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Q8WZ64

- ARAP2_HUMAN

UniProt

Q8WZ64 - ARAP2_HUMAN

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Protein

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2

Gene
ARAP2, CENTD1, KIAA0580
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri700 – 72324C4-typeAdd
BLAST

GO - Molecular functioni

  1. ARF GTPase activator activity Source: InterPro
  2. phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. regulation of ARF GTPase activity Source: InterPro
  2. regulation of small GTPase mediated signal transduction Source: Reactome
  3. small GTPase mediated signal transduction Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2
Alternative name(s):
Centaurin-delta-1
Short name:
Cnt-d1
Protein PARX
Gene namesi
Name:ARAP2
Synonyms:CENTD1, KIAA0580
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:16924. ARAP2.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytosol Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164715938.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17041704Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2PRO_0000074212Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei77 – 771Phosphotyrosine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8WZ64.
PaxDbiQ8WZ64.
PRIDEiQ8WZ64.

PTM databases

PhosphoSiteiQ8WZ64.

Expressioni

Tissue specificityi

Detected in brain, thymus, lymph node, thyroid, spinal cord, trachea, heart, skeletal muscle, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes.1 Publication

Gene expression databases

ArrayExpressiQ8WZ64.
BgeeiQ8WZ64.
CleanExiHS_ARAP2.
GenevestigatoriQ8WZ64.

Organism-specific databases

HPAiHPA035925.

Interactioni

Protein-protein interaction databases

BioGridi125547. 1 interaction.
IntActiQ8WZ64. 3 interactions.
MINTiMINT-7969711.
STRINGi9606.ENSP00000302895.

Structurei

Secondary structure

1
1704
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi11 – 166
Turni17 – 193
Helixi21 – 233
Helixi24 – 307
Helixi36 – 405
Helixi43 – 497
Helixi54 – 7017
Beta strandi485 – 4917
Beta strandi494 – 4985
Beta strandi501 – 5077
Beta strandi509 – 51810
Beta strandi526 – 5283
Turni529 – 5313
Beta strandi532 – 5387
Turni539 – 5413
Beta strandi542 – 5498
Beta strandi552 – 5554
Helixi559 – 57618

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X40NMR-A1-78[»]
2CODNMR-A483-584[»]
ProteinModelPortaliQ8WZ64.
SMRiQ8WZ64. Positions 6-79, 488-584, 586-681, 687-916, 919-1001, 1128-1289.

Miscellaneous databases

EvolutionaryTraceiQ8WZ64.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 7065SAMAdd
BLAST
Domaini482 – 57493PH 1Add
BLAST
Domaini587 – 67993PH 2Add
BLAST
Domaini676 – 811136Arf-GAPAdd
BLAST
Domaini878 – 1003126PH 3Add
BLAST
Domaini1014 – 1114101PH 4Add
BLAST
Domaini1116 – 1297182Rho-GAPAdd
BLAST
Domaini1326 – 142095Ras-associatingAdd
BLAST
Domaini1434 – 1537104PH 5Add
BLAST

Sequence similaritiesi

Contains 1 Arf-GAP domain.
Contains 5 PH domains.
Contains 1 Rho-GAP domain.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri700 – 72324C4-typeAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5347.
HOGENOMiHOG000246988.
HOVERGENiHBG095947.
InParanoidiQ8WZ64.
KOiK12490.
OMAiEQDFKSG.
OrthoDBiEOG7F24T4.
PhylomeDBiQ8WZ64.
TreeFamiTF105769.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
1.10.555.10. 1 hit.
2.30.29.30. 4 hits.
InterProiIPR001164. ArfGAP.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000159. Ras-assoc.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view]
PfamiPF01412. ArfGap. 1 hit.
PF00169. PH. 4 hits.
PF00788. RA. 1 hit.
PF00620. RhoGAP. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00105. ArfGap. 1 hit.
SM00233. PH. 5 hits.
SM00324. RhoGAP. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF48350. SSF48350. 1 hit.
PROSITEiPS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 4 hits.
PS50200. RA. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WZ64-1 [UniParc]FASTAAdd to Basket

« Hide

MSSVSEVNVD IKDFLMSINL EQYLLHFHES GFTTVKDCAA INDSLLQKIG     50
ISPTGHRRRI LKQLQIILSK MQDIPIYANV HKTKKNDDPS KDYHVPSSDQ 100
NICIELSNSG SVQTSSPPQL ETVRKNLEDS DASVERSQYP QSDDKLSPPK 150
RDFPTAEEPH LNLGSLNDSL FGSDNIKIES LITKKTVDHT VEEQQTEKVK 200
LITENLSKLP NADSECLSFV GCSTSGTNSG NGTNGLLEGS PPSPFFKFQG 250
EMIVNDLYVP SSPILAPVRS RSKLVSRPSR SFLLRHRPVP EIPGSTKGVS 300
GSYFRERRNV ATSTEKSVAW QNSNEENSSS IFPYGETFLF QRLENSKKRS 350
IKNEFLTQGE ALKGEAATAT NSFIIKSSIY DNRKEKISED KVEDIWIPRE 400
DKNNFLIDTA SESEYSTVEE CFQSLRRKNS KASKSRTQKA LILDSVNRHS 450
YPLSSTSGNA DSSAVSSQAI SPYACFYGAS AKKVKSGWLD KLSPQGKRMF 500
QKRWVKFDGL SISYYNNEKE MYSKGIIPLS AISTVRVQGD NKFEVVTTQR 550
TFVFRVEKEE ERNDWISILL NALKSQSLTS QSQAVVTPEK CGYLELRGYK 600
AKIFTVLSGN SVWLCKNEQD FKSGLGITII PMNVANVKQV DRTVKQSFEI 650
ITPYRSFSFT AETEKEKQDW IEAVQQSIAE TLSDYEVAEK IWFNESNRSC 700
ADCKAPDPDW ASINLCVVIC KKCAGQHRSL GPKDSKVRSL KMDASIWSNE 750
LIELFIVIGN KRANDFWAGN LQKDEELHMD SPVEKRKNFI TQKYKEGKFR 800
KTLLASLTKE ELNKALCAAV VKPDVLETMA LLFSGADVMC ATGDPVHSTP 850
YLLAKKAGQS LQMEFLYHNK FSDFPQHDIH SEGVLSQESS QSTFLCDFLY 900
QAPSAASKLS SEKKLLEETN KKWCVLEGGF LSYYENDKST TPNGTININE 950
VICLAIHKED FYLNTGPIFI FEIYLPSERV FLFGAETSQA QRKWTEAIAK 1000
HFVPLFAENL TEADYDLIGQ LFYKDCHALD QWRKGWFAMD KSSLHFCLQM 1050
QEVQGDRMHL RRLQELTIST MVQNGEKLDV LLLVEKGRTL YIHGHTKLDF 1100
TVWHTAIEKA AGTDGNALQD QQLSKNDVPI IVNSCIAFVT QYGLGCKYIY 1150
QKNGDPLHIS ELLESFKKDA RSFKLRAGKH QLEDVTAVLK SFLSDIDDAL 1200
LTKELYPYWI SALDTQDDKE RIKKYGAFIR SLPGVNRATL AAIIEHLYRV 1250
QKCSEINHMN AHNLALVFSS CLFQTKGQTS EEVNVIEDLI NNYVEIFEVK 1300
EDQVKQMDIE NSFITKWKDT QVSQAGDLLI EVYVERKEPD CSIIIRISPV 1350
MEAEELTNDI LAIKNIIPTK GDIWATFEVI ENEELERPLH YKENVLEQVL 1400
RWSSLAEPGS AYLVVKRFLT ADTIKHCSDR STLGSIKEGI LKIKEEPSKI 1450
LSGNKFQDRY FVLRDGFLFL YKDVKSSKHD KMFSLSSMKF YRGVKKKMKP 1500
PTSWGLTAYS EKHHWHLCCD SSRTQTEWMT SIFIAQHEYD IWPPAGKERK 1550
RSITKNPKIG GLPLIPIQHE GNATLARKNI ESARAELERL RLSEKCDKES 1600
VDSSLKERAS MVAHCLEHKD DKLRNRPRKH RSFNCLEDTE PEAPLGQPKG 1650
HKGLKTLRKT EDRNSKATLD SDHKLPSRVI EELNVVLQRS RTLPKELQDE 1700
QILK 1704
Length:1,704
Mass (Da):193,452
Last modified:October 5, 2010 - v3
Checksum:iA5A13EE08D43A9A0
GO

Sequence cautioni

The sequence AAL04166.1 differs from that shown. Reason: Frameshift at position 1579.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti384 – 3841K → N.
Corresponds to variant rs35468501 [ dbSNP | Ensembl ].
VAR_055530
Natural varianti1006 – 10061F → L.
Corresponds to variant rs35218548 [ dbSNP | Ensembl ].
VAR_055531
Natural varianti1523 – 15231R → Q.3 Publications
Corresponds to variant rs4833069 [ dbSNP | Ensembl ].
VAR_027952

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti227 – 2271T → I in AAL32459. 1 Publication
Sequence conflicti532 – 5321I → V in AAL32459. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY049733 mRNA. Translation: AAL12170.1.
AF439781 mRNA. Translation: AAL32459.1.
AC098827 Genomic DNA. No translation available.
AC104078 Genomic DNA. No translation available.
AC108033 Genomic DNA. Translation: AAY40927.1.
AC109818 Genomic DNA. No translation available.
AC116623 Genomic DNA. No translation available.
AB011152 mRNA. Translation: BAA25506.2.
AF411982 mRNA. Translation: AAL04166.1. Frameshift.
CCDSiCCDS3441.1.
PIRiT00342.
RefSeqiNP_056045.2. NM_015230.3.
XP_005262695.1. XM_005262638.2.
UniGeneiHs.479451.

Genome annotation databases

EnsembliENST00000303965; ENSP00000302895; ENSG00000047365.
GeneIDi116984.
KEGGihsa:116984.
UCSCiuc003gsq.2. human.

Polymorphism databases

DMDMi308153629.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY049733 mRNA. Translation: AAL12170.1 .
AF439781 mRNA. Translation: AAL32459.1 .
AC098827 Genomic DNA. No translation available.
AC104078 Genomic DNA. No translation available.
AC108033 Genomic DNA. Translation: AAY40927.1 .
AC109818 Genomic DNA. No translation available.
AC116623 Genomic DNA. No translation available.
AB011152 mRNA. Translation: BAA25506.2 .
AF411982 mRNA. Translation: AAL04166.1 . Frameshift.
CCDSi CCDS3441.1.
PIRi T00342.
RefSeqi NP_056045.2. NM_015230.3.
XP_005262695.1. XM_005262638.2.
UniGenei Hs.479451.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1X40 NMR - A 1-78 [» ]
2COD NMR - A 483-584 [» ]
ProteinModelPortali Q8WZ64.
SMRi Q8WZ64. Positions 6-79, 488-584, 586-681, 687-916, 919-1001, 1128-1289.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125547. 1 interaction.
IntActi Q8WZ64. 3 interactions.
MINTi MINT-7969711.
STRINGi 9606.ENSP00000302895.

PTM databases

PhosphoSitei Q8WZ64.

Polymorphism databases

DMDMi 308153629.

Proteomic databases

MaxQBi Q8WZ64.
PaxDbi Q8WZ64.
PRIDEi Q8WZ64.

Protocols and materials databases

DNASUi 116984.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000303965 ; ENSP00000302895 ; ENSG00000047365 .
GeneIDi 116984.
KEGGi hsa:116984.
UCSCi uc003gsq.2. human.

Organism-specific databases

CTDi 116984.
GeneCardsi GC04M035950.
H-InvDB HIX0004149.
HGNCi HGNC:16924. ARAP2.
HPAi HPA035925.
MIMi 606645. gene.
neXtProti NX_Q8WZ64.
PharmGKBi PA164715938.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5347.
HOGENOMi HOG000246988.
HOVERGENi HBG095947.
InParanoidi Q8WZ64.
KOi K12490.
OMAi EQDFKSG.
OrthoDBi EOG7F24T4.
PhylomeDBi Q8WZ64.
TreeFami TF105769.

Enzyme and pathway databases

Reactomei REACT_11051. Rho GTPase cycle.

Miscellaneous databases

EvolutionaryTracei Q8WZ64.
GeneWikii CENTD1.
GenomeRNAii 116984.
NextBioi 80056.
PROi Q8WZ64.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8WZ64.
Bgeei Q8WZ64.
CleanExi HS_ARAP2.
Genevestigatori Q8WZ64.

Family and domain databases

Gene3Di 1.10.150.50. 1 hit.
1.10.555.10. 1 hit.
2.30.29.30. 4 hits.
InterProi IPR001164. ArfGAP.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000159. Ras-assoc.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view ]
Pfami PF01412. ArfGap. 1 hit.
PF00169. PH. 4 hits.
PF00788. RA. 1 hit.
PF00620. RhoGAP. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view ]
PRINTSi PR00405. REVINTRACTNG.
SMARTi SM00105. ArfGap. 1 hit.
SM00233. PH. 5 hits.
SM00324. RhoGAP. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view ]
SUPFAMi SSF47769. SSF47769. 1 hit.
SSF48350. SSF48350. 1 hit.
PROSITEi PS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 4 hits.
PS50200. RA. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT GLN-1523.
  2. Wong J.A., Chen Z., Marignani P.A., Yu M., Zhao Y., Vallis K.A.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLN-1523.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 74-1704, VARIANT GLN-1523.
    Tissue: Brain.
  5. Ohara O., Nagase T., Ishikawa K.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  6. "KIAA0580 as a member (centaurin delta1) of ArfGAP-domain centaurin family."
    Hong W.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 742-1605.
  7. "Solution structure of the N-terminal PH domain and of the SAM domain of human ARAP2."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 1-78 AND 483-584.

Entry informationi

Entry nameiARAP2_HUMAN
AccessioniPrimary (citable) accession number: Q8WZ64
Secondary accession number(s): Q4W5D2
, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 5, 2010
Last modified: September 3, 2014
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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