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Q8WZ47

- Q8WZ47_HUMAN

UniProt

Q8WZ47 - Q8WZ47_HUMAN

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Protein
Submitted name:

Sex determining region Y

Gene
SRY
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. male sex determination Source: InterPro
  3. sex differentiation Source: UniProtKB-KW
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

ActivatorSAAS annotations

Keywords - Biological processi

Differentiation, Sexual differentiationSAAS annotations, Transcription, Transcription regulationSAAS annotations

Keywords - Ligandi

Calmodulin-bindingSAAS annotations, DNA-bindingSAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
Sex determining region YImported
Gene namesi
Name:SRYImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotations

Interactioni

Protein-protein interaction databases

MINTiMINT-1208803.

Structurei

3D structure databases

ProteinModelPortaliQ8WZ47.

Family & Domainsi

Sequence similaritiesi

Contains HMG box DNA-binding domain.SAAS annotations

Phylogenomic databases

HOVERGENiHBG008712.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR017253. SRY.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
PIRSFiPIRSF037653. SRY. 1 hit.
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8WZ47-1 [UniParc]FASTAAdd to Basket

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MQSYASAMLS VFNSDDYSPA VQENIPALRR SSSFLCTESC NSKYQCETGE    50
NSKGNVQDGV KRPMNAFIVW SRDQRRKMAL ENPRMRNSEI SKQLGYQWKM 100
LTEAEKWPFF QEAQKLQAMH REKYPNYKYR PRRKAKMLPK NCSLLPADPA 150
SVLCSEVQLD NRLYRDDCTK ATHSRMEHQL GHLPPINAAS SPQQRDRY 198
Length:198
Mass (Da):23,032
Last modified:March 1, 2002 - v1
Checksum:i7725A9452C308121
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei198 – 1981Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ421270 Genomic DNA. Translation: CAD13147.1.
UniGeneiHs.1992.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ421270 Genomic DNA. Translation: CAD13147.1 .
UniGenei Hs.1992.

3D structure databases

ProteinModelPortali Q8WZ47.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1208803.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG008712.

Family and domain databases

Gene3Di 1.10.30.10. 1 hit.
InterProi IPR009071. HMG_box_dom.
IPR017253. SRY.
[Graphical view ]
Pfami PF00505. HMG_box. 1 hit.
[Graphical view ]
PIRSFi PIRSF037653. SRY. 1 hit.
SMARTi SM00398. HMG. 1 hit.
[Graphical view ]
SUPFAMi SSF47095. SSF47095. 1 hit.
PROSITEi PS50118. HMG_BOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A point mutation R59G within the HMG-SRY box in a female 45,X/46,X,psu dic(Y)(pter=AEq11::q11=AEpter)."
    Fernandez R., Marchal J.A., Sanchez A., Pasaro E.
    Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ8WZ47_HUMAN
AccessioniPrimary (citable) accession number: Q8WZ47
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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