ID   MAFIP_HUMAN             Reviewed;         124 AA.
AC   Q8WZ33;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   27-MAR-2024, entry version 114.
DE   RecName: Full=MaFF-interacting protein;
DE   AltName: Full=Tektin-4 like protein PP5644;
GN   Name=MAFIP; Synonyms=MIP; ORFNames=PP5644;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15498874; DOI=10.1073/pnas.0404089101;
RA   Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X.,
RA   Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.,
RA   Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.;
RT   "Large-scale cDNA transfection screening for genes related to cancer
RT   development and progression.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
RN   [2]
RP   FUNCTION, INTERACTION WITH MIS18A, AND TISSUE SPECIFICITY.
RX   PubMed=15881666; DOI=10.1007/s11010-005-5907-6;
RA   Ye X.-X., Lu H., Yu Y., Ding N., Zhang N.-L., Huo K.-K., Wan D.-F.,
RA   Li Y.-Y., Gu J.-R.;
RT   "PP5644 interacts with phosphatidylinositol-4-phosphate adaptor protein-1
RT   associated protein-1.";
RL   Mol. Cell. Biochem. 271:151-158(2005).
RN   [3]
RP   FUNCTION, INTERACTION WITH MAFF, AND SUBCELLULAR LOCATION.
RX   PubMed=16549056; DOI=10.1016/j.abb.2006.02.011;
RA   Ye X., Li Y., Huang Q., Yu Y., Yuan H., Wang P., Wan D., Gu J., Huo K.,
RA   Li Y.-Y., Lu H.;
RT   "The novel human gene MIP functions as a co-activator of hMafF.";
RL   Arch. Biochem. Biophys. 449:87-93(2006).
CC   -!- FUNCTION: Acts as a coactivator of MAFF transcriptional activity.
CC       Inhibits cell growth and colony-forming efficiency.
CC       {ECO:0000269|PubMed:15881666, ECO:0000269|PubMed:16549056}.
CC   -!- SUBUNIT: Interacts with MIS18A. Interacts (via its coiled-coil region)
CC       with MAFF. {ECO:0000269|PubMed:15881666, ECO:0000269|PubMed:16549056}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16549056}. Nucleus,
CC       nucleolus {ECO:0000269|PubMed:16549056}. Note=Interaction with MAFF
CC       induces its translocation from the cytoplasm to the nucleolus.
CC   -!- TISSUE SPECIFICITY: Strongly expressed in brain, kidney and ovary.
CC       Moderately expressed in liver, spleen, thymus, prostate, testis, small
CC       intestine and colon. Weakly expressed in heart, placenta, lung and
CC       leukocytes. {ECO:0000269|PubMed:15881666}.
CC   -!- SIMILARITY: Belongs to the tektin family. {ECO:0000305}.
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DR   EMBL; AF289559; AAL55743.1; -; mRNA.
DR   AlphaFoldDB; Q8WZ33; -.
DR   SMR; Q8WZ33; -.
DR   IntAct; Q8WZ33; 3.
DR   STRING; 9606.ENSP00000483280; -.
DR   iPTMnet; Q8WZ33; -.
DR   PhosphoSitePlus; Q8WZ33; -.
DR   BioMuta; HGNC:31102; -.
DR   MassIVE; Q8WZ33; -.
DR   PaxDb; 9606-ENSP00000483280; -.
DR   PeptideAtlas; Q8WZ33; -.
DR   UCSC; uc059ghq.1; human.
DR   AGR; HGNC:31102; -.
DR   GeneCards; MAFIP; -.
DR   HGNC; HGNC:31102; MAFIP.
DR   HPA; ENSG00000277400; Low tissue specificity.
DR   neXtProt; NX_Q8WZ33; -.
DR   VEuPathDB; HostDB:ENSG00000277400; -.
DR   eggNOG; KOG2685; Eukaryota.
DR   GeneTree; ENSGT00910000148674; -.
DR   HOGENOM; CLU_2003146_0_0_1; -.
DR   InParanoid; Q8WZ33; -.
DR   OMA; MAHRTCY; -.
DR   PhylomeDB; Q8WZ33; -.
DR   SignaLink; Q8WZ33; -.
DR   Pharos; Q8WZ33; Tdark.
DR   PRO; PR:Q8WZ33; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q8WZ33; Protein.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0060294; P:cilium movement involved in cell motility; IEA:InterPro.
DR   InterPro; IPR048256; Tektin-like.
DR   InterPro; IPR000435; Tektins.
DR   PANTHER; PTHR19960; TEKTIN; 1.
DR   PANTHER; PTHR19960:SF12; TEKTIN-4; 1.
DR   Pfam; PF03148; Tektin; 1.
DR   Genevisible; Q8WZ33; HS.
PE   1: Evidence at protein level;
KW   Coiled coil; Cytoplasm; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..124
FT                   /note="MaFF-interacting protein"
FT                   /id="PRO_0000348286"
FT   COILED          54..96
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   124 AA;  13947 MW;  A864BD2516DF72F8 CRC64;
     MLCPRAAFLV GSFHGVFPGP PASSHWEFWV PSTPVGAYFC PPQPQLTPPN TPKLVSEVEE
     LYKSITALRE KLLQAEQSLR NLKDIHMSLE KDVTAMTNSV FIDRQKCMAH RTCYPTILQL
     AGYQ
//