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Protein

Olfactory receptor 1E3

Gene

OR1E3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1E3
Alternative name(s):
Olfactory receptor 17-210
Short name:
OR17-210
Olfactory receptor OR17-7
Gene namesi
Name:OR1E3
Synonyms:OR1E3P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:8191. OR1E3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
Transmembranei29 – 49Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini50 – 107CytoplasmicSequence analysisAdd BLAST58
Transmembranei108 – 128Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini129 – 141ExtracellularSequence analysisAdd BLAST13
Transmembranei142 – 162Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini163 – 195CytoplasmicSequence analysisAdd BLAST33
Transmembranei196 – 216Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini217 – 242ExtracellularSequence analysisAdd BLAST26
Transmembranei243 – 263Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini264 – 271CytoplasmicSequence analysis8
Transmembranei272 – 292Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini293 – 310ExtracellularSequence analysisAdd BLAST18
Transmembranei311 – 331Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini332 – 343CytoplasmicSequence analysisAdd BLAST12

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi166215840.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003159431 – 343Olfactory receptor 1E3Add BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8WZA6.

Structurei

3D structure databases

ProteinModelPortaliQ8WZA6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG017625.
InParanoidiQ8WZA6.
PhylomeDBiQ8WZA6.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8WZA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKKNQTMIS EFLLLGLPIQ PEQQNLFYAL FLAVYLTTLL GNLLVIVLIR
60 70 80 90 100
LDSHLHMPMY LCLSNLSFSD LCFSSVTMPK LLQNMQSQNP SIPFADCLAQ
110 120 130 140 150
MYFHLFYGVL ESFLLVVMAY HCYVAICFPL HYTTIMSPKC CLGLLTLSWL
160 170 180 190 200
LTTAHATLHT LLMARLSFCA ENVIPHFFCD TSTLLKLACS NTQVNGWVMF
210 220 230 240 250
FMGGLILVIP FLLLIMSCAR IVSTILRVPS TGGIQKAFST CGPHLSVVSL
260 270 280 290 300
FYGTIIGLYL CPLTNHNTVK DTVMAVMYTG VTHMLNPFIY SLRNRDMRGN
310 320 330 340
PGQSLQHKEN FFVFKIVIVG ILPLLNLVGV VKLIMKYHSK SVA
Length:343
Mass (Da):38,518
Last modified:January 15, 2008 - v2
Checksum:iD20294E28EF1A787
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24Q → R in AF087929 (PubMed:10673334).Curated1
Sequence conflicti141 – 143CLG → WLA in AAA18353 (PubMed:8004088).Curated3
Sequence conflicti164 – 165AR → GS in AAA18353 (PubMed:8004088).Curated2

Polymorphismi

A single nucleotide deletion at position Leu-17 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC097370 Genomic DNA. No translation available.
AF087929 Genomic DNA. No translation available.
U04690 Genomic DNA. Translation: AAA18353.1.
AF399437 Genomic DNA. No translation available.
BK004549 Genomic DNA. No translation available.
PIRiI38482.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiOR1E3_HUMAN
AccessioniPrimary (citable) accession number: Q8WZA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: May 10, 2017
This is version 82 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families