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Protein

Transmembrane protein 158

Gene

TMEM158

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide.By similarity

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 158
Alternative name(s):
40 kDa BINP-binding protein
Short name:
p40BBP
Ras-induced senescence protein 1
Gene namesi
Name:TMEM158
Synonyms:HBBP, RIS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:30293. TMEM158.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei231 – 25121HelicalSequence analysisAdd
BLAST
Transmembranei273 – 29321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128395777.

Polymorphism and mutation databases

DMDMi408360199.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 300280Transmembrane protein 158PRO_0000285128Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8WZ71.
PRIDEiQ8WZ71.

Expressioni

Inductioni

Up-regulated during Ras-induced senesence.1 Publication

Gene expression databases

CleanExiHS_TMEM158.
GenevisibleiQ8WZ71. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000422431.

Structurei

3D structure databases

ProteinModelPortaliQ8WZ71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi67 – 726Poly-Ala
Compositional biasi165 – 1728Poly-Ala
Compositional biasi263 – 29230Ala-richAdd
BLAST

Sequence similaritiesi

Belongs to the TMEM158 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXR9. Eukaryota.
ENOG410YHSY. LUCA.
GeneTreeiENSGT00390000009719.
HOVERGENiHBG098266.
InParanoidiQ8WZ71.
OMAiSTNAHGR.
OrthoDBiEOG7NKKMP.
PhylomeDBiQ8WZ71.
TreeFamiTF339241.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WZ71-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPLLAALLA AACPLPPVRG GAADAPGLLG VPSNASVNAS SADEPIAPRL
60 70 80 90 100
LASAAPGPPE RPGPEEAAAA AAPCNISVQR QMLSSLLVRW GRPRGFQCDL
110 120 130 140 150
LLFSTNAHGR AFFAAAFHRV GPPLLIEHLG LAAGGAQQDL RLCVGCGWVR
160 170 180 190 200
GRRTGRLRPA AAPSAAAATA GAPTALPAYP AAEPPGPLWL QGEPLHFCCL
210 220 230 240 250
DFSLEELQGE PGWRLNRKPI ESTLVACFMT LVIVVWSVAA LIWPVPIIAG
260 270 280 290 300
FLPNGMEQRR TTASTTAATP AAVPAGTTAA AAAAAAAAAA AAVTSGVATK
Length:300
Mass (Da):30,404
Last modified:October 3, 2012 - v2
Checksum:iA555CC499B7FE0DC
GO
Isoform 2 (identifier: Q8WZ71-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     273-286: Missing.

Note: No experimental confirmation available.
Show »
Length:286
Mass (Da):29,309
Checksum:iD375F4A2482F19D9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti67 – 671A → T in AAL30845 (PubMed:11822868).Curated
Sequence conflicti67 – 671A → T in BAC05687 (Ref. 2) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei273 – 28614Missing in isoform 2. 1 PublicationVSP_024826Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF438313 mRNA. Translation: AAL30845.1.
AB078417 mRNA. Translation: BAC05687.1.
AC010170 Genomic DNA. No translation available.
BC057390 mRNA. Translation: AAH57390.1.
AL080235 mRNA. Translation: CAB45781.1.
CCDSiCCDS54573.1. [Q8WZ71-1]
PIRiT12547.
RefSeqiNP_056259.2. NM_015444.2. [Q8WZ71-1]
UniGeneiHs.740403.

Genome annotation databases

EnsembliENST00000503771; ENSP00000422431; ENSG00000249992. [Q8WZ71-1]
GeneIDi25907.
KEGGihsa:25907.
UCSCiuc011baf.3. human. [Q8WZ71-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF438313 mRNA. Translation: AAL30845.1.
AB078417 mRNA. Translation: BAC05687.1.
AC010170 Genomic DNA. No translation available.
BC057390 mRNA. Translation: AAH57390.1.
AL080235 mRNA. Translation: CAB45781.1.
CCDSiCCDS54573.1. [Q8WZ71-1]
PIRiT12547.
RefSeqiNP_056259.2. NM_015444.2. [Q8WZ71-1]
UniGeneiHs.740403.

3D structure databases

ProteinModelPortaliQ8WZ71.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000422431.

Polymorphism and mutation databases

DMDMi408360199.

Proteomic databases

PaxDbiQ8WZ71.
PRIDEiQ8WZ71.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000503771; ENSP00000422431; ENSG00000249992. [Q8WZ71-1]
GeneIDi25907.
KEGGihsa:25907.
UCSCiuc011baf.3. human. [Q8WZ71-1]

Organism-specific databases

CTDi25907.
GeneCardsiTMEM158.
H-InvDBHIX0003239.
HGNCiHGNC:30293. TMEM158.
neXtProtiNX_Q8WZ71.
PharmGKBiPA128395777.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXR9. Eukaryota.
ENOG410YHSY. LUCA.
GeneTreeiENSGT00390000009719.
HOVERGENiHBG098266.
InParanoidiQ8WZ71.
OMAiSTNAHGR.
OrthoDBiEOG7NKKMP.
PhylomeDBiQ8WZ71.
TreeFamiTF339241.

Miscellaneous databases

ChiTaRSiTMEM158. human.
GeneWikiiTMEM158.
GenomeRNAii25907.
PROiQ8WZ71.

Gene expression databases

CleanExiHS_TMEM158.
GenevisibleiQ8WZ71. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a candidate tumor-suppressor gene specifically activated during Ras-induced senescence."
    Barradas M., Gonos E.S., Zebedee Z., Kolettas E., Petropoulou C., Delgado M.D., Leon J., Hara E., Serrano M.
    Exp. Cell Res. 273:127-137(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION.
  2. "Isolation of human homologue of rat p40BBp (brain specific binding protein."
    Hama T.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Hippocampus.
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Uterus.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 151-300 (ISOFORM 1).
    Tissue: Uterus.

Entry informationi

Entry nameiTM158_HUMAN
AccessioniPrimary (citable) accession number: Q8WZ71
Secondary accession number(s): Q6PFW5, Q9Y4M1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 3, 2012
Last modified: June 8, 2016
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.