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Q8WZ19

- BACD1_HUMAN

UniProt

Q8WZ19 - BACD1_HUMAN

Protein

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

Gene

KCTD13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration.1 Publication

    Pathwayi

    GO - Molecular functioni

    1. GTP-Rho binding Source: UniProtKB

    GO - Biological processi

    1. cell migration Source: UniProtKB
    2. DNA replication Source: UniProtKB
    3. negative regulation of Rho protein signal transduction Source: UniProtKB
    4. positive regulation of DNA replication Source: Ensembl
    5. proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
    6. protein homooligomerization Source: InterPro
    7. protein ubiquitination Source: UniProtKB
    8. stress fiber assembly Source: UniProtKB

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1
    Short name:
    hBACURD1
    Alternative name(s):
    BTB/POZ domain-containing protein KCTD13
    Polymerase delta-interacting protein 1
    TNFAIP1-like protein
    Gene namesi
    Name:KCTD13
    Synonyms:BACURD1, PDIP1, POLDIP1
    ORF Names:FKSG86, PP6832
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:22234. KCTD13.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. Cul3-RING ubiquitin ligase complex Source: UniProtKB
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi84 – 863VLI → AAA: Abolishes interaction with CUL3 and induces abnormal actin stress fibers. 1 Publication

    Organism-specific databases

    PharmGKBiPA134907908.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 329329BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1PRO_0000191297Add
    BLAST

    Proteomic databases

    MaxQBiQ8WZ19.
    PaxDbiQ8WZ19.
    PRIDEiQ8WZ19.

    PTM databases

    PhosphoSiteiQ8WZ19.

    Expressioni

    Tissue specificityi

    Expressed in a wide variety of tissues.1 Publication

    Inductioni

    By TNF and IL6/interleukin-6.1 Publication

    Gene expression databases

    ArrayExpressiQ8WZ19.
    BgeeiQ8WZ19.
    CleanExiHS_KCTD13.
    GenevestigatoriQ8WZ19.

    Organism-specific databases

    HPAiHPA043524.

    Interactioni

    Subunit structurei

    Component of the BCR(BACURD1) E3 ubiquitin ligase complex, at least composed of CUL3, KCTD13/BACURD1 and RBX1. Interacts with RHOA; with a preference for RhoA-GDP. Interacts with POLD2 and PCNA.2 Publications

    Protein-protein interaction databases

    BioGridi129001. 20 interactions.
    IntActiQ8WZ19. 12 interactions.
    MINTiMINT-1458356.
    STRINGi9606.ENSP00000311202.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WZ19.
    SMRiQ8WZ19. Positions 40-167.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini41 – 10969BTBPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the BACURD family.Curated
    Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG257745.
    HOGENOMiHOG000294088.
    HOVERGENiHBG052219.
    InParanoidiQ8WZ19.
    KOiK15074.
    OMAiDEDGREH.
    OrthoDBiEOG7PS1G1.
    PhylomeDBiQ8WZ19.
    TreeFamiTF315649.

    Family and domain databases

    Gene3Di3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR003131. T1-type_BTB.
    [Graphical view]
    PfamiPF02214. BTB_2. 1 hit.
    [Graphical view]
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.
    PROSITEiPS50097. BTB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8WZ19-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAEASGPAA AAAPSLEAPK PSGLEPGPAA YGLKPLTPNS KYVKLNVGGS    50
    LHYTTLRTLT GQDTMLKAMF SGRVEVLTDA GGWVLIDRSG RHFGTILNYL 100
    RDGSVPLPES TRELGELLGE ARYYLVQGLI EDCQLALQQK RETLSPLCLI 150
    PMVTSPREEQ QLLASTSKPV VKLLHNRSNN KYSYTSTSDD NLLKNIELFD 200
    KLALRFHGRL LFLKDVLGDE ICCWSFYGQG RKIAEVCCTS IVYATEKKQT 250
    KVEFPEARIF EETLNILIYE TPRGPDPALL EATGGAAGAG GAGRGEDEEN 300
    REHRVRRIHV RRHITHDERP HGQQIVFKD 329
    Length:329
    Mass (Da):36,357
    Last modified:March 1, 2002 - v1
    Checksum:i17A8AC2DBE81EE78
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti251 – 2511K → N in AAK27301. 1 PublicationCurated
    Sequence conflicti328 – 3281K → R in AAK27301. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF401315 mRNA. Translation: AAL14962.2.
    AY027918 mRNA. Translation: AAK27301.1.
    AF289573 mRNA. Translation: AAL55757.1.
    AK289630 mRNA. Translation: BAF82319.1.
    AC120114 Genomic DNA. No translation available.
    CH471238 Genomic DNA. Translation: EAW79969.1.
    BC036228 mRNA. Translation: AAH36228.1.
    CCDSiCCDS10661.1.
    RefSeqiNP_849194.1. NM_178863.4.
    UniGeneiHs.534590.

    Genome annotation databases

    EnsembliENST00000308768; ENSP00000311202; ENSG00000174943.
    ENST00000568000; ENSP00000455785; ENSG00000174943.
    GeneIDi253980.
    KEGGihsa:253980.
    UCSCiuc002duv.4. human.

    Polymorphism databases

    DMDMi51701604.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF401315 mRNA. Translation: AAL14962.2 .
    AY027918 mRNA. Translation: AAK27301.1 .
    AF289573 mRNA. Translation: AAL55757.1 .
    AK289630 mRNA. Translation: BAF82319.1 .
    AC120114 Genomic DNA. No translation available.
    CH471238 Genomic DNA. Translation: EAW79969.1 .
    BC036228 mRNA. Translation: AAH36228.1 .
    CCDSi CCDS10661.1.
    RefSeqi NP_849194.1. NM_178863.4.
    UniGenei Hs.534590.

    3D structure databases

    ProteinModelPortali Q8WZ19.
    SMRi Q8WZ19. Positions 40-167.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 129001. 20 interactions.
    IntActi Q8WZ19. 12 interactions.
    MINTi MINT-1458356.
    STRINGi 9606.ENSP00000311202.

    PTM databases

    PhosphoSitei Q8WZ19.

    Polymorphism databases

    DMDMi 51701604.

    Proteomic databases

    MaxQBi Q8WZ19.
    PaxDbi Q8WZ19.
    PRIDEi Q8WZ19.

    Protocols and materials databases

    DNASUi 253980.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000308768 ; ENSP00000311202 ; ENSG00000174943 .
    ENST00000568000 ; ENSP00000455785 ; ENSG00000174943 .
    GeneIDi 253980.
    KEGGi hsa:253980.
    UCSCi uc002duv.4. human.

    Organism-specific databases

    CTDi 253980.
    GeneCardsi GC16M029918.
    HGNCi HGNC:22234. KCTD13.
    HPAi HPA043524.
    MIMi 608947. gene.
    neXtProti NX_Q8WZ19.
    PharmGKBi PA134907908.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG257745.
    HOGENOMi HOG000294088.
    HOVERGENi HBG052219.
    InParanoidi Q8WZ19.
    KOi K15074.
    OMAi DEDGREH.
    OrthoDBi EOG7PS1G1.
    PhylomeDBi Q8WZ19.
    TreeFami TF315649.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    GeneWikii KCTD13.
    GenomeRNAii 253980.
    NextBioi 92216.
    PROi Q8WZ19.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8WZ19.
    Bgeei Q8WZ19.
    CleanExi HS_KCTD13.
    Genevestigatori Q8WZ19.

    Family and domain databases

    Gene3Di 3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR003131. T1-type_BTB.
    [Graphical view ]
    Pfami PF02214. BTB_2. 1 hit.
    [Graphical view ]
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    PROSITEi PS50097. BTB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A tumor necrosis factor alpha- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase delta and proliferating cell nuclear antigen."
      He H., Tan C.-K., Downey K.M., So A.G.
      Proc. Natl. Acad. Sci. U.S.A. 98:11979-11984(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INTERACTION WITH PCNA AND POLD2, TISSUE SPECIFICITY, INDUCTION.
    2. He H., Tan C.-K., Downey K.M., So A.G.
      Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. "Cloning and characterization of FKSG86, a novel gene encoding a TNFAIP1-like protein."
      Wang Y.-G., Gong L.
      Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Amygdala.
    6. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    9. "Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement."
      Chen Y., Yang Z., Meng M., Zhao Y., Dong N., Yan H., Liu L., Ding M., Peng H.B., Shao F.
      Mol. Cell 35:841-855(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN A BCR (BTB-CUL3-RBX1) E3 UBIQUITIN LIGASE COMPLEX, INTERACTION WITH RHOA, MUTAGENESIS OF 84-VAL--ILE-86.

    Entry informationi

    Entry nameiBACD1_HUMAN
    AccessioniPrimary (citable) accession number: Q8WZ19
    Secondary accession number(s): A8K0R5, Q96P93, Q96SA1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3