Q8WZ82 (OVCA2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ovarian cancer-associated gene 2 protein

Gene names

Name:

OVCA2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Tissue specificity	Ubiquitously expressed. Ref.1 Ref.2
Post-translational modification	Proteolytically degraded in response to RA and 4HPR treatment in a time- and dose-dependent manner in the promyelocytic leukemia cell line HL60.
Sequence similarities	Belongs to the UPF0483 (OVCA2) family.
Caution	Encoded in an intron of the gene DPH1/OVCA1 (same strand).

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	response to retinoic acid Inferred from direct assay Ref.2. Source: UniProtKB
Cellular component	cytoplasm Inferred from direct assay. Source: UniProtKB
Molecular function	hydrolase activity Non-traceable author statement Ref.2. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 227	227	Ovarian cancer-associated gene 2 protein		PRO_0000300876
Experimental info
	Sequence conflict	84	1	S → C in AAH40696. Ref.4
	Sequence conflict	150	1	G → S in AAC62628. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8WZ82 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: E4A4694A7E30FBD8	FASTA	227	24,418
	10 20 30 40 50 60 MAAQRPLRVL CLAGFRQSER GFREKTGALR KALRGRAELV CLSGPHPVPD PPGPEGARSD 70 80 90 100 110 120 FGSCPPEEQP RGWWFSEQEA DVFSALEEPA VCRGLEESLG MVAQALNRLG PFDGLLGFSQ 130 140 150 160 170 180 GAALAALVCA LGQAGDPRFP LPRFILLVSG FCPRGIGFKE SILQRPLSLP SLHVFGDTDK 190 200 210 220 VIPSQESVQL ASQFPGAITL THSGGHFIPA AAPQRQAYLK FLDQFAE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of two candidate tumor suppressor genes on chromosome 17p13.3." Schultz D.C., Vanderveer L., Berman D.B., Hamilton T.C., Wong A.J., Godwin A.K. Cancer Res. 56:1997-2002(1996) [PubMed: 8616839] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Ovary.
[2]	"OVCA2 is downregulated and degraded during retinoid-induced apoptosis." Prowse A.H., Vanderveer L., Milling S.W., Pan Z.Z., Dunbrack R.L., Xu X.X., Godwin A.K. Int. J. Cancer 99:185-192(2002) [PubMed: 11979432] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, PROTEOLYTIC DEGRADATION.
[3]	"OVCA locus." Godwin A.K., Vanderveer L.A., Schultz D.C. Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Duodenum and Skin.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF073528 mRNA. Translation: AAC62628.1. AF321875 mRNA. Translation: AAL35713.1. AF335321 Genomic DNA. Translation: AAN04659.1. BC040696 mRNA. Translation: AAH40696.1. BC041170 mRNA. Translation: AAH41170.1.
IPI	IPI00103884.
RefSeq	NP_543012.1. NM_080822.2.
UniGene	Hs.513856.
3D structure databases
ProteinModelPortal	Q8WZ82.
SMR	Q8WZ82. Positions 113-150, 166-224.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8WZ82.
Polymorphism databases
DMDM	74731010.
Proteomic databases
PeptideAtlas	Q8WZ82.
PRIDE	Q8WZ82.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000263084; ENSP00000263084; ENSG00000214014.
GeneID	124641.
KEGG	hsa:124641.
UCSC	uc002ftx.1. human.
Organism-specific databases
CTD	124641.
GeneCards	GC17P001945.
H-InvDB	HIX0013414.
HGNC	HGNC:24203. OVCA2.
MIM	607896. gene.
neXtProt	NX_Q8WZ82.
PharmGKB	PA165432281.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000003541.
HOGENOM	HBG383462.
HOVERGEN	HBG108224.
InParanoid	Q8WZ82.
OMA	QGACFVG.
OrthoDB	EOG40S0GK.
PhylomeDB	Q8WZ82.
Gene expression databases
ArrayExpress	Q8WZ82.
Genevestigator	Q8WZ82.
Family and domain databases
InterPro	IPR005645. Serine_hydrolase_FSH. [Graphical view]
Pfam	PF03959. FSH1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	81353.
SOURCE	Search...

Entry information

Entry name

OVCA2_HUMAN

Accession

Primary (citable) accession number: Q8WZ82
Secondary accession number(s): Q86XN3, Q8IW87, Q9UCX9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.