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Q8WZA2

- RPGF4_HUMAN

UniProt

Q8WZA2 - RPGF4_HUMAN

Protein

Rap guanine nucleotide exchange factor 4

Gene

RAPGEF4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2 By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi43 – 166124cAMP 1Add
    BLAST
    Nucleotide bindingi356 – 476121cAMP 2Add
    BLAST

    GO - Molecular functioni

    1. cAMP binding Source: UniProtKB
    2. cAMP-dependent protein kinase regulator activity Source: InterPro
    3. guanyl-nucleotide exchange factor activity Source: ProtInc
    4. protein binding Source: UniProtKB
    5. Ras GTPase binding Source: UniProtKB
    6. Ras guanyl-nucleotide exchange factor activity Source: UniProtKB

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. calcium ion-dependent exocytosis Source: Ensembl
    3. cAMP-mediated signaling Source: Ensembl
    4. energy reserve metabolic process Source: Reactome
    5. G-protein coupled receptor signaling pathway Source: ProtInc
    6. insulin secretion Source: Ensembl
    7. platelet activation Source: Reactome
    8. positive regulation of GTPase activity Source: GOC
    9. positive regulation of Ras GTPase activity Source: GOC
    10. regulation of exocytosis Source: Ensembl
    11. regulation of insulin secretion Source: Reactome
    12. small GTPase mediated signal transduction Source: InterPro
    13. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Keywords - Biological processi

    Exocytosis

    Keywords - Ligandi

    cAMP, cAMP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_15523. Integrin alphaIIb beta3 signaling.
    REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
    REACT_18325. Regulation of insulin secretion.
    REACT_23898. Rap1 signalling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rap guanine nucleotide exchange factor 4
    Alternative name(s):
    Exchange factor directly activated by cAMP 2
    Exchange protein directly activated by cAMP 2
    Short name:
    EPAC 2
    cAMP-regulated guanine nucleotide exchange factor II
    Short name:
    cAMP-GEFII
    Gene namesi
    Name:RAPGEF4
    Synonyms:CGEF2, EPAC2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:16626. RAPGEF4.

    Subcellular locationi

    Cytoplasm. Membrane By similarity; Peripheral membrane protein By similarity

    GO - Cellular componenti

    1. cAMP-dependent protein kinase complex Source: InterPro
    2. cytosol Source: Ensembl
    3. membrane Source: ProtInc
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134861108.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10111011Rap guanine nucleotide exchange factor 4PRO_0000068870Add
    BLAST

    Proteomic databases

    PaxDbiQ8WZA2.
    PRIDEiQ8WZA2.

    PTM databases

    PhosphoSiteiQ8WZA2.

    Expressioni

    Tissue specificityi

    Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels.

    Gene expression databases

    ArrayExpressiQ8WZA2.
    BgeeiQ8WZA2.
    CleanExiHS_RAPGEF4.
    GenevestigatoriQ8WZA2.

    Organism-specific databases

    HPAiCAB004388.
    HPA028968.

    Interactioni

    Subunit structurei

    Interacts with RIMS1 and RIMS2. Probably part of a complex with RIMS2 and GTP-activated RAB3A By similarity.By similarity

    Protein-protein interaction databases

    BioGridi116253. 5 interactions.
    IntActiQ8WZA2. 1 interaction.
    MINTiMINT-2869318.
    STRINGi9606.ENSP00000380271.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WZA2.
    SMRiQ8WZA2. Positions 11-1009.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini216 – 29176DEPPROSITE-ProRule annotationAdd
    BLAST
    Domaini496 – 634139N-terminal Ras-GEFPROSITE-ProRule annotationAdd
    BLAST
    Domaini772 – 1009238Ras-GEFPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The N-terminal nucleotide phosphate binding region cAMP 1 has a much lower affinity for cAMP as compared to cAMP 2.
    The DEP domain is involved in membrane localization independent from regulation by cAMP.By similarity

    Sequence similaritiesi

    Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 DEP domain.PROSITE-ProRule annotation
    Contains 1 N-terminal Ras-GEF domain.PROSITE-ProRule annotation
    Contains 1 Ras-GEF domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0664.
    HOGENOMiHOG000230545.
    HOVERGENiHBG056985.
    InParanoidiQ8WZA2.
    KOiK04351.
    OMAiTIYDWEL.
    OrthoDBiEOG7ZD1TF.
    PhylomeDBiQ8WZA2.
    TreeFamiTF313184.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    1.10.840.10. 1 hit.
    2.60.120.10. 2 hits.
    InterProiIPR002373. cAMP/cGMP_kin.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR000591. DEP_dom.
    IPR000159. Ras-assoc.
    IPR000651. Ras-like_Gua-exchang_fac_N.
    IPR019804. Ras_G-nucl-exch_fac_CS.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    IPR014710. RmlC-like_jellyroll.
    IPR029071. Ubiquitin-rel_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 2 hits.
    PF00610. DEP. 1 hit.
    PF00788. RA. 1 hit.
    PF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    [Graphical view]
    PRINTSiPR00103. CAMPKINASE.
    SMARTiSM00100. cNMP. 2 hits.
    SM00049. DEP. 1 hit.
    SM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 1 hit.
    [Graphical view]
    SUPFAMiSSF48366. SSF48366. 2 hits.
    SSF51206. SSF51206. 2 hits.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
    PS50186. DEP. 1 hit.
    PS00720. RASGEF. 1 hit.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative promoter usage and alternative splicing. Align

    Isoform 1 (identifier: Q8WZA2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVAAHAAHSS SSAEWIACLD KRPLERSSED VDIIFTRLKE VKAFEKFHPN     50
    LLHQICLCGY YENLEKGITL FRQGDIGTNW YAVLAGSLDV KVSETSSHQD 100
    AVTICTLGIG TAFGESILDN TPRHATIVTR ESSELLRIEQ KDFKALWEKY 150
    RQYMAGLLAP PYGVMETGSN NDRIPDKENT PLIEPHVPLR PANTITKVPS 200
    EKILRAGKIL RNAILSRAPH MIRDRKYHLK TYRQCCVGTE LVDWMMQQTP 250
    CVHSRTQAVG MWQVLLEDGV LNHVDQEHHF QDKYLFYRFL DDEHEDAPLP 300
    TEEEKKECDE ELQDTMLLLS QMGPDAHMRM ILRKPPGQRT VDDLEIIYEE 350
    LLHIKALSHL STTVKRELAG VLIFESHAKG GTVLFNQGEE GTSWYIILKG 400
    SVNVVIYGKG VVCTLHEGDD FGKLALVNDA PRAASIVLRE DNCHFLRVDK 450
    EDFNRILRDV EANTVRLKEH DQDVLVLEKV PAGNRASNQG NSQPQQKYTV 500
    MSGTPEKILE HFLETIRLEA TLNEATDSVL NDFIMMHCVF MPNTQLCPAL 550
    VAHYHAQPSQ GTEQEKMDYA LNNKRRVIRL VLQWAAMYGD LLQEDDVSMA 600
    FLEEFYVSVS DDARMIAALK EQLPELEKIV KQISEDAKAP QKKHKVLLQQ 650
    FNTGDERAQK RQPIRGSDEV LFKVYCMDHT YTTIRVPVAT SVKEVISAVA 700
    DKLGSGEGLI IVKMSSGGEK VVLKPNDVSV FTTLTINGRL FACPREQFDS 750
    LTPLPEQEGP TVGTVGTFEL MSSKDLAYQM TIYDWELFNC VHELELIYHT 800
    FGRHNFKKTT ANLDLFLRRF NEIQFWVVTE ICLCSQLSKR VQLLKKFIKI 850
    AAHCKEYKNL NSFFAIVMGL SNVAVSRLAL TWEKLPSKFK KFYAEFESLM 900
    DPSRNHRAYR LTVAKLEPPL IPFMPLLIKD MTFTHEGNKT FIDNLVNFEK 950
    MRMIANTART VRYYRSQPFN PDAAQANKNH QDVRSYVRQL NVIDNQRTLS 1000
    QMSHRLEPRR P 1011

    Note: Produced by alternative promoter usage. Promoter analysis was carried out in mouse.

    Length:1,011
    Mass (Da):115,522
    Last modified:March 1, 2002 - v1
    Checksum:i9427C5F92F2FFAD1
    GO
    Isoform 2 (identifier: Q8WZA2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-315: Missing.

    Note: Produced by alternative promoter usage. Promoter analysis was carried out in mouse.

    Show »
    Length:696
    Mass (Da):79,492
    Checksum:i936C1CEC6FA169C8
    GO
    Isoform 3 (identifier: Q8WZA2-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-144: Missing.
         145-148: ALWE → MLYK

    Note: Produced by alternative splicing of isoform 1. No experimental confirmation available.

    Show »
    Length:867
    Mass (Da):99,523
    Checksum:i5CA711EAD3DBEE66
    GO
    Isoform 4 (identifier: Q8WZA2-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-153: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:858
    Mass (Da):98,248
    Checksum:iAD52D5D0637CF299
    GO
    Isoform 5 (identifier: Q8WZA2-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-153: Missing.
         180-197: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:840
    Mass (Da):96,269
    Checksum:i6FF8498DB079C13C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti324 – 3241P → R in AAH40183. (PubMed:15489334)Curated
    Sequence conflicti511 – 5111H → R in AAH40183. (PubMed:15489334)Curated
    Sequence conflicti647 – 6471L → I in AAH40183. (PubMed:15489334)Curated
    Sequence conflicti679 – 6791H → P in AAH24004. (PubMed:15489334)Curated
    Sequence conflicti732 – 7321T → M in AAH24004. (PubMed:15489334)Curated
    Sequence conflicti873 – 8731V → I in AAD03422. (PubMed:9856955)Curated
    Sequence conflicti902 – 9021P → T in AAH40183. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 315315Missing in isoform 2. 1 PublicationVSP_007611Add
    BLAST
    Alternative sequencei1 – 153153Missing in isoform 4 and isoform 5. 1 PublicationVSP_054423Add
    BLAST
    Alternative sequencei1 – 144144Missing in isoform 3. 2 PublicationsVSP_007612Add
    BLAST
    Alternative sequencei145 – 1484ALWE → MLYK in isoform 3. 2 PublicationsVSP_007613
    Alternative sequencei180 – 19718Missing in isoform 5. 1 PublicationVSP_054424Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U78516 mRNA. Translation: AAD03422.1.
    AB027471 mRNA. Translation: BAB72179.1.
    AK294445 mRNA. Translation: BAH11769.1.
    AK296340 mRNA. Translation: BAH12322.1.
    AK304278 mRNA. Translation: BAH14148.1.
    AK313084 mRNA. Translation: BAG35910.1.
    AK316072 mRNA. Translation: BAH14443.1.
    AC009484 Genomic DNA. No translation available.
    AC018712 Genomic DNA. No translation available.
    AC019046 Genomic DNA. No translation available.
    AC104086 Genomic DNA. No translation available.
    BC024004 mRNA. Translation: AAH24004.1.
    BC040183 mRNA. Translation: AAH40183.1.
    CCDSiCCDS42775.1. [Q8WZA2-1]
    CCDS42776.1. [Q8WZA2-3]
    CCDS63060.1. [Q8WZA2-4]
    CCDS63061.1. [Q8WZA2-5]
    RefSeqiNP_001093867.1. NM_001100397.1. [Q8WZA2-3]
    NP_001269828.1. NM_001282899.1. [Q8WZA2-4]
    NP_001269829.1. NM_001282900.1. [Q8WZA2-5]
    NP_001269830.1. NM_001282901.1.
    NP_008954.2. NM_007023.3. [Q8WZA2-1]
    XP_006712268.1. XM_006712205.1. [Q8WZA2-5]
    UniGeneiHs.470646.

    Genome annotation databases

    EnsembliENST00000397081; ENSP00000380271; ENSG00000091428. [Q8WZA2-1]
    ENST00000397087; ENSP00000380276; ENSG00000091428. [Q8WZA2-3]
    ENST00000538974; ENSP00000440135; ENSG00000091428. [Q8WZA2-5]
    ENST00000540783; ENSP00000440250; ENSG00000091428. [Q8WZA2-4]
    GeneIDi11069.
    KEGGihsa:11069.
    UCSCiuc002uhv.4. human. [Q8WZA2-1]
    uc002uhw.4. human. [Q8WZA2-3]

    Polymorphism databases

    DMDMi32171491.

    Keywords - Coding sequence diversityi

    Alternative promoter usage, Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U78516 mRNA. Translation: AAD03422.1 .
    AB027471 mRNA. Translation: BAB72179.1 .
    AK294445 mRNA. Translation: BAH11769.1 .
    AK296340 mRNA. Translation: BAH12322.1 .
    AK304278 mRNA. Translation: BAH14148.1 .
    AK313084 mRNA. Translation: BAG35910.1 .
    AK316072 mRNA. Translation: BAH14443.1 .
    AC009484 Genomic DNA. No translation available.
    AC018712 Genomic DNA. No translation available.
    AC019046 Genomic DNA. No translation available.
    AC104086 Genomic DNA. No translation available.
    BC024004 mRNA. Translation: AAH24004.1 .
    BC040183 mRNA. Translation: AAH40183.1 .
    CCDSi CCDS42775.1. [Q8WZA2-1 ]
    CCDS42776.1. [Q8WZA2-3 ]
    CCDS63060.1. [Q8WZA2-4 ]
    CCDS63061.1. [Q8WZA2-5 ]
    RefSeqi NP_001093867.1. NM_001100397.1. [Q8WZA2-3 ]
    NP_001269828.1. NM_001282899.1. [Q8WZA2-4 ]
    NP_001269829.1. NM_001282900.1. [Q8WZA2-5 ]
    NP_001269830.1. NM_001282901.1.
    NP_008954.2. NM_007023.3. [Q8WZA2-1 ]
    XP_006712268.1. XM_006712205.1. [Q8WZA2-5 ]
    UniGenei Hs.470646.

    3D structure databases

    ProteinModelPortali Q8WZA2.
    SMRi Q8WZA2. Positions 11-1009.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116253. 5 interactions.
    IntActi Q8WZA2. 1 interaction.
    MINTi MINT-2869318.
    STRINGi 9606.ENSP00000380271.

    Chemistry

    ChEMBLi CHEMBL2029198.
    GuidetoPHARMACOLOGYi 1293.

    PTM databases

    PhosphoSitei Q8WZA2.

    Polymorphism databases

    DMDMi 32171491.

    Proteomic databases

    PaxDbi Q8WZA2.
    PRIDEi Q8WZA2.

    Protocols and materials databases

    DNASUi 11069.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000397081 ; ENSP00000380271 ; ENSG00000091428 . [Q8WZA2-1 ]
    ENST00000397087 ; ENSP00000380276 ; ENSG00000091428 . [Q8WZA2-3 ]
    ENST00000538974 ; ENSP00000440135 ; ENSG00000091428 . [Q8WZA2-5 ]
    ENST00000540783 ; ENSP00000440250 ; ENSG00000091428 . [Q8WZA2-4 ]
    GeneIDi 11069.
    KEGGi hsa:11069.
    UCSCi uc002uhv.4. human. [Q8WZA2-1 ]
    uc002uhw.4. human. [Q8WZA2-3 ]

    Organism-specific databases

    CTDi 11069.
    GeneCardsi GC02P173600.
    HGNCi HGNC:16626. RAPGEF4.
    HPAi CAB004388.
    HPA028968.
    MIMi 606058. gene.
    neXtProti NX_Q8WZA2.
    PharmGKBi PA134861108.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0664.
    HOGENOMi HOG000230545.
    HOVERGENi HBG056985.
    InParanoidi Q8WZA2.
    KOi K04351.
    OMAi TIYDWEL.
    OrthoDBi EOG7ZD1TF.
    PhylomeDBi Q8WZA2.
    TreeFami TF313184.

    Enzyme and pathway databases

    Reactomei REACT_15523. Integrin alphaIIb beta3 signaling.
    REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
    REACT_18325. Regulation of insulin secretion.
    REACT_23898. Rap1 signalling.

    Miscellaneous databases

    ChiTaRSi RAPGEF4. human.
    GeneWikii RAPGEF4.
    GenomeRNAii 11069.
    NextBioi 35478932.
    PROi Q8WZA2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8WZA2.
    Bgeei Q8WZA2.
    CleanExi HS_RAPGEF4.
    Genevestigatori Q8WZA2.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    1.10.840.10. 1 hit.
    2.60.120.10. 2 hits.
    InterProi IPR002373. cAMP/cGMP_kin.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR000591. DEP_dom.
    IPR000159. Ras-assoc.
    IPR000651. Ras-like_Gua-exchang_fac_N.
    IPR019804. Ras_G-nucl-exch_fac_CS.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    IPR014710. RmlC-like_jellyroll.
    IPR029071. Ubiquitin-rel_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 2 hits.
    PF00610. DEP. 1 hit.
    PF00788. RA. 1 hit.
    PF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00103. CAMPKINASE.
    SMARTi SM00100. cNMP. 2 hits.
    SM00049. DEP. 1 hit.
    SM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48366. SSF48366. 2 hits.
    SSF51206. SSF51206. 2 hits.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
    PS50186. DEP. 1 hit.
    PS00720. RASGEF. 1 hit.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
    2. "Characterization of the gene EPAC2: structure, chromosomal localization, tissue expression, and identification of the liver-specific isoform."
      Ueno H., Shibasaki T., Iwanaga T., Takahashi K., Yokoyama Y., Liu L.M., Yokoi N., Ozaki N., Matsukura S., Yano H., Seino S.
      Genomics 78:91-98(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE PROMOTER USAGE.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 4 AND 5).
      Tissue: Amygdala, Hippocampus, Thalamus and Trachea.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Hypothalamus and Testis.
    6. "Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs."
      de Rooij J., Rehmann H., van Triest M., Cool R.H., Wittinghofer A., Bos J.L.
      J. Biol. Chem. 275:20829-20836(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiRPGF4_HUMAN
    AccessioniPrimary (citable) accession number: Q8WZA2
    Secondary accession number(s): B2R7R3
    , B7Z283, B7Z3T6, B7Z912, O95636, Q8IXK6, Q8TAA4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2003
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3