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Protein

Cortactin-binding protein 2

Gene

CTTNBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cortactin-binding protein 2
Short name:
CortBP2
Gene namesi
Name:CTTNBP2
Synonyms:C7orf8, CORTBP2, KIAA1758
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:15679. CTTNBP2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26774.

Polymorphism and mutation databases

BioMutaiCTTNBP2.
DMDMi74751641.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16631663Cortactin-binding protein 2PRO_0000227002Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1524 – 15241PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8WZ74.
PaxDbiQ8WZ74.
PRIDEiQ8WZ74.

PTM databases

iPTMnetiQ8WZ74.
PhosphoSiteiQ8WZ74.

Expressioni

Tissue specificityi

Highest expression in brain. Also expressed in kidney, pancreas, lung, heart, liver, skeletal muscle and placenta.1 Publication

Gene expression databases

BgeeiQ8WZ74.
CleanExiHS_CTTNBP2.
ExpressionAtlasiQ8WZ74. baseline and differential.
GenevisibleiQ8WZ74. HS.

Organism-specific databases

HPAiCAB009151.
HPA044654.

Interactioni

Subunit structurei

Interacts with CTTN/cortactin SH3 domain. Interacts with STRN, STRN4/zinedin and MOB4/phocein; this interaction may regulate dendritic spine distribution of STRN and STRN4 in hippocampal neurons. Activation of glutamate receptors weakens the interaction with STRN and STRN4.By similarity

Protein-protein interaction databases

BioGridi123842. 26 interactions.
IntActiQ8WZ74. 25 interactions.
STRINGi9606.ENSP00000160373.

Structurei

3D structure databases

ProteinModelPortaliQ8WZ74.
SMRiQ8WZ74. Positions 680-966.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati709 – 73931ANK 1Add
BLAST
Repeati743 – 77230ANK 2Add
BLAST
Repeati776 – 80530ANK 3Add
BLAST
Repeati809 – 83830ANK 4Add
BLAST
Repeati842 – 87130ANK 5Add
BLAST
Repeati912 – 94231ANK 6Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili119 – 276158Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi371 – 561191Pro-richAdd
BLAST

Sequence similaritiesi

Contains 6 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IGN3. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00680000099614.
HOGENOMiHOG000112055.
HOVERGENiHBG073485.
InParanoidiQ8WZ74.
OMAiKHRQMAA.
OrthoDBiEOG77M8NN.
PhylomeDBiQ8WZ74.
TreeFamiTF325130.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR019131. Cortactin-binding_p2_N.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF09727. CortBP2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WZ74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATDGASCEP DLSRAPEDAA GAAAEAAKKE FDVDTLSKSE LRMLLSVMEG
60 70 80 90 100
ELEARDLVIE ALRARRKEVF IQERYGRFNL NDPFLALQRD YEAGAGDKEK
110 120 130 140 150
KPVCTNPLSI LEAVMAHCKK MQERMSAQLA AAESRQKKLE MEKLQLQALE
160 170 180 190 200
QEHKKLAARL EEERGKNKQV VLMLVKECKQ LSGKVIEEAQ KLEDVMAKLE
210 220 230 240 250
EEKKKTNELE EELSAEKRRS TEMEAQMEKQ LSEFDTEREQ LRAKLNREEA
260 270 280 290 300
HTTDLKEEID KMRKMIEQLK RGSDSKPSLS LPRKTKDRRL VSISVGTEGT
310 320 330 340 350
VTRSVACQTD LVTENADHMK KLPLTMPVKP STGSPLVSAN AKGSVCTSAT
360 370 380 390 400
MARPGIDRQA SYGDLIGASV PAFPPPSANK IEENGPSTGS TPDPTSSTPP
410 420 430 440 450
LPSNAAPPTA QTPGIAPQNS QAPPMHSLHS PCANTSLHPG LNPRIQAARF
460 470 480 490 500
RFQGNANDPD QNGNTTQSPP SRDVSPTSRD NLVAKQLARN TVTQALSRFT
510 520 530 540 550
SPQAGAPSRP GVPPTGDVGT HPPVGRTSLK THGVARVDRG NPPPIPPKKP
560 570 580 590 600
GLSQTPSPPH PQLKVIIDSS RASNTGAKVD NKTVASTPSS LPQGNRVINE
610 620 630 640 650
ENLPKSSSPQ LPPKPSIDLT VAPAGCAVSA LATSQVGAWP AATPGLNQPA
660 670 680 690 700
CSDSSLVIPT TIAFCSSINP VSASSCRPGA SDSLLVTASG WSPSLTPLLM
710 720 730 740 750
SGGPAPLAGR PTLLQQAAAQ GNVTLLSMLL NEEGLDINYS CEDGHSALYS
760 770 780 790 800
AAKNGHTDCV RLLLSAEAQV NAADKNGFTP LCAAAAQGHF ECVELLISYD
810 820 830 840 850
ANINHAADGG QTPLYLACKN GNKECIKLLL EAGTNRSVKT TDGWTPVHAA
860 870 880 890 900
VDTGNVDSLK LLMYHRIPAH GNSFNEEESE SSVFDLDGGE ESPEGISKPV
910 920 930 940 950
VPADLINHAN REGWTAAHIA ASKGFKNCLE ILCRHGGLEP ERRDKCNRTV
960 970 980 990 1000
HDVATDDCKH LLENLNALKI PLRISVGEIE PSNYGSDDLE CENTICALNI
1010 1020 1030 1040 1050
RKQTSWDDFS KAVSQALTNH FQAISSDGWW SLEDVTCNNT TDSNIGLSAR
1060 1070 1080 1090 1100
SIRSITLGNV PWSVGQSFAQ SPWDFMRKNK AEHITVLLSG PQEGCLSSVT
1110 1120 1130 1140 1150
YASMIPLQMM QNYLRLVEQY HNVIFHGPEG SLQDYIVHQL ALCLKHRQMA
1160 1170 1180 1190 1200
AGFSCEIVRA EVDAGFSKEQ LLDLFISSAC LIPVKQSPSK KKIIIILENL
1210 1220 1230 1240 1250
EKSSLSELLR DFLAPLENRS TESPCTFQKG NGLSECYYFH ENCFLMGTIA
1260 1270 1280 1290 1300
KACLQGSDLL VQQHFRWVQL RWDGEPMQGL LQRFLRRKVV NKFKGQAPSP
1310 1320 1330 1340 1350
CDPVCKIVDW ALSVWRQLNS CLARLGTPEA LLGPKYFLSC PVVPGHAQVT
1360 1370 1380 1390 1400
VKWMSKLWNG VIAPRVQEAI LSRASVKRQP GFGQTTAKRH PSQGQQAVVK
1410 1420 1430 1440 1450
AALSILLNKA VLHGCPLPRA ELDQHTADFK GGSFPLSIVS SYNTCNKKKG
1460 1470 1480 1490 1500
ESGAWRKVNT SPRRKSGRFS LPTWNKPDLS TEGMKNKTIS QLNCNRNASL
1510 1520 1530 1540 1550
SKQKSLENDL SLTLNLDQRL SLGSDDEADL VKELQSMCSS KSESDISKIA
1560 1570 1580 1590 1600
DSRDDLRMFD SSGNNPVLSA TINNLRMPVS QKEVSPLSSH QTTECSNSKS
1610 1620 1630 1640 1650
KTELGVSRVK SFLPVPRSKV TQCSQNTKRS SSSSNTRQIE INNNSKEVNW
1660
NLHKNEHLEK PNK
Length:1,663
Mass (Da):181,051
Last modified:March 1, 2002 - v1
Checksum:i367B933A177D6E3B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1148 – 11481Q → K.
Corresponds to variant rs10274022 [ dbSNP | Ensembl ].
VAR_048294
Natural varianti1213 – 12131L → V.1 Publication
Corresponds to variant rs62617115 [ dbSNP | Ensembl ].
VAR_025535

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF377960 mRNA. Translation: AAL32176.1.
DQ354388 Genomic DNA. Translation: ABC79049.1.
DQ354389 Genomic DNA. Translation: ABC79051.1.
DQ354390 Genomic DNA. Translation: ABC79053.1.
DQ354391 Genomic DNA. Translation: ABC79055.1.
DQ356257 Genomic DNA. Translation: ABC87052.1.
DQ356259 Genomic DNA. Translation: ABC87056.1.
DQ356260 Genomic DNA. Translation: ABC87058.1.
DQ356261 Genomic DNA. Translation: ABC87060.1.
DQ356262 Genomic DNA. Translation: ABC87062.1.
DQ356264 Genomic DNA. Translation: ABC87066.1.
AC004240 Genomic DNA. Translation: AAC04501.2.
BC106000 mRNA. Translation: AAI06001.1.
AB051545 mRNA. Translation: BAB21849.1.
CCDSiCCDS5774.1.
RefSeqiNP_219499.1. NM_033427.2.
UniGeneiHs.592285.

Genome annotation databases

EnsembliENST00000160373; ENSP00000160373; ENSG00000077063.
GeneIDi83992.
KEGGihsa:83992.
UCSCiuc003vjf.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF377960 mRNA. Translation: AAL32176.1.
DQ354388 Genomic DNA. Translation: ABC79049.1.
DQ354389 Genomic DNA. Translation: ABC79051.1.
DQ354390 Genomic DNA. Translation: ABC79053.1.
DQ354391 Genomic DNA. Translation: ABC79055.1.
DQ356257 Genomic DNA. Translation: ABC87052.1.
DQ356259 Genomic DNA. Translation: ABC87056.1.
DQ356260 Genomic DNA. Translation: ABC87058.1.
DQ356261 Genomic DNA. Translation: ABC87060.1.
DQ356262 Genomic DNA. Translation: ABC87062.1.
DQ356264 Genomic DNA. Translation: ABC87066.1.
AC004240 Genomic DNA. Translation: AAC04501.2.
BC106000 mRNA. Translation: AAI06001.1.
AB051545 mRNA. Translation: BAB21849.1.
CCDSiCCDS5774.1.
RefSeqiNP_219499.1. NM_033427.2.
UniGeneiHs.592285.

3D structure databases

ProteinModelPortaliQ8WZ74.
SMRiQ8WZ74. Positions 680-966.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123842. 26 interactions.
IntActiQ8WZ74. 25 interactions.
STRINGi9606.ENSP00000160373.

PTM databases

iPTMnetiQ8WZ74.
PhosphoSiteiQ8WZ74.

Polymorphism and mutation databases

BioMutaiCTTNBP2.
DMDMi74751641.

Proteomic databases

MaxQBiQ8WZ74.
PaxDbiQ8WZ74.
PRIDEiQ8WZ74.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000160373; ENSP00000160373; ENSG00000077063.
GeneIDi83992.
KEGGihsa:83992.
UCSCiuc003vjf.4. human.

Organism-specific databases

CTDi83992.
GeneCardsiCTTNBP2.
HGNCiHGNC:15679. CTTNBP2.
HPAiCAB009151.
HPA044654.
MIMi609772. gene.
neXtProtiNX_Q8WZ74.
PharmGKBiPA26774.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGN3. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00680000099614.
HOGENOMiHOG000112055.
HOVERGENiHBG073485.
InParanoidiQ8WZ74.
OMAiKHRQMAA.
OrthoDBiEOG77M8NN.
PhylomeDBiQ8WZ74.
TreeFamiTF325130.

Miscellaneous databases

ChiTaRSiCTTNBP2. human.
GeneWikiiCTTNBP2.
GenomeRNAii83992.
NextBioi73152.
PROiQ8WZ74.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WZ74.
CleanExiHS_CTTNBP2.
ExpressionAtlasiQ8WZ74. baseline and differential.
GenevisibleiQ8WZ74. HS.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR019131. Cortactin-binding_p2_N.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF09727. CortBP2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the human cortactin-binding protein-2 gene from the autism candidate region at 7q31."
    Cheung J., Petek E., Nakabayashi K., Tsui L.-C., Vincent J.B., Scherer S.W.
    Genomics 78:7-11(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-1213, TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  5. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
    DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-1663.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1524, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCTTB2_HUMAN
AccessioniPrimary (citable) accession number: Q8WZ74
Secondary accession number(s): O43389, Q7LG11, Q9C0A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 1, 2002
Last modified: March 16, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.