KLHL6

Functionⁱ

Involved in B-lymphocyte antigen receptor signaling and germinal center formation.By similarity

GO - Molecular functionⁱ

DNA binding transcription factor activity Source: GO_Central
transcription regulatory region sequence-specific DNA binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

B cell receptor signaling pathway Source: Ensembl
germinal center formation Source: Ensembl
positive regulation of transcription, DNA-templated Source: GO_Central
regulation of transcription by RNA polymerase II Source: GO_Central

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Kelch-like protein 6
Gene namesⁱ	Name:KLHL6
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000172578.11.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18653. KLHL6.
MIMⁱ	614214. gene.
neXtProtⁱ	NX_Q8WZ60.

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	89857.
Open Targets More...OpenTargetsⁱ	ENSG00000172578.
PharmGKBⁱ	PA38621.

Polymorphism and mutation databases

BioMutaⁱ	KLHL6.
DMDMⁱ	229462964.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000119106	1 – 621	Kelch-like protein 6Add BLAST		621

Proteomic databases

EPDⁱ	Q8WZ60.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8WZ60.
PaxDbⁱ	Q8WZ60.
PeptideAtlas More...PeptideAtlasⁱ	Q8WZ60.
PRIDEⁱ	Q8WZ60.
TopDownProteomicsⁱ	Q8WZ60.

PTM databases

iPTMnetⁱ	Q8WZ60.
PhosphoSitePlusⁱ	Q8WZ60.

Expressionⁱ

Tissue specificityⁱ

Found in germinal center B-cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000172578.
CleanExⁱ	HS_KLHL6.
ExpressionAtlasⁱ	Q8WZ60. baseline and differential.
Genevisibleⁱ	Q8WZ60. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA024512.

HPAⁱ

HPA024512.

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
PPP1R1B	Q9UD71	3	EBI-6426464,EBI-722119
SBDS	Q9Y3A5	3	EBI-6426464,EBI-1046471
TMPO	P42167	4	EBI-6426464,EBI-455283

Show more details

Protein-protein interaction databases

BioGridⁱ	124622. 9 interactors.
IntActⁱ	Q8WZ60. 9 interactors.
STRINGⁱ	9606.ENSP00000341342.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8WZ60.
SMRⁱ	Q8WZ60.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	72 – 139	BTBPROSITE-ProRule annotationAdd BLAST	68
Domainⁱ	174 – 276	BACKAdd BLAST	103
Repeatⁱ	320 – 367	Kelch 1Add BLAST	48
Repeatⁱ	378 – 421	Kelch 2Add BLAST	44
Repeatⁱ	422 – 468	Kelch 3Add BLAST	47
Repeatⁱ	470 – 516	Kelch 4Add BLAST	47
Repeatⁱ	517 – 558	Kelch 5Add BLAST	42
Repeatⁱ	560 – 606	Kelch 6Add BLAST	47

Keywords - Domainⁱ

Kelch repeat, Repeat

Phylogenomic databases

eggNOGⁱ	KOG4441. Eukaryota. ENOG410XNX8. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000143979.
HOGENOMⁱ	HOG000230817.
HOVERGENⁱ	HBG108068.
InParanoidⁱ	Q8WZ60.
KEGG Orthology (KO) More...KOⁱ	K10444.
OMAⁱ	RHKQSER.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G037V.
PhylomeDBⁱ	Q8WZ60.
TreeFamⁱ	TF351654.

Family and domain databases

Gene3Dⁱ	2.120.10.80. 1 hit.
InterProⁱ	View protein in InterPro IPR011705. BACK. IPR017096. BTB-kelch_protein. IPR000210. BTB/POZ_dom. IPR015915. Kelch-typ_b-propeller. IPR006652. Kelch_1. IPR029851. KLHL6. IPR011333. SKP1/BTB/POZ_sf.
PANTHERⁱ	PTHR24411:SF4. PTHR24411:SF4. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07707. BACK. 1 hit. PF00651. BTB. 1 hit. PF01344. Kelch_1. 3 hits.
PIRSFⁱ	PIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTⁱ	View protein in SMART SM00875. BACK. 1 hit. SM00225. BTB. 1 hit. SM00612. Kelch. 5 hits.
SUPFAMⁱ	SSF117281. SSF117281. 1 hit. SSF54695. SSF54695. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50097. BTB. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8WZ60-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLMAGQRGAW TMGDVVEKSL EGPLAPSTDE PSQKTGDLVE ILNGEKVKFD 
        60         70         80         90        100
DAGLSLILQN GLETLRMENA LTDVILCVDI QEFSCHRVVL AAASNYFRAM 
       110        120        130        140        150
FCNDLKEKYE KRIIIKGVDA ETMHTLLDYT YTSKALITKQ NVQRVLEAAN 
       160        170        180        190        200
LFQFLRMVDA CASFLTEALN PENCVGILRL ADTHSLDSLK KQVQSYIIQN 
       210        220        230        240        250
FVQILNSEEF LDLPVDTLHH ILKSDDLYVT EEAQVFETVM SWVRHKPSER 
       260        270        280        290        300
LCLLPYVLEN VRLPLLDPWY FVETVEADPL IRQCPEVFPL LQEARMYHLS 
       310        320        330        340        350
GNEIISERTK PRMHEFQSEV FMIIGGCTKD ERFVAEVTCL DPLRRSRLEV 
       360        370        380        390        400
AKLPLTEHEL ESENKKWVEF ACVTLKNEVY ISGGKETQHD VWKYNSSINK 
       410        420        430        440        450
WIQIEYLNIG RWRHKMVVLG GKVYVIGGFD GLQRINNVET YDPFHNCWSE 
       460        470        480        490        500
AAPLLVHVSS FAATSHKKKL YVIGGGPNGK LATDKTQCYD PSTNKWSLKA 
       510        520        530        540        550
AMPVEAKCIN AVSFRDRIYV VGGAMRALYA YSPLEDSWCL VTQLSHERAS 
       560        570        580        590        600
CGIAPCNNRL YITGGRDEKN EVIATVLCWD PEAQKLTEEC VLPRGVSHHG 
       610        620 
SVTIRKSYTH IRRIVPGAVS V

Length:621

Mass (Da):70,359

Last modified:May 5, 2009 - v3

Checksum:ⁱ267FD90AEC6629E4

GO

Sequence cautionⁱ

The sequence AAH32348 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAL35594 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAG37078 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	11	T → R in AAL35594 (PubMed:12617994).Curated	1
Sequence conflictⁱ	94	S → G in BAG37078 (PubMed:14702039).Curated	1
Sequence conflictⁱ	112	R → G in BAG37078 (PubMed:14702039).Curated	1
Sequence conflictⁱ	363	E → G in AAL35594 (PubMed:12617994).Curated	1
Sequence conflictⁱ	495	K → R in BAG37078 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_056125	518	I → V. Corresponds to variant dbSNP:rs35354575Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK097125 mRNA. Translation: BAC04957.1. AK314473 mRNA. Translation: BAG37078.1. Different initiation. AC092960 Genomic DNA. No translation available. AC069211 Genomic DNA. No translation available. CH471052 Genomic DNA. Translation: EAW78324.1. CH471052 Genomic DNA. Translation: EAW78325.1. BC032348 mRNA. Translation: AAH32348.1. Different initiation. AF441792 mRNA. Translation: AAL35594.1. Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3245.2.
NCBI Reference Sequences More...RefSeqⁱ	NP_569713.2. NM_130446.2.
UniGeneⁱ	Hs.659147.

Genome annotation databases

Ensemblⁱ	ENST00000341319; ENSP00000341342; ENSG00000172578.
GeneIDⁱ	89857.
KEGGⁱ	hsa:89857.
UCSC genome browser More...UCSCⁱ	uc003flr.4. human.

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8WZ60	A0A0C4DGF2 A0A2J8M579	Homo sapiens (Human) Pan troglodytes (Chimpanzee)	621	UniRef100_Q8WZ60	Cluster: Kelch-like protein 6	3

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8WZ60	Q6V595 UPI000B7B9CDC UPI0000E08AC2 UPI00075F8B0D UPI00062ACC03 UPI00094315A4 UPI00038EC47E UPI000333D5E5 H2QNT7 D2H2B7 +115	Mus musculus (Mouse) Papio anubis (Olive baboon) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Rhinolophus sinicus (Chinese rufous horseshoe bat) Chinchilla lanigera (Long-tailed chinchilla) (Chinchilla villidera) Octodon degus (Degu) (Sciurus degus) Pan troglodytes (Chimpanzee) Ailuropoda melanoleuca (Giant panda) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) And more	619	UniRef90_Q6V595	Cluster: Kelch-like protein 6	126

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8WZ60	Q6V595 UPI000B7B9CDC UPI0000E08AC2 UPI00075F8B0D UPI00062ACC03 UPI000333D5E5 UPI00094315A4 UPI00038EC47E UPI0007627A06 M3WLX0 +219	Mus musculus (Mouse) Papio anubis (Olive baboon) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Octodon degus (Degu) (Sciurus degus) Rhinolophus sinicus (Chinese rufous horseshoe bat) Chinchilla lanigera (Long-tailed chinchilla) (Chinchilla villidera) Marmota marmota marmota (Alpine marmot) Felis catus (Cat) (Felis silvestris catus) Physeter catodon (Sperm whale) (Physeter macrocephalus) And more	619	UniRef50_Q6V595	Cluster: Kelch-like protein 6	230

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK097125 mRNA. Translation: BAC04957.1. AK314473 mRNA. Translation: BAG37078.1. Different initiation. AC092960 Genomic DNA. No translation available. AC069211 Genomic DNA. No translation available. CH471052 Genomic DNA. Translation: EAW78324.1. CH471052 Genomic DNA. Translation: EAW78325.1. BC032348 mRNA. Translation: AAH32348.1. Different initiation. AF441792 mRNA. Translation: AAL35594.1. Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3245.2.
NCBI Reference Sequences More...RefSeqⁱ	NP_569713.2. NM_130446.2.
UniGeneⁱ	Hs.659147.

3D structure databases

ProteinModelPortalⁱ	Q8WZ60.
SMRⁱ	Q8WZ60.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	124622. 9 interactors.
IntActⁱ	Q8WZ60. 9 interactors.
STRINGⁱ	9606.ENSP00000341342.

PTM databases

iPTMnetⁱ	Q8WZ60.
PhosphoSitePlusⁱ	Q8WZ60.

Polymorphism and mutation databases

BioMutaⁱ	KLHL6.
DMDMⁱ	229462964.

Proteomic databases

EPDⁱ	Q8WZ60.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8WZ60.
PaxDbⁱ	Q8WZ60.
PeptideAtlas More...PeptideAtlasⁱ	Q8WZ60.
PRIDEⁱ	Q8WZ60.
TopDownProteomicsⁱ	Q8WZ60.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	89857.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000341319; ENSP00000341342; ENSG00000172578.
GeneIDⁱ	89857.
KEGGⁱ	hsa:89857.
UCSC genome browser More...UCSCⁱ	uc003flr.4. human.

Organism-specific databases

CTDⁱ	89857.
DisGeNET More...DisGeNETⁱ	89857.
EuPathDBⁱ	HostDB:ENSG00000172578.11.
GeneCardsⁱ	KLHL6.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18653. KLHL6.
Human Protein Atlas More...HPAⁱ	HPA024512.
MIMⁱ	614214. gene.
neXtProtⁱ	NX_Q8WZ60.
Open Targets More...OpenTargetsⁱ	ENSG00000172578.
PharmGKBⁱ	PA38621.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4441. Eukaryota. ENOG410XNX8. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000143979.
HOGENOMⁱ	HOG000230817.
HOVERGENⁱ	HBG108068.
InParanoidⁱ	Q8WZ60.
KEGG Orthology (KO) More...KOⁱ	K10444.
OMAⁱ	RHKQSER.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G037V.
PhylomeDBⁱ	Q8WZ60.
TreeFamⁱ	TF351654.

Miscellaneous databases

ChiTaRSⁱ	KLHL6. human.
GenomeRNAiⁱ	89857.
Protein Ontology More...PROⁱ	PR:Q8WZ60.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000172578.
CleanExⁱ	HS_KLHL6.
ExpressionAtlasⁱ	Q8WZ60. baseline and differential.
Genevisibleⁱ	Q8WZ60. HS.

Family and domain databases

Gene3Dⁱ	2.120.10.80. 1 hit.
InterProⁱ	View protein in InterPro IPR011705. BACK. IPR017096. BTB-kelch_protein. IPR000210. BTB/POZ_dom. IPR015915. Kelch-typ_b-propeller. IPR006652. Kelch_1. IPR029851. KLHL6. IPR011333. SKP1/BTB/POZ_sf.
PANTHERⁱ	PTHR24411:SF4. PTHR24411:SF4. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07707. BACK. 1 hit. PF00651. BTB. 1 hit. PF01344. Kelch_1. 3 hits.
PIRSFⁱ	PIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTⁱ	View protein in SMART SM00875. BACK. 1 hit. SM00225. BTB. 1 hit. SM00612. Kelch. 5 hits.
SUPFAMⁱ	SSF117281. SSF117281. 1 hit. SSF54695. SSF54695. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50097. BTB. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KLHL6_HUMAN
Accessionⁱ	Q8WZ60Primary (citable) accession number: Q8WZ60 Secondary accession number(s): B2RB31 , D3DNS8, Q8N5I1, Q8N892
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 12, 2003
	Last sequence update:	May 5, 2009
	Last modified:	March 28, 2018
	This is version 143 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8WZ60 (KLHL6_HUMAN)

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Kelch-like protein 6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ