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Protein
Submitted name:

Microphthalmia-associated transcription factor

Gene

MITF-C

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Microphthalmia-associated transcription factorImported
Submitted name:
Microphthalmia-associated transcription factor isoformImported
Gene namesi
Name:MITF-CImported
Synonyms:MITFImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:7105. MITF.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PeptideAtlasiQ8WYR3.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000295600.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 11763MITF_TFEB_C_3_NInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili59 – 8729Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1318. Eukaryota.
ENOG4110SME. LUCA.
GeneTreeiENSGT00390000004402.

Family and domain databases

InterProiIPR031867. MiT/TFE_N.
IPR030532. MITF.
[Graphical view]
PANTHERiPTHR12565:SF91. PTHR12565:SF91. 1 hit.
PfamiPF15951. MITF_TFEB_C_3_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8WYR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHLENTSVV FPRAIFSLCE KETRKLTLCL FSRSSSAEHP GASKPPISSS
60 70 80 90 100
SMTSRILLRQ QLMREQMQEQ ERREQQQKLQ AAQFMQQRVP VSQTPAINVS
110
VPTTLPSATQ VPMEVLK
Length:117
Mass (Da):13,196
Last modified:March 1, 2002 - v1
Checksum:iFEE41E3128219AE5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei117 – 1171Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC099326 Genomic DNA. No translation available.
AC104445 Genomic DNA. No translation available.
AC104449 Genomic DNA. No translation available.
AC124915 Genomic DNA. No translation available.
AB006988 mRNA. Translation: BAB83926.1.
RefSeqiNP_006713.1. NM_006722.2.
UniGeneiHs.166017.
Hs.618266.

Genome annotation databases

EnsembliENST00000457080; ENSP00000391276; ENSG00000187098.
GeneIDi4286.
UCSCiuc062lld.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC099326 Genomic DNA. No translation available.
AC104445 Genomic DNA. No translation available.
AC104449 Genomic DNA. No translation available.
AC124915 Genomic DNA. No translation available.
AB006988 mRNA. Translation: BAB83926.1.
RefSeqiNP_006713.1. NM_006722.2.
UniGeneiHs.166017.
Hs.618266.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000295600.

Proteomic databases

PeptideAtlasiQ8WYR3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000457080; ENSP00000391276; ENSG00000187098.
GeneIDi4286.
UCSCiuc062lld.1. human.

Organism-specific databases

CTDi4286.
HGNCiHGNC:7105. MITF.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1318. Eukaryota.
ENOG4110SME. LUCA.
GeneTreeiENSGT00390000004402.

Miscellaneous databases

GenomeRNAii4286.

Family and domain databases

InterProiIPR031867. MiT/TFE_N.
IPR030532. MITF.
[Graphical view]
PANTHERiPTHR12565:SF91. PTHR12565:SF91. 1 hit.
PfamiPF15951. MITF_TFEB_C_3_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of cDNA encoding a novel microphthalmia-associated transcription factor isoform with a distinct amino-terminus."
    Fuse N., Yasumoto K., Takeda K., Amae S., Yoshizawa M., Udono T., Takahashi K., Tamai M., Tomita Y., Tachibana M., Shibahara S.
    J. Biochem. 126:1043-1051(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: KidneyImported.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiQ8WYR3_HUMAN
AccessioniPrimary (citable) accession number: Q8WYR3
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: July 6, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.