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Q8WZ82

- OVCA2_HUMAN

UniProt

Q8WZ82 - OVCA2_HUMAN

Protein

Ovarian cancer-associated gene 2 protein

Gene

OVCA2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. hydrolase activity Source: UniProtKB

    GO - Biological processi

    1. metabolic process Source: GOC
    2. response to retinoic acid Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ovarian cancer-associated gene 2 protein
    Gene namesi
    Name:OVCA2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:24203. OVCA2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165432281.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 227227Ovarian cancer-associated gene 2 proteinPRO_0000300876Add
    BLAST

    Post-translational modificationi

    Proteolytically degraded in response to RA and 4HPR treatment in a time- and dose-dependent manner in the promyelocytic leukemia cell line HL-60.

    Proteomic databases

    MaxQBiQ8WZ82.
    PaxDbiQ8WZ82.
    PeptideAtlasiQ8WZ82.
    PRIDEiQ8WZ82.

    PTM databases

    PhosphoSiteiQ8WZ82.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed.2 Publications

    Gene expression databases

    GenevestigatoriQ8WZ82.

    Interactioni

    Protein-protein interaction databases

    BioGridi125881. 1 interaction.
    STRINGi9606.ENSP00000263084.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WZ82.
    SMRiQ8WZ82. Positions 8-209.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UPF0483 (OVCA2) family.Curated

    Phylogenomic databases

    eggNOGiNOG290051.
    HOGENOMiHOG000007638.
    HOVERGENiHBG108224.
    InParanoidiQ8WZ82.
    OMAiSKANWRN.
    OrthoDBiEOG78SQK8.
    PhylomeDBiQ8WZ82.
    TreeFamiTF313006.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR005645. Serine_hydrolase_FSH.
    [Graphical view]
    PfamiPF03959. FSH1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8WZ82-1 [UniParc]FASTAAdd to Basket

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    MAAQRPLRVL CLAGFRQSER GFREKTGALR KALRGRAELV CLSGPHPVPD    50
    PPGPEGARSD FGSCPPEEQP RGWWFSEQEA DVFSALEEPA VCRGLEESLG 100
    MVAQALNRLG PFDGLLGFSQ GAALAALVCA LGQAGDPRFP LPRFILLVSG 150
    FCPRGIGFKE SILQRPLSLP SLHVFGDTDK VIPSQESVQL ASQFPGAITL 200
    THSGGHFIPA AAPQRQAYLK FLDQFAE 227
    Length:227
    Mass (Da):24,418
    Last modified:March 1, 2002 - v1
    Checksum:iE4A4694A7E30FBD8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti84 – 841S → C in AAH40696. (PubMed:15489334)Curated
    Sequence conflicti150 – 1501G → S in AAC62628. (PubMed:8616839)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF073528 mRNA. Translation: AAC62628.1.
    AF321875 mRNA. Translation: AAL35713.1.
    AF335321 Genomic DNA. Translation: AAN04659.1.
    BC040696 mRNA. Translation: AAH40696.1.
    BC041170 mRNA. Translation: AAH41170.1.
    CCDSiCCDS11015.1.
    RefSeqiNP_543012.1. NM_080822.2.
    UniGeneiHs.513856.

    Genome annotation databases

    EnsembliENST00000572195; ENSP00000461388; ENSG00000262664.
    GeneIDi124641.
    KEGGihsa:124641.
    UCSCiuc002ftx.3. human.

    Polymorphism databases

    DMDMi74731010.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF073528 mRNA. Translation: AAC62628.1 .
    AF321875 mRNA. Translation: AAL35713.1 .
    AF335321 Genomic DNA. Translation: AAN04659.1 .
    BC040696 mRNA. Translation: AAH40696.1 .
    BC041170 mRNA. Translation: AAH41170.1 .
    CCDSi CCDS11015.1.
    RefSeqi NP_543012.1. NM_080822.2.
    UniGenei Hs.513856.

    3D structure databases

    ProteinModelPortali Q8WZ82.
    SMRi Q8WZ82. Positions 8-209.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125881. 1 interaction.
    STRINGi 9606.ENSP00000263084.

    PTM databases

    PhosphoSitei Q8WZ82.

    Polymorphism databases

    DMDMi 74731010.

    Proteomic databases

    MaxQBi Q8WZ82.
    PaxDbi Q8WZ82.
    PeptideAtlasi Q8WZ82.
    PRIDEi Q8WZ82.

    Protocols and materials databases

    DNASUi 124641.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000572195 ; ENSP00000461388 ; ENSG00000262664 .
    GeneIDi 124641.
    KEGGi hsa:124641.
    UCSCi uc002ftx.3. human.

    Organism-specific databases

    CTDi 124641.
    GeneCardsi GC17P001945.
    HGNCi HGNC:24203. OVCA2.
    MIMi 607896. gene.
    neXtProti NX_Q8WZ82.
    PharmGKBi PA165432281.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG290051.
    HOGENOMi HOG000007638.
    HOVERGENi HBG108224.
    InParanoidi Q8WZ82.
    OMAi SKANWRN.
    OrthoDBi EOG78SQK8.
    PhylomeDBi Q8WZ82.
    TreeFami TF313006.

    Miscellaneous databases

    GenomeRNAii 124641.
    NextBioi 81353.
    PROi Q8WZ82.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q8WZ82.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR005645. Serine_hydrolase_FSH.
    [Graphical view ]
    Pfami PF03959. FSH1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of two candidate tumor suppressor genes on chromosome 17p13.3."
      Schultz D.C., Vanderveer L., Berman D.B., Hamilton T.C., Wong A.J., Godwin A.K.
      Cancer Res. 56:1997-2002(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Ovary.
    2. "OVCA2 is downregulated and degraded during retinoid-induced apoptosis."
      Prowse A.H., Vanderveer L., Milling S.W., Pan Z.Z., Dunbrack R.L., Xu X.X., Godwin A.K.
      Int. J. Cancer 99:185-192(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, PROTEOLYTIC DEGRADATION.
    3. "OVCA locus."
      Godwin A.K., Vanderveer L.A., Schultz D.C.
      Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Duodenum and Skin.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiOVCA2_HUMAN
    AccessioniPrimary (citable) accession number: Q8WZ82
    Secondary accession number(s): Q86XN3, Q8IW87, Q9UCX9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Encoded in an intron of the gene DPH1/OVCA1 (same strand).Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families
    4. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3