Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 5P3

Gene

OR5P3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor (Potential). May be involved in taste perception.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-32821-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5P3
Alternative name(s):
Olfactory receptor OR11-94
Olfactory receptor-like protein JCG1
Gene namesi
Name:OR5P3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14784. OR5P3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 196ExtracellularSequence analysisAdd BLAST36
Transmembranei197 – 217Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 311CytoplasmicSequence analysisAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000182334.
ENSG00000278253.
ENSG00000280808.
PharmGKBiPA32562.

Polymorphism and mutation databases

BioMutaiOR5P3.
DMDMi20532191.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506111 – 311Olfactory receptor 5P3Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8WZ94.
PRIDEiQ8WZ94.

Expressioni

Tissue specificityi

Expressed in the tongue.

Gene expression databases

BgeeiENSG00000182334.
CleanExiHS_OR5P3.
ExpressionAtlasiQ8WZ94. baseline and differential.
GenevisibleiQ8WZ94. HS.

Organism-specific databases

HPAiHPA060787.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000332068.

Structurei

3D structure databases

ProteinModelPortaliQ8WZ94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJST. Eukaryota.
ENOG410ZSS8. LUCA.
GeneTreeiENSGT00550000074423.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8WZ94.
KOiK04257.
OMAiRRSHHLH.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8WZ94.
TreeFamiTF338848.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WZ94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTGNDTTVV EFTLLGLSED TTVCAILFLV FLGIYVVTLM GNISIIVLIR
60 70 80 90 100
RSHHLHTPMY IFLCHLAFVD IGYSSSVTPV MLMSFLRKET SLPVAGCVAQ
110 120 130 140 150
LCSVVTFGTA ECFLLAAMAY DRYVAICSPL LYSTCMSPGV CIILVGMSYL
160 170 180 190 200
GGCVNAWTFI GCLLRLSFCG PNKVNHFFCD YSPLLKLACS HDFTFEIIPA
210 220 230 240 250
ISSGSIIVAT VCVIAISYIY ILITILKMHS TKGRHKAFST CTSHLTAVTL
260 270 280 290 300
FYGTITFIYV MPKSSYSTDQ NKVVSVFYTV VIPMLNPLIY SLRNKEIKGA
310
LKRELRIKIF S
Length:311
Mass (Da):34,296
Last modified:March 1, 2002 - v1
Checksum:iD6E37E03C317DAA3
GO

Sequence cautioni

The sequence BAC05990 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048048158T → K.Corresponds to variant rs16932503dbSNPEnsembl.1
Natural variantiVAR_048094251F → L.Corresponds to variant rs364427dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF158377 mRNA. Translation: AAL32991.1.
AB065770 Genomic DNA. Translation: BAC05990.1. Different initiation.
CH471064 Genomic DNA. Translation: EAW68645.1.
BK004321 Genomic DNA. Translation: DAA04719.1.
CCDSiCCDS7783.1.
RefSeqiNP_703146.1. NM_153445.1.
UniGeneiHs.351825.

Genome annotation databases

EnsembliENST00000328375; ENSP00000332068; ENSG00000182334.
ENST00000619725; ENSP00000482237; ENSG00000278253.
ENST00000630502; ENSP00000486070; ENSG00000280808.
GeneIDi120066.
KEGGihsa:120066.
UCSCiuc010rbg.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF158377 mRNA. Translation: AAL32991.1.
AB065770 Genomic DNA. Translation: BAC05990.1. Different initiation.
CH471064 Genomic DNA. Translation: EAW68645.1.
BK004321 Genomic DNA. Translation: DAA04719.1.
CCDSiCCDS7783.1.
RefSeqiNP_703146.1. NM_153445.1.
UniGeneiHs.351825.

3D structure databases

ProteinModelPortaliQ8WZ94.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000332068.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR5P3.
DMDMi20532191.

Proteomic databases

PaxDbiQ8WZ94.
PRIDEiQ8WZ94.

Protocols and materials databases

DNASUi120066.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328375; ENSP00000332068; ENSG00000182334.
ENST00000619725; ENSP00000482237; ENSG00000278253.
ENST00000630502; ENSP00000486070; ENSG00000280808.
GeneIDi120066.
KEGGihsa:120066.
UCSCiuc010rbg.2. human.

Organism-specific databases

CTDi120066.
GeneCardsiOR5P3.
HGNCiHGNC:14784. OR5P3.
HPAiHPA060787.
neXtProtiNX_Q8WZ94.
OpenTargetsiENSG00000182334.
ENSG00000278253.
ENSG00000280808.
PharmGKBiPA32562.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJST. Eukaryota.
ENOG410ZSS8. LUCA.
GeneTreeiENSGT00550000074423.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8WZ94.
KOiK04257.
OMAiRRSHHLH.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8WZ94.
TreeFamiTF338848.

Enzyme and pathway databases

BioCyciZFISH:G66-32821-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5P3.
GenomeRNAii120066.
PROiQ8WZ94.

Gene expression databases

BgeeiENSG00000182334.
CleanExiHS_OR5P3.
ExpressionAtlasiQ8WZ94. baseline and differential.
GenevisibleiQ8WZ94. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR5P3_HUMAN
AccessioniPrimary (citable) accession number: Q8WZ94
Secondary accession number(s): Q6IFE1, Q8NGM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.