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Protein

Immunity-related GTPase family Q protein

Gene

IRGQ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Immunity-related GTPase family Q protein
Gene namesi
Name:IRGQ
Synonyms:IRGQ1
ORF Names:FKSG27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:24868. IRGQ.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671653.

Polymorphism and mutation databases

BioMutaiIRGQ.
DMDMi74751646.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 623623Immunity-related GTPase family Q proteinPRO_0000264463Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei203 – 2031PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WZA9.
MaxQBiQ8WZA9.
PaxDbiQ8WZA9.
PeptideAtlasiQ8WZA9.
PRIDEiQ8WZA9.

PTM databases

iPTMnetiQ8WZA9.
PhosphoSiteiQ8WZA9.

Expressioni

Gene expression databases

BgeeiQ8WZA9.
CleanExiHS_IRGQ.
ExpressionAtlasiQ8WZA9. baseline and differential.
GenevisibleiQ8WZA9. HS.

Organism-specific databases

HPAiHPA043254.

Interactioni

Protein-protein interaction databases

BioGridi125975. 16 interactions.
IntActiQ8WZA9. 7 interactions.
STRINGi9606.ENSP00000387535.

Structurei

3D structure databases

ProteinModelPortaliQ8WZA9.
SMRiQ8WZA9. Positions 8-33.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini223 – 449227IRG-type GAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili155 – 18026Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi288 – 2914Poly-Ala
Compositional biasi358 – 3614Poly-Gly
Compositional biasi449 – 617169Ala-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IH4F. Eukaryota.
ENOG41114NV. LUCA.
GeneTreeiENSGT00510000048991.
HOGENOMiHOG000060088.
HOVERGENiHBG081807.
InParanoidiQ8WZA9.
OMAiALSFLWP.
OrthoDBiEOG7N37CM.
PhylomeDBiQ8WZA9.
TreeFamiTF331897.

Family and domain databases

InterProiIPR030385. G_IRG_dom.
[Graphical view]
PROSITEiPS51716. G_IRG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WZA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPPQGDVTA LFLGPPGLGK SALIAALCDK DVETLEAPEG RPDSGVPSLR
60 70 80 90 100
AAGPGLFLGE LSCPPAAPGP WAAEANVLVL VLPGPEGNGE PLAPALGEAA
110 120 130 140 150
LAALARGTPL LAVRNLRPGD SQTAAQARDQ TAALLNSAGL GAADLFVLPA
160 170 180 190 200
NCGSSDGCEE LERLRAALQS QAEALRRLLP PAQDGFEVLG AAELEAVREA
210 220 230 240 250
FETGGLEAAL SWVRSGLERL GSARLDLAVA GKADVGLVVD MLLGLDPGDP
260 270 280 290 300
GAAPASVPTA PTPFPAPERP NVVLWTVPLG HTGTATTAAA ASHPTHYDAL
310 320 330 340 350
ILVTPGAPTE KDWAQVQALL LPDAPLVCVR TDGEGEDPEC LGEGKMENPK
360 370 380 390 400
GESLKNAGGG GLENALSKGR EKCSAGSQKA GSGEGPGKAG SEGLQQVVGM
410 420 430 440 450
KKSGGGDSER AAALSPEDET WEVLEEAPPP VFPLRPGGLP GLCEWLRRAL
460 470 480 490 500
PPAQAGALLL ALPPASPSAA RTKAAALRAG AWRPALLASL AAAAAPLPGL
510 520 530 540 550
GWACDVALLR GQLAEWRRGL GLEPTALARR ERALGLASGE LAARAHFPGP
560 570 580 590 600
VTRAEVEARL GAWAGEGTAG GAALGALSFL WPAGGAAATG GLGYRAAHGV
610 620
LLQALDEMRA DAEAVLAPPE PAQ
Length:623
Mass (Da):62,717
Last modified:March 1, 2002 - v1
Checksum:i6D7231134A3A799B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322648 mRNA. Translation: AAL33884.1.
CH471126 Genomic DNA. Translation: EAW57205.1.
BC137020 mRNA. Translation: AAI37021.1.
BC137021 mRNA. Translation: AAI37022.1.
CCDSiCCDS33040.1.
RefSeqiNP_001007562.1. NM_001007561.2.
XP_005258572.1. XM_005258515.2.
XP_005258573.1. XM_005258516.2.
UniGeneiHs.6217.

Genome annotation databases

EnsembliENST00000422989; ENSP00000387535; ENSG00000167378.
ENST00000602269; ENSP00000472250; ENSG00000167378.
GeneIDi126298.
KEGGihsa:126298.
UCSCiuc002oww.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322648 mRNA. Translation: AAL33884.1.
CH471126 Genomic DNA. Translation: EAW57205.1.
BC137020 mRNA. Translation: AAI37021.1.
BC137021 mRNA. Translation: AAI37022.1.
CCDSiCCDS33040.1.
RefSeqiNP_001007562.1. NM_001007561.2.
XP_005258572.1. XM_005258515.2.
XP_005258573.1. XM_005258516.2.
UniGeneiHs.6217.

3D structure databases

ProteinModelPortaliQ8WZA9.
SMRiQ8WZA9. Positions 8-33.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125975. 16 interactions.
IntActiQ8WZA9. 7 interactions.
STRINGi9606.ENSP00000387535.

PTM databases

iPTMnetiQ8WZA9.
PhosphoSiteiQ8WZA9.

Polymorphism and mutation databases

BioMutaiIRGQ.
DMDMi74751646.

Proteomic databases

EPDiQ8WZA9.
MaxQBiQ8WZA9.
PaxDbiQ8WZA9.
PeptideAtlasiQ8WZA9.
PRIDEiQ8WZA9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000422989; ENSP00000387535; ENSG00000167378.
ENST00000602269; ENSP00000472250; ENSG00000167378.
GeneIDi126298.
KEGGihsa:126298.
UCSCiuc002oww.3. human.

Organism-specific databases

CTDi126298.
GeneCardsiIRGQ.
HGNCiHGNC:24868. IRGQ.
HPAiHPA043254.
neXtProtiNX_Q8WZA9.
PharmGKBiPA142671653.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH4F. Eukaryota.
ENOG41114NV. LUCA.
GeneTreeiENSGT00510000048991.
HOGENOMiHOG000060088.
HOVERGENiHBG081807.
InParanoidiQ8WZA9.
OMAiALSFLWP.
OrthoDBiEOG7N37CM.
PhylomeDBiQ8WZA9.
TreeFamiTF331897.

Miscellaneous databases

ChiTaRSiIRGQ. human.
GenomeRNAii126298.
PROiQ8WZA9.

Gene expression databases

BgeeiQ8WZA9.
CleanExiHS_IRGQ.
ExpressionAtlasiQ8WZA9. baseline and differential.
GenevisibleiQ8WZA9. HS.

Family and domain databases

InterProiIPR030385. G_IRG_dom.
[Graphical view]
PROSITEiPS51716. G_IRG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of FKSG27, a novel gene related to cervical tumor."
    Wang Y.-G., Gong L.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Lubec G., Chen W.-Q., Sun Y.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-20; 166-176; 178-214; 389-401; 533-544 AND 596-609, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Fetal brain cortex.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-203, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiIRGQ_HUMAN
AccessioniPrimary (citable) accession number: Q8WZA9
Secondary accession number(s): B2RNP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 1, 2002
Last modified: June 8, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.