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Q8WZ79

- DNS2B_HUMAN

UniProt

Q8WZ79 - DNS2B_HUMAN

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Protein

Deoxyribonuclease-2-beta

Gene

DNASE2B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation.2 Publications

Catalytic activityi

Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotide end-products.

GO - Molecular functioni

  1. deoxyribonuclease II activity Source: RefGenome

GO - Biological processi

  1. apoptotic DNA fragmentation Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

BRENDAi3.1.22.1. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribonuclease-2-beta (EC:3.1.22.1)
Alternative name(s):
DNase II-like acid DNase
DNase2-like acid DNase
Deoxyribonuclease II beta
Short name:
DNase II beta
Endonuclease DLAD
Gene namesi
Name:DNASE2B
Synonyms:DLAD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:28875. DNASE2B.

Subcellular locationi

Lysosome Curated

GO - Cellular componenti

  1. extracellular region Source: Ensembl
  2. intracellular Source: RefGenome
  3. lysosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134993904.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 361334Deoxyribonuclease-2-betaPRO_0000007295Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi81 – 811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi278 – 2781N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8WZ79.
PRIDEiQ8WZ79.

PTM databases

PhosphoSiteiQ8WZ79.

Expressioni

Tissue specificityi

Highly expressed in the eye lens and in salivary gland. Detected at lower levels in lung, prostate and lymph node. Isoform 2 is lung specific.3 Publications

Gene expression databases

BgeeiQ8WZ79.
CleanExiHS_DNASE2B.
ExpressionAtlasiQ8WZ79. baseline and differential.
GenevestigatoriQ8WZ79.

Interactioni

Protein-protein interaction databases

BioGridi121838. 32 interactions.
STRINGi9606.ENSP00000359699.

Structurei

3D structure databases

ProteinModelPortaliQ8WZ79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNase II family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG145330.
GeneTreeiENSGT00390000002634.
HOGENOMiHOG000261682.
HOVERGENiHBG051387.
InParanoidiQ8WZ79.
KOiK01158.
OMAiSSYQDHA.
OrthoDBiEOG7F5122.
PhylomeDBiQ8WZ79.
TreeFamiTF314536.

Family and domain databases

InterProiIPR004947. DNase_II.
[Graphical view]
PANTHERiPTHR10858. PTHR10858. 1 hit.
PfamiPF03265. DNase_II. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8WZ79-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKQKMMARLL RTSFALLFLG LFGVLGAATI SCRNEEGKAV DWFTFYKLPK
60 70 80 90 100
RQNKESGETG LEYLYLDSTT RSWRKSEQLM NDTKSVLGRT LQQLYEAYAS
110 120 130 140 150
KSNNTAYLIY NDGVPKPVNY SRKYGHTKGL LLWNRVQGFW LIHSIPQFPP
160 170 180 190 200
IPEEGYDYPP TGRRNGQSGI CITFKYNQYE AIDSQLLVCN PNVYSCSIPA
210 220 230 240 250
TFHQELIHMP QLCTRASSSE IPGRLLTTLQ SAQGQKFLHF AKSDSFLDDI
260 270 280 290 300
FAAWMAQRLK THLLTETWQR KRQELPSNCS LPYHVYNIKA IKLSRHSYFS
310 320 330 340 350
SYQDHAKWCI SQKGTKNRWT CIGDLNRSPH QAFRSGGFIC TQNWQIYQAF
360
QGLVLYYESC K
Length:361
Mass (Da):41,713
Last modified:March 1, 2002 - v1
Checksum:iC6FDD3F58F62CAC0
GO
Isoform 2 (identifier: Q8WZ79-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-208: Missing.

Show »
Length:153
Mass (Da):17,816
Checksum:iABF4ED379AFA9FCF
GO

Sequence cautioni

The sequence AAF76893.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31Q → H.
Corresponds to variant rs3738573 [ dbSNP | Ensembl ].
VAR_059250
Natural varianti47 – 471K → R.
Corresponds to variant rs3754274 [ dbSNP | Ensembl ].
VAR_048872
Natural varianti51 – 511R → K.
Corresponds to variant rs3754274 [ dbSNP | Ensembl ].
VAR_059251

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 208208Missing in isoform 2. 1 PublicationVSP_009812Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF333389 mRNA. Translation: AAL34448.1.
AF334602 Genomic DNA. Translation: AAL34449.1.
AF274571 mRNA. Translation: AAF76893.1. Different initiation.
AL359273 Genomic DNA. Translation: CAH73126.1.
AL359273 Genomic DNA. Translation: CAH73127.1.
CH471097 Genomic DNA. Translation: EAW73238.1.
CH471097 Genomic DNA. Translation: EAW73239.1.
CCDSiCCDS44167.1. [Q8WZ79-1]
CCDS694.1. [Q8WZ79-2]
RefSeqiNP_067056.2. NM_021233.2. [Q8WZ79-1]
NP_490649.1. NM_058248.1. [Q8WZ79-2]
UniGeneiHs.129142.

Genome annotation databases

EnsembliENST00000370662; ENSP00000359696; ENSG00000137976. [Q8WZ79-2]
ENST00000370665; ENSP00000359699; ENSG00000137976. [Q8WZ79-1]
GeneIDi58511.
KEGGihsa:58511.
UCSCiuc001djt.1. human. [Q8WZ79-1]
uc001dju.1. human. [Q8WZ79-2]

Polymorphism databases

DMDMi46395921.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF333389 mRNA. Translation: AAL34448.1 .
AF334602 Genomic DNA. Translation: AAL34449.1 .
AF274571 mRNA. Translation: AAF76893.1 . Different initiation.
AL359273 Genomic DNA. Translation: CAH73126.1 .
AL359273 Genomic DNA. Translation: CAH73127.1 .
CH471097 Genomic DNA. Translation: EAW73238.1 .
CH471097 Genomic DNA. Translation: EAW73239.1 .
CCDSi CCDS44167.1. [Q8WZ79-1 ]
CCDS694.1. [Q8WZ79-2 ]
RefSeqi NP_067056.2. NM_021233.2. [Q8WZ79-1 ]
NP_490649.1. NM_058248.1. [Q8WZ79-2 ]
UniGenei Hs.129142.

3D structure databases

ProteinModelPortali Q8WZ79.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121838. 32 interactions.
STRINGi 9606.ENSP00000359699.

PTM databases

PhosphoSitei Q8WZ79.

Polymorphism databases

DMDMi 46395921.

Proteomic databases

PaxDbi Q8WZ79.
PRIDEi Q8WZ79.

Protocols and materials databases

DNASUi 58511.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000370662 ; ENSP00000359696 ; ENSG00000137976 . [Q8WZ79-2 ]
ENST00000370665 ; ENSP00000359699 ; ENSG00000137976 . [Q8WZ79-1 ]
GeneIDi 58511.
KEGGi hsa:58511.
UCSCi uc001djt.1. human. [Q8WZ79-1 ]
uc001dju.1. human. [Q8WZ79-2 ]

Organism-specific databases

CTDi 58511.
GeneCardsi GC01P084864.
HGNCi HGNC:28875. DNASE2B.
MIMi 608057. gene.
neXtProti NX_Q8WZ79.
PharmGKBi PA134993904.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG145330.
GeneTreei ENSGT00390000002634.
HOGENOMi HOG000261682.
HOVERGENi HBG051387.
InParanoidi Q8WZ79.
KOi K01158.
OMAi SSYQDHA.
OrthoDBi EOG7F5122.
PhylomeDBi Q8WZ79.
TreeFami TF314536.

Enzyme and pathway databases

BRENDAi 3.1.22.1. 2681.

Miscellaneous databases

GenomeRNAii 58511.
NextBioi 65041.
PROi Q8WZ79.
SOURCEi Search...

Gene expression databases

Bgeei Q8WZ79.
CleanExi HS_DNASE2B.
ExpressionAtlasi Q8WZ79. baseline and differential.
Genevestigatori Q8WZ79.

Family and domain databases

InterProi IPR004947. DNase_II.
[Graphical view ]
PANTHERi PTHR10858. PTHR10858. 1 hit.
Pfami PF03265. DNase_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of the DLAD/Dlad genes, which lie head-to-head with the genes for urate oxidase."
    Shiokawa D., Tanuma S.
    Biochem. Biophys. Res. Commun. 288:1119-1128(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY.
    Tissue: Lung.
  2. "The cloning, genomic structure, localization, and expression of human deoxyribonuclease IIbeta."
    Krieser R.J., MacLea K.S., Park J.P., Eastman A.
    Gene 269:205-216(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiDNS2B_HUMAN
AccessioniPrimary (citable) accession number: Q8WZ79
Secondary accession number(s): Q5VXD0
, Q5VXD1, Q8WZ80, Q9NQW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3