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UniProtKB - Q8WZ60 (KLHL6_HUMAN)

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Protein

Kelch-like protein 6

Gene

KLHL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in B-lymphocyte antigen receptor signaling and germinal center formation.By similarity

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 6
Gene namesi
Name:KLHL6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:18653. KLHL6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi89857.
OpenTargetsiENSG00000172578.
PharmGKBiPA38621.

Polymorphism and mutation databases

BioMutaiKLHL6.
DMDMi229462964.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001191061 – 621Kelch-like protein 6Add BLAST621

Proteomic databases

EPDiQ8WZ60.
MaxQBiQ8WZ60.
PaxDbiQ8WZ60.
PeptideAtlasiQ8WZ60.
PRIDEiQ8WZ60.
TopDownProteomicsiQ8WZ60.

PTM databases

iPTMnetiQ8WZ60.
PhosphoSitePlusiQ8WZ60.

Expressioni

Tissue specificityi

Found in germinal center B-cells.1 Publication

Gene expression databases

BgeeiENSG00000172578.
CleanExiHS_KLHL6.
ExpressionAtlasiQ8WZ60. baseline and differential.
GenevisibleiQ8WZ60. HS.

Organism-specific databases

HPAiHPA024512.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP1R1BQ9UD713EBI-6426464,EBI-722119

Protein-protein interaction databases

BioGridi124622. 6 interactors.
IntActiQ8WZ60. 4 interactors.
STRINGi9606.ENSP00000341342.

Structurei

3D structure databases

ProteinModelPortaliQ8WZ60.
SMRiQ8WZ60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 139BTBPROSITE-ProRule annotationAdd BLAST68
Domaini174 – 276BACKAdd BLAST103
Repeati320 – 367Kelch 1Add BLAST48
Repeati378 – 421Kelch 2Add BLAST44
Repeati422 – 468Kelch 3Add BLAST47
Repeati470 – 516Kelch 4Add BLAST47
Repeati517 – 558Kelch 5Add BLAST42
Repeati560 – 606Kelch 6Add BLAST47

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00880000137845.
HOGENOMiHOG000230817.
HOVERGENiHBG108068.
InParanoidiQ8WZ60.
KOiK10444.
OMAiRHKQSER.
OrthoDBiEOG091G037V.
PhylomeDBiQ8WZ60.
TreeFamiTF351654.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiView protein in InterPro
IPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR029851. KLHL6.
IPR011333. SKP1/BTB/POZ.
PANTHERiPTHR24411:SF40. PTHR24411:SF40. 1 hit.
PfamiView protein in Pfam
PF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 3 hits.
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiView protein in SMART
SM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 5 hits.
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiView protein in PROSITE
PS50097. BTB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8WZ60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLMAGQRGAW TMGDVVEKSL EGPLAPSTDE PSQKTGDLVE ILNGEKVKFD 
        60         70         80         90        100
DAGLSLILQN GLETLRMENA LTDVILCVDI QEFSCHRVVL AAASNYFRAM 
       110        120        130        140        150
FCNDLKEKYE KRIIIKGVDA ETMHTLLDYT YTSKALITKQ NVQRVLEAAN 
       160        170        180        190        200
LFQFLRMVDA CASFLTEALN PENCVGILRL ADTHSLDSLK KQVQSYIIQN 
       210        220        230        240        250
FVQILNSEEF LDLPVDTLHH ILKSDDLYVT EEAQVFETVM SWVRHKPSER 
       260        270        280        290        300
LCLLPYVLEN VRLPLLDPWY FVETVEADPL IRQCPEVFPL LQEARMYHLS 
       310        320        330        340        350
GNEIISERTK PRMHEFQSEV FMIIGGCTKD ERFVAEVTCL DPLRRSRLEV 
       360        370        380        390        400
AKLPLTEHEL ESENKKWVEF ACVTLKNEVY ISGGKETQHD VWKYNSSINK 
       410        420        430        440        450
WIQIEYLNIG RWRHKMVVLG GKVYVIGGFD GLQRINNVET YDPFHNCWSE 
       460        470        480        490        500
AAPLLVHVSS FAATSHKKKL YVIGGGPNGK LATDKTQCYD PSTNKWSLKA 
       510        520        530        540        550
AMPVEAKCIN AVSFRDRIYV VGGAMRALYA YSPLEDSWCL VTQLSHERAS 
       560        570        580        590        600
CGIAPCNNRL YITGGRDEKN EVIATVLCWD PEAQKLTEEC VLPRGVSHHG 
       610        620 
SVTIRKSYTH IRRIVPGAVS V
Length:621
Mass (Da):70,359
Last modified:May 5, 2009 - v3
Checksum:i267FD90AEC6629E4
GO

Sequence cautioni

The sequence AAH32348 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAL35594 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG37078 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11T → R in AAL35594 (PubMed:12617994).Curated1
Sequence conflicti94S → G in BAG37078 (PubMed:14702039).Curated1
Sequence conflicti112R → G in BAG37078 (PubMed:14702039).Curated1
Sequence conflicti363E → G in AAL35594 (PubMed:12617994).Curated1
Sequence conflicti495K → R in BAG37078 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_056125518I → V. Corresponds to variant dbSNP:rs35354575Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097125 mRNA. Translation: BAC04957.1.
AK314473 mRNA. Translation: BAG37078.1. Different initiation.
AC092960 Genomic DNA. No translation available.
AC069211 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78324.1.
CH471052 Genomic DNA. Translation: EAW78325.1.
BC032348 mRNA. Translation: AAH32348.1. Different initiation.
AF441792 mRNA. Translation: AAL35594.1. Different initiation.
CCDSiCCDS3245.2.
RefSeqiNP_569713.2. NM_130446.2.
UniGeneiHs.659147.

Genome annotation databases

EnsembliENST00000341319; ENSP00000341342; ENSG00000172578.
GeneIDi89857.
KEGGihsa:89857.
UCSCiuc003flr.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097125 mRNA. Translation: BAC04957.1.
AK314473 mRNA. Translation: BAG37078.1. Different initiation.
AC092960 Genomic DNA. No translation available.
AC069211 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78324.1.
CH471052 Genomic DNA. Translation: EAW78325.1.
BC032348 mRNA. Translation: AAH32348.1. Different initiation.
AF441792 mRNA. Translation: AAL35594.1. Different initiation.
CCDSiCCDS3245.2.
RefSeqiNP_569713.2. NM_130446.2.
UniGeneiHs.659147.

3D structure databases

ProteinModelPortaliQ8WZ60.
SMRiQ8WZ60.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124622. 6 interactors.
IntActiQ8WZ60. 4 interactors.
STRINGi9606.ENSP00000341342.

PTM databases

iPTMnetiQ8WZ60.
PhosphoSitePlusiQ8WZ60.

Polymorphism and mutation databases

BioMutaiKLHL6.
DMDMi229462964.

Proteomic databases

EPDiQ8WZ60.
MaxQBiQ8WZ60.
PaxDbiQ8WZ60.
PeptideAtlasiQ8WZ60.
PRIDEiQ8WZ60.
TopDownProteomicsiQ8WZ60.

Protocols and materials databases

DNASUi89857.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341319; ENSP00000341342; ENSG00000172578.
GeneIDi89857.
KEGGihsa:89857.
UCSCiuc003flr.4. human.

Organism-specific databases

CTDi89857.
DisGeNETi89857.
GeneCardsiKLHL6.
HGNCiHGNC:18653. KLHL6.
HPAiHPA024512.
MIMi614214. gene.
neXtProtiNX_Q8WZ60.
OpenTargetsiENSG00000172578.
PharmGKBiPA38621.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00880000137845.
HOGENOMiHOG000230817.
HOVERGENiHBG108068.
InParanoidiQ8WZ60.
KOiK10444.
OMAiRHKQSER.
OrthoDBiEOG091G037V.
PhylomeDBiQ8WZ60.
TreeFamiTF351654.

Miscellaneous databases

ChiTaRSiKLHL6. human.
GenomeRNAii89857.
PROiPR:Q8WZ60.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172578.
CleanExiHS_KLHL6.
ExpressionAtlasiQ8WZ60. baseline and differential.
GenevisibleiQ8WZ60. HS.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiView protein in InterPro
IPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR029851. KLHL6.
IPR011333. SKP1/BTB/POZ.
PANTHERiPTHR24411:SF40. PTHR24411:SF40. 1 hit.
PfamiView protein in Pfam
PF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 3 hits.
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiView protein in SMART
SM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 5 hits.
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiView protein in PROSITE
PS50097. BTB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKLHL6_HUMAN
AccessioniPrimary (citable) accession number: Q8WZ60
Secondary accession number(s): B2RB31
, D3DNS8, Q8N5I1, Q8N892
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: May 5, 2009
Last modified: June 7, 2017
This is version 136 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.