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Q8WZ82

- OVCA2_HUMAN

UniProt

Q8WZ82 - OVCA2_HUMAN

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Protein
Ovarian cancer-associated gene 2 protein
Gene
OVCA2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. hydrolase activity Source: UniProtKB

GO - Biological processi

  1. metabolic process Source: GOC
  2. response to retinoic acid Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ovarian cancer-associated gene 2 protein
Gene namesi
Name:OVCA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:24203. OVCA2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165432281.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 227227Ovarian cancer-associated gene 2 protein
PRO_0000300876Add
BLAST

Post-translational modificationi

Proteolytically degraded in response to RA and 4HPR treatment in a time- and dose-dependent manner in the promyelocytic leukemia cell line HL-60.

Proteomic databases

MaxQBiQ8WZ82.
PaxDbiQ8WZ82.
PeptideAtlasiQ8WZ82.
PRIDEiQ8WZ82.

PTM databases

PhosphoSiteiQ8WZ82.

Expressioni

Tissue specificityi

Ubiquitously expressed.2 Publications

Gene expression databases

GenevestigatoriQ8WZ82.

Interactioni

Protein-protein interaction databases

BioGridi125881. 1 interaction.
STRINGi9606.ENSP00000263084.

Structurei

3D structure databases

ProteinModelPortaliQ8WZ82.
SMRiQ8WZ82. Positions 8-209.

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0483 (OVCA2) family.

Phylogenomic databases

eggNOGiNOG290051.
HOGENOMiHOG000007638.
HOVERGENiHBG108224.
InParanoidiQ8WZ82.
OMAiSKANWRN.
OrthoDBiEOG78SQK8.
PhylomeDBiQ8WZ82.
TreeFamiTF313006.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR005645. Serine_hydrolase_FSH.
[Graphical view]
PfamiPF03959. FSH1. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8WZ82-1 [UniParc]FASTAAdd to Basket

« Hide

MAAQRPLRVL CLAGFRQSER GFREKTGALR KALRGRAELV CLSGPHPVPD    50
PPGPEGARSD FGSCPPEEQP RGWWFSEQEA DVFSALEEPA VCRGLEESLG 100
MVAQALNRLG PFDGLLGFSQ GAALAALVCA LGQAGDPRFP LPRFILLVSG 150
FCPRGIGFKE SILQRPLSLP SLHVFGDTDK VIPSQESVQL ASQFPGAITL 200
THSGGHFIPA AAPQRQAYLK FLDQFAE 227
Length:227
Mass (Da):24,418
Last modified:March 1, 2002 - v1
Checksum:iE4A4694A7E30FBD8
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti84 – 841S → C in AAH40696. 1 Publication
Sequence conflicti150 – 1501G → S in AAC62628. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF073528 mRNA. Translation: AAC62628.1.
AF321875 mRNA. Translation: AAL35713.1.
AF335321 Genomic DNA. Translation: AAN04659.1.
BC040696 mRNA. Translation: AAH40696.1.
BC041170 mRNA. Translation: AAH41170.1.
CCDSiCCDS11015.1.
RefSeqiNP_543012.1. NM_080822.2.
UniGeneiHs.513856.

Genome annotation databases

EnsembliENST00000572195; ENSP00000461388; ENSG00000262664.
GeneIDi124641.
KEGGihsa:124641.
UCSCiuc002ftx.3. human.

Polymorphism databases

DMDMi74731010.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF073528 mRNA. Translation: AAC62628.1 .
AF321875 mRNA. Translation: AAL35713.1 .
AF335321 Genomic DNA. Translation: AAN04659.1 .
BC040696 mRNA. Translation: AAH40696.1 .
BC041170 mRNA. Translation: AAH41170.1 .
CCDSi CCDS11015.1.
RefSeqi NP_543012.1. NM_080822.2.
UniGenei Hs.513856.

3D structure databases

ProteinModelPortali Q8WZ82.
SMRi Q8WZ82. Positions 8-209.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125881. 1 interaction.
STRINGi 9606.ENSP00000263084.

PTM databases

PhosphoSitei Q8WZ82.

Polymorphism databases

DMDMi 74731010.

Proteomic databases

MaxQBi Q8WZ82.
PaxDbi Q8WZ82.
PeptideAtlasi Q8WZ82.
PRIDEi Q8WZ82.

Protocols and materials databases

DNASUi 124641.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000572195 ; ENSP00000461388 ; ENSG00000262664 .
GeneIDi 124641.
KEGGi hsa:124641.
UCSCi uc002ftx.3. human.

Organism-specific databases

CTDi 124641.
GeneCardsi GC17P001945.
HGNCi HGNC:24203. OVCA2.
MIMi 607896. gene.
neXtProti NX_Q8WZ82.
PharmGKBi PA165432281.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG290051.
HOGENOMi HOG000007638.
HOVERGENi HBG108224.
InParanoidi Q8WZ82.
OMAi SKANWRN.
OrthoDBi EOG78SQK8.
PhylomeDBi Q8WZ82.
TreeFami TF313006.

Miscellaneous databases

GenomeRNAii 124641.
NextBioi 81353.
PROi Q8WZ82.
SOURCEi Search...

Gene expression databases

Genevestigatori Q8WZ82.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR005645. Serine_hydrolase_FSH.
[Graphical view ]
Pfami PF03959. FSH1. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of two candidate tumor suppressor genes on chromosome 17p13.3."
    Schultz D.C., Vanderveer L., Berman D.B., Hamilton T.C., Wong A.J., Godwin A.K.
    Cancer Res. 56:1997-2002(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Ovary.
  2. "OVCA2 is downregulated and degraded during retinoid-induced apoptosis."
    Prowse A.H., Vanderveer L., Milling S.W., Pan Z.Z., Dunbrack R.L., Xu X.X., Godwin A.K.
    Int. J. Cancer 99:185-192(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, PROTEOLYTIC DEGRADATION.
  3. "OVCA locus."
    Godwin A.K., Vanderveer L.A., Schultz D.C.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Duodenum and Skin.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiOVCA2_HUMAN
AccessioniPrimary (citable) accession number: Q8WZ82
Secondary accession number(s): Q86XN3, Q8IW87, Q9UCX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Encoded in an intron of the gene DPH1/OVCA1 (same strand).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

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