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Protein
Submitted name:

Microphthalmia-associated transcription factor

Gene

MITF

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Microphthalmia-associated transcription factorImported
Submitted name:
Microphthalmia-associated transcription factor isoformImported
Gene namesi
Name:MITFImported
Synonyms:MITF-CImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000187098.14
HGNCiHGNC:7105 MITF

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000187098

Expressioni

Gene expression databases

BgeeiENSG00000187098

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 117MITF_TFEB_C_3_NInterPro annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili59 – 87Sequence analysisAdd BLAST29

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1318 Eukaryota
ENOG4110SME LUCA
GeneTreeiENSGT00390000004402

Family and domain databases

InterProiView protein in InterPro
IPR031867 MiT/TFE_N
IPR030532 MITF
PANTHERiPTHR12565:SF91 PTHR12565:SF91, 1 hit
PfamiView protein in Pfam
PF15951 MITF_TFEB_C_3_N, 1 hit

Sequencei

Sequence statusi: Fragment.

Q8WYR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHLENTSVV FPRAIFSLCE KETRKLTLCL FSRSSSAEHP GASKPPISSS
60 70 80 90 100
SMTSRILLRQ QLMREQMQEQ ERREQQQKLQ AAQFMQQRVP VSQTPAINVS
110
VPTTLPSATQ VPMEVLK
Length:117
Mass (Da):13,196
Last modified:March 1, 2002 - v1
Checksum:iFEE41E3128219AE5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei117Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC099326 Genomic DNA No translation available.
AC104445 Genomic DNA No translation available.
AC104449 Genomic DNA No translation available.
AC124915 Genomic DNA No translation available.
AB006988 mRNA Translation: BAB83926.1
RefSeqiNP_006713.1, NM_006722.2
UniGeneiHs.166017
Hs.618266

Genome annotation databases

EnsembliENST00000457080; ENSP00000391276; ENSG00000187098
GeneIDi4286
UCSCiuc062lld.1 human

Similar proteinsi

Entry informationi

Entry nameiQ8WYR3_HUMAN
AccessioniPrimary (citable) accession number: Q8WYR3
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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