SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8WYR1

- PI3R5_HUMAN

UniProt

Q8WYR1 - PI3R5_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Phosphoinositide 3-kinase regulatory subunit 5
Gene
PIK3R5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG By similarity.

Enzyme regulationi

Greatly activated by G gamma proteins By similarity.

GO - Molecular functioni

  1. 1-phosphatidylinositol-3-kinase regulator activity Source: Ensembl
  2. G-protein beta/gamma-subunit complex binding Source: UniProtKB

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: UniProtKB
  2. blood coagulation Source: Reactome
  3. cell death Source: UniProtKB-KW
  4. phosphatidylinositol 3-kinase signaling Source: UniProtKB
  5. phosphatidylinositol biosynthetic process Source: Reactome
  6. phospholipid metabolic process Source: Reactome
  7. platelet activation Source: Reactome
  8. positive regulation of MAP kinase activity Source: UniProtKB
  9. positive regulation of protein kinase B signaling Source: UniProtKB
  10. small molecule metabolic process Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

BioCyciMetaCyc:HS13887-MONOMER.
ReactomeiREACT_121025. Synthesis of PIPs at the plasma membrane.
REACT_1695. GPVI-mediated activation cascade.
REACT_19290. G beta:gamma signalling through PI3Kgamma.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide 3-kinase regulatory subunit 5
Short name:
PI3-kinase regulatory subunit 5
Alternative name(s):
PI3-kinase p101 subunit
Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit
Short name:
PtdIns-3-kinase regulatory subunit
Protein FOAP-2
PtdIns-3-kinase p101
p101-PI3K
Gene namesi
Name:PIK3R5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:30035. PIK3R5.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. 1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. cytosol Source: Reactome
  4. membrane Source: UniProtKB
  5. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Involvement in diseasei

Ataxia-oculomotor apraxia 3 (AOA3) [MIM:615217]: An autosomal recessive disease characterized by cerebellar ataxia, oculomotor apraxia, areflexia and peripheral neuropathy.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti629 – 6291P → S in AOA3. 1 Publication
Corresponds to variant rs61761068 [ dbSNP | Ensembl ].
VAR_067052

Keywords - Diseasei

Disease mutation, Neurodegeneration

Organism-specific databases

MIMi615217. phenotype.
Orphaneti64753. Spinocerebellar ataxia with axonal neuropathy type 2.
PharmGKBiPA134890823.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 880880Phosphoinositide 3-kinase regulatory subunit 5
PRO_0000058421Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Modified residuei458 – 4581Phosphoserine1 Publication
Modified residuei507 – 5071Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8WYR1.
PaxDbiQ8WYR1.
PRIDEiQ8WYR1.

PTM databases

PhosphoSiteiQ8WYR1.

Expressioni

Tissue specificityi

Ubiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli.2 Publications

Gene expression databases

ArrayExpressiQ8WYR1.
BgeeiQ8WYR1.
CleanExiHS_PIK3R5.
GenevestigatoriQ8WYR1.

Organism-specific databases

HPAiHPA052247.

Interactioni

Subunit structurei

Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit. Interacts with beta-gamma G protein dimers.1 Publication

Protein-protein interaction databases

BioGridi117079. 5 interactions.
IntActiQ8WYR1. 6 interactions.
STRINGi9606.ENSP00000269300.

Structurei

3D structure databases

ProteinModelPortaliQ8WYR1.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 10177Heterodimerization By similarity
Add
BLAST
Regioni653 – 753101Interaction with beta-gamma G protein dimers By similarity
Add
BLAST

Domaini

The heterodimerization region allows the binding to the catalytic subunit.

Phylogenomic databases

eggNOGiNOG27692.
HOVERGENiHBG079651.
InParanoidiQ8WYR1.
KOiK02649.
OMAiTRAIKAS.
OrthoDBiEOG7RV9FH.
PhylomeDBiQ8WYR1.
TreeFamiTF102035.

Family and domain databases

InterProiIPR019522. PIK3R5/6.
[Graphical view]
PfamiPF10486. PI3K_1B_p101. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8WYR1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MQPGATTCTE DRIQHALERC LHGLSLSRRS TSWSAGLCLN CWSLQELVSR    50
DPGHFLILLE QILQKTREVQ EKGTYDLLTP LALLFYSTVL CTPHFPPDSD 100
LLLKAASTYH RFLTWPVPYC SICQELLTFI DAELKAPGIS YQRLVRAEQG 150
LPIRSHRSST VTVLLLNPVE VQAEFLAVAN KLSTPGHSPH SAYTTLLLHA 200
FQATFGAHCD VPGLHCRLQA KTLAELEDIF TETAEAQELA SGIGDAAEAR 250
RWLRTKLQAV GEKAGFPGVL DTAKPGKLHT IPIPVARCYT YSWSQDSFDI 300
LQEILLKEQE LLQPGILGDD EEEEEEEEEV EEDLETDGHC AERDSLLSTS 350
SLASHDSTLS LASSQASGPA LSRHLLTSFV SGLSDGMDSG YVEDSEESSS 400
EWPWRRGSQE RRGHRRPGQK FIRIYKLFKS TSQLVLRRDS RSLEGSSDTA 450
LPLRRAGSLC SPLDEPVSPP SRAQRSRSLP QPKLGTQLPS WLLAPASRPQ 500
RRRPFLSGDE DPKASTLRVV VFGSDRISGK VARAYSNLRR LENNRPLLTR 550
FFKLQFFYVP VKRSHGTSPG ACPPPRSQTP SPPTDSPRHA SPGELGTTPW 600
EESTNDISHY LGMLDPWYER NVLGLMHLPP EVLCQQSLKA EAQALEGSPT 650
QLPILADMLL YYCRFAARPV LLQVYQTELT FITGEKTTEI FIHSLELGHS 700
AATRAIKASG PGSKRLGIDG DREAVPLTLQ IIYSKGAISG RSRWSNLEKV 750
CTSVNLNKAC RKQEELDSSM EALTLNLTEV VKRQNSKSKK GFNQISTSQI 800
KVDKVQIIGS NSCPFAVCLD QDERKILQSV VRCEVSPCYK PEKSDLSSPP 850
QTPPDLPAQA APDLCSLLCL PIMTFSGALP 880
Length:880
Mass (Da):97,348
Last modified:March 1, 2002 - v1
Checksum:i70E356773B148A8A
GO
Isoform 2 (identifier: Q8WYR1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-386: Missing.

Note: No experimental confirmation available.

Show »
Length:494
Mass (Da):54,878
Checksum:iC8962DD01304C8C3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti28 – 281R → C in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036227
Natural varianti629 – 6291P → S in AOA3. 1 Publication
Corresponds to variant rs61761068 [ dbSNP | Ensembl ].
VAR_067052

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 386386Missing in isoform 2.
VSP_016388Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 151H → L in AAW63122. 1 Publication
Sequence conflicti29 – 291R → C in AAW63122. 1 Publication
Sequence conflicti47 – 471L → Q in AAW63122. 1 Publication
Sequence conflicti95 – 951F → L in AAW63122. 1 Publication
Sequence conflicti171 – 1711V → E in AAW63122. 1 Publication
Sequence conflicti220 – 29778AKTLA…WSQDS → TLQNQGSSIPSPSLSPGATP TAGARTALTSCRKSCSRNRS CSSQGSWEMMKRRKRRRRRW RRTWKLMGTVPREIPCSP in AAW63122. 1 Publication
Add
BLAST
Sequence conflicti299 – 36870DILQE…SQASG → GNIEGDPGPRRPDSAGLASL QTSCRKSCSRNRSYSSQGSW EMMKRRERRRRRWRRTWKLT GTVPREIPCS in AAW63121. 1 Publication
Add
BLAST
Sequence conflicti674 – 6741V → L in AAD33397. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB028925 mRNA. Translation: BAB82464.1.
AF128881 mRNA. Translation: AAD33397.1.
EU332864 Genomic DNA. Translation: ABY87553.1.
CH471108 Genomic DNA. Translation: EAW90035.1.
CH471108 Genomic DNA. Translation: EAW90036.1.
BC028212 mRNA. Translation: AAH28212.1.
AY725851 mRNA. Translation: AAW63121.1.
AY725852 mRNA. Translation: AAW63122.1.
AY725853 mRNA. Translation: AAW63123.1.
AY725854 mRNA. Translation: AAW63124.1.
CCDSiCCDS11147.1. [Q8WYR1-1]
RefSeqiNP_001136105.1. NM_001142633.2. [Q8WYR1-1]
NP_001238780.1. NM_001251851.1. [Q8WYR1-2]
NP_001238781.1. NM_001251852.1. [Q8WYR1-2]
NP_001238782.1. NM_001251853.1. [Q8WYR1-2]
NP_001238784.1. NM_001251855.1. [Q8WYR1-2]
NP_055123.2. NM_014308.3. [Q8WYR1-1]
XP_005256636.1. XM_005256579.2. [Q8WYR1-1]
UniGeneiHs.278901.
Hs.738684.

Genome annotation databases

EnsembliENST00000447110; ENSP00000392812; ENSG00000141506. [Q8WYR1-1]
ENST00000581552; ENSP00000462433; ENSG00000141506. [Q8WYR1-1]
GeneIDi23533.
KEGGihsa:23533.
UCSCiuc002glt.3. human. [Q8WYR1-1]

Polymorphism databases

DMDMi74716480.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB028925 mRNA. Translation: BAB82464.1 .
AF128881 mRNA. Translation: AAD33397.1 .
EU332864 Genomic DNA. Translation: ABY87553.1 .
CH471108 Genomic DNA. Translation: EAW90035.1 .
CH471108 Genomic DNA. Translation: EAW90036.1 .
BC028212 mRNA. Translation: AAH28212.1 .
AY725851 mRNA. Translation: AAW63121.1 .
AY725852 mRNA. Translation: AAW63122.1 .
AY725853 mRNA. Translation: AAW63123.1 .
AY725854 mRNA. Translation: AAW63124.1 .
CCDSi CCDS11147.1. [Q8WYR1-1 ]
RefSeqi NP_001136105.1. NM_001142633.2. [Q8WYR1-1 ]
NP_001238780.1. NM_001251851.1. [Q8WYR1-2 ]
NP_001238781.1. NM_001251852.1. [Q8WYR1-2 ]
NP_001238782.1. NM_001251853.1. [Q8WYR1-2 ]
NP_001238784.1. NM_001251855.1. [Q8WYR1-2 ]
NP_055123.2. NM_014308.3. [Q8WYR1-1 ]
XP_005256636.1. XM_005256579.2. [Q8WYR1-1 ]
UniGenei Hs.278901.
Hs.738684.

3D structure databases

ProteinModelPortali Q8WYR1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117079. 5 interactions.
IntActi Q8WYR1. 6 interactions.
STRINGi 9606.ENSP00000269300.

Chemistry

BindingDBi Q8WYR1.

PTM databases

PhosphoSitei Q8WYR1.

Polymorphism databases

DMDMi 74716480.

Proteomic databases

MaxQBi Q8WYR1.
PaxDbi Q8WYR1.
PRIDEi Q8WYR1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000447110 ; ENSP00000392812 ; ENSG00000141506 . [Q8WYR1-1 ]
ENST00000581552 ; ENSP00000462433 ; ENSG00000141506 . [Q8WYR1-1 ]
GeneIDi 23533.
KEGGi hsa:23533.
UCSCi uc002glt.3. human. [Q8WYR1-1 ]

Organism-specific databases

CTDi 23533.
GeneCardsi GC17M008724.
H-InvDB HIX0027111.
HGNCi HGNC:30035. PIK3R5.
HPAi HPA052247.
MIMi 611317. gene.
615217. phenotype.
neXtProti NX_Q8WYR1.
Orphaneti 64753. Spinocerebellar ataxia with axonal neuropathy type 2.
PharmGKBi PA134890823.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG27692.
HOVERGENi HBG079651.
InParanoidi Q8WYR1.
KOi K02649.
OMAi TRAIKAS.
OrthoDBi EOG7RV9FH.
PhylomeDBi Q8WYR1.
TreeFami TF102035.

Enzyme and pathway databases

BioCyci MetaCyc:HS13887-MONOMER.
Reactomei REACT_121025. Synthesis of PIPs at the plasma membrane.
REACT_1695. GPVI-mediated activation cascade.
REACT_19290. G beta:gamma signalling through PI3Kgamma.

Miscellaneous databases

ChiTaRSi PIK3R5. human.
GeneWikii PIK3R5.
GenomeRNAii 23533.
NextBioi 46026.
PROi Q8WYR1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8WYR1.
Bgeei Q8WYR1.
CleanExi HS_PIK3R5.
Genevestigatori Q8WYR1.

Family and domain databases

InterProi IPR019522. PIK3R5/6.
[Graphical view ]
Pfami PF10486. PI3K_1B_p101. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a human novel gene, FOAP-2, which are highly expressed in macrophages."
    Yazaki M., Fujii Y., Tsuritani K., Yajima Y., Amemiya T., Ukai Y., Naito K., Kawaguchi A., Takayama K.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "G-beta gamma regulated phosphatidylinositol 3-kinase."
    Stephens L., Hawkins P.T., Braselmann S.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. SeattleSNPs variation discovery resource
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Blood.
  6. "Identification of alternative transcripts of human P101-PI3K."
    Reichwald K., Gausmann U., Karagyozov L., Platzer M.
    Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-369 (ISOFORM 1).
    Tissue: Peripheral blood leukocyte and Spleen.
  7. "p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma."
    Suire S., Coadwell J., Ferguson G.J., Davidson K., Hawkins P., Stephens L.
    Curr. Biol. 15:566-570(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PIK3CG, TISSUE SPECIFICITY.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-458 AND SER-507, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: TISSUE SPECIFICITY, VARIANT AOA3 SER-629.
  10. Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-28.

Entry informationi

Entry nameiPI3R5_HUMAN
AccessioniPrimary (citable) accession number: Q8WYR1
Secondary accession number(s): B0LPH4
, D3DTS3, Q5G936, Q5G938, Q5G939, Q8IZ23, Q9Y2Y2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2002
Last modified: September 3, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi