Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphoinositide 3-kinase regulatory subunit 5

Gene

PIK3R5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity).By similarity

Enzyme regulationi

Greatly activated by G gamma proteins.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BioCyciMetaCyc:HS13887-MONOMER
ReactomeiR-HSA-114604 GPVI-mediated activation cascade
R-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-392451 G beta:gamma signalling through PI3Kgamma

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide 3-kinase regulatory subunit 5
Short name:
PI3-kinase regulatory subunit 5
Alternative name(s):
PI3-kinase p101 subunit
Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit
Short name:
PtdIns-3-kinase regulatory subunit
Protein FOAP-2
PtdIns-3-kinase p101
p101-PI3K
Gene namesi
Name:PIK3R5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000141506.13
HGNCiHGNC:30035 PIK3R5
MIMi611317 gene
neXtProtiNX_Q8WYR1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Involvement in diseasei

Ataxia-oculomotor apraxia 3 (AOA3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disease characterized by cerebellar ataxia, oculomotor apraxia, areflexia and peripheral neuropathy.
See also OMIM:615217
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_067052629P → S in AOA3. 1 PublicationCorresponds to variant dbSNP:rs61761068EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Neurodegeneration

Organism-specific databases

DisGeNETi23533
MalaCardsiPIK3R5
MIMi615217 phenotype
OpenTargetsiENSG00000141506
Orphaneti64753 Spinocerebellar ataxia with axonal neuropathy type 2
PharmGKBiPA134890823

Chemistry databases

ChEMBLiCHEMBL3559703

Polymorphism and mutation databases

BioMutaiPIK3R5
DMDMi74716480

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000584211 – 880Phosphoinositide 3-kinase regulatory subunit 5Add BLAST880

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei458PhosphoserineCombined sources1
Modified residuei507PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8WYR1
PaxDbiQ8WYR1
PeptideAtlasiQ8WYR1
PRIDEiQ8WYR1

PTM databases

iPTMnetiQ8WYR1
PhosphoSitePlusiQ8WYR1

Expressioni

Tissue specificityi

Ubiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli.2 Publications

Gene expression databases

BgeeiENSG00000141506
CleanExiHS_PIK3R5
ExpressionAtlasiQ8WYR1 baseline and differential
GenevisibleiQ8WYR1 HS

Organism-specific databases

HPAiHPA044505
HPA052247
HPA052412

Interactioni

Subunit structurei

Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit. Interacts with beta-gamma G protein dimers.1 Publication

Protein-protein interaction databases

BioGridi117079, 6 interactors
IntActiQ8WYR1, 7 interactors
STRINGi9606.ENSP00000392812

Chemistry databases

BindingDBiQ8WYR1

Structurei

3D structure databases

ProteinModelPortaliQ8WYR1
SMRiQ8WYR1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 101HeterodimerizationBy similarityAdd BLAST77
Regioni653 – 753Interaction with beta-gamma G protein dimersBy similarityAdd BLAST101

Domaini

The heterodimerization region allows the binding to the catalytic subunit.

Phylogenomic databases

eggNOGiENOG410IES2 Eukaryota
ENOG410Y2ZG LUCA
GeneTreeiENSGT00530000063753
HOVERGENiHBG079651
InParanoidiQ8WYR1
KOiK21290
OMAiEDRIQHA
OrthoDBiEOG091G01F0
PhylomeDBiQ8WYR1
TreeFamiTF102035

Family and domain databases

InterProiView protein in InterPro
IPR019522 PIK3R5/6
PfamiView protein in Pfam
PF10486 PI3K_1B_p101, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WYR1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQPGATTCTE DRIQHALERC LHGLSLSRRS TSWSAGLCLN CWSLQELVSR
60 70 80 90 100
DPGHFLILLE QILQKTREVQ EKGTYDLLTP LALLFYSTVL CTPHFPPDSD
110 120 130 140 150
LLLKAASTYH RFLTWPVPYC SICQELLTFI DAELKAPGIS YQRLVRAEQG
160 170 180 190 200
LPIRSHRSST VTVLLLNPVE VQAEFLAVAN KLSTPGHSPH SAYTTLLLHA
210 220 230 240 250
FQATFGAHCD VPGLHCRLQA KTLAELEDIF TETAEAQELA SGIGDAAEAR
260 270 280 290 300
RWLRTKLQAV GEKAGFPGVL DTAKPGKLHT IPIPVARCYT YSWSQDSFDI
310 320 330 340 350
LQEILLKEQE LLQPGILGDD EEEEEEEEEV EEDLETDGHC AERDSLLSTS
360 370 380 390 400
SLASHDSTLS LASSQASGPA LSRHLLTSFV SGLSDGMDSG YVEDSEESSS
410 420 430 440 450
EWPWRRGSQE RRGHRRPGQK FIRIYKLFKS TSQLVLRRDS RSLEGSSDTA
460 470 480 490 500
LPLRRAGSLC SPLDEPVSPP SRAQRSRSLP QPKLGTQLPS WLLAPASRPQ
510 520 530 540 550
RRRPFLSGDE DPKASTLRVV VFGSDRISGK VARAYSNLRR LENNRPLLTR
560 570 580 590 600
FFKLQFFYVP VKRSHGTSPG ACPPPRSQTP SPPTDSPRHA SPGELGTTPW
610 620 630 640 650
EESTNDISHY LGMLDPWYER NVLGLMHLPP EVLCQQSLKA EAQALEGSPT
660 670 680 690 700
QLPILADMLL YYCRFAARPV LLQVYQTELT FITGEKTTEI FIHSLELGHS
710 720 730 740 750
AATRAIKASG PGSKRLGIDG DREAVPLTLQ IIYSKGAISG RSRWSNLEKV
760 770 780 790 800
CTSVNLNKAC RKQEELDSSM EALTLNLTEV VKRQNSKSKK GFNQISTSQI
810 820 830 840 850
KVDKVQIIGS NSCPFAVCLD QDERKILQSV VRCEVSPCYK PEKSDLSSPP
860 870 880
QTPPDLPAQA APDLCSLLCL PIMTFSGALP
Length:880
Mass (Da):97,348
Last modified:March 1, 2002 - v1
Checksum:i70E356773B148A8A
GO
Isoform 2 (identifier: Q8WYR1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-386: Missing.

Note: No experimental confirmation available.
Show »
Length:494
Mass (Da):54,878
Checksum:iC8962DD01304C8C3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15H → L in AAW63122 (Ref. 6) Curated1
Sequence conflicti29R → C in AAW63122 (Ref. 6) Curated1
Sequence conflicti47L → Q in AAW63122 (Ref. 6) Curated1
Sequence conflicti95F → L in AAW63122 (Ref. 6) Curated1
Sequence conflicti171V → E in AAW63122 (Ref. 6) Curated1
Sequence conflicti220 – 297AKTLA…WSQDS → TLQNQGSSIPSPSLSPGATP TAGARTALTSCRKSCSRNRS CSSQGSWEMMKRRKRRRRRW RRTWKLMGTVPREIPCSP in AAW63122 (Ref. 6) CuratedAdd BLAST78
Sequence conflicti299 – 368DILQE…SQASG → GNIEGDPGPRRPDSAGLASL QTSCRKSCSRNRSYSSQGSW EMMKRRERRRRRWRRTWKLT GTVPREIPCS in AAW63121 (Ref. 6) CuratedAdd BLAST70
Sequence conflicti674V → L in AAD33397 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03622728R → C in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs371789171Ensembl.1
Natural variantiVAR_067052629P → S in AOA3. 1 PublicationCorresponds to variant dbSNP:rs61761068EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0163881 – 386Missing in isoform 2. 1 PublicationAdd BLAST386

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028925 mRNA Translation: BAB82464.1
AF128881 mRNA Translation: AAD33397.1
EU332864 Genomic DNA Translation: ABY87553.1
CH471108 Genomic DNA Translation: EAW90035.1
CH471108 Genomic DNA Translation: EAW90036.1
BC028212 mRNA Translation: AAH28212.1
AY725851 mRNA Translation: AAW63121.1
AY725852 mRNA Translation: AAW63122.1
AY725853 mRNA Translation: AAW63123.1
AY725854 mRNA Translation: AAW63124.1
CCDSiCCDS11147.1 [Q8WYR1-1]
CCDS73986.1 [Q8WYR1-2]
RefSeqiNP_001136105.1, NM_001142633.2 [Q8WYR1-1]
NP_001238780.1, NM_001251851.1 [Q8WYR1-2]
NP_001238781.1, NM_001251852.1 [Q8WYR1-2]
NP_001238782.1, NM_001251853.1 [Q8WYR1-2]
NP_001238784.1, NM_001251855.1 [Q8WYR1-2]
NP_055123.2, NM_014308.3 [Q8WYR1-1]
UniGeneiHs.278901
Hs.738684

Genome annotation databases

EnsembliENST00000447110; ENSP00000392812; ENSG00000141506 [Q8WYR1-1]
ENST00000581552; ENSP00000462433; ENSG00000141506 [Q8WYR1-1]
ENST00000611902; ENSP00000477795; ENSG00000141506 [Q8WYR1-2]
ENST00000616147; ENSP00000484211; ENSG00000141506 [Q8WYR1-2]
ENST00000623421; ENSP00000485280; ENSG00000141506 [Q8WYR1-2]
GeneIDi23533
KEGGihsa:23533
UCSCiuc002glt.4 human [Q8WYR1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPI3R5_HUMAN
AccessioniPrimary (citable) accession number: Q8WYR1
Secondary accession number(s): B0LPH4
, D3DTS3, Q5G936, Q5G938, Q5G939, Q8IZ23, Q9Y2Y2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health