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Protein

Rap guanine nucleotide exchange factor 4

Gene

RAPGEF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2 (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi43 – 166124cAMP 1Add
BLAST
Nucleotide bindingi356 – 476121cAMP 2Add
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Biological processi

Exocytosis

Keywords - Ligandi

cAMP, cAMP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_15523. Integrin alphaIIb beta3 signaling.
REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_18325. Regulation of insulin secretion.
REACT_23898. Rap1 signalling.

Names & Taxonomyi

Protein namesi
Recommended name:
Rap guanine nucleotide exchange factor 4
Alternative name(s):
Exchange factor directly activated by cAMP 2
Exchange protein directly activated by cAMP 2
Short name:
EPAC 2
cAMP-regulated guanine nucleotide exchange factor II
Short name:
cAMP-GEFII
Gene namesi
Name:RAPGEF4
Synonyms:CGEF2, EPAC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:16626. RAPGEF4.

Subcellular locationi

GO - Cellular componenti

  • cAMP-dependent protein kinase complex Source: InterPro
  • cytosol Source: Ensembl
  • membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134861108.

Polymorphism and mutation databases

BioMutaiRAPGEF4.
DMDMi32171491.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10111011Rap guanine nucleotide exchange factor 4PRO_0000068870Add
BLAST

Proteomic databases

PaxDbiQ8WZA2.
PRIDEiQ8WZA2.

PTM databases

PhosphoSiteiQ8WZA2.

Expressioni

Tissue specificityi

Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels.

Gene expression databases

BgeeiQ8WZA2.
CleanExiHS_RAPGEF4.
ExpressionAtlasiQ8WZA2. baseline and differential.
GenevisibleiQ8WZA2. HS.

Organism-specific databases

HPAiCAB004388.
HPA028968.

Interactioni

Subunit structurei

Interacts with RIMS1 and RIMS2. Probably part of a complex with RIMS2 and GTP-activated RAB3A (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
C16orf45Q96MC53EBI-948476,EBI-718468

Protein-protein interaction databases

BioGridi116253. 10 interactions.
IntActiQ8WZA2. 3 interactions.
MINTiMINT-2869318.
STRINGi9606.ENSP00000380271.

Structurei

3D structure databases

ProteinModelPortaliQ8WZA2.
SMRiQ8WZA2. Positions 11-1009.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini216 – 29176DEPPROSITE-ProRule annotationAdd
BLAST
Domaini496 – 634139N-terminal Ras-GEFPROSITE-ProRule annotationAdd
BLAST
Domaini772 – 1009238Ras-GEFPROSITE-ProRule annotationAdd
BLAST

Domaini

The N-terminal nucleotide phosphate binding region cAMP 1 has a much lower affinity for cAMP as compared to cAMP 2.
The DEP domain is involved in membrane localization independent from regulation by cAMP.By similarity

Sequence similaritiesi

Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 DEP domain.PROSITE-ProRule annotation
Contains 1 N-terminal Ras-GEF domain.PROSITE-ProRule annotation
Contains 1 Ras-GEF domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0664.
GeneTreeiENSGT00800000124012.
HOGENOMiHOG000230545.
HOVERGENiHBG056985.
InParanoidiQ8WZA2.
KOiK04351.
OMAiTIYDWEL.
OrthoDBiEOG7ZD1TF.
PhylomeDBiQ8WZA2.
TreeFamiTF313184.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.840.10. 1 hit.
2.60.120.10. 2 hits.
InterProiIPR002373. cAMP/cGMP_kin.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR000591. DEP_dom.
IPR000159. Ras-assoc.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR014710. RmlC-like_jellyroll.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF00610. DEP. 1 hit.
PF00788. RA. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
PRINTSiPR00103. CAMPKINASE.
SMARTiSM00100. cNMP. 2 hits.
SM00049. DEP. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 2 hits.
SSF51206. SSF51206. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
PS50186. DEP. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WZA2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVAAHAAHSS SSAEWIACLD KRPLERSSED VDIIFTRLKE VKAFEKFHPN
60 70 80 90 100
LLHQICLCGY YENLEKGITL FRQGDIGTNW YAVLAGSLDV KVSETSSHQD
110 120 130 140 150
AVTICTLGIG TAFGESILDN TPRHATIVTR ESSELLRIEQ KDFKALWEKY
160 170 180 190 200
RQYMAGLLAP PYGVMETGSN NDRIPDKENT PLIEPHVPLR PANTITKVPS
210 220 230 240 250
EKILRAGKIL RNAILSRAPH MIRDRKYHLK TYRQCCVGTE LVDWMMQQTP
260 270 280 290 300
CVHSRTQAVG MWQVLLEDGV LNHVDQEHHF QDKYLFYRFL DDEHEDAPLP
310 320 330 340 350
TEEEKKECDE ELQDTMLLLS QMGPDAHMRM ILRKPPGQRT VDDLEIIYEE
360 370 380 390 400
LLHIKALSHL STTVKRELAG VLIFESHAKG GTVLFNQGEE GTSWYIILKG
410 420 430 440 450
SVNVVIYGKG VVCTLHEGDD FGKLALVNDA PRAASIVLRE DNCHFLRVDK
460 470 480 490 500
EDFNRILRDV EANTVRLKEH DQDVLVLEKV PAGNRASNQG NSQPQQKYTV
510 520 530 540 550
MSGTPEKILE HFLETIRLEA TLNEATDSVL NDFIMMHCVF MPNTQLCPAL
560 570 580 590 600
VAHYHAQPSQ GTEQEKMDYA LNNKRRVIRL VLQWAAMYGD LLQEDDVSMA
610 620 630 640 650
FLEEFYVSVS DDARMIAALK EQLPELEKIV KQISEDAKAP QKKHKVLLQQ
660 670 680 690 700
FNTGDERAQK RQPIRGSDEV LFKVYCMDHT YTTIRVPVAT SVKEVISAVA
710 720 730 740 750
DKLGSGEGLI IVKMSSGGEK VVLKPNDVSV FTTLTINGRL FACPREQFDS
760 770 780 790 800
LTPLPEQEGP TVGTVGTFEL MSSKDLAYQM TIYDWELFNC VHELELIYHT
810 820 830 840 850
FGRHNFKKTT ANLDLFLRRF NEIQFWVVTE ICLCSQLSKR VQLLKKFIKI
860 870 880 890 900
AAHCKEYKNL NSFFAIVMGL SNVAVSRLAL TWEKLPSKFK KFYAEFESLM
910 920 930 940 950
DPSRNHRAYR LTVAKLEPPL IPFMPLLIKD MTFTHEGNKT FIDNLVNFEK
960 970 980 990 1000
MRMIANTART VRYYRSQPFN PDAAQANKNH QDVRSYVRQL NVIDNQRTLS
1010
QMSHRLEPRR P
Note: Produced by alternative promoter usage. Promoter analysis was carried out in mouse.
Length:1,011
Mass (Da):115,522
Last modified:March 1, 2002 - v1
Checksum:i9427C5F92F2FFAD1
GO
Isoform 2 (identifier: Q8WZA2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-315: Missing.

Note: Produced by alternative promoter usage. Promoter analysis was carried out in mouse.
Show »
Length:696
Mass (Da):79,492
Checksum:i936C1CEC6FA169C8
GO
Isoform 3 (identifier: Q8WZA2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-144: Missing.
     145-148: ALWE → MLYK

Note: Produced by alternative splicing of isoform 1. No experimental confirmation available.
Show »
Length:867
Mass (Da):99,523
Checksum:i5CA711EAD3DBEE66
GO
Isoform 4 (identifier: Q8WZA2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: Missing.

Note: No experimental confirmation available.
Show »
Length:858
Mass (Da):98,248
Checksum:iAD52D5D0637CF299
GO
Isoform 5 (identifier: Q8WZA2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: Missing.
     180-197: Missing.

Note: No experimental confirmation available.
Show »
Length:840
Mass (Da):96,269
Checksum:i6FF8498DB079C13C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti324 – 3241P → R in AAH40183 (PubMed:15489334).Curated
Sequence conflicti511 – 5111H → R in AAH40183 (PubMed:15489334).Curated
Sequence conflicti647 – 6471L → I in AAH40183 (PubMed:15489334).Curated
Sequence conflicti679 – 6791H → P in AAH24004 (PubMed:15489334).Curated
Sequence conflicti732 – 7321T → M in AAH24004 (PubMed:15489334).Curated
Sequence conflicti873 – 8731V → I in AAD03422 (PubMed:9856955).Curated
Sequence conflicti902 – 9021P → T in AAH40183 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 315315Missing in isoform 2. 1 PublicationVSP_007611Add
BLAST
Alternative sequencei1 – 153153Missing in isoform 4 and isoform 5. 1 PublicationVSP_054423Add
BLAST
Alternative sequencei1 – 144144Missing in isoform 3. 2 PublicationsVSP_007612Add
BLAST
Alternative sequencei145 – 1484ALWE → MLYK in isoform 3. 2 PublicationsVSP_007613
Alternative sequencei180 – 19718Missing in isoform 5. 1 PublicationVSP_054424Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78516 mRNA. Translation: AAD03422.1.
AB027471 mRNA. Translation: BAB72179.1.
AK294445 mRNA. Translation: BAH11769.1.
AK296340 mRNA. Translation: BAH12322.1.
AK304278 mRNA. Translation: BAH14148.1.
AK313084 mRNA. Translation: BAG35910.1.
AK316072 mRNA. Translation: BAH14443.1.
AC009484 Genomic DNA. No translation available.
AC018712 Genomic DNA. No translation available.
AC019046 Genomic DNA. No translation available.
AC104086 Genomic DNA. No translation available.
BC024004 mRNA. Translation: AAH24004.1.
BC040183 mRNA. Translation: AAH40183.1.
CCDSiCCDS42775.1. [Q8WZA2-1]
CCDS42776.1. [Q8WZA2-3]
CCDS63060.1. [Q8WZA2-4]
CCDS63061.1. [Q8WZA2-5]
RefSeqiNP_001093867.1. NM_001100397.1. [Q8WZA2-3]
NP_001269828.1. NM_001282899.1. [Q8WZA2-4]
NP_001269829.1. NM_001282900.1. [Q8WZA2-5]
NP_001269830.1. NM_001282901.1.
NP_008954.2. NM_007023.3. [Q8WZA2-1]
XP_006712268.1. XM_006712205.2. [Q8WZA2-5]
UniGeneiHs.470646.

Genome annotation databases

EnsembliENST00000397081; ENSP00000380271; ENSG00000091428.
ENST00000397087; ENSP00000380276; ENSG00000091428. [Q8WZA2-3]
ENST00000538974; ENSP00000440135; ENSG00000091428. [Q8WZA2-5]
ENST00000540783; ENSP00000440250; ENSG00000091428. [Q8WZA2-4]
GeneIDi11069.
KEGGihsa:11069.
UCSCiuc002uhv.4. human. [Q8WZA2-1]
uc002uhw.4. human. [Q8WZA2-3]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78516 mRNA. Translation: AAD03422.1.
AB027471 mRNA. Translation: BAB72179.1.
AK294445 mRNA. Translation: BAH11769.1.
AK296340 mRNA. Translation: BAH12322.1.
AK304278 mRNA. Translation: BAH14148.1.
AK313084 mRNA. Translation: BAG35910.1.
AK316072 mRNA. Translation: BAH14443.1.
AC009484 Genomic DNA. No translation available.
AC018712 Genomic DNA. No translation available.
AC019046 Genomic DNA. No translation available.
AC104086 Genomic DNA. No translation available.
BC024004 mRNA. Translation: AAH24004.1.
BC040183 mRNA. Translation: AAH40183.1.
CCDSiCCDS42775.1. [Q8WZA2-1]
CCDS42776.1. [Q8WZA2-3]
CCDS63060.1. [Q8WZA2-4]
CCDS63061.1. [Q8WZA2-5]
RefSeqiNP_001093867.1. NM_001100397.1. [Q8WZA2-3]
NP_001269828.1. NM_001282899.1. [Q8WZA2-4]
NP_001269829.1. NM_001282900.1. [Q8WZA2-5]
NP_001269830.1. NM_001282901.1.
NP_008954.2. NM_007023.3. [Q8WZA2-1]
XP_006712268.1. XM_006712205.2. [Q8WZA2-5]
UniGeneiHs.470646.

3D structure databases

ProteinModelPortaliQ8WZA2.
SMRiQ8WZA2. Positions 11-1009.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116253. 10 interactions.
IntActiQ8WZA2. 3 interactions.
MINTiMINT-2869318.
STRINGi9606.ENSP00000380271.

Chemistry

BindingDBiQ8WZA2.
ChEMBLiCHEMBL2029198.
GuidetoPHARMACOLOGYi1293.

PTM databases

PhosphoSiteiQ8WZA2.

Polymorphism and mutation databases

BioMutaiRAPGEF4.
DMDMi32171491.

Proteomic databases

PaxDbiQ8WZA2.
PRIDEiQ8WZA2.

Protocols and materials databases

DNASUi11069.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397081; ENSP00000380271; ENSG00000091428.
ENST00000397087; ENSP00000380276; ENSG00000091428. [Q8WZA2-3]
ENST00000538974; ENSP00000440135; ENSG00000091428. [Q8WZA2-5]
ENST00000540783; ENSP00000440250; ENSG00000091428. [Q8WZA2-4]
GeneIDi11069.
KEGGihsa:11069.
UCSCiuc002uhv.4. human. [Q8WZA2-1]
uc002uhw.4. human. [Q8WZA2-3]

Organism-specific databases

CTDi11069.
GeneCardsiGC02P173600.
HGNCiHGNC:16626. RAPGEF4.
HPAiCAB004388.
HPA028968.
MIMi606058. gene.
neXtProtiNX_Q8WZA2.
PharmGKBiPA134861108.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0664.
GeneTreeiENSGT00800000124012.
HOGENOMiHOG000230545.
HOVERGENiHBG056985.
InParanoidiQ8WZA2.
KOiK04351.
OMAiTIYDWEL.
OrthoDBiEOG7ZD1TF.
PhylomeDBiQ8WZA2.
TreeFamiTF313184.

Enzyme and pathway databases

ReactomeiREACT_15523. Integrin alphaIIb beta3 signaling.
REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_18325. Regulation of insulin secretion.
REACT_23898. Rap1 signalling.

Miscellaneous databases

ChiTaRSiRAPGEF4. human.
GeneWikiiRAPGEF4.
GenomeRNAii11069.
NextBioi35478932.
PROiQ8WZA2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WZA2.
CleanExiHS_RAPGEF4.
ExpressionAtlasiQ8WZA2. baseline and differential.
GenevisibleiQ8WZA2. HS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.840.10. 1 hit.
2.60.120.10. 2 hits.
InterProiIPR002373. cAMP/cGMP_kin.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR000591. DEP_dom.
IPR000159. Ras-assoc.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR014710. RmlC-like_jellyroll.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF00610. DEP. 1 hit.
PF00788. RA. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
PRINTSiPR00103. CAMPKINASE.
SMARTiSM00100. cNMP. 2 hits.
SM00049. DEP. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 2 hits.
SSF51206. SSF51206. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
PS50186. DEP. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
  2. "Characterization of the gene EPAC2: structure, chromosomal localization, tissue expression, and identification of the liver-specific isoform."
    Ueno H., Shibasaki T., Iwanaga T., Takahashi K., Yokoyama Y., Liu L.M., Yokoi N., Ozaki N., Matsukura S., Yano H., Seino S.
    Genomics 78:91-98(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE PROMOTER USAGE.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 4 AND 5).
    Tissue: Amygdala, Hippocampus, Thalamus and Trachea.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Hypothalamus and Testis.
  6. "Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs."
    de Rooij J., Rehmann H., van Triest M., Cool R.H., Wittinghofer A., Bos J.L.
    J. Biol. Chem. 275:20829-20836(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiRPGF4_HUMAN
AccessioniPrimary (citable) accession number: Q8WZA2
Secondary accession number(s): B2R7R3
, B7Z283, B7Z3T6, B7Z912, O95636, Q8IXK6, Q8TAA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: March 1, 2002
Last modified: July 22, 2015
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.