UniProtKB - Q8WZ60 (KLHL6_HUMAN)
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Protein
Kelch-like protein 6
Gene
KLHL6
Organism
Homo sapiens (Human)
Status
Functioni
Involved in B-lymphocyte antigen receptor signaling and germinal center formation.By similarity
GO - Molecular functioni
- DNA binding transcription factor activity Source: GO_Central
- transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- B cell receptor signaling pathway Source: Ensembl
- germinal center formation Source: Ensembl
- positive regulation of transcription, DNA-templated Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: Kelch-like protein 6 |
Gene namesi | Name:KLHL6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000172578.11. |
HGNCi | HGNC:18653. KLHL6. |
MIMi | 614214. gene. |
neXtProti | NX_Q8WZ60. |
Subcellular locationi
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 89857. |
OpenTargetsi | ENSG00000172578. |
PharmGKBi | PA38621. |
Polymorphism and mutation databases
BioMutai | KLHL6. |
DMDMi | 229462964. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000119106 | 1 – 621 | Kelch-like protein 6Add BLAST | 621 |
Proteomic databases
EPDi | Q8WZ60. |
MaxQBi | Q8WZ60. |
PaxDbi | Q8WZ60. |
PeptideAtlasi | Q8WZ60. |
PRIDEi | Q8WZ60. |
TopDownProteomicsi | Q8WZ60. |
PTM databases
iPTMneti | Q8WZ60. |
PhosphoSitePlusi | Q8WZ60. |
Expressioni
Tissue specificityi
Found in germinal center B-cells.1 Publication
Gene expression databases
Bgeei | ENSG00000172578. |
CleanExi | HS_KLHL6. |
ExpressionAtlasi | Q8WZ60. baseline and differential. |
Genevisiblei | Q8WZ60. HS. |
Organism-specific databases
HPAi | HPA024512. |
Interactioni
Binary interactionsi
Protein-protein interaction databases
BioGridi | 124622. 9 interactors. |
IntActi | Q8WZ60. 9 interactors. |
STRINGi | 9606.ENSP00000341342. |
Structurei
3D structure databases
ProteinModelPortali | Q8WZ60. |
SMRi | Q8WZ60. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 72 – 139 | BTBPROSITE-ProRule annotationAdd BLAST | 68 | |
Domaini | 174 – 276 | BACKAdd BLAST | 103 | |
Repeati | 320 – 367 | Kelch 1Add BLAST | 48 | |
Repeati | 378 – 421 | Kelch 2Add BLAST | 44 | |
Repeati | 422 – 468 | Kelch 3Add BLAST | 47 | |
Repeati | 470 – 516 | Kelch 4Add BLAST | 47 | |
Repeati | 517 – 558 | Kelch 5Add BLAST | 42 | |
Repeati | 560 – 606 | Kelch 6Add BLAST | 47 |
Keywords - Domaini
Kelch repeat, RepeatPhylogenomic databases
eggNOGi | KOG4441. Eukaryota. ENOG410XNX8. LUCA. |
GeneTreei | ENSGT00910000143979. |
HOGENOMi | HOG000230817. |
HOVERGENi | HBG108068. |
InParanoidi | Q8WZ60. |
KOi | K10444. |
OMAi | RHKQSER. |
OrthoDBi | EOG091G037V. |
PhylomeDBi | Q8WZ60. |
TreeFami | TF351654. |
Family and domain databases
Gene3Di | 2.120.10.80. 1 hit. |
InterProi | View protein in InterPro IPR011705. BACK. IPR017096. BTB-kelch_protein. IPR000210. BTB/POZ_dom. IPR015915. Kelch-typ_b-propeller. IPR006652. Kelch_1. IPR029851. KLHL6. IPR011333. SKP1/BTB/POZ_sf. |
PANTHERi | PTHR24411:SF4. PTHR24411:SF4. 1 hit. |
Pfami | View protein in Pfam PF07707. BACK. 1 hit. PF00651. BTB. 1 hit. PF01344. Kelch_1. 3 hits. |
PIRSFi | PIRSF037037. Kelch-like_protein_gigaxonin. 1 hit. |
SMARTi | View protein in SMART SM00875. BACK. 1 hit. SM00225. BTB. 1 hit. SM00612. Kelch. 5 hits. |
SUPFAMi | SSF117281. SSF117281. 1 hit. SSF54695. SSF54695. 1 hit. |
PROSITEi | View protein in PROSITE PS50097. BTB. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q8WZ60-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLMAGQRGAW TMGDVVEKSL EGPLAPSTDE PSQKTGDLVE ILNGEKVKFD
60 70 80 90 100
DAGLSLILQN GLETLRMENA LTDVILCVDI QEFSCHRVVL AAASNYFRAM
110 120 130 140 150
FCNDLKEKYE KRIIIKGVDA ETMHTLLDYT YTSKALITKQ NVQRVLEAAN
160 170 180 190 200
LFQFLRMVDA CASFLTEALN PENCVGILRL ADTHSLDSLK KQVQSYIIQN
210 220 230 240 250
FVQILNSEEF LDLPVDTLHH ILKSDDLYVT EEAQVFETVM SWVRHKPSER
260 270 280 290 300
LCLLPYVLEN VRLPLLDPWY FVETVEADPL IRQCPEVFPL LQEARMYHLS
310 320 330 340 350
GNEIISERTK PRMHEFQSEV FMIIGGCTKD ERFVAEVTCL DPLRRSRLEV
360 370 380 390 400
AKLPLTEHEL ESENKKWVEF ACVTLKNEVY ISGGKETQHD VWKYNSSINK
410 420 430 440 450
WIQIEYLNIG RWRHKMVVLG GKVYVIGGFD GLQRINNVET YDPFHNCWSE
460 470 480 490 500
AAPLLVHVSS FAATSHKKKL YVIGGGPNGK LATDKTQCYD PSTNKWSLKA
510 520 530 540 550
AMPVEAKCIN AVSFRDRIYV VGGAMRALYA YSPLEDSWCL VTQLSHERAS
560 570 580 590 600
CGIAPCNNRL YITGGRDEKN EVIATVLCWD PEAQKLTEEC VLPRGVSHHG
610 620
SVTIRKSYTH IRRIVPGAVS V
Sequence cautioni
The sequence AAH32348 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAL35594 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG37078 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 11 | T → R in AAL35594 (PubMed:12617994).Curated | 1 | |
Sequence conflicti | 94 | S → G in BAG37078 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 112 | R → G in BAG37078 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 363 | E → G in AAL35594 (PubMed:12617994).Curated | 1 | |
Sequence conflicti | 495 | K → R in BAG37078 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_056125 | 518 | I → V. Corresponds to variant dbSNP:rs35354575Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK097125 mRNA. Translation: BAC04957.1. AK314473 mRNA. Translation: BAG37078.1. Different initiation. AC092960 Genomic DNA. No translation available. AC069211 Genomic DNA. No translation available. CH471052 Genomic DNA. Translation: EAW78324.1. CH471052 Genomic DNA. Translation: EAW78325.1. BC032348 mRNA. Translation: AAH32348.1. Different initiation. AF441792 mRNA. Translation: AAL35594.1. Different initiation. |
CCDSi | CCDS3245.2. |
RefSeqi | NP_569713.2. NM_130446.2. |
UniGenei | Hs.659147. |
Genome annotation databases
Ensembli | ENST00000341319; ENSP00000341342; ENSG00000172578. |
GeneIDi | 89857. |
KEGGi | hsa:89857. |
UCSCi | uc003flr.4. human. |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | KLHL6_HUMAN | |
Accessioni | Q8WZ60Primary (citable) accession number: Q8WZ60 Secondary accession number(s): B2RB31 Q8N892 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 12, 2003 |
Last sequence update: | May 5, 2009 | |
Last modified: | March 28, 2018 | |
This is version 143 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |