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Protein

Immunity-related GTPase family Q protein

Gene

IRGQ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Immunity-related GTPase family Q protein
Gene namesi
Name:IRGQ
Synonyms:IRGQ1
ORF Names:FKSG27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000167378.8
HGNCiHGNC:24868 IRGQ
neXtProtiNX_Q8WZA9

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167378
PharmGKBiPA142671653

Polymorphism and mutation databases

BioMutaiIRGQ
DMDMi74751646

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002644631 – 623Immunity-related GTPase family Q proteinAdd BLAST623

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei203PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WZA9
MaxQBiQ8WZA9
PaxDbiQ8WZA9
PeptideAtlasiQ8WZA9
PRIDEiQ8WZA9

PTM databases

iPTMnetiQ8WZA9
PhosphoSitePlusiQ8WZA9

Expressioni

Gene expression databases

BgeeiENSG00000167378
CleanExiHS_IRGQ
ExpressionAtlasiQ8WZA9 baseline and differential
GenevisibleiQ8WZA9 HS

Organism-specific databases

HPAiHPA043254
HPA050338

Interactioni

Protein-protein interaction databases

BioGridi125975, 16 interactors
IntActiQ8WZA9, 7 interactors
STRINGi9606.ENSP00000387535

Structurei

3D structure databases

ProteinModelPortaliQ8WZA9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini223 – 449IRG-type GAdd BLAST227

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili155 – 180Sequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi288 – 291Poly-Ala4
Compositional biasi358 – 361Poly-Gly4
Compositional biasi449 – 617Ala-richAdd BLAST169

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IH4F Eukaryota
ENOG41114NV LUCA
GeneTreeiENSGT00510000048991
HOGENOMiHOG000060088
HOVERGENiHBG081807
InParanoidiQ8WZA9
OMAiPGLFLGE
OrthoDBiEOG091G09OD
PhylomeDBiQ8WZA9
TreeFamiTF331897

Family and domain databases

InterProiView protein in InterPro
IPR030385 G_IRG_dom
PROSITEiView protein in PROSITE
PS51716 G_IRG, 1 hit

Sequencei

Sequence statusi: Complete.

Q8WZA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPPQGDVTA LFLGPPGLGK SALIAALCDK DVETLEAPEG RPDSGVPSLR
60 70 80 90 100
AAGPGLFLGE LSCPPAAPGP WAAEANVLVL VLPGPEGNGE PLAPALGEAA
110 120 130 140 150
LAALARGTPL LAVRNLRPGD SQTAAQARDQ TAALLNSAGL GAADLFVLPA
160 170 180 190 200
NCGSSDGCEE LERLRAALQS QAEALRRLLP PAQDGFEVLG AAELEAVREA
210 220 230 240 250
FETGGLEAAL SWVRSGLERL GSARLDLAVA GKADVGLVVD MLLGLDPGDP
260 270 280 290 300
GAAPASVPTA PTPFPAPERP NVVLWTVPLG HTGTATTAAA ASHPTHYDAL
310 320 330 340 350
ILVTPGAPTE KDWAQVQALL LPDAPLVCVR TDGEGEDPEC LGEGKMENPK
360 370 380 390 400
GESLKNAGGG GLENALSKGR EKCSAGSQKA GSGEGPGKAG SEGLQQVVGM
410 420 430 440 450
KKSGGGDSER AAALSPEDET WEVLEEAPPP VFPLRPGGLP GLCEWLRRAL
460 470 480 490 500
PPAQAGALLL ALPPASPSAA RTKAAALRAG AWRPALLASL AAAAAPLPGL
510 520 530 540 550
GWACDVALLR GQLAEWRRGL GLEPTALARR ERALGLASGE LAARAHFPGP
560 570 580 590 600
VTRAEVEARL GAWAGEGTAG GAALGALSFL WPAGGAAATG GLGYRAAHGV
610 620
LLQALDEMRA DAEAVLAPPE PAQ
Length:623
Mass (Da):62,717
Last modified:March 1, 2002 - v1
Checksum:i6D7231134A3A799B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322648 mRNA Translation: AAL33884.1
CH471126 Genomic DNA Translation: EAW57205.1
BC137020 mRNA Translation: AAI37021.1
BC137021 mRNA Translation: AAI37022.1
CCDSiCCDS33040.1
RefSeqiNP_001007562.1, NM_001007561.2
XP_005258572.1, XM_005258515.3
UniGeneiHs.6217

Genome annotation databases

EnsembliENST00000422989; ENSP00000387535; ENSG00000167378
ENST00000602269; ENSP00000472250; ENSG00000167378
GeneIDi126298
KEGGihsa:126298
UCSCiuc002oww.3 human

Similar proteinsi

Entry informationi

Entry nameiIRGQ_HUMAN
AccessioniPrimary (citable) accession number: Q8WZA9
Secondary accession number(s): B2RNP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health