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Protein
Submitted name:

Microphthalmia-associated transcription factor

Gene

MITF-C

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Microphthalmia-associated transcription factorImported
Submitted name:
Microphthalmia-associated transcription factor isoformImported
Gene namesi
Name:MITF-CImported
Synonyms:MITFImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000187098.14.
HGNCiHGNC:7105. MITF.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000187098.

PTM / Processingi

Proteomic databases

MaxQBiQ8WYR3.

Expressioni

Gene expression databases

BgeeiENSG00000187098.
ExpressionAtlasiQ8WYR3. baseline and differential.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 117MITF_TFEB_C_3_NInterPro annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili59 – 87Sequence analysisAdd BLAST29

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1318. Eukaryota.
ENOG4110SME. LUCA.
GeneTreeiENSGT00390000004402.

Family and domain databases

InterProiView protein in InterPro
IPR031867. MiT/TFE_N.
IPR030532. MITF.
PANTHERiPTHR12565:SF91. PTHR12565:SF91. 1 hit.
PfamiView protein in Pfam
PF15951. MITF_TFEB_C_3_N. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q8WYR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHLENTSVV FPRAIFSLCE KETRKLTLCL FSRSSSAEHP GASKPPISSS
60 70 80 90 100
SMTSRILLRQ QLMREQMQEQ ERREQQQKLQ AAQFMQQRVP VSQTPAINVS
110
VPTTLPSATQ VPMEVLK
Length:117
Mass (Da):13,196
Last modified:March 1, 2002 - v1
Checksum:iFEE41E3128219AE5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei117Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC099326 Genomic DNA. No translation available.
AC104445 Genomic DNA. No translation available.
AC104449 Genomic DNA. No translation available.
AC124915 Genomic DNA. No translation available.
AB006988 mRNA. Translation: BAB83926.1.
RefSeqiNP_006713.1. NM_006722.2.
UniGeneiHs.166017.
Hs.618266.

Genome annotation databases

EnsembliENST00000457080; ENSP00000391276; ENSG00000187098.
GeneIDi4286.
UCSCiuc062lld.1. human.

Similar proteinsi

Entry informationi

Entry nameiQ8WYR3_HUMAN
AccessioniPrimary (citable) accession number: Q8WYR3
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: November 22, 2017
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported