Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transmembrane protein 158

Gene

TMEM158

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide.By similarity

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 158
Alternative name(s):
40 kDa BINP-binding protein
Short name:
p40BBP
Ras-induced senescence protein 1
Gene namesi
Name:TMEM158
Synonyms:HBBP, RIS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000249992.1
HGNCiHGNC:30293 TMEM158
neXtProtiNX_Q8WZ71

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei231 – 251HelicalSequence analysisAdd BLAST21
Transmembranei273 – 293HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi25907
OpenTargetsiENSG00000249992
PharmGKBiPA128395777

Polymorphism and mutation databases

DMDMi408360199

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000028512821 – 300Transmembrane protein 158Add BLAST280

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8WZ71
PeptideAtlasiQ8WZ71
PRIDEiQ8WZ71

PTM databases

iPTMnetiQ8WZ71
PhosphoSitePlusiQ8WZ71

Expressioni

Inductioni

Up-regulated during Ras-induced senescence.1 Publication

Gene expression databases

BgeeiENSG00000249992
CleanExiHS_TMEM158
GenevisibleiQ8WZ71 HS

Interactioni

Protein-protein interaction databases

IntActiQ8WZ71, 2 interactors
MINTiQ8WZ71
STRINGi9606.ENSP00000422431

Structurei

3D structure databases

ProteinModelPortaliQ8WZ71
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi67 – 72Poly-Ala6
Compositional biasi165 – 172Poly-Ala8
Compositional biasi263 – 292Ala-richAdd BLAST30

Sequence similaritiesi

Belongs to the TMEM158 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXR9 Eukaryota
ENOG410YHSY LUCA
GeneTreeiENSGT00390000009719
HOVERGENiHBG098266
InParanoidiQ8WZ71
OMAiSTNAHGR
OrthoDBiEOG091G0IH2
PhylomeDBiQ8WZ71
TreeFamiTF339241

Family and domain databases

InterProiView protein in InterPro
IPR038962 TMEM158
PANTHERiPTHR38324 PTHR38324, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WZ71-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPLLAALLA AACPLPPVRG GAADAPGLLG VPSNASVNAS SADEPIAPRL
60 70 80 90 100
LASAAPGPPE RPGPEEAAAA AAPCNISVQR QMLSSLLVRW GRPRGFQCDL
110 120 130 140 150
LLFSTNAHGR AFFAAAFHRV GPPLLIEHLG LAAGGAQQDL RLCVGCGWVR
160 170 180 190 200
GRRTGRLRPA AAPSAAAATA GAPTALPAYP AAEPPGPLWL QGEPLHFCCL
210 220 230 240 250
DFSLEELQGE PGWRLNRKPI ESTLVACFMT LVIVVWSVAA LIWPVPIIAG
260 270 280 290 300
FLPNGMEQRR TTASTTAATP AAVPAGTTAA AAAAAAAAAA AAVTSGVATK
Length:300
Mass (Da):30,404
Last modified:October 3, 2012 - v2
Checksum:iA555CC499B7FE0DC
GO
Isoform 2 (identifier: Q8WZ71-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     273-286: Missing.

Note: No experimental confirmation available.
Show »
Length:286
Mass (Da):29,309
Checksum:iD375F4A2482F19D9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti67A → T in AAL30845 (PubMed:11822868).Curated1
Sequence conflicti67A → T in BAC05687 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024826273 – 286Missing in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF438313 mRNA Translation: AAL30845.1
AB078417 mRNA Translation: BAC05687.1
AC010170 Genomic DNA No translation available.
BC057390 mRNA Translation: AAH57390.1
AL080235 mRNA Translation: CAB45781.1
CCDSiCCDS54573.1 [Q8WZ71-1]
PIRiT12547
RefSeqiNP_056259.2, NM_015444.2 [Q8WZ71-1]
UniGeneiHs.740403

Genome annotation databases

EnsembliENST00000503771; ENSP00000422431; ENSG00000249992 [Q8WZ71-1]
GeneIDi25907
KEGGihsa:25907
UCSCiuc011baf.3 human [Q8WZ71-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTM158_HUMAN
AccessioniPrimary (citable) accession number: Q8WZ71
Secondary accession number(s): Q6PFW5, Q9Y4M1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 3, 2012
Last modified: May 23, 2018
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health