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Protein

Olfactory receptor 5P2

Gene

OR5P2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor (Potential). May be involved in taste perception.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-30718-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5P2
Alternative name(s):
Olfactory receptor-like protein JCG3
Gene namesi
Name:OR5P2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14783. OR5P2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
Transmembranei29 – 42Helical; Name=1Sequence analysisAdd BLAST14
Topological domaini43 – 50CytoplasmicSequence analysis8
Transmembranei51 – 71Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini72 – 95ExtracellularSequence analysisAdd BLAST24
Transmembranei96 – 116Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini117 – 135CytoplasmicSequence analysisAdd BLAST19
Transmembranei136 – 156Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini157 – 192ExtracellularSequence analysisAdd BLAST36
Transmembranei193 – 213Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini214 – 233CytoplasmicSequence analysisAdd BLAST20
Transmembranei234 – 254Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini255 – 267ExtracellularSequence analysisAdd BLAST13
Transmembranei268 – 288Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini289 – 322CytoplasmicSequence analysisAdd BLAST34

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000183303.
ENSG00000276025.
ENSG00000280931.
PharmGKBiPA32561.

Polymorphism and mutation databases

BioMutaiOR5P2.
DMDMi20532190.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506101 – 322Olfactory receptor 5P2Add BLAST322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi93 ↔ 185PROSITE-ProRule annotation
Glycosylationi259N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8WZ92.
PRIDEiQ8WZ92.

Expressioni

Tissue specificityi

Expressed in the tongue.

Gene expression databases

BgeeiENSG00000183303.
CleanExiHS_OR5P2.
ExpressionAtlasiQ8WZ92. baseline and differential.
GenevisibleiQ8WZ92. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000331823.

Structurei

3D structure databases

ProteinModelPortaliQ8WZ92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJST. Eukaryota.
ENOG410ZSS8. LUCA.
GeneTreeiENSGT00550000074423.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8WZ92.
KOiK04257.
OMAiFFATVEC.
OrthoDBiEOG091G0CLJ.
PhylomeDBiQ8WZ92.
TreeFamiTF338848.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WZ92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSLKDGNHT ALTGFILLGL TDDPILRVIL FMIILSGNLS IIILIRISSQ
60 70 80 90 100
LHHPMYFFLS HLAFADMAYS SSVTPNMLVN FLVERNTVSY LGCAIQLGSA
110 120 130 140 150
AFFATVECVL LAAMAYDRFV AICSPLLYST KMSTQVSVQL LLVVYIAGFL
160 170 180 190 200
IAVSYTTSFY FLLFCGPNQV NHFFCDFAPL LELSCSDISV STVVLSFSSG
210 220 230 240 250
SIIVVTVCVI AVCYIYILIT ILKMRSTEGH HKAFSTCTSH LTVVTLFYGT
260 270 280 290 300
ITFIYVMPNF SYSTDQNKVV SVLYTVVIPM LNPLIYSLRN KEIKGALKRE
310 320
LVRKILSHDA CYFSRTSNND IT
Length:322
Mass (Da):35,786
Last modified:March 1, 2002 - v1
Checksum:i0D4F4FBD4FD00FEC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0532037G → R.Corresponds to variant rs1482804dbSNPEnsembl.1
Natural variantiVAR_053204318N → D.Corresponds to variant rs7949771dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173006 mRNA. Translation: AAL32992.1.
AB065767 Genomic DNA. Translation: BAC05987.1.
BC101710 mRNA. Translation: AAI01711.1.
BC113557 mRNA. Translation: AAI13558.1.
CCDSiCCDS7782.1.
RefSeqiNP_703145.1. NM_153444.1.
UniGeneiHs.351824.

Genome annotation databases

EnsembliENST00000329434; ENSP00000331823; ENSG00000183303.
ENST00000611603; ENSP00000480613; ENSG00000276025.
ENST00000625920; ENSP00000486671; ENSG00000280931.
GeneIDi120065.
KEGGihsa:120065.
UCSCiuc001mfp.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173006 mRNA. Translation: AAL32992.1.
AB065767 Genomic DNA. Translation: BAC05987.1.
BC101710 mRNA. Translation: AAI01711.1.
BC113557 mRNA. Translation: AAI13558.1.
CCDSiCCDS7782.1.
RefSeqiNP_703145.1. NM_153444.1.
UniGeneiHs.351824.

3D structure databases

ProteinModelPortaliQ8WZ92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000331823.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR5P2.
DMDMi20532190.

Proteomic databases

PaxDbiQ8WZ92.
PRIDEiQ8WZ92.

Protocols and materials databases

DNASUi120065.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329434; ENSP00000331823; ENSG00000183303.
ENST00000611603; ENSP00000480613; ENSG00000276025.
ENST00000625920; ENSP00000486671; ENSG00000280931.
GeneIDi120065.
KEGGihsa:120065.
UCSCiuc001mfp.2. human.

Organism-specific databases

CTDi120065.
GeneCardsiOR5P2.
HGNCiHGNC:14783. OR5P2.
neXtProtiNX_Q8WZ92.
OpenTargetsiENSG00000183303.
ENSG00000276025.
ENSG00000280931.
PharmGKBiPA32561.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJST. Eukaryota.
ENOG410ZSS8. LUCA.
GeneTreeiENSGT00550000074423.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8WZ92.
KOiK04257.
OMAiFFATVEC.
OrthoDBiEOG091G0CLJ.
PhylomeDBiQ8WZ92.
TreeFamiTF338848.

Enzyme and pathway databases

BioCyciZFISH:G66-30718-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5P2.
GenomeRNAii120065.
PROiQ8WZ92.

Gene expression databases

BgeeiENSG00000183303.
CleanExiHS_OR5P2.
ExpressionAtlasiQ8WZ92. baseline and differential.
GenevisibleiQ8WZ92. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR5P2_HUMAN
AccessioniPrimary (citable) accession number: Q8WZ92
Secondary accession number(s): Q3MIS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.