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Q8WZ33 (MAFIP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
MaFF-interacting protein
Alternative name(s):
Tektin-4 like protein PP5644
Gene names
Name:MAFIP
Synonyms:MIP
ORF Names:PP5644
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length124 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as coactivator of MAFF transcriptional activity. Inhibits cell growth and colony-forming efficiency. Ref.2 Ref.3

Subunit structure

Interacts with MIS18A. Interacts (via its coiled-coil region) with MAFF. Ref.2 Ref.3

Subcellular location

Cytoplasm. Nucleusnucleolus. Note: Interaction with MAFF induces its translocation from the cytoplasm to the nucleolus. Ref.3

Tissue specificity

Strongly expressed in brain, kidney and ovary. Moderately expressed in liver, spleen, thymus, prostate, testis, small intestine and colon. Weakly expressed in heart, placenta, lung and leukocytes. Ref.2

Sequence similarities

Belongs to the tektin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 124124MaFF-interacting protein
PRO_0000348286

Regions

Coiled coil54 – 9643 Potential

Sequences

Sequence LengthMass (Da)Tools
Q8WZ33 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: A864BD2516DF72F8

FASTA12413,947
        10         20         30         40         50         60 
MLCPRAAFLV GSFHGVFPGP PASSHWEFWV PSTPVGAYFC PPQPQLTPPN TPKLVSEVEE 

        70         80         90        100        110        120 
LYKSITALRE KLLQAEQSLR NLKDIHMSLE KDVTAMTNSV FIDRQKCMAH RTCYPTILQL 


AGYQ 

« Hide

References

« Hide 'large scale' references
[1]"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. expand/collapse author list , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"PP5644 interacts with phosphatidylinositol-4-phosphate adaptor protein-1 associated protein-1."
Ye X.-X., Lu H., Yu Y., Ding N., Zhang N.-L., Huo K.-K., Wan D.-F., Li Y.-Y., Gu J.-R.
Mol. Cell. Biochem. 271:151-158(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH MIS18A, TISSUE SPECIFICITY.
[3]"The novel human gene MIP functions as a co-activator of hMafF."
Ye X., Li Y., Huang Q., Yu Y., Yuan H., Wang P., Wan D., Gu J., Huo K., Li Y.-Y., Lu H.
Arch. Biochem. Biophys. 449:87-93(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH MAFF, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF289559 mRNA. Translation: AAL55743.1.
UniGeneHs.626311.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid608214. 3 interactions.
IntActQ8WZ33. 3 interactions.

Proteomic databases

PRIDEQ8WZ33.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GeneCardsGC04M9U0054.
H-InvDBHIX0004695.
HIX0175052.
HIX0175120.
HGNCHGNC:31102. MAFIP.
neXtProtNX_Q8WZ33.
GenAtlasSearch...

Phylogenomic databases

PhylomeDBQ8WZ33.

Gene expression databases

GenevestigatorQ8WZ33.

Family and domain databases

InterProIPR000435. Tektin.
[Graphical view]
PANTHERPTHR19960. PTHR19960. 1 hit.
PfamPF03148. Tektin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMAFIP. human.
PROQ8WZ33.

Entry information

Entry nameMAFIP_HUMAN
AccessionPrimary (citable) accession number: Q8WZ33
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: March 1, 2002
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM