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Protein

Protein LZIC

Gene

LZIC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LZIC
Alternative name(s):
Leucine zipper and CTNNBIP1 domain-containing protein
Leucine zipper and ICAT homologous domain-containing protein
Gene namesi
Name:LZIC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162441.11.
HGNCiHGNC:17497. LZIC.

Pathology & Biotechi

Organism-specific databases

DisGeNETi84328.
OpenTargetsiENSG00000162441.
PharmGKBiPA30504.

Polymorphism and mutation databases

BioMutaiLZIC.
DMDMi74751644.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002636911 – 190Protein LZICAdd BLAST190

Proteomic databases

EPDiQ8WZA0.
MaxQBiQ8WZA0.
PaxDbiQ8WZA0.
PeptideAtlasiQ8WZA0.
PRIDEiQ8WZA0.
TopDownProteomicsiQ8WZA0-1. [Q8WZA0-1]

PTM databases

iPTMnetiQ8WZA0.
PhosphoSitePlusiQ8WZA0.

Expressioni

Tissue specificityi

Ubiquitously expressed, with highest levels in kidney. Up-regulated in several cases of gastric cancers.1 Publication

Gene expression databases

BgeeiENSG00000162441.
CleanExiHS_LZIC.
ExpressionAtlasiQ8WZA0. baseline and differential.
GenevisibleiQ8WZA0. HS.

Organism-specific databases

HPAiHPA028184.
HPA058614.

Interactioni

Subunit structurei

Does not interact with CTNNB1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124052. 13 interactors.
IntActiQ8WZA0. 5 interactors.
STRINGi9606.ENSP00000366418.

Structurei

3D structure databases

ProteinModelPortaliQ8WZA0.
SMRiQ8WZA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili2 – 63Sequence analysisAdd BLAST62

Sequence similaritiesi

Belongs to the CTNNBIP1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IHES. Eukaryota.
ENOG410ZY5B. LUCA.
GeneTreeiENSGT00860000133817.
HOGENOMiHOG000008163.
HOVERGENiHBG080109.
InParanoidiQ8WZA0.
OMAiIMSGDMT.
OrthoDBiEOG091G0RZ1.
PhylomeDBiQ8WZA0.
TreeFamiTF314533.

Family and domain databases

Gene3Di1.10.10.490. 1 hit.
InterProiView protein in InterPro
IPR009428. ICAT.
PfamiView protein in Pfam
PF06384. ICAT. 1 hit.
SUPFAMiSSF81730. SSF81730. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WZA0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASRGKTETS KLKQNLEEQL DRLMQQLQDL EECREELDTD EYEETKKETL
60 70 80 90 100
EQLSEFNDSL KKIMSGNMTL VDELSGMQLA IQAAISQAFK TPEVIRLFAK
110 120 130 140 150
KQPGQLRTRL AEMDRDLMVG KLERDLYTQQ KVEILTALRK LGEKLTADDE
160 170 180 190
AFLSANAGAI LSQFEKVSTD LGSGDKILAL ASFEVEKTKK
Length:190
Mass (Da):21,495
Last modified:March 1, 2002 - v1
Checksum:i2DDDD7B788F42DD8
GO
Isoform 2 (identifier: Q8WZA0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MNNFIFLKFMTLGTSRTGEIKM

Note: No experimental confirmation available.
Show »
Length:211
Mass (Da):23,925
Checksum:iA3366D6FFB6F7C5E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053371104G → D. Corresponds to variant dbSNP:rs2304778Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0560831M → MNNFIFLKFMTLGTSRTGEI KM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB060688 mRNA. Translation: BAB72100.1.
AK304348 mRNA. Translation: BAG65192.1.
AK312550 mRNA. Translation: BAG35447.1.
AL357140 Genomic DNA. Translation: CAI16887.1.
CH471130 Genomic DNA. Translation: EAW71633.1.
BC007240 mRNA. Translation: AAH07240.2.
BC063443 mRNA. Translation: AAH63443.1.
CCDSiCCDS107.1. [Q8WZA0-1]
RefSeqiNP_001303902.1. NM_001316973.1. [Q8WZA0-1]
NP_001303903.1. NM_001316974.1. [Q8WZA0-2]
NP_115744.2. NM_032368.4. [Q8WZA0-1]
UniGeneiHs.327252.
Hs.592551.
Hs.733062.

Genome annotation databases

EnsembliENST00000377213; ENSP00000366418; ENSG00000162441. [Q8WZA0-1]
ENST00000377223; ENSP00000366430; ENSG00000162441. [Q8WZA0-1]
ENST00000400903; ENSP00000383695; ENSG00000162441. [Q8WZA0-1]
GeneIDi84328.
KEGGihsa:84328.
UCSCiuc001aqm.4. human. [Q8WZA0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLZIC_HUMAN
AccessioniPrimary (citable) accession number: Q8WZA0
Secondary accession number(s): B2R6F0, B4E2N0, Q96IU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 1, 2002
Last modified: September 27, 2017
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families