Q8WZ74 (CTTB2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cortactin-binding protein 2
Short name=CortBP2

Gene names

Name:	CTTNBP2
Synonyms:	C7orf8, CORTBP2, KIAA1758

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1663 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance By similarity.
Subunit structure	Interacts with CTTN/cortactin SH3 domain By similarity. Interacts with STRN, STRN4/zinedin and MOB4/phocein; this interaction may regulate dendritic spine distribution of STRN and STRN4 in hippocampal neurons By similarity. Activation of glutamate receptors weakens the interaction with STRN and STRN4 By similarity.
Subcellular location	Cytoplasm › cell cortex By similarity. Cell projection › dendritic spine By similarity. Note: Remains associated with dendritic spines even after glutamate stimulation By similarity.
Tissue specificity	Highest expression in brain. Also expressed in kidney, pancreas, lung, heart, liver, skeletal muscle and placenta. Ref.1
Sequence similarities	Contains 6 ANK repeats.

Ontologies

Keywords
Cellular component	Cell projection Cytoplasm
Coding sequence diversity	Polymorphism
Domain	ANK repeat Coiled coil Repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	brain development Inferred from electronic annotation. Source: Compara
Cellular_component	synaptic vesicle Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1663	1663	Cortactin-binding protein 2		PRO_0000227002
Regions
	Repeat	709 – 739	31	ANK 1
	Repeat	743 – 772	30	ANK 2
	Repeat	776 – 805	30	ANK 3
	Repeat	809 – 838	30	ANK 4
	Repeat	842 – 871	30	ANK 5
	Repeat	912 – 942	31	ANK 6
	Coiled coil	119 – 276	158	Potential
	Compositional bias	371 – 561	191	Pro-rich
Amino acid modifications
	Modified residue	1524	1	Phosphoserine Ref.6
Natural variations
	Natural variant	1148	1	Q → K. Corresponds to variant rs10274022 [ dbSNP | Ensembl ].		VAR_048294
	Natural variant	1213	1	L → V. Ref.1		VAR_025535

Sequences

	Sequence		Length	Mass (Da)
	Q8WZ74 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 367B933A177D6E3B	FASTA	1,663	181,051
	10 20 30 40 50 60 MATDGASCEP DLSRAPEDAA GAAAEAAKKE FDVDTLSKSE LRMLLSVMEG ELEARDLVIE 70 80 90 100 110 120 ALRARRKEVF IQERYGRFNL NDPFLALQRD YEAGAGDKEK KPVCTNPLSI LEAVMAHCKK 130 140 150 160 170 180 MQERMSAQLA AAESRQKKLE MEKLQLQALE QEHKKLAARL EEERGKNKQV VLMLVKECKQ 190 200 210 220 230 240 LSGKVIEEAQ KLEDVMAKLE EEKKKTNELE EELSAEKRRS TEMEAQMEKQ LSEFDTEREQ 250 260 270 280 290 300 LRAKLNREEA HTTDLKEEID KMRKMIEQLK RGSDSKPSLS LPRKTKDRRL VSISVGTEGT 310 320 330 340 350 360 VTRSVACQTD LVTENADHMK KLPLTMPVKP STGSPLVSAN AKGSVCTSAT MARPGIDRQA 370 380 390 400 410 420 SYGDLIGASV PAFPPPSANK IEENGPSTGS TPDPTSSTPP LPSNAAPPTA QTPGIAPQNS 430 440 450 460 470 480 QAPPMHSLHS PCANTSLHPG LNPRIQAARF RFQGNANDPD QNGNTTQSPP SRDVSPTSRD 490 500 510 520 530 540 NLVAKQLARN TVTQALSRFT SPQAGAPSRP GVPPTGDVGT HPPVGRTSLK THGVARVDRG 550 560 570 580 590 600 NPPPIPPKKP GLSQTPSPPH PQLKVIIDSS RASNTGAKVD NKTVASTPSS LPQGNRVINE 610 620 630 640 650 660 ENLPKSSSPQ LPPKPSIDLT VAPAGCAVSA LATSQVGAWP AATPGLNQPA CSDSSLVIPT 670 680 690 700 710 720 TIAFCSSINP VSASSCRPGA SDSLLVTASG WSPSLTPLLM SGGPAPLAGR PTLLQQAAAQ 730 740 750 760 770 780 GNVTLLSMLL NEEGLDINYS CEDGHSALYS AAKNGHTDCV RLLLSAEAQV NAADKNGFTP 790 800 810 820 830 840 LCAAAAQGHF ECVELLISYD ANINHAADGG QTPLYLACKN GNKECIKLLL EAGTNRSVKT 850 860 870 880 890 900 TDGWTPVHAA VDTGNVDSLK LLMYHRIPAH GNSFNEEESE SSVFDLDGGE ESPEGISKPV 910 920 930 940 950 960 VPADLINHAN REGWTAAHIA ASKGFKNCLE ILCRHGGLEP ERRDKCNRTV HDVATDDCKH 970 980 990 1000 1010 1020 LLENLNALKI PLRISVGEIE PSNYGSDDLE CENTICALNI RKQTSWDDFS KAVSQALTNH 1030 1040 1050 1060 1070 1080 FQAISSDGWW SLEDVTCNNT TDSNIGLSAR SIRSITLGNV PWSVGQSFAQ SPWDFMRKNK 1090 1100 1110 1120 1130 1140 AEHITVLLSG PQEGCLSSVT YASMIPLQMM QNYLRLVEQY HNVIFHGPEG SLQDYIVHQL 1150 1160 1170 1180 1190 1200 ALCLKHRQMA AGFSCEIVRA EVDAGFSKEQ LLDLFISSAC LIPVKQSPSK KKIIIILENL 1210 1220 1230 1240 1250 1260 EKSSLSELLR DFLAPLENRS TESPCTFQKG NGLSECYYFH ENCFLMGTIA KACLQGSDLL 1270 1280 1290 1300 1310 1320 VQQHFRWVQL RWDGEPMQGL LQRFLRRKVV NKFKGQAPSP CDPVCKIVDW ALSVWRQLNS 1330 1340 1350 1360 1370 1380 CLARLGTPEA LLGPKYFLSC PVVPGHAQVT VKWMSKLWNG VIAPRVQEAI LSRASVKRQP 1390 1400 1410 1420 1430 1440 GFGQTTAKRH PSQGQQAVVK AALSILLNKA VLHGCPLPRA ELDQHTADFK GGSFPLSIVS 1450 1460 1470 1480 1490 1500 SYNTCNKKKG ESGAWRKVNT SPRRKSGRFS LPTWNKPDLS TEGMKNKTIS QLNCNRNASL 1510 1520 1530 1540 1550 1560 SKQKSLENDL SLTLNLDQRL SLGSDDEADL VKELQSMCSS KSESDISKIA DSRDDLRMFD 1570 1580 1590 1600 1610 1620 SSGNNPVLSA TINNLRMPVS QKEVSPLSSH QTTECSNSKS KTELGVSRVK SFLPVPRSKV 1630 1640 1650 1660 TQCSQNTKRS SSSSNTRQIE INNNSKEVNW NLHKNEHLEK PNK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of the human cortactin-binding protein-2 gene from the autism candidate region at 7q31." Cheung J., Petek E., Nakabayashi K., Tsui L.-C., Vincent J.B., Scherer S.W. Genomics 78:7-11(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-1213, TISSUE SPECIFICITY.
[2]	Stacy R., Subramanian S., Deodato C., Burkhardt P., Song Y., Paddock M., Chang J., Zhou Y., Haugen E., Waring D., Chapman P., Hayden H., Levy R., Wu Z., Rouse G., James R., Phelps K., Olson M.V., Kaul R. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[5]	"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O. DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-1663.
[6]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1524, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF377960 mRNA. Translation: AAL32176.1. DQ354388 Genomic DNA. Translation: ABC79049.1. DQ354389 Genomic DNA. Translation: ABC79051.1. DQ354390 Genomic DNA. Translation: ABC79053.1. DQ354391 Genomic DNA. Translation: ABC79055.1. DQ356257 Genomic DNA. Translation: ABC87052.1. DQ356259 Genomic DNA. Translation: ABC87056.1. DQ356260 Genomic DNA. Translation: ABC87058.1. DQ356261 Genomic DNA. Translation: ABC87060.1. DQ356262 Genomic DNA. Translation: ABC87062.1. DQ356264 Genomic DNA. Translation: ABC87066.1. AC004240 Genomic DNA. Translation: AAC04501.2. BC106000 mRNA. Translation: AAI06001.1. AB051545 mRNA. Translation: BAB21849.1.
IPI	IPI00103869.
RefSeq	NP_219499.1. NM_033427.2.
UniGene	Hs.592285.
3D structure databases
ProteinModelPortal	Q8WZ74.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8WZ74. 25 interactions.
STRING	9606.ENSP00000160373.
PTM databases
PhosphoSite	Q8WZ74.
Polymorphism databases
DMDM	74751641.
Proteomic databases
PaxDb	Q8WZ74.
PRIDE	Q8WZ74.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000160373; ENSP00000160373; ENSG00000077063.
GeneID	83992.
KEGG	hsa:83992.
UCSC	uc003vjf.3. human.
Organism-specific databases
CTD	83992.
GeneCards	GC07M117350.
HGNC	HGNC:15679. CTTNBP2.
HPA	CAB009151.
MIM	609772. gene.
neXtProt	NX_Q8WZ74.
PharmGKB	PA26774.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0666.
HOGENOM	HOG000112055.
HOVERGEN	HBG073485.
InParanoid	Q8WZ74.
OMA	SQALTNH.
OrthoDB	EOG4W9J3Q.
PhylomeDB	Q8WZ74.
Gene expression databases
ArrayExpress	Q8WZ74.
Bgee	Q8WZ74.
CleanEx	HS_CTTNBP2.
Genevestigator	Q8WZ74.
GermOnline	ENSG00000077063. Homo sapiens.
Family and domain databases
Gene3D	1.25.40.20. 2 hits.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR019131. Cortactin-binding_p2_N. [Graphical view]
Pfam	PF00023. Ank. 1 hit. PF12796. Ank_2. 1 hit. PF09727. CortBP2. 2 hits. [Graphical view]
SMART	SM00248. ANK. 6 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 4 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	83992.
NextBio	73152.
SOURCE	Search...

Entry information

Entry name

CTTB2_HUMAN

Accession

Primary (citable) accession number: Q8WZ74
Secondary accession number(s): O43389, Q7LG11, Q9C0A5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.