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Protein

Kelch-like protein 6

Gene

KLHL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in B-lymphocyte antigen receptor signaling and germinal center formation.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 6
Gene namesi
Name:KLHL6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:18653. KLHL6.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38621.

Polymorphism and mutation databases

BioMutaiKLHL6.
DMDMi229462964.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 621621Kelch-like protein 6PRO_0000119106Add
BLAST

Proteomic databases

EPDiQ8WZ60.
MaxQBiQ8WZ60.
PaxDbiQ8WZ60.
PeptideAtlasiQ8WZ60.
PRIDEiQ8WZ60.
TopDownProteomicsiQ8WZ60.

PTM databases

iPTMnetiQ8WZ60.
PhosphoSiteiQ8WZ60.

Expressioni

Tissue specificityi

Found in germinal center B-cells.1 Publication

Gene expression databases

BgeeiQ8WZ60.
CleanExiHS_KLHL6.
ExpressionAtlasiQ8WZ60. baseline and differential.
GenevisibleiQ8WZ60. HS.

Organism-specific databases

HPAiHPA024512.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP1R1BQ9UD713EBI-6426464,EBI-722119

Protein-protein interaction databases

BioGridi124622. 6 interactions.
IntActiQ8WZ60. 4 interactions.
STRINGi9606.ENSP00000341342.

Structurei

3D structure databases

ProteinModelPortaliQ8WZ60.
SMRiQ8WZ60. Positions 62-298, 305-620.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini72 – 13968BTBPROSITE-ProRule annotationAdd
BLAST
Domaini174 – 276103BACKAdd
BLAST
Repeati320 – 36748Kelch 1Add
BLAST
Repeati378 – 42144Kelch 2Add
BLAST
Repeati422 – 46847Kelch 3Add
BLAST
Repeati470 – 51647Kelch 4Add
BLAST
Repeati517 – 55842Kelch 5Add
BLAST
Repeati560 – 60647Kelch 6Add
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00840000129689.
HOGENOMiHOG000230817.
HOVERGENiHBG108068.
InParanoidiQ8WZ60.
KOiK10444.
OMAiVQNYIIQ.
OrthoDBiEOG7HHWRM.
PhylomeDBiQ8WZ60.
TreeFamiTF351654.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR029851. KLHL6.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24411:SF4. PTHR24411:SF4. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 3 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WZ60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLMAGQRGAW TMGDVVEKSL EGPLAPSTDE PSQKTGDLVE ILNGEKVKFD
60 70 80 90 100
DAGLSLILQN GLETLRMENA LTDVILCVDI QEFSCHRVVL AAASNYFRAM
110 120 130 140 150
FCNDLKEKYE KRIIIKGVDA ETMHTLLDYT YTSKALITKQ NVQRVLEAAN
160 170 180 190 200
LFQFLRMVDA CASFLTEALN PENCVGILRL ADTHSLDSLK KQVQSYIIQN
210 220 230 240 250
FVQILNSEEF LDLPVDTLHH ILKSDDLYVT EEAQVFETVM SWVRHKPSER
260 270 280 290 300
LCLLPYVLEN VRLPLLDPWY FVETVEADPL IRQCPEVFPL LQEARMYHLS
310 320 330 340 350
GNEIISERTK PRMHEFQSEV FMIIGGCTKD ERFVAEVTCL DPLRRSRLEV
360 370 380 390 400
AKLPLTEHEL ESENKKWVEF ACVTLKNEVY ISGGKETQHD VWKYNSSINK
410 420 430 440 450
WIQIEYLNIG RWRHKMVVLG GKVYVIGGFD GLQRINNVET YDPFHNCWSE
460 470 480 490 500
AAPLLVHVSS FAATSHKKKL YVIGGGPNGK LATDKTQCYD PSTNKWSLKA
510 520 530 540 550
AMPVEAKCIN AVSFRDRIYV VGGAMRALYA YSPLEDSWCL VTQLSHERAS
560 570 580 590 600
CGIAPCNNRL YITGGRDEKN EVIATVLCWD PEAQKLTEEC VLPRGVSHHG
610 620
SVTIRKSYTH IRRIVPGAVS V
Length:621
Mass (Da):70,359
Last modified:May 5, 2009 - v3
Checksum:i267FD90AEC6629E4
GO

Sequence cautioni

The sequence AAH32348.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAL35594.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAG37078.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 111T → R in AAL35594 (PubMed:12617994).Curated
Sequence conflicti94 – 941S → G in BAG37078 (PubMed:14702039).Curated
Sequence conflicti112 – 1121R → G in BAG37078 (PubMed:14702039).Curated
Sequence conflicti363 – 3631E → G in AAL35594 (PubMed:12617994).Curated
Sequence conflicti495 – 4951K → R in BAG37078 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti518 – 5181I → V.
Corresponds to variant rs35354575 [ dbSNP | Ensembl ].
VAR_056125

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097125 mRNA. Translation: BAC04957.1.
AK314473 mRNA. Translation: BAG37078.1. Different initiation.
AC092960 Genomic DNA. No translation available.
AC069211 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78324.1.
CH471052 Genomic DNA. Translation: EAW78325.1.
BC032348 mRNA. Translation: AAH32348.1. Different initiation.
AF441792 mRNA. Translation: AAL35594.1. Different initiation.
CCDSiCCDS3245.2.
RefSeqiNP_569713.2. NM_130446.2.
UniGeneiHs.659147.

Genome annotation databases

EnsembliENST00000341319; ENSP00000341342; ENSG00000172578.
GeneIDi89857.
KEGGihsa:89857.
UCSCiuc003flr.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097125 mRNA. Translation: BAC04957.1.
AK314473 mRNA. Translation: BAG37078.1. Different initiation.
AC092960 Genomic DNA. No translation available.
AC069211 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78324.1.
CH471052 Genomic DNA. Translation: EAW78325.1.
BC032348 mRNA. Translation: AAH32348.1. Different initiation.
AF441792 mRNA. Translation: AAL35594.1. Different initiation.
CCDSiCCDS3245.2.
RefSeqiNP_569713.2. NM_130446.2.
UniGeneiHs.659147.

3D structure databases

ProteinModelPortaliQ8WZ60.
SMRiQ8WZ60. Positions 62-298, 305-620.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124622. 6 interactions.
IntActiQ8WZ60. 4 interactions.
STRINGi9606.ENSP00000341342.

PTM databases

iPTMnetiQ8WZ60.
PhosphoSiteiQ8WZ60.

Polymorphism and mutation databases

BioMutaiKLHL6.
DMDMi229462964.

Proteomic databases

EPDiQ8WZ60.
MaxQBiQ8WZ60.
PaxDbiQ8WZ60.
PeptideAtlasiQ8WZ60.
PRIDEiQ8WZ60.
TopDownProteomicsiQ8WZ60.

Protocols and materials databases

DNASUi89857.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341319; ENSP00000341342; ENSG00000172578.
GeneIDi89857.
KEGGihsa:89857.
UCSCiuc003flr.4. human.

Organism-specific databases

CTDi89857.
GeneCardsiKLHL6.
HGNCiHGNC:18653. KLHL6.
HPAiHPA024512.
MIMi614214. gene.
neXtProtiNX_Q8WZ60.
PharmGKBiPA38621.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00840000129689.
HOGENOMiHOG000230817.
HOVERGENiHBG108068.
InParanoidiQ8WZ60.
KOiK10444.
OMAiVQNYIIQ.
OrthoDBiEOG7HHWRM.
PhylomeDBiQ8WZ60.
TreeFamiTF351654.

Miscellaneous databases

ChiTaRSiKLHL6. human.
GenomeRNAii89857.
PROiQ8WZ60.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WZ60.
CleanExiHS_KLHL6.
ExpressionAtlasiQ8WZ60. baseline and differential.
GenevisibleiQ8WZ60. HS.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR029851. KLHL6.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24411:SF4. PTHR24411:SF4. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 3 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen and Thymus.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood.
  5. "Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells."
    Gupta-Rossi N., Storck S., Griebel P.J., Reynaud C.-A., Weill J.-C., Dahan A.
    Mol. Immunol. 39:791-799(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-621, TISSUE SPECIFICITY.

Entry informationi

Entry nameiKLHL6_HUMAN
AccessioniPrimary (citable) accession number: Q8WZ60
Secondary accession number(s): B2RB31
, D3DNS8, Q8N5I1, Q8N892
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: May 5, 2009
Last modified: July 6, 2016
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.