Unreviewed, UniProtKB/TrEMBL Q8WZ56 (Q8WZ56_HUMAN)

Names and origin

Protein names	Recommended name:     Serine/threonine-protein phosphatase RuleBase RU004273V0     EC=3.1.3.16 RuleBase RU004273V0
Organism	Homo sapiens (Human) EMBL AAL35904.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	A phosphoprotein + H2O = a protein + phosphate. RuleBase RU004273V0
Sequence similarities	Belongs to the PPP phosphatase family.

Ontologies

Keywords
Ligand	Iron RuleBase RU004273V0
Molecular function	Hydrolase Spearmint SPM006186 RuleBase RU004273V0
Gene Ontology (GO)
Biological process	negative regulation of Ras protein signal transduction Inferred from electronic annotation. Source: Compara negative regulation of apoptosis Inferred from electronic annotation. Source: Compara proteasomal ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: Compara protein amino acid dephosphorylation Inferred from electronic annotation. Source: Compara regulation of gene expression Inferred from electronic annotation. Source: Compara response to antibiotic Inferred from electronic annotation. Source: Compara response to hydrogen peroxide Inferred from electronic annotation. Source: Compara
Cellular component	cytoplasm Inferred from electronic annotation. Source: Compara protein phosphatase type 2A complex Inferred from electronic annotation. Source: Compara
Molecular function	iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein C-terminus binding Inferred from electronic annotation. Source: Compara protein domain specific binding Inferred from electronic annotation. Source: Compara protein heterodimerization activity Inferred from sequence or structural similarity. Source: UniProtKB protein serine/threonine phosphatase activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8WZ56-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: D43BB3C3C7446D55	FASTA	309	35,631
	10 20 30 40 50 60 MDEKLFTKEL DQWVEQLNEC KQLNENQVRT LCEKAKEILT KESNVQEVRC PVTVCGDVHG 70 80 90 100 110 120 QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VALKVRYPER ITILRGNHES 130 140 150 160 170 180 RQITQVYGFY DECLRKYGNA NVWKYFTDLF DYLPLTALVD GQIFCLHGGL SPSIDTLDHI 190 200 210 220 230 240 RALDRLQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGYTF GQDISETFNH ANGLTLVSRA 250 260 270 280 290 300 HQLVMEGYNW CHDRNVVTIF SAPNYCYRCG NQAAIMELDD TLKYSFLQFD PAPRRGEPHV TRRTPDYFL

References

[1]	"Cloning of catalytic subunit of human heart protein phosphatase type 2A." Mishra S., Tiwari N., Sabbah H.N., Gupta R.C. Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Heart EMBL AAL35904.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF444006 mRNA. Translation: AAL35904.1.
IPI	IPI00429689.
UniGene	Hs.491440
3D structure databases
HSSP	HSSP built from PDB template 1IT6 based on UniProtKB P36873.
SMR	Q8WZ56. Positions 2-309.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8WZ56.
Genome annotation databases
Ensembl	ENST00000221138; ENSP00000221138; ENSG00000104695; Homo sapiens. [Genome view] ENST00000397308; ENSP00000380475; ENSG00000104695; Homo sapiens. [Genome view] ENST00000406655; ENSP00000384493; ENSG00000104695; Homo sapiens. [Genome view]
Organism-specific databases
HGNC	HGNC:9300. PPP2CB.
Phylogenomic databases
HOVERGEN	Q8WZ56.
Gene expression databases
ArrayExpress	Q8WZ56.
Bgee	Q8WZ56.
Family and domain databases
InterPro	IPR004843. M-pesterase. IPR006186. Ser/Thr-sp_prot-phosphatase. [Graphical view]
PANTHER	PTHR11668. T_phtase_apaH. 1 hit.
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PRINTS	PR00114. STPHPHTASE.
SMART	SM00156. PP2Ac. 1 hit. [Graphical view]
PROSITE	PS00125. SER_THR_PHOSPHATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q8WZ56_HUMAN

Accession

Primary (citable) accession number: Q8WZ56

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2002
Last sequence update:	March 1, 2002
Last modified:	February 9, 2010
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.