Q8WZ47 (Q8WZ47_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Sex-determining region Y protein PIRNR PIRNR037653

Gene names

Name:

SRY EMBL CAD13147.1

Organism

Homo sapiens (Human) EMBL CAD13147.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	198 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Transcriptional regulator that controls a genetic switch in male development By similarity. PIRNR PIRNR037653
Sequence similarities	Belongs to the SRY family. PIRNR PIRNR037653 Contains 1 HMG box DNA-binding domain. SAAS SAAS009071

Ontologies

Keywords
Biological process	Differentiation Sexual differentiation PIRNR PIRNR037653 SAAS SAAS009071 Transcription Transcription regulation PIRNR PIRNR037653 SAAS SAAS009071
Cellular component	Nucleus PIRNR PIRNR037653 SAAS SAAS009071
Ligand	Calmodulin-binding SAAS SAAS009071 DNA-binding PIRNR PIRNR037653 SAAS SAAS009071
Molecular function	Activator PIRNR PIRNR037653 SAAS SAAS009071
Gene Ontology (GO)
Biological_process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW male sex determination Inferred from electronic annotation. Source: InterPro sex differentiation Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	198	1	EMBL CAD13147.1

Sequences

	Sequence		Length	Mass (Da)
	Q8WZ47 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 7725A9452C308121	FASTA	198	23,032
	10 20 30 40 50 60 MQSYASAMLS VFNSDDYSPA VQENIPALRR SSSFLCTESC NSKYQCETGE NSKGNVQDGV 70 80 90 100 110 120 KRPMNAFIVW SRDQRRKMAL ENPRMRNSEI SKQLGYQWKM LTEAEKWPFF QEAQKLQAMH 130 140 150 160 170 180 REKYPNYKYR PRRKAKMLPK NCSLLPADPA SVLCSEVQLD NRLYRDDCTK ATHSRMEHQL 190 GHLPPINAAS SPQQRDRY

References

[1]	"A point mutation R59G within the HMG-SRY box in a female 45,X/46,X,psu dic(Y)(pter=AEq11::q11=AEpter)." Fernandez R., Marchal J.A., Sanchez A., Pasaro E. Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ421270 Genomic DNA. Translation: CAD13147.1.
IPI	IPI00011568.
UniGene	Hs.1992.
3D structure databases
HSSP	HSSP built from PDB template 1HRY based on UniProtKB Q05066.
ProteinModelPortal	Q8WZ47.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1208803.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG008712.
Family and domain databases
Gene3D	1.10.30.10. 1 hit.
InterPro	IPR009071. HMG_box_dom. IPR017253. TF_Sry. [Graphical view]
PANTHER	PTHR10270:SF48. PTHR10270:SF48. 1 hit.
Pfam	PF00505. HMG_box. 1 hit. [Graphical view]
PIRSF	PIRSF037653. SRY. 1 hit.
SMART	SM00398. HMG. 1 hit. [Graphical view]
SUPFAM	SSF47095. HMG-box. 1 hit.
PROSITE	PS50118. HMG_BOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q8WZ47_HUMAN

Accession

Primary (citable) accession number: Q8WZ47

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2002
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.