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Q8WZ64

- ARAP2_HUMAN

UniProt

Q8WZ64 - ARAP2_HUMAN

Protein

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2

Gene

ARAP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 3 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri700 – 72324C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ARF GTPase activator activity Source: InterPro
    2. phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. regulation of ARF GTPase activity Source: InterPro
    2. regulation of small GTPase mediated signal transduction Source: Reactome
    3. small GTPase mediated signal transduction Source: Reactome

    Keywords - Molecular functioni

    GTPase activation

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_11051. Rho GTPase cycle.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2
    Alternative name(s):
    Centaurin-delta-1
    Short name:
    Cnt-d1
    Protein PARX
    Gene namesi
    Name:ARAP2
    Synonyms:CENTD1, KIAA0580
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:16924. ARAP2.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytosol Source: Reactome

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164715938.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 17041704Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2PRO_0000074212Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei77 – 771PhosphotyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8WZ64.
    PaxDbiQ8WZ64.
    PRIDEiQ8WZ64.

    PTM databases

    PhosphoSiteiQ8WZ64.

    Expressioni

    Tissue specificityi

    Detected in brain, thymus, lymph node, thyroid, spinal cord, trachea, heart, skeletal muscle, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes.1 Publication

    Gene expression databases

    ArrayExpressiQ8WZ64.
    BgeeiQ8WZ64.
    CleanExiHS_ARAP2.
    GenevestigatoriQ8WZ64.

    Organism-specific databases

    HPAiHPA035925.

    Interactioni

    Protein-protein interaction databases

    BioGridi125547. 1 interaction.
    IntActiQ8WZ64. 3 interactions.
    MINTiMINT-7969711.
    STRINGi9606.ENSP00000302895.

    Structurei

    Secondary structure

    1
    1704
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi11 – 166
    Turni17 – 193
    Helixi21 – 233
    Helixi24 – 307
    Helixi36 – 405
    Helixi43 – 497
    Helixi54 – 7017
    Beta strandi485 – 4917
    Beta strandi494 – 4985
    Beta strandi501 – 5077
    Beta strandi509 – 51810
    Beta strandi526 – 5283
    Turni529 – 5313
    Beta strandi532 – 5387
    Turni539 – 5413
    Beta strandi542 – 5498
    Beta strandi552 – 5554
    Helixi559 – 57618

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1X40NMR-A1-78[»]
    2CODNMR-A483-584[»]
    ProteinModelPortaliQ8WZ64.
    SMRiQ8WZ64. Positions 6-79, 488-584, 586-681, 687-916, 919-1001, 1128-1289.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8WZ64.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 7065SAMPROSITE-ProRule annotationAdd
    BLAST
    Domaini482 – 57493PH 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini587 – 67993PH 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini676 – 811136Arf-GAPPROSITE-ProRule annotationAdd
    BLAST
    Domaini878 – 1003126PH 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini1014 – 1114101PH 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini1116 – 1297182Rho-GAPPROSITE-ProRule annotationAdd
    BLAST
    Domaini1326 – 142095Ras-associatingPROSITE-ProRule annotationAdd
    BLAST
    Domaini1434 – 1537104PH 5PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Arf-GAP domain.PROSITE-ProRule annotation
    Contains 5 PH domains.PROSITE-ProRule annotation
    Contains 1 Ras-associating domain.PROSITE-ProRule annotation
    Contains 1 Rho-GAP domain.PROSITE-ProRule annotation
    Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri700 – 72324C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5347.
    HOGENOMiHOG000246988.
    HOVERGENiHBG095947.
    InParanoidiQ8WZ64.
    KOiK12490.
    OMAiEQDFKSG.
    OrthoDBiEOG7F24T4.
    PhylomeDBiQ8WZ64.
    TreeFamiTF105769.

    Family and domain databases

    Gene3Di1.10.150.50. 1 hit.
    1.10.555.10. 1 hit.
    2.30.29.30. 4 hits.
    InterProiIPR001164. ArfGAP.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000159. Ras-assoc.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    [Graphical view]
    PfamiPF01412. ArfGap. 1 hit.
    PF00169. PH. 4 hits.
    PF00788. RA. 1 hit.
    PF00620. RhoGAP. 1 hit.
    PF00536. SAM_1. 1 hit.
    [Graphical view]
    PRINTSiPR00405. REVINTRACTNG.
    SMARTiSM00105. ArfGap. 1 hit.
    SM00233. PH. 5 hits.
    SM00324. RhoGAP. 1 hit.
    SM00454. SAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    SSF48350. SSF48350. 1 hit.
    PROSITEiPS50115. ARFGAP. 1 hit.
    PS50003. PH_DOMAIN. 4 hits.
    PS50200. RA. 1 hit.
    PS50238. RHOGAP. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8WZ64-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSVSEVNVD IKDFLMSINL EQYLLHFHES GFTTVKDCAA INDSLLQKIG     50
    ISPTGHRRRI LKQLQIILSK MQDIPIYANV HKTKKNDDPS KDYHVPSSDQ 100
    NICIELSNSG SVQTSSPPQL ETVRKNLEDS DASVERSQYP QSDDKLSPPK 150
    RDFPTAEEPH LNLGSLNDSL FGSDNIKIES LITKKTVDHT VEEQQTEKVK 200
    LITENLSKLP NADSECLSFV GCSTSGTNSG NGTNGLLEGS PPSPFFKFQG 250
    EMIVNDLYVP SSPILAPVRS RSKLVSRPSR SFLLRHRPVP EIPGSTKGVS 300
    GSYFRERRNV ATSTEKSVAW QNSNEENSSS IFPYGETFLF QRLENSKKRS 350
    IKNEFLTQGE ALKGEAATAT NSFIIKSSIY DNRKEKISED KVEDIWIPRE 400
    DKNNFLIDTA SESEYSTVEE CFQSLRRKNS KASKSRTQKA LILDSVNRHS 450
    YPLSSTSGNA DSSAVSSQAI SPYACFYGAS AKKVKSGWLD KLSPQGKRMF 500
    QKRWVKFDGL SISYYNNEKE MYSKGIIPLS AISTVRVQGD NKFEVVTTQR 550
    TFVFRVEKEE ERNDWISILL NALKSQSLTS QSQAVVTPEK CGYLELRGYK 600
    AKIFTVLSGN SVWLCKNEQD FKSGLGITII PMNVANVKQV DRTVKQSFEI 650
    ITPYRSFSFT AETEKEKQDW IEAVQQSIAE TLSDYEVAEK IWFNESNRSC 700
    ADCKAPDPDW ASINLCVVIC KKCAGQHRSL GPKDSKVRSL KMDASIWSNE 750
    LIELFIVIGN KRANDFWAGN LQKDEELHMD SPVEKRKNFI TQKYKEGKFR 800
    KTLLASLTKE ELNKALCAAV VKPDVLETMA LLFSGADVMC ATGDPVHSTP 850
    YLLAKKAGQS LQMEFLYHNK FSDFPQHDIH SEGVLSQESS QSTFLCDFLY 900
    QAPSAASKLS SEKKLLEETN KKWCVLEGGF LSYYENDKST TPNGTININE 950
    VICLAIHKED FYLNTGPIFI FEIYLPSERV FLFGAETSQA QRKWTEAIAK 1000
    HFVPLFAENL TEADYDLIGQ LFYKDCHALD QWRKGWFAMD KSSLHFCLQM 1050
    QEVQGDRMHL RRLQELTIST MVQNGEKLDV LLLVEKGRTL YIHGHTKLDF 1100
    TVWHTAIEKA AGTDGNALQD QQLSKNDVPI IVNSCIAFVT QYGLGCKYIY 1150
    QKNGDPLHIS ELLESFKKDA RSFKLRAGKH QLEDVTAVLK SFLSDIDDAL 1200
    LTKELYPYWI SALDTQDDKE RIKKYGAFIR SLPGVNRATL AAIIEHLYRV 1250
    QKCSEINHMN AHNLALVFSS CLFQTKGQTS EEVNVIEDLI NNYVEIFEVK 1300
    EDQVKQMDIE NSFITKWKDT QVSQAGDLLI EVYVERKEPD CSIIIRISPV 1350
    MEAEELTNDI LAIKNIIPTK GDIWATFEVI ENEELERPLH YKENVLEQVL 1400
    RWSSLAEPGS AYLVVKRFLT ADTIKHCSDR STLGSIKEGI LKIKEEPSKI 1450
    LSGNKFQDRY FVLRDGFLFL YKDVKSSKHD KMFSLSSMKF YRGVKKKMKP 1500
    PTSWGLTAYS EKHHWHLCCD SSRTQTEWMT SIFIAQHEYD IWPPAGKERK 1550
    RSITKNPKIG GLPLIPIQHE GNATLARKNI ESARAELERL RLSEKCDKES 1600
    VDSSLKERAS MVAHCLEHKD DKLRNRPRKH RSFNCLEDTE PEAPLGQPKG 1650
    HKGLKTLRKT EDRNSKATLD SDHKLPSRVI EELNVVLQRS RTLPKELQDE 1700
    QILK 1704
    Length:1,704
    Mass (Da):193,452
    Last modified:October 5, 2010 - v3
    Checksum:iA5A13EE08D43A9A0
    GO

    Sequence cautioni

    The sequence AAL04166.1 differs from that shown. Reason: Frameshift at position 1579.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti227 – 2271T → I in AAL32459. 1 PublicationCurated
    Sequence conflicti532 – 5321I → V in AAL32459. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti384 – 3841K → N.
    Corresponds to variant rs35468501 [ dbSNP | Ensembl ].
    VAR_055530
    Natural varianti1006 – 10061F → L.
    Corresponds to variant rs35218548 [ dbSNP | Ensembl ].
    VAR_055531
    Natural varianti1523 – 15231R → Q.3 Publications
    Corresponds to variant rs4833069 [ dbSNP | Ensembl ].
    VAR_027952

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY049733 mRNA. Translation: AAL12170.1.
    AF439781 mRNA. Translation: AAL32459.1.
    AC098827 Genomic DNA. No translation available.
    AC104078 Genomic DNA. No translation available.
    AC108033 Genomic DNA. Translation: AAY40927.1.
    AC109818 Genomic DNA. No translation available.
    AC116623 Genomic DNA. No translation available.
    AB011152 mRNA. Translation: BAA25506.2.
    AF411982 mRNA. Translation: AAL04166.1. Frameshift.
    CCDSiCCDS3441.1.
    PIRiT00342.
    RefSeqiNP_056045.2. NM_015230.3.
    XP_005262695.1. XM_005262638.2.
    UniGeneiHs.479451.

    Genome annotation databases

    EnsembliENST00000303965; ENSP00000302895; ENSG00000047365.
    GeneIDi116984.
    KEGGihsa:116984.
    UCSCiuc003gsq.2. human.

    Polymorphism databases

    DMDMi308153629.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY049733 mRNA. Translation: AAL12170.1 .
    AF439781 mRNA. Translation: AAL32459.1 .
    AC098827 Genomic DNA. No translation available.
    AC104078 Genomic DNA. No translation available.
    AC108033 Genomic DNA. Translation: AAY40927.1 .
    AC109818 Genomic DNA. No translation available.
    AC116623 Genomic DNA. No translation available.
    AB011152 mRNA. Translation: BAA25506.2 .
    AF411982 mRNA. Translation: AAL04166.1 . Frameshift.
    CCDSi CCDS3441.1.
    PIRi T00342.
    RefSeqi NP_056045.2. NM_015230.3.
    XP_005262695.1. XM_005262638.2.
    UniGenei Hs.479451.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1X40 NMR - A 1-78 [» ]
    2COD NMR - A 483-584 [» ]
    ProteinModelPortali Q8WZ64.
    SMRi Q8WZ64. Positions 6-79, 488-584, 586-681, 687-916, 919-1001, 1128-1289.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125547. 1 interaction.
    IntActi Q8WZ64. 3 interactions.
    MINTi MINT-7969711.
    STRINGi 9606.ENSP00000302895.

    PTM databases

    PhosphoSitei Q8WZ64.

    Polymorphism databases

    DMDMi 308153629.

    Proteomic databases

    MaxQBi Q8WZ64.
    PaxDbi Q8WZ64.
    PRIDEi Q8WZ64.

    Protocols and materials databases

    DNASUi 116984.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000303965 ; ENSP00000302895 ; ENSG00000047365 .
    GeneIDi 116984.
    KEGGi hsa:116984.
    UCSCi uc003gsq.2. human.

    Organism-specific databases

    CTDi 116984.
    GeneCardsi GC04M035950.
    H-InvDB HIX0004149.
    HGNCi HGNC:16924. ARAP2.
    HPAi HPA035925.
    MIMi 606645. gene.
    neXtProti NX_Q8WZ64.
    PharmGKBi PA164715938.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5347.
    HOGENOMi HOG000246988.
    HOVERGENi HBG095947.
    InParanoidi Q8WZ64.
    KOi K12490.
    OMAi EQDFKSG.
    OrthoDBi EOG7F24T4.
    PhylomeDBi Q8WZ64.
    TreeFami TF105769.

    Enzyme and pathway databases

    Reactomei REACT_11051. Rho GTPase cycle.

    Miscellaneous databases

    EvolutionaryTracei Q8WZ64.
    GeneWikii CENTD1.
    GenomeRNAii 116984.
    NextBioi 80056.
    PROi Q8WZ64.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8WZ64.
    Bgeei Q8WZ64.
    CleanExi HS_ARAP2.
    Genevestigatori Q8WZ64.

    Family and domain databases

    Gene3Di 1.10.150.50. 1 hit.
    1.10.555.10. 1 hit.
    2.30.29.30. 4 hits.
    InterProi IPR001164. ArfGAP.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000159. Ras-assoc.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    [Graphical view ]
    Pfami PF01412. ArfGap. 1 hit.
    PF00169. PH. 4 hits.
    PF00788. RA. 1 hit.
    PF00620. RhoGAP. 1 hit.
    PF00536. SAM_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00405. REVINTRACTNG.
    SMARTi SM00105. ArfGap. 1 hit.
    SM00233. PH. 5 hits.
    SM00324. RhoGAP. 1 hit.
    SM00454. SAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    SSF48350. SSF48350. 1 hit.
    PROSITEi PS50115. ARFGAP. 1 hit.
    PS50003. PH_DOMAIN. 4 hits.
    PS50200. RA. 1 hit.
    PS50238. RHOGAP. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT GLN-1523.
    2. Wong J.A., Chen Z., Marignani P.A., Yu M., Zhao Y., Vallis K.A.
      Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLN-1523.
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 74-1704, VARIANT GLN-1523.
      Tissue: Brain.
    5. Ohara O., Nagase T., Ishikawa K.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    6. "KIAA0580 as a member (centaurin delta1) of ArfGAP-domain centaurin family."
      Hong W.
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 742-1605.
    7. "Solution structure of the N-terminal PH domain and of the SAM domain of human ARAP2."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 1-78 AND 483-584.

    Entry informationi

    Entry nameiARAP2_HUMAN
    AccessioniPrimary (citable) accession number: Q8WZ64
    Secondary accession number(s): Q4W5D2
    , Q7Z2L5, Q96L70, Q96P49, Q9Y4E4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 120 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3