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Q8WZ19

- BACD1_HUMAN

UniProt

Q8WZ19 - BACD1_HUMAN

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Protein

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

Gene

KCTD13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration.1 Publication

Pathwayi

GO - Molecular functioni

  1. GTP-Rho binding Source: UniProtKB

GO - Biological processi

  1. cell migration Source: UniProtKB
  2. DNA replication Source: UniProtKB
  3. negative regulation of Rho protein signal transduction Source: UniProtKB
  4. positive regulation of DNA replication Source: Ensembl
  5. proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
  6. protein homooligomerization Source: InterPro
  7. protein ubiquitination Source: UniProtKB
  8. stress fiber assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1
Short name:
hBACURD1
Alternative name(s):
BTB/POZ domain-containing protein KCTD13
Polymerase delta-interacting protein 1
TNFAIP1-like protein
Gene namesi
Name:KCTD13
Synonyms:BACURD1, PDIP1, POLDIP1
ORF Names:FKSG86, PP6832
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:22234. KCTD13.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. Cul3-RING ubiquitin ligase complex Source: UniProtKB
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi84 – 863VLI → AAA: Abolishes interaction with CUL3 and induces abnormal actin stress fibers. 1 Publication

Organism-specific databases

PharmGKBiPA134907908.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1PRO_0000191297Add
BLAST

Proteomic databases

MaxQBiQ8WZ19.
PaxDbiQ8WZ19.
PRIDEiQ8WZ19.

PTM databases

PhosphoSiteiQ8WZ19.

Expressioni

Tissue specificityi

Expressed in a wide variety of tissues.1 Publication

Inductioni

By TNF and IL6/interleukin-6.1 Publication

Gene expression databases

BgeeiQ8WZ19.
CleanExiHS_KCTD13.
ExpressionAtlasiQ8WZ19. baseline and differential.
GenevestigatoriQ8WZ19.

Organism-specific databases

HPAiHPA043524.

Interactioni

Subunit structurei

Component of the BCR(BACURD1) E3 ubiquitin ligase complex, at least composed of CUL3, KCTD13/BACURD1 and RBX1. Interacts with RHOA; with a preference for RhoA-GDP. Interacts with POLD2 and PCNA.2 Publications

Protein-protein interaction databases

BioGridi129001. 24 interactions.
IntActiQ8WZ19. 12 interactions.
MINTiMINT-1458356.
STRINGi9606.ENSP00000311202.

Structurei

3D structure databases

ProteinModelPortaliQ8WZ19.
SMRiQ8WZ19. Positions 40-167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 10969BTBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the BACURD family.Curated
Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG257745.
GeneTreeiENSGT00530000063071.
HOGENOMiHOG000294088.
HOVERGENiHBG052219.
InParanoidiQ8WZ19.
KOiK15074.
OMAiDEDGREH.
OrthoDBiEOG7PS1G1.
PhylomeDBiQ8WZ19.
TreeFamiTF315649.

Family and domain databases

Gene3Di3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WZ19-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAEASGPAA AAAPSLEAPK PSGLEPGPAA YGLKPLTPNS KYVKLNVGGS
60 70 80 90 100
LHYTTLRTLT GQDTMLKAMF SGRVEVLTDA GGWVLIDRSG RHFGTILNYL
110 120 130 140 150
RDGSVPLPES TRELGELLGE ARYYLVQGLI EDCQLALQQK RETLSPLCLI
160 170 180 190 200
PMVTSPREEQ QLLASTSKPV VKLLHNRSNN KYSYTSTSDD NLLKNIELFD
210 220 230 240 250
KLALRFHGRL LFLKDVLGDE ICCWSFYGQG RKIAEVCCTS IVYATEKKQT
260 270 280 290 300
KVEFPEARIF EETLNILIYE TPRGPDPALL EATGGAAGAG GAGRGEDEEN
310 320
REHRVRRIHV RRHITHDERP HGQQIVFKD
Length:329
Mass (Da):36,357
Last modified:March 1, 2002 - v1
Checksum:i17A8AC2DBE81EE78
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti251 – 2511K → N in AAK27301. 1 PublicationCurated
Sequence conflicti328 – 3281K → R in AAK27301. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF401315 mRNA. Translation: AAL14962.2.
AY027918 mRNA. Translation: AAK27301.1.
AF289573 mRNA. Translation: AAL55757.1.
AK289630 mRNA. Translation: BAF82319.1.
AC120114 Genomic DNA. No translation available.
CH471238 Genomic DNA. Translation: EAW79969.1.
BC036228 mRNA. Translation: AAH36228.1.
CCDSiCCDS10661.1.
RefSeqiNP_849194.1. NM_178863.4.
UniGeneiHs.534590.

Genome annotation databases

EnsembliENST00000308768; ENSP00000311202; ENSG00000174943.
ENST00000568000; ENSP00000455785; ENSG00000174943.
GeneIDi253980.
KEGGihsa:253980.
UCSCiuc002duv.4. human.

Polymorphism databases

DMDMi51701604.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF401315 mRNA. Translation: AAL14962.2 .
AY027918 mRNA. Translation: AAK27301.1 .
AF289573 mRNA. Translation: AAL55757.1 .
AK289630 mRNA. Translation: BAF82319.1 .
AC120114 Genomic DNA. No translation available.
CH471238 Genomic DNA. Translation: EAW79969.1 .
BC036228 mRNA. Translation: AAH36228.1 .
CCDSi CCDS10661.1.
RefSeqi NP_849194.1. NM_178863.4.
UniGenei Hs.534590.

3D structure databases

ProteinModelPortali Q8WZ19.
SMRi Q8WZ19. Positions 40-167.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 129001. 24 interactions.
IntActi Q8WZ19. 12 interactions.
MINTi MINT-1458356.
STRINGi 9606.ENSP00000311202.

PTM databases

PhosphoSitei Q8WZ19.

Polymorphism databases

DMDMi 51701604.

Proteomic databases

MaxQBi Q8WZ19.
PaxDbi Q8WZ19.
PRIDEi Q8WZ19.

Protocols and materials databases

DNASUi 253980.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000308768 ; ENSP00000311202 ; ENSG00000174943 .
ENST00000568000 ; ENSP00000455785 ; ENSG00000174943 .
GeneIDi 253980.
KEGGi hsa:253980.
UCSCi uc002duv.4. human.

Organism-specific databases

CTDi 253980.
GeneCardsi GC16M029922.
HGNCi HGNC:22234. KCTD13.
HPAi HPA043524.
MIMi 608947. gene.
neXtProti NX_Q8WZ19.
PharmGKBi PA134907908.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG257745.
GeneTreei ENSGT00530000063071.
HOGENOMi HOG000294088.
HOVERGENi HBG052219.
InParanoidi Q8WZ19.
KOi K15074.
OMAi DEDGREH.
OrthoDBi EOG7PS1G1.
PhylomeDBi Q8WZ19.
TreeFami TF315649.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

GeneWikii KCTD13.
GenomeRNAii 253980.
NextBioi 92216.
PROi Q8WZ19.
SOURCEi Search...

Gene expression databases

Bgeei Q8WZ19.
CleanExi HS_KCTD13.
ExpressionAtlasi Q8WZ19. baseline and differential.
Genevestigatori Q8WZ19.

Family and domain databases

Gene3Di 3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR003131. T1-type_BTB.
[Graphical view ]
Pfami PF02214. BTB_2. 1 hit.
[Graphical view ]
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
PROSITEi PS50097. BTB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A tumor necrosis factor alpha- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase delta and proliferating cell nuclear antigen."
    He H., Tan C.-K., Downey K.M., So A.G.
    Proc. Natl. Acad. Sci. U.S.A. 98:11979-11984(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INTERACTION WITH PCNA AND POLD2, TISSUE SPECIFICITY, INDUCTION.
  2. He H., Tan C.-K., Downey K.M., So A.G.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Cloning and characterization of FKSG86, a novel gene encoding a TNFAIP1-like protein."
    Wang Y.-G., Gong L.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  6. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  9. "Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement."
    Chen Y., Yang Z., Meng M., Zhao Y., Dong N., Yan H., Liu L., Ding M., Peng H.B., Shao F.
    Mol. Cell 35:841-855(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN A BCR (BTB-CUL3-RBX1) E3 UBIQUITIN LIGASE COMPLEX, INTERACTION WITH RHOA, MUTAGENESIS OF 84-VAL--ILE-86.

Entry informationi

Entry nameiBACD1_HUMAN
AccessioniPrimary (citable) accession number: Q8WZ19
Secondary accession number(s): A8K0R5, Q96P93, Q96SA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: March 1, 2002
Last modified: November 26, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3