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Protein
Submitted name:

Microphthalmia-associated transcription factor

Gene

MITF-C

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Microphthalmia-associated transcription factorImported
Submitted name:
Microphthalmia-associated transcription factor isoformImported
Gene namesi
Name:MITF-CImported
Synonyms:MITFImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:7105. MITF.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000187098.

Expressioni

Gene expression databases

BgeeiENSG00000187098.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000295600.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 117MITF_TFEB_C_3_NInterPro annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili59 – 87Sequence analysisAdd BLAST29

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1318. Eukaryota.
ENOG4110SME. LUCA.
GeneTreeiENSGT00390000004402.

Family and domain databases

InterProiView protein in InterPro
IPR031867. MiT/TFE_N.
IPR030532. MITF.
PANTHERiPTHR12565:SF258. PTHR12565:SF258. 1 hit.
PfamiView protein in Pfam
PF15951. MITF_TFEB_C_3_N. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q8WYR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHLENTSVV FPRAIFSLCE KETRKLTLCL FSRSSSAEHP GASKPPISSS
60 70 80 90 100
SMTSRILLRQ QLMREQMQEQ ERREQQQKLQ AAQFMQQRVP VSQTPAINVS
110
VPTTLPSATQ VPMEVLK
Length:117
Mass (Da):13,196
Last modified:March 1, 2002 - v1
Checksum:iFEE41E3128219AE5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei117Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC099326 Genomic DNA. No translation available.
AC104445 Genomic DNA. No translation available.
AC104449 Genomic DNA. No translation available.
AC124915 Genomic DNA. No translation available.
AB006988 mRNA. Translation: BAB83926.1.
RefSeqiNP_006713.1. NM_006722.2.
UniGeneiHs.166017.
Hs.618266.

Genome annotation databases

EnsembliENST00000457080; ENSP00000391276; ENSG00000187098.
GeneIDi4286.
UCSCiuc062lld.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC099326 Genomic DNA. No translation available.
AC104445 Genomic DNA. No translation available.
AC104449 Genomic DNA. No translation available.
AC124915 Genomic DNA. No translation available.
AB006988 mRNA. Translation: BAB83926.1.
RefSeqiNP_006713.1. NM_006722.2.
UniGeneiHs.166017.
Hs.618266.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000295600.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000457080; ENSP00000391276; ENSG00000187098.
GeneIDi4286.
UCSCiuc062lld.1. human.

Organism-specific databases

CTDi4286.
HGNCiHGNC:7105. MITF.
OpenTargetsiENSG00000187098.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1318. Eukaryota.
ENOG4110SME. LUCA.
GeneTreeiENSGT00390000004402.

Miscellaneous databases

GenomeRNAii4286.

Gene expression databases

BgeeiENSG00000187098.

Family and domain databases

InterProiView protein in InterPro
IPR031867. MiT/TFE_N.
IPR030532. MITF.
PANTHERiPTHR12565:SF258. PTHR12565:SF258. 1 hit.
PfamiView protein in Pfam
PF15951. MITF_TFEB_C_3_N. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ8WYR3_HUMAN
AccessioniPrimary (citable) accession number: Q8WYR3
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: May 10, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.