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Protein

Sex-determining region Y protein

Gene

SRY

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ActivatorSAAS annotation

Keywords - Biological processi

Differentiation, Sexual differentiationSAAS annotation, Transcription, Transcription regulationSAAS annotation

Keywords - Ligandi

Calmodulin-bindingSAAS annotation, DNA-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Sex-determining region Y proteinSAAS annotation
Gene namesi
Name:SRYImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Interactioni

Protein-protein interaction databases

MINTiMINT-1208803.
STRINGi9606.ENSP00000372547.

Structurei

3D structure databases

ProteinModelPortaliQ8WZ47.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains HMG box DNA-binding domain.SAAS annotation

Phylogenomic databases

HOVERGENiHBG008712.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR017253. SRY.
[Graphical view]
PANTHERiPTHR10270:SF199. PTHR10270:SF199. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
PIRSFiPIRSF037653. SRY. 1 hit.
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8WZ47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSYASAMLS VFNSDDYSPA VQENIPALRR SSSFLCTESC NSKYQCETGE
60 70 80 90 100
NSKGNVQDGV KRPMNAFIVW SRDQRRKMAL ENPRMRNSEI SKQLGYQWKM
110 120 130 140 150
LTEAEKWPFF QEAQKLQAMH REKYPNYKYR PRRKAKMLPK NCSLLPADPA
160 170 180 190
SVLCSEVQLD NRLYRDDCTK ATHSRMEHQL GHLPPINAAS SPQQRDRY
Length:198
Mass (Da):23,032
Last modified:March 1, 2002 - v1
Checksum:i7725A9452C308121
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei198 – 1981Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ421270 Genomic DNA. Translation: CAD13147.1.
UniGeneiHs.1992.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ421270 Genomic DNA. Translation: CAD13147.1.
UniGeneiHs.1992.

3D structure databases

ProteinModelPortaliQ8WZ47.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1208803.
STRINGi9606.ENSP00000372547.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG008712.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR017253. SRY.
[Graphical view]
PANTHERiPTHR10270:SF199. PTHR10270:SF199. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
PIRSFiPIRSF037653. SRY. 1 hit.
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A point mutation R59G within the HMG-SRY box in a female 45,X/46,X,psu dic(Y)(pter=AEq11::q11=AEpter)."
    Fernandez R., Marchal J.A., Sanchez A., Pasaro E.
    Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ8WZ47_HUMAN
AccessioniPrimary (citable) accession number: Q8WZ47
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: July 22, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.