Reviewed, UniProtKB/Swiss-Prot Q8WZ82 (OVCA2_HUMAN)

Names and origin

Protein names

Recommended name:
    Ovarian cancer-associated gene 2 protein

Gene names

Name:

OVCA2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Tissue specificity	Ubiquitously expressed.
Post-translational modification	Proteolytically degraded in response to RA and 4HPR treatment in a time- and dose-dependent manner in the promyelocytic leukemia cell line HL60.
Sequence similarities	Belongs to the UPF0483 (OVCA2) family.
Caution	Encoded in an intron of the gene DPH1/OVCA1 (same strand).

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 227	227	Ovarian cancer-associated gene 2 protein		PRO_0000300876
Experimental info
	Sequence conflict	84	1	S → C in AAH40696. Ref.4
	Sequence conflict	150	1	G → S in AAC62628. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8WZ82-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: E4A4694A7E30FBD8	FASTA	227	24,418
	10 20 30 40 50 60 MAAQRPLRVL CLAGFRQSER GFREKTGALR KALRGRAELV CLSGPHPVPD PPGPEGARSD 70 80 90 100 110 120 FGSCPPEEQP RGWWFSEQEA DVFSALEEPA VCRGLEESLG MVAQALNRLG PFDGLLGFSQ 130 140 150 160 170 180 GAALAALVCA LGQAGDPRFP LPRFILLVSG FCPRGIGFKE SILQRPLSLP SLHVFGDTDK 190 200 210 220 VIPSQESVQL ASQFPGAITL THSGGHFIPA AAPQRQAYLK FLDQFAE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of two candidate tumor suppressor genes on chromosome 17p13.3." Schultz D.C., Vanderveer L., Berman D.B., Hamilton T.C., Wong A.J., Godwin A.K. Cancer Res. 56:1997-2002(1996) [PubMed: 8616839] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Ovary.
[2]	"OVCA2 is downregulated and degraded during retinoid-induced apoptosis." Prowse A.H., Vanderveer L., Milling S.W., Pan Z.Z., Dunbrack R.L., Xu X.X., Godwin A.K. Int. J. Cancer 99:185-192(2002) [PubMed: 11979432] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, PROTEOLYTIC DEGRADATION.
[3]	"OVCA locus." Godwin A.K., Vanderveer L.A., Schultz D.C. Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Duodenum and Skin.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF073528 mRNA. Translation: AAC62628.1. AF321875 mRNA. Translation: AAL35713.1. AF335321 Genomic DNA. Translation: AAN04659.1. BC040696 mRNA. Translation: AAH40696.1. BC041170 mRNA. Translation: AAH41170.1.
RefSeq	NP_543012.1.
UniGene	Hs.513856
3D structure databases
ModBase	Search...
Proteomic databases
PeptideAtlas	Q8WZ82.
Genome annotation databases
Ensembl	ENSG00000214014. Homo sapiens. [Contig view]
GeneID	124641.
KEGG	hsa:124641.
Organism-specific databases
MIM	607896. gene.
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q8WZ82.
Gene expression databases
ArrayExpress	Q8WZ82.
Family and domain databases
InterPro	IPR005645. DUF341. [Graphical view]
Pfam	PF03959. FSH1. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
LinkHub	Q8WZ82.
NextBio	81353.
SOURCE	Search...

Entry information

Entry name

OVCA2_HUMAN

Accession

Primary (citable) accession number: Q8WZ82
Secondary accession number(s): Q86XN3, Q8IW87, Q9UCX9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	March 1, 2002
Last modified:	November 4, 2008
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)