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Protein

Ovarian cancer-associated gene 2 protein

Gene

OVCA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • hydrolase activity Source: UniProtKB

GO - Biological processi

  • metabolic process Source: GOC
  • response to retinoic acid Source: UniProtKB
Complete GO annotation...

Protein family/group databases

ESTHERihuman-OVCA2. FSH1.

Names & Taxonomyi

Protein namesi
Recommended name:
Ovarian cancer-associated gene 2 protein
Gene namesi
Name:OVCA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:24203. OVCA2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165432281.

Polymorphism and mutation databases

BioMutaiOVCA2.
DMDMi74731010.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 227227Ovarian cancer-associated gene 2 proteinPRO_0000300876Add
BLAST

Post-translational modificationi

Proteolytically degraded in response to RA and 4HPR treatment in a time- and dose-dependent manner in the promyelocytic leukemia cell line HL-60.

Proteomic databases

MaxQBiQ8WZ82.
PaxDbiQ8WZ82.
PeptideAtlasiQ8WZ82.
PRIDEiQ8WZ82.

PTM databases

PhosphoSiteiQ8WZ82.

Expressioni

Tissue specificityi

Ubiquitously expressed.2 Publications

Gene expression databases

GenevisibleiQ8WZ82. HS.

Interactioni

Protein-protein interaction databases

BioGridi125881. 3 interactions.
STRINGi9606.ENSP00000461388.

Structurei

3D structure databases

ProteinModelPortaliQ8WZ82.
SMRiQ8WZ82. Positions 8-209.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0483 (OVCA2) family.Curated

Phylogenomic databases

eggNOGiNOG290051.
GeneTreeiENSGT00390000003541.
HOGENOMiHOG000007638.
HOVERGENiHBG108224.
InParanoidiQ8WZ82.
OMAiSKANWRN.
OrthoDBiEOG78SQK8.
PhylomeDBiQ8WZ82.
TreeFamiTF313006.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR005645. Serine_hydrolase_FSH.
[Graphical view]
PfamiPF03959. FSH1. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8WZ82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQRPLRVL CLAGFRQSER GFREKTGALR KALRGRAELV CLSGPHPVPD
60 70 80 90 100
PPGPEGARSD FGSCPPEEQP RGWWFSEQEA DVFSALEEPA VCRGLEESLG
110 120 130 140 150
MVAQALNRLG PFDGLLGFSQ GAALAALVCA LGQAGDPRFP LPRFILLVSG
160 170 180 190 200
FCPRGIGFKE SILQRPLSLP SLHVFGDTDK VIPSQESVQL ASQFPGAITL
210 220
THSGGHFIPA AAPQRQAYLK FLDQFAE
Length:227
Mass (Da):24,418
Last modified:March 1, 2002 - v1
Checksum:iE4A4694A7E30FBD8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti84 – 841S → C in AAH40696 (PubMed:15489334).Curated
Sequence conflicti150 – 1501G → S in AAC62628 (PubMed:8616839).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073528 mRNA. Translation: AAC62628.1.
AF321875 mRNA. Translation: AAL35713.1.
AF335321 Genomic DNA. Translation: AAN04659.1.
BC040696 mRNA. Translation: AAH40696.1.
BC041170 mRNA. Translation: AAH41170.1.
CCDSiCCDS11015.1.
RefSeqiNP_543012.1. NM_080822.2.
UniGeneiHs.513856.

Genome annotation databases

EnsembliENST00000572195; ENSP00000461388; ENSG00000262664.
GeneIDi124641.
KEGGihsa:124641.
UCSCiuc002ftx.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073528 mRNA. Translation: AAC62628.1.
AF321875 mRNA. Translation: AAL35713.1.
AF335321 Genomic DNA. Translation: AAN04659.1.
BC040696 mRNA. Translation: AAH40696.1.
BC041170 mRNA. Translation: AAH41170.1.
CCDSiCCDS11015.1.
RefSeqiNP_543012.1. NM_080822.2.
UniGeneiHs.513856.

3D structure databases

ProteinModelPortaliQ8WZ82.
SMRiQ8WZ82. Positions 8-209.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125881. 3 interactions.
STRINGi9606.ENSP00000461388.

Protein family/group databases

ESTHERihuman-OVCA2. FSH1.

PTM databases

PhosphoSiteiQ8WZ82.

Polymorphism and mutation databases

BioMutaiOVCA2.
DMDMi74731010.

Proteomic databases

MaxQBiQ8WZ82.
PaxDbiQ8WZ82.
PeptideAtlasiQ8WZ82.
PRIDEiQ8WZ82.

Protocols and materials databases

DNASUi124641.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000572195; ENSP00000461388; ENSG00000262664.
GeneIDi124641.
KEGGihsa:124641.
UCSCiuc002ftx.3. human.

Organism-specific databases

CTDi124641.
GeneCardsiGC17P001945.
HGNCiHGNC:24203. OVCA2.
MIMi607896. gene.
neXtProtiNX_Q8WZ82.
PharmGKBiPA165432281.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG290051.
GeneTreeiENSGT00390000003541.
HOGENOMiHOG000007638.
HOVERGENiHBG108224.
InParanoidiQ8WZ82.
OMAiSKANWRN.
OrthoDBiEOG78SQK8.
PhylomeDBiQ8WZ82.
TreeFamiTF313006.

Miscellaneous databases

GenomeRNAii124641.
NextBioi81353.
PROiQ8WZ82.
SOURCEiSearch...

Gene expression databases

GenevisibleiQ8WZ82. HS.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR005645. Serine_hydrolase_FSH.
[Graphical view]
PfamiPF03959. FSH1. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of two candidate tumor suppressor genes on chromosome 17p13.3."
    Schultz D.C., Vanderveer L., Berman D.B., Hamilton T.C., Wong A.J., Godwin A.K.
    Cancer Res. 56:1997-2002(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Ovary.
  2. "OVCA2 is downregulated and degraded during retinoid-induced apoptosis."
    Prowse A.H., Vanderveer L., Milling S.W., Pan Z.Z., Dunbrack R.L., Xu X.X., Godwin A.K.
    Int. J. Cancer 99:185-192(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, PROTEOLYTIC DEGRADATION.
  3. "OVCA locus."
    Godwin A.K., Vanderveer L.A., Schultz D.C.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Duodenum and Skin.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiOVCA2_HUMAN
AccessioniPrimary (citable) accession number: Q8WZ82
Secondary accession number(s): Q86XN3, Q8IW87, Q9UCX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2002
Last modified: June 24, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Encoded in an intron of the gene DPH1/OVCA1 (same strand).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.