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Q8WZA2

- RPGF4_HUMAN

UniProt

Q8WZA2 - RPGF4_HUMAN

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Protein
Rap guanine nucleotide exchange factor 4
Gene
RAPGEF4, CGEF2, EPAC2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2 By similarity.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi43 – 166124cAMP 1
Add
BLAST
Nucleotide bindingi356 – 476121cAMP 2
Add
BLAST

GO - Molecular functioni

  1. Ras GTPase binding Source: UniProtKB
  2. Ras guanyl-nucleotide exchange factor activity Source: UniProtKB
  3. cAMP binding Source: UniProtKB
  4. cAMP-dependent protein kinase regulator activity Source: InterPro
  5. guanyl-nucleotide exchange factor activity Source: ProtInc
  6. protein binding Source: UniProtKB

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: ProtInc
  2. blood coagulation Source: Reactome
  3. cAMP-mediated signaling Source: Ensembl
  4. calcium ion-dependent exocytosis Source: Ensembl
  5. energy reserve metabolic process Source: Reactome
  6. insulin secretion Source: Ensembl
  7. platelet activation Source: Reactome
  8. regulation of GTPase activity Source: GOC
  9. regulation of Ras GTPase activity Source: GOC
  10. regulation of exocytosis Source: Ensembl
  11. regulation of insulin secretion Source: Reactome
  12. small GTPase mediated signal transduction Source: InterPro
  13. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Biological processi

Exocytosis

Keywords - Ligandi

cAMP, cAMP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_15523. Integrin alphaIIb beta3 signaling.
REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_18325. Regulation of insulin secretion.
REACT_23898. Rap1 signalling.

Names & Taxonomyi

Protein namesi
Recommended name:
Rap guanine nucleotide exchange factor 4
Alternative name(s):
Exchange factor directly activated by cAMP 2
Exchange protein directly activated by cAMP 2
Short name:
EPAC 2
cAMP-regulated guanine nucleotide exchange factor II
Short name:
cAMP-GEFII
Gene namesi
Name:RAPGEF4
Synonyms:CGEF2, EPAC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:16626. RAPGEF4.

Subcellular locationi

GO - Cellular componenti

  1. cAMP-dependent protein kinase complex Source: InterPro
  2. cytosol Source: Ensembl
  3. membrane Source: ProtInc
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134861108.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10111011Rap guanine nucleotide exchange factor 4
PRO_0000068870Add
BLAST

Proteomic databases

PaxDbiQ8WZA2.
PRIDEiQ8WZA2.

PTM databases

PhosphoSiteiQ8WZA2.

Expressioni

Tissue specificityi

Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels.

Gene expression databases

ArrayExpressiQ8WZA2.
BgeeiQ8WZA2.
CleanExiHS_RAPGEF4.
GenevestigatoriQ8WZA2.

Organism-specific databases

HPAiCAB004388.
HPA028968.

Interactioni

Subunit structurei

Interacts with RIMS1 and RIMS2. Probably part of a complex with RIMS2 and GTP-activated RAB3A By similarity.

Protein-protein interaction databases

BioGridi116253. 5 interactions.
IntActiQ8WZA2. 1 interaction.
MINTiMINT-2869318.
STRINGi9606.ENSP00000380271.

Structurei

3D structure databases

ProteinModelPortaliQ8WZA2.
SMRiQ8WZA2. Positions 11-1009.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini216 – 29176DEP
Add
BLAST
Domaini496 – 634139N-terminal Ras-GEF
Add
BLAST
Domaini772 – 1009238Ras-GEF
Add
BLAST

Domaini

The N-terminal nucleotide phosphate binding region cAMP 1 has a much lower affinity for cAMP as compared to cAMP 2.
The DEP domain is involved in membrane localization independent from regulation by cAMP By similarity.

Sequence similaritiesi

Contains 1 DEP domain.
Contains 1 Ras-GEF domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000230545.
HOVERGENiHBG056985.
InParanoidiQ8WZA2.
KOiK04351.
OMAiTIYDWEL.
OrthoDBiEOG7ZD1TF.
PhylomeDBiQ8WZA2.
TreeFamiTF313184.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.840.10. 1 hit.
2.60.120.10. 2 hits.
InterProiIPR002373. cAMP/cGMP_kin.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR000591. DEP_dom.
IPR000159. Ras-assoc.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
IPR014710. RmlC-like_jellyroll.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF00610. DEP. 1 hit.
PF00788. RA. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
PRINTSiPR00103. CAMPKINASE.
SMARTiSM00100. cNMP. 2 hits.
SM00049. DEP. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 2 hits.
SSF51206. SSF51206. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
PS50186. DEP. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative promoter usage and alternative splicing. Align

Isoform 1 (identifier: Q8WZA2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVAAHAAHSS SSAEWIACLD KRPLERSSED VDIIFTRLKE VKAFEKFHPN     50
LLHQICLCGY YENLEKGITL FRQGDIGTNW YAVLAGSLDV KVSETSSHQD 100
AVTICTLGIG TAFGESILDN TPRHATIVTR ESSELLRIEQ KDFKALWEKY 150
RQYMAGLLAP PYGVMETGSN NDRIPDKENT PLIEPHVPLR PANTITKVPS 200
EKILRAGKIL RNAILSRAPH MIRDRKYHLK TYRQCCVGTE LVDWMMQQTP 250
CVHSRTQAVG MWQVLLEDGV LNHVDQEHHF QDKYLFYRFL DDEHEDAPLP 300
TEEEKKECDE ELQDTMLLLS QMGPDAHMRM ILRKPPGQRT VDDLEIIYEE 350
LLHIKALSHL STTVKRELAG VLIFESHAKG GTVLFNQGEE GTSWYIILKG 400
SVNVVIYGKG VVCTLHEGDD FGKLALVNDA PRAASIVLRE DNCHFLRVDK 450
EDFNRILRDV EANTVRLKEH DQDVLVLEKV PAGNRASNQG NSQPQQKYTV 500
MSGTPEKILE HFLETIRLEA TLNEATDSVL NDFIMMHCVF MPNTQLCPAL 550
VAHYHAQPSQ GTEQEKMDYA LNNKRRVIRL VLQWAAMYGD LLQEDDVSMA 600
FLEEFYVSVS DDARMIAALK EQLPELEKIV KQISEDAKAP QKKHKVLLQQ 650
FNTGDERAQK RQPIRGSDEV LFKVYCMDHT YTTIRVPVAT SVKEVISAVA 700
DKLGSGEGLI IVKMSSGGEK VVLKPNDVSV FTTLTINGRL FACPREQFDS 750
LTPLPEQEGP TVGTVGTFEL MSSKDLAYQM TIYDWELFNC VHELELIYHT 800
FGRHNFKKTT ANLDLFLRRF NEIQFWVVTE ICLCSQLSKR VQLLKKFIKI 850
AAHCKEYKNL NSFFAIVMGL SNVAVSRLAL TWEKLPSKFK KFYAEFESLM 900
DPSRNHRAYR LTVAKLEPPL IPFMPLLIKD MTFTHEGNKT FIDNLVNFEK 950
MRMIANTART VRYYRSQPFN PDAAQANKNH QDVRSYVRQL NVIDNQRTLS 1000
QMSHRLEPRR P 1011

Note: Produced by alternative promoter usage. Promoter analysis was carried out in mouse.

Length:1,011
Mass (Da):115,522
Last modified:March 1, 2002 - v1
Checksum:i9427C5F92F2FFAD1
GO
Isoform 2 (identifier: Q8WZA2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-315: Missing.

Note: Produced by alternative promoter usage. Promoter analysis was carried out in mouse.

Show »
Length:696
Mass (Da):79,492
Checksum:i936C1CEC6FA169C8
GO
Isoform 3 (identifier: Q8WZA2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-144: Missing.
     145-148: ALWE → MLYK

Note: Produced by alternative splicing of isoform 1. No experimental confirmation available.

Show »
Length:867
Mass (Da):99,523
Checksum:i5CA711EAD3DBEE66
GO
Isoform 4 (identifier: Q8WZA2-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: Missing.

Note: No experimental confirmation available.

Show »
Length:858
Mass (Da):98,248
Checksum:iAD52D5D0637CF299
GO
Isoform 5 (identifier: Q8WZA2-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: Missing.
     180-197: Missing.

Note: No experimental confirmation available.

Show »
Length:840
Mass (Da):96,269
Checksum:i6FF8498DB079C13C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 315315Missing in isoform 2.
VSP_007611Add
BLAST
Alternative sequencei1 – 153153Missing in isoform 4 and isoform 5.
VSP_054423Add
BLAST
Alternative sequencei1 – 144144Missing in isoform 3.
VSP_007612Add
BLAST
Alternative sequencei145 – 1484ALWE → MLYK in isoform 3.
VSP_007613
Alternative sequencei180 – 19718Missing in isoform 5.
VSP_054424Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti324 – 3241P → R in AAH40183. 1 Publication
Sequence conflicti511 – 5111H → R in AAH40183. 1 Publication
Sequence conflicti647 – 6471L → I in AAH40183. 1 Publication
Sequence conflicti679 – 6791H → P in AAH24004. 1 Publication
Sequence conflicti732 – 7321T → M in AAH24004. 1 Publication
Sequence conflicti873 – 8731V → I in AAD03422. 1 Publication
Sequence conflicti902 – 9021P → T in AAH40183. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U78516 mRNA. Translation: AAD03422.1.
AB027471 mRNA. Translation: BAB72179.1.
AK294445 mRNA. Translation: BAH11769.1.
AK296340 mRNA. Translation: BAH12322.1.
AK304278 mRNA. Translation: BAH14148.1.
AK313084 mRNA. Translation: BAG35910.1.
AK316072 mRNA. Translation: BAH14443.1.
AC009484 Genomic DNA. No translation available.
AC018712 Genomic DNA. No translation available.
AC019046 Genomic DNA. No translation available.
AC104086 Genomic DNA. No translation available.
BC024004 mRNA. Translation: AAH24004.1.
BC040183 mRNA. Translation: AAH40183.1.
CCDSiCCDS42775.1. [Q8WZA2-1]
CCDS42776.1. [Q8WZA2-3]
CCDS63060.1. [Q8WZA2-4]
CCDS63061.1. [Q8WZA2-5]
RefSeqiNP_001093867.1. NM_001100397.1. [Q8WZA2-3]
NP_001269828.1. NM_001282899.1. [Q8WZA2-4]
NP_001269829.1. NM_001282900.1. [Q8WZA2-5]
NP_001269830.1. NM_001282901.1.
NP_008954.2. NM_007023.3. [Q8WZA2-1]
XP_006712268.1. XM_006712205.1. [Q8WZA2-5]
UniGeneiHs.470646.

Genome annotation databases

EnsembliENST00000397081; ENSP00000380271; ENSG00000091428. [Q8WZA2-1]
ENST00000397087; ENSP00000380276; ENSG00000091428. [Q8WZA2-3]
ENST00000538974; ENSP00000440135; ENSG00000091428.
ENST00000539331; ENSP00000437384; ENSG00000091428.
ENST00000540783; ENSP00000440250; ENSG00000091428.
GeneIDi11069.
KEGGihsa:11069.
UCSCiuc002uhv.4. human. [Q8WZA2-1]
uc002uhw.4. human. [Q8WZA2-3]

Polymorphism databases

DMDMi32171491.

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U78516 mRNA. Translation: AAD03422.1 .
AB027471 mRNA. Translation: BAB72179.1 .
AK294445 mRNA. Translation: BAH11769.1 .
AK296340 mRNA. Translation: BAH12322.1 .
AK304278 mRNA. Translation: BAH14148.1 .
AK313084 mRNA. Translation: BAG35910.1 .
AK316072 mRNA. Translation: BAH14443.1 .
AC009484 Genomic DNA. No translation available.
AC018712 Genomic DNA. No translation available.
AC019046 Genomic DNA. No translation available.
AC104086 Genomic DNA. No translation available.
BC024004 mRNA. Translation: AAH24004.1 .
BC040183 mRNA. Translation: AAH40183.1 .
CCDSi CCDS42775.1. [Q8WZA2-1 ]
CCDS42776.1. [Q8WZA2-3 ]
CCDS63060.1. [Q8WZA2-4 ]
CCDS63061.1. [Q8WZA2-5 ]
RefSeqi NP_001093867.1. NM_001100397.1. [Q8WZA2-3 ]
NP_001269828.1. NM_001282899.1. [Q8WZA2-4 ]
NP_001269829.1. NM_001282900.1. [Q8WZA2-5 ]
NP_001269830.1. NM_001282901.1.
NP_008954.2. NM_007023.3. [Q8WZA2-1 ]
XP_006712268.1. XM_006712205.1. [Q8WZA2-5 ]
UniGenei Hs.470646.

3D structure databases

ProteinModelPortali Q8WZA2.
SMRi Q8WZA2. Positions 11-1009.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116253. 5 interactions.
IntActi Q8WZA2. 1 interaction.
MINTi MINT-2869318.
STRINGi 9606.ENSP00000380271.

Chemistry

ChEMBLi CHEMBL2029198.
GuidetoPHARMACOLOGYi 1293.

PTM databases

PhosphoSitei Q8WZA2.

Polymorphism databases

DMDMi 32171491.

Proteomic databases

PaxDbi Q8WZA2.
PRIDEi Q8WZA2.

Protocols and materials databases

DNASUi 11069.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000397081 ; ENSP00000380271 ; ENSG00000091428 . [Q8WZA2-1 ]
ENST00000397087 ; ENSP00000380276 ; ENSG00000091428 . [Q8WZA2-3 ]
ENST00000538974 ; ENSP00000440135 ; ENSG00000091428 .
ENST00000539331 ; ENSP00000437384 ; ENSG00000091428 .
ENST00000540783 ; ENSP00000440250 ; ENSG00000091428 .
GeneIDi 11069.
KEGGi hsa:11069.
UCSCi uc002uhv.4. human. [Q8WZA2-1 ]
uc002uhw.4. human. [Q8WZA2-3 ]

Organism-specific databases

CTDi 11069.
GeneCardsi GC02P173600.
HGNCi HGNC:16626. RAPGEF4.
HPAi CAB004388.
HPA028968.
MIMi 606058. gene.
neXtProti NX_Q8WZA2.
PharmGKBi PA134861108.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0664.
HOGENOMi HOG000230545.
HOVERGENi HBG056985.
InParanoidi Q8WZA2.
KOi K04351.
OMAi TIYDWEL.
OrthoDBi EOG7ZD1TF.
PhylomeDBi Q8WZA2.
TreeFami TF313184.

Enzyme and pathway databases

Reactomei REACT_15523. Integrin alphaIIb beta3 signaling.
REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_18325. Regulation of insulin secretion.
REACT_23898. Rap1 signalling.

Miscellaneous databases

ChiTaRSi RAPGEF4. human.
GeneWikii RAPGEF4.
GenomeRNAii 11069.
NextBioi 35478932.
PROi Q8WZA2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8WZA2.
Bgeei Q8WZA2.
CleanExi HS_RAPGEF4.
Genevestigatori Q8WZA2.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
1.10.840.10. 1 hit.
2.60.120.10. 2 hits.
InterProi IPR002373. cAMP/cGMP_kin.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR000591. DEP_dom.
IPR000159. Ras-assoc.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
IPR014710. RmlC-like_jellyroll.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF00610. DEP. 1 hit.
PF00788. RA. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view ]
PRINTSi PR00103. CAMPKINASE.
SMARTi SM00100. cNMP. 2 hits.
SM00049. DEP. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view ]
SUPFAMi SSF48366. SSF48366. 2 hits.
SSF51206. SSF51206. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
PS50186. DEP. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
  2. "Characterization of the gene EPAC2: structure, chromosomal localization, tissue expression, and identification of the liver-specific isoform."
    Ueno H., Shibasaki T., Iwanaga T., Takahashi K., Yokoyama Y., Liu L.M., Yokoi N., Ozaki N., Matsukura S., Yano H., Seino S.
    Genomics 78:91-98(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE PROMOTER USAGE.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 4 AND 5).
    Tissue: Amygdala, Hippocampus, Thalamus and Trachea.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Hypothalamus and Testis.
  6. "Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs."
    de Rooij J., Rehmann H., van Triest M., Cool R.H., Wittinghofer A., Bos J.L.
    J. Biol. Chem. 275:20829-20836(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiRPGF4_HUMAN
AccessioniPrimary (citable) accession number: Q8WZA2
Secondary accession number(s): B2R7R3
, B7Z283, B7Z3T6, B7Z912, O95636, Q8IXK6, Q8TAA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: March 1, 2002
Last modified: September 3, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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