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Q8WZ47

- Q8WZ47_HUMAN

UniProt

Q8WZ47 - Q8WZ47_HUMAN

Protein
Submitted name:

Sex determining region Y

Gene

SRY

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. male sex determination Source: InterPro
    3. sex differentiation Source: UniProtKB-KW
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    ActivatorSAAS annotation

    Keywords - Biological processi

    Differentiation, Sexual differentiationSAAS annotation, Transcription, Transcription regulationSAAS annotation

    Keywords - Ligandi

    Calmodulin-bindingSAAS annotation, DNA-bindingSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Sex determining region YImported
    Gene namesi
    Name:SRYImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-KW

    Keywords - Cellular componenti

    NucleusSAAS annotation

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-1208803.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WZ47.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains HMG box DNA-binding domain.SAAS annotation

    Phylogenomic databases

    HOVERGENiHBG008712.

    Family and domain databases

    Gene3Di1.10.30.10. 1 hit.
    InterProiIPR009071. HMG_box_dom.
    IPR017253. SRY.
    [Graphical view]
    PfamiPF00505. HMG_box. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037653. SRY. 1 hit.
    SMARTiSM00398. HMG. 1 hit.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 1 hit.
    PROSITEiPS50118. HMG_BOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q8WZ47-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQSYASAMLS VFNSDDYSPA VQENIPALRR SSSFLCTESC NSKYQCETGE    50
    NSKGNVQDGV KRPMNAFIVW SRDQRRKMAL ENPRMRNSEI SKQLGYQWKM 100
    LTEAEKWPFF QEAQKLQAMH REKYPNYKYR PRRKAKMLPK NCSLLPADPA 150
    SVLCSEVQLD NRLYRDDCTK ATHSRMEHQL GHLPPINAAS SPQQRDRY 198
    Length:198
    Mass (Da):23,032
    Last modified:March 1, 2002 - v1
    Checksum:i7725A9452C308121
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei198 – 1981Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ421270 Genomic DNA. Translation: CAD13147.1.
    UniGeneiHs.1992.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ421270 Genomic DNA. Translation: CAD13147.1 .
    UniGenei Hs.1992.

    3D structure databases

    ProteinModelPortali Q8WZ47.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1208803.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG008712.

    Family and domain databases

    Gene3Di 1.10.30.10. 1 hit.
    InterProi IPR009071. HMG_box_dom.
    IPR017253. SRY.
    [Graphical view ]
    Pfami PF00505. HMG_box. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037653. SRY. 1 hit.
    SMARTi SM00398. HMG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 1 hit.
    PROSITEi PS50118. HMG_BOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A point mutation R59G within the HMG-SRY box in a female 45,X/46,X,psu dic(Y)(pter=AEq11::q11=AEpter)."
      Fernandez R., Marchal J.A., Sanchez A., Pasaro E.
      Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ8WZ47_HUMAN
    AccessioniPrimary (citable) accession number: Q8WZ47
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.