Reviewed, UniProtKB/Swiss-Prot Q8WZA9 (IRGQ_HUMAN)

Names and origin

Protein names

Recommended name:
    Immunity-related GTPase family Q protein

Gene names

Name:	IRGQ
Synonyms:	IRGQ1
ORF Names:	FKSG27

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	623 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

Ontologies

Keywords
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
GABARAPL2	P60520	1	EBI-1055331,EBI-720116

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 623	623	Immunity-related GTPase family Q protein		PRO_0000264463
Regions
	Coiled coil	155 – 180	26	Potential
	Compositional bias	288 – 291	4	Poly-Ala
	Compositional bias	358 – 361	4	Poly-Gly
	Compositional bias	449 – 617	169	Ala-rich
Amino acid modifications
	Modified residue	203	1	Phosphothreonine Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q8WZA9-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 6D7231134A3A799B	FASTA	623	62,717
	10 20 30 40 50 60 MPPPQGDVTA LFLGPPGLGK SALIAALCDK DVETLEAPEG RPDSGVPSLR AAGPGLFLGE 70 80 90 100 110 120 LSCPPAAPGP WAAEANVLVL VLPGPEGNGE PLAPALGEAA LAALARGTPL LAVRNLRPGD 130 140 150 160 170 180 SQTAAQARDQ TAALLNSAGL GAADLFVLPA NCGSSDGCEE LERLRAALQS QAEALRRLLP 190 200 210 220 230 240 PAQDGFEVLG AAELEAVREA FETGGLEAAL SWVRSGLERL GSARLDLAVA GKADVGLVVD 250 260 270 280 290 300 MLLGLDPGDP GAAPASVPTA PTPFPAPERP NVVLWTVPLG HTGTATTAAA ASHPTHYDAL 310 320 330 340 350 360 ILVTPGAPTE KDWAQVQALL LPDAPLVCVR TDGEGEDPEC LGEGKMENPK GESLKNAGGG 370 380 390 400 410 420 GLENALSKGR EKCSAGSQKA GSGEGPGKAG SEGLQQVVGM KKSGGGDSER AAALSPEDET 430 440 450 460 470 480 WEVLEEAPPP VFPLRPGGLP GLCEWLRRAL PPAQAGALLL ALPPASPSAA RTKAAALRAG 490 500 510 520 530 540 AWRPALLASL AAAAAPLPGL GWACDVALLR GQLAEWRRGL GLEPTALARR ERALGLASGE 550 560 570 580 590 600 LAARAHFPGP VTRAEVEARL GAWAGEGTAG GAALGALSFL WPAGGAAATG GLGYRAAHGV 610 620 LLQALDEMRA DAEAVLAPPE PAQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of FKSG27, a novel gene related to cervical tumor." Wang Y.-G., Gong L. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Lubec G., Chen W.-Q., Sun Y. Submitted (DEC-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-20; 166-176; 178-214; 389-401; 533-544 AND 596-609, MASS SPECTROMETRY. Tissue: Fetal brain cortex.
[3]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-203, MASS SPECTROMETRY.
[4]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF322648 mRNA. Translation: AAL33884.1.
IPI	IPI00103925.
RefSeq	NP_001007562.1.
UniGene	Hs.546476 Hs.6217 Hs.690127
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8WZA9. 1 interaction.
PTM databases
PhosphoSite	Q8WZA9.
Proteomic databases
PeptideAtlas	Q8WZA9.
PRIDE	Q8WZA9.
Genome annotation databases
Ensembl	ENSG00000167378. Homo sapiens. [Contig view]
GeneID	126298.
KEGG	hsa:126298.
Organism-specific databases
GeneCards	GC19M048792.
HGNC	HGNC:24868. IRGQ.
PharmGKB	PA142671653.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q8WZA9.
OMA	Q8WZA9. WAGEGTA.
Gene expression databases
ArrayExpress	Q8WZA9.
Bgee	Q8WZA9.
CleanEx	HS_IRGQ.
GermOnline	ENSG00000167378. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	81757.

Entry information

Entry name

IRGQ_HUMAN

Accession

Primary (citable) accession number: Q8WZA9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	March 1, 2002
Last modified:	June 16, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)