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Q8WZ82 (OVCA2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ovarian cancer-associated gene 2 protein
Gene names
Name:OVCA2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length227 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Tissue specificity

Ubiquitously expressed. Ref.1 Ref.2

Post-translational modification

Proteolytically degraded in response to RA and 4HPR treatment in a time- and dose-dependent manner in the promyelocytic leukemia cell line HL-60.

Sequence similarities

Belongs to the UPF0483 (OVCA2) family.

Caution

Encoded in an intron of the gene DPH1/OVCA1 (same strand).

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmetabolic process

Non-traceable author statement Ref.2. Source: GOC

response to retinoic acid

Inferred from direct assay Ref.2. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 16368187. Source: UniProtKB

nucleus

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionhydrolase activity

Non-traceable author statement Ref.2. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 227227Ovarian cancer-associated gene 2 protein
PRO_0000300876

Experimental info

Sequence conflict841S → C in AAH40696. Ref.4
Sequence conflict1501G → S in AAC62628. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8WZ82 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: E4A4694A7E30FBD8

FASTA22724,418
        10         20         30         40         50         60 
MAAQRPLRVL CLAGFRQSER GFREKTGALR KALRGRAELV CLSGPHPVPD PPGPEGARSD 

        70         80         90        100        110        120 
FGSCPPEEQP RGWWFSEQEA DVFSALEEPA VCRGLEESLG MVAQALNRLG PFDGLLGFSQ 

       130        140        150        160        170        180 
GAALAALVCA LGQAGDPRFP LPRFILLVSG FCPRGIGFKE SILQRPLSLP SLHVFGDTDK 

       190        200        210        220 
VIPSQESVQL ASQFPGAITL THSGGHFIPA AAPQRQAYLK FLDQFAE 

« Hide

References

« Hide 'large scale' references
[1]"Identification of two candidate tumor suppressor genes on chromosome 17p13.3."
Schultz D.C., Vanderveer L., Berman D.B., Hamilton T.C., Wong A.J., Godwin A.K.
Cancer Res. 56:1997-2002(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Ovary.
[2]"OVCA2 is downregulated and degraded during retinoid-induced apoptosis."
Prowse A.H., Vanderveer L., Milling S.W., Pan Z.Z., Dunbrack R.L., Xu X.X., Godwin A.K.
Int. J. Cancer 99:185-192(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, PROTEOLYTIC DEGRADATION.
[3]"OVCA locus."
Godwin A.K., Vanderveer L.A., Schultz D.C.
Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Duodenum and Skin.
[5]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF073528 mRNA. Translation: AAC62628.1.
AF321875 mRNA. Translation: AAL35713.1.
AF335321 Genomic DNA. Translation: AAN04659.1.
BC040696 mRNA. Translation: AAH40696.1.
BC041170 mRNA. Translation: AAH41170.1.
CCDSCCDS11015.1.
RefSeqNP_543012.1. NM_080822.2.
UniGeneHs.513856.

3D structure databases

ProteinModelPortalQ8WZ82.
SMRQ8WZ82. Positions 8-209.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125881. 1 interaction.
STRING9606.ENSP00000263084.

PTM databases

PhosphoSiteQ8WZ82.

Polymorphism databases

DMDM74731010.

Proteomic databases

MaxQBQ8WZ82.
PaxDbQ8WZ82.
PeptideAtlasQ8WZ82.
PRIDEQ8WZ82.

Protocols and materials databases

DNASU124641.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000572195; ENSP00000461388; ENSG00000262664.
GeneID124641.
KEGGhsa:124641.
UCSCuc002ftx.3. human.

Organism-specific databases

CTD124641.
GeneCardsGC17P001945.
HGNCHGNC:24203. OVCA2.
MIM607896. gene.
neXtProtNX_Q8WZ82.
PharmGKBPA165432281.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG290051.
HOGENOMHOG000007638.
HOVERGENHBG108224.
InParanoidQ8WZ82.
OMASKANWRN.
OrthoDBEOG78SQK8.
PhylomeDBQ8WZ82.
TreeFamTF313006.

Gene expression databases

GenevestigatorQ8WZ82.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR005645. Serine_hydrolase_FSH.
[Graphical view]
PfamPF03959. FSH1. 1 hit.
[Graphical view]
SUPFAMSSF53474. SSF53474. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi124641.
NextBio81353.
PROQ8WZ82.
SOURCESearch...

Entry information

Entry nameOVCA2_HUMAN
AccessionPrimary (citable) accession number: Q8WZ82
Secondary accession number(s): Q86XN3, Q8IW87, Q9UCX9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Uncharacterized protein families (UPF)

List of uncharacterized protein family (UPF) entries

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM