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Protein

Kelch-like protein 6

Gene

KLHL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in B-lymphocyte antigen receptor signaling and germinal center formation.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 6
Gene namesi
Name:KLHL6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000172578.11.
HGNCiHGNC:18653. KLHL6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi89857.
OpenTargetsiENSG00000172578.
PharmGKBiPA38621.

Polymorphism and mutation databases

BioMutaiKLHL6.
DMDMi229462964.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001191061 – 621Kelch-like protein 6Add BLAST621

Proteomic databases

EPDiQ8WZ60.
MaxQBiQ8WZ60.
PaxDbiQ8WZ60.
PeptideAtlasiQ8WZ60.
PRIDEiQ8WZ60.
TopDownProteomicsiQ8WZ60.

PTM databases

iPTMnetiQ8WZ60.
PhosphoSitePlusiQ8WZ60.

Expressioni

Tissue specificityi

Found in germinal center B-cells.1 Publication

Gene expression databases

BgeeiENSG00000172578.
CleanExiHS_KLHL6.
ExpressionAtlasiQ8WZ60. baseline and differential.
GenevisibleiQ8WZ60. HS.

Organism-specific databases

HPAiHPA024512.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi124622. 9 interactors.
IntActiQ8WZ60. 8 interactors.
STRINGi9606.ENSP00000341342.

Structurei

3D structure databases

ProteinModelPortaliQ8WZ60.
SMRiQ8WZ60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 139BTBPROSITE-ProRule annotationAdd BLAST68
Domaini174 – 276BACKAdd BLAST103
Repeati320 – 367Kelch 1Add BLAST48
Repeati378 – 421Kelch 2Add BLAST44
Repeati422 – 468Kelch 3Add BLAST47
Repeati470 – 516Kelch 4Add BLAST47
Repeati517 – 558Kelch 5Add BLAST42
Repeati560 – 606Kelch 6Add BLAST47

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00900000140791.
HOGENOMiHOG000230817.
HOVERGENiHBG108068.
InParanoidiQ8WZ60.
KOiK10444.
OMAiRHKQSER.
OrthoDBiEOG091G037V.
PhylomeDBiQ8WZ60.
TreeFamiTF351654.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiView protein in InterPro
IPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR029851. KLHL6.
IPR011333. SKP1/BTB/POZ_sf.
PANTHERiPTHR24411:SF4. PTHR24411:SF4. 1 hit.
PfamiView protein in Pfam
PF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 3 hits.
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiView protein in SMART
SM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 5 hits.
SUPFAMiSSF117281. SSF117281. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEiView protein in PROSITE
PS50097. BTB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8WZ60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLMAGQRGAW TMGDVVEKSL EGPLAPSTDE PSQKTGDLVE ILNGEKVKFD
60 70 80 90 100
DAGLSLILQN GLETLRMENA LTDVILCVDI QEFSCHRVVL AAASNYFRAM
110 120 130 140 150
FCNDLKEKYE KRIIIKGVDA ETMHTLLDYT YTSKALITKQ NVQRVLEAAN
160 170 180 190 200
LFQFLRMVDA CASFLTEALN PENCVGILRL ADTHSLDSLK KQVQSYIIQN
210 220 230 240 250
FVQILNSEEF LDLPVDTLHH ILKSDDLYVT EEAQVFETVM SWVRHKPSER
260 270 280 290 300
LCLLPYVLEN VRLPLLDPWY FVETVEADPL IRQCPEVFPL LQEARMYHLS
310 320 330 340 350
GNEIISERTK PRMHEFQSEV FMIIGGCTKD ERFVAEVTCL DPLRRSRLEV
360 370 380 390 400
AKLPLTEHEL ESENKKWVEF ACVTLKNEVY ISGGKETQHD VWKYNSSINK
410 420 430 440 450
WIQIEYLNIG RWRHKMVVLG GKVYVIGGFD GLQRINNVET YDPFHNCWSE
460 470 480 490 500
AAPLLVHVSS FAATSHKKKL YVIGGGPNGK LATDKTQCYD PSTNKWSLKA
510 520 530 540 550
AMPVEAKCIN AVSFRDRIYV VGGAMRALYA YSPLEDSWCL VTQLSHERAS
560 570 580 590 600
CGIAPCNNRL YITGGRDEKN EVIATVLCWD PEAQKLTEEC VLPRGVSHHG
610 620
SVTIRKSYTH IRRIVPGAVS V
Length:621
Mass (Da):70,359
Last modified:May 5, 2009 - v3
Checksum:i267FD90AEC6629E4
GO

Sequence cautioni

The sequence AAH32348 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAL35594 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG37078 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11T → R in AAL35594 (PubMed:12617994).Curated1
Sequence conflicti94S → G in BAG37078 (PubMed:14702039).Curated1
Sequence conflicti112R → G in BAG37078 (PubMed:14702039).Curated1
Sequence conflicti363E → G in AAL35594 (PubMed:12617994).Curated1
Sequence conflicti495K → R in BAG37078 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_056125518I → V. Corresponds to variant dbSNP:rs35354575Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097125 mRNA. Translation: BAC04957.1.
AK314473 mRNA. Translation: BAG37078.1. Different initiation.
AC092960 Genomic DNA. No translation available.
AC069211 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78324.1.
CH471052 Genomic DNA. Translation: EAW78325.1.
BC032348 mRNA. Translation: AAH32348.1. Different initiation.
AF441792 mRNA. Translation: AAL35594.1. Different initiation.
CCDSiCCDS3245.2.
RefSeqiNP_569713.2. NM_130446.2.
UniGeneiHs.659147.

Genome annotation databases

EnsembliENST00000341319; ENSP00000341342; ENSG00000172578.
GeneIDi89857.
KEGGihsa:89857.
UCSCiuc003flr.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKLHL6_HUMAN
AccessioniPrimary (citable) accession number: Q8WZ60
Secondary accession number(s): B2RB31
, D3DNS8, Q8N5I1, Q8N892
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: May 5, 2009
Last modified: November 22, 2017
This is version 140 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot