificity phosphatase ibp1PRO_0000256254Add
BLAST

Proteomic databases

MaxQBiQ8WZK3.

Interactioni

Protein-protein interaction databases

BioGridi277728. 13 interactions.
MINTiMINT-4701059.

Structurei

3D structure databases

ProteinModelPortaliQ8WZK3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 133115RhodanesePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MPI phosphatase family.Curated
Contains 1 rhodanese domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000162894.
InParanoidiQ8WZK3.
KOiK18065.
OMAiRITESKE.
OrthoDBiEOG092C5E20.
PhylomeDBiQ8WZK3.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
InterProiIPR001763. Rhodanese-like_dom.
[Graphical view]
PfamiPF00581. Rhodanese. 1 hit.
[Graphical view]
SMARTiSM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WZK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTLSYVSPD ALKGWLMESP NEISIIDVRD YDYEGERIPG SVRIPSDTFL
60 70 80 90 100
ASVDQHVDDL MKKRSLIVHC TYSQVRGPKA ARVLSEILRN RITESKEKLS
110 120 130
LSQKEKLFQN LPTVYILHGG FSAWKRRYGG QQGLIEYD
Length:138
Mass (Da):15,778
Last modified:March 1, 2002 - v1
Checksum:i48B69E211539AECF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB46700.1.
PIRiT40714.
RefSeqiNP_595247.1. NM_001021153.2.

Genome annotation databases

EnsemblFungiiSPBC839.07.1; SPBC839.07.1:pep; SPBC839.07.
GeneIDi2541214.
KEGGispo:SPBC839.07.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB46700.1.
PIRiT40714.
RefSeqiNP_595247.1. NM_001021153.2.

3D structure databases

ProteinModelPortaliQ8WZK3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277728. 13 interactions.
MINTiMINT-4701059.

Proteomic databases

MaxQBiQ8WZK3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC839.07.1; SPBC839.07.1:pep; SPBC839.07.
GeneIDi2541214.
KEGGispo:SPBC839.07.

Organism-specific databases

EuPathDBiFungiDB:SPBC839.07.
PomBaseiSPBC839.07. ibp1.

Phylogenomic databases

HOGENOMiHOG000162894.
InParanoidiQ8WZK3.
KOiK18065.
OMAiRITESKE.
OrthoDBiEOG092C5E20.
PhylomeDBiQ8WZK3.

Miscellaneous databases

PROiQ8WZK3.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
InterProiIPR001763. Rhodanese-like_dom.
[Graphical view]
PfamiPF00581. Rhodanese. 1 hit.
[Graphical view]
SMARTiSM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIBP1_SCHPO
AccessioniPrimary (citable) accession number: Q8WZK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.