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Protein

Esterase OVCA2

Gene

OVCA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Encoded in an intron of the gene DPH1/OVCA1 (same strand).Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei119Charge relay systemBy similarity1
Active sitei179Charge relay systemBy similarity1
Active sitei206Charge relay systemBy similarity1

GO - Molecular functioni

  • hydrolase activity Source: UniProtKB

GO - Biological processi

  • response to retinoic acid Source: UniProtKB

Keywordsi

Molecular functionHydrolase

Protein family/group databases

ESTHERihuman-OVCA2 FSH1

Names & Taxonomyi

Protein namesi
Recommended name:
Esterase OVCA2 (EC:3.1.2.-Curated)
Alternative name(s):
Ovarian cancer-associated gene 2 protein
Gene namesi
Name:OVCA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000262664.2
HGNCiHGNC:24203 OVCA2
MIMi607896 gene
neXtProtiNX_Q8WZ82

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi124641
OpenTargetsiENSG00000262664
PharmGKBiPA165432281

Polymorphism and mutation databases

BioMutaiOVCA2
DMDMi74731010

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003008761 – 227Esterase OVCA2Add BLAST227

Post-translational modificationi

Proteolytically degraded in response to RA and 4HPR treatment in a time- and dose-dependent manner in the promyelocytic leukemia cell line HL-60.

Proteomic databases

EPDiQ8WZ82
MaxQBiQ8WZ82
PaxDbiQ8WZ82
PeptideAtlasiQ8WZ82
PRIDEiQ8WZ82

PTM databases

iPTMnetiQ8WZ82
PhosphoSitePlusiQ8WZ82

Expressioni

Tissue specificityi

Ubiquitously expressed.2 Publications

Gene expression databases

BgeeiENSG00000262664
GenevisibleiQ8WZ82 HS

Organism-specific databases

HPAiHPA059002

Interactioni

Protein-protein interaction databases

BioGridi1258813 interactors.
STRINGi9606.ENSP00000461388

Structurei

3D structure databases

ProteinModelPortaliQ8WZ82
SMRiQ8WZ82
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LovG family.Curated

Phylogenomic databases

eggNOGiKOG2551 Eukaryota
ENOG4111JYH LUCA
GeneTreeiENSGT00390000003541
HOGENOMiHOG000007638
HOVERGENiHBG108224
InParanoidiQ8WZ82
OMAiKHPGGHF
OrthoDBiEOG091G0L5H
PhylomeDBiQ8WZ82
TreeFamiTF313006

Family and domain databases

Gene3Di3.40.50.18201 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR005645 FSH_dom
PfamiView protein in Pfam
PF03959 FSH1, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

Q8WZ82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQRPLRVL CLAGFRQSER GFREKTGALR KALRGRAELV CLSGPHPVPD
60 70 80 90 100
PPGPEGARSD FGSCPPEEQP RGWWFSEQEA DVFSALEEPA VCRGLEESLG
110 120 130 140 150
MVAQALNRLG PFDGLLGFSQ GAALAALVCA LGQAGDPRFP LPRFILLVSG
160 170 180 190 200
FCPRGIGFKE SILQRPLSLP SLHVFGDTDK VIPSQESVQL ASQFPGAITL
210 220
THSGGHFIPA AAPQRQAYLK FLDQFAE
Length:227
Mass (Da):24,418
Last modified:March 1, 2002 - v1
Checksum:iE4A4694A7E30FBD8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti84S → C in AAH40696 (PubMed:15489334).Curated1
Sequence conflicti150G → S in AAC62628 (PubMed:8616839).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073528 mRNA Translation: AAC62628.1
AF321875 mRNA Translation: AAL35713.1
AF335321 Genomic DNA Translation: AAN04659.1
BC040696 mRNA Translation: AAH40696.1
BC041170 mRNA Translation: AAH41170.1
CCDSiCCDS11015.1
RefSeqiNP_543012.1, NM_080822.2
UniGeneiHs.513856

Genome annotation databases

EnsembliENST00000572195; ENSP00000461388; ENSG00000262664
GeneIDi124641
KEGGihsa:124641
UCSCiuc002ftx.4 human

Similar proteinsi

Entry informationi

Entry nameiOVCA2_HUMAN
AccessioniPrimary (citable) accession number: Q8WZ82
Secondary accession number(s): Q86XN3, Q8IW87, Q9UCX9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome