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Protein

Olfactory receptor 5P2

Gene

OR5P2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor (Potential). May be involved in taste perception.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5P2
Alternative name(s):
Olfactory receptor-like protein JCG3
Gene namesi
Name:OR5P2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14783. OR5P2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828ExtracellularSequence analysisAdd
BLAST
Transmembranei29 – 4214Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini43 – 508CytoplasmicSequence analysis
Transmembranei51 – 7121Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini72 – 9524ExtracellularSequence analysisAdd
BLAST
Transmembranei96 – 11621Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini117 – 13519CytoplasmicSequence analysisAdd
BLAST
Transmembranei136 – 15621Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini157 – 19236ExtracellularSequence analysisAdd
BLAST
Transmembranei193 – 21321Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini214 – 23320CytoplasmicSequence analysisAdd
BLAST
Transmembranei234 – 25421Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini255 – 26713ExtracellularSequence analysisAdd
BLAST
Transmembranei268 – 28821Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini289 – 32234CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32561.

Polymorphism and mutation databases

BioMutaiOR5P2.
DMDMi20532190.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Olfactory receptor 5P2PRO_0000150610Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence analysis
Disulfide bondi93 ↔ 185PROSITE-ProRule annotation
Glycosylationi259 – 2591N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8WZ92.
PRIDEiQ8WZ92.

Expressioni

Tissue specificityi

Expressed in the tongue.

Gene expression databases

BgeeiQ8WZ92.
CleanExiHS_OR5P2.
GenevisibleiQ8WZ92. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000331823.

Structurei

3D structure databases

ProteinModelPortaliQ8WZ92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJST. Eukaryota.
ENOG410ZSS8. LUCA.
GeneTreeiENSGT00550000074423.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8WZ92.
KOiK04257.
OMAiFFATVEC.
OrthoDBiEOG761BVH.
PhylomeDBiQ8WZ92.
TreeFamiTF338848.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WZ92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSLKDGNHT ALTGFILLGL TDDPILRVIL FMIILSGNLS IIILIRISSQ
60 70 80 90 100
LHHPMYFFLS HLAFADMAYS SSVTPNMLVN FLVERNTVSY LGCAIQLGSA
110 120 130 140 150
AFFATVECVL LAAMAYDRFV AICSPLLYST KMSTQVSVQL LLVVYIAGFL
160 170 180 190 200
IAVSYTTSFY FLLFCGPNQV NHFFCDFAPL LELSCSDISV STVVLSFSSG
210 220 230 240 250
SIIVVTVCVI AVCYIYILIT ILKMRSTEGH HKAFSTCTSH LTVVTLFYGT
260 270 280 290 300
ITFIYVMPNF SYSTDQNKVV SVLYTVVIPM LNPLIYSLRN KEIKGALKRE
310 320
LVRKILSHDA CYFSRTSNND IT
Length:322
Mass (Da):35,786
Last modified:March 1, 2002 - v1
Checksum:i0D4F4FBD4FD00FEC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71G → R.
Corresponds to variant rs1482804 [ dbSNP | Ensembl ].
VAR_053203
Natural varianti318 – 3181N → D.
Corresponds to variant rs7949771 [ dbSNP | Ensembl ].
VAR_053204

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173006 mRNA. Translation: AAL32992.1.
AB065767 Genomic DNA. Translation: BAC05987.1.
BC101710 mRNA. Translation: AAI01711.1.
BC113557 mRNA. Translation: AAI13558.1.
CCDSiCCDS7782.1.
RefSeqiNP_703145.1. NM_153444.1.
UniGeneiHs.351824.

Genome annotation databases

EnsembliENST00000329434; ENSP00000331823; ENSG00000183303.
ENST00000611603; ENSP00000480613; ENSG00000276025.
ENST00000625920; ENSP00000486671; ENSG00000280931.
GeneIDi120065.
KEGGihsa:120065.
UCSCiuc001mfp.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173006 mRNA. Translation: AAL32992.1.
AB065767 Genomic DNA. Translation: BAC05987.1.
BC101710 mRNA. Translation: AAI01711.1.
BC113557 mRNA. Translation: AAI13558.1.
CCDSiCCDS7782.1.
RefSeqiNP_703145.1. NM_153444.1.
UniGeneiHs.351824.

3D structure databases

ProteinModelPortaliQ8WZ92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000331823.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR5P2.
DMDMi20532190.

Proteomic databases

PaxDbiQ8WZ92.
PRIDEiQ8WZ92.

Protocols and materials databases

DNASUi120065.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329434; ENSP00000331823; ENSG00000183303.
ENST00000611603; ENSP00000480613; ENSG00000276025.
ENST00000625920; ENSP00000486671; ENSG00000280931.
GeneIDi120065.
KEGGihsa:120065.
UCSCiuc001mfp.2. human.

Organism-specific databases

CTDi120065.
GeneCardsiOR5P2.
HGNCiHGNC:14783. OR5P2.
neXtProtiNX_Q8WZ92.
PharmGKBiPA32561.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJST. Eukaryota.
ENOG410ZSS8. LUCA.
GeneTreeiENSGT00550000074423.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8WZ92.
KOiK04257.
OMAiFFATVEC.
OrthoDBiEOG761BVH.
PhylomeDBiQ8WZ92.
TreeFamiTF338848.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5P2.
GenomeRNAii120065.
NextBioi80508.
PROiQ8WZ92.

Gene expression databases

BgeeiQ8WZ92.
CleanExiHS_OR5P2.
GenevisibleiQ8WZ92. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "New GPCRs from a human lingual cDNA library."
    Gaudin J.-C., Breuils L., Haertle T.
    Chem. Senses 26:1157-1166(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Tongue.
  2. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiOR5P2_HUMAN
AccessioniPrimary (citable) accession number: Q8WZ92
Secondary accession number(s): Q3MIS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: March 1, 2002
Last modified: March 16, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.