Q8WYQ4 (CV015_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein C22orf15

Alternative name(s):
Protein N27C7-3

Gene names

Name:

C22orf15

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	148 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8WYQ4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8WYQ4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     84-84: K → SKVAQE
     109-148: EELRRLSGLSSVGHNWRKRMGTRRGRHEQSPTSRPRKGPD → GANRQQPSRTPLAESGIAEKLHQQEGQGP

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 148	148	Uncharacterized protein C22orf15		PRO_0000079576
Natural variations
	Alternative sequence	84	1	K → SKVAQE in isoform 2.		VSP_014462
	Alternative sequence	109 – 148	40	EELRR…RKGPD → GANRQQPSRTPLAESGIAEK LHQQEGQGP in isoform 2.		VSP_014463

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 6DDF102E8B3DAC47	FASTA	148	16,487
	10 20 30 40 50 60 MFIKVMFGAG CSVLVNTSCR LVNLTAHLRQ KAGLPPDATI ALLAEDGNLV SLEEDLKEGA 70 80 90 100 110 120 SRAQTMGNSL LKERAIYVLV RIIKGEDMAS TRYESLLENL DDHYPELAEE LRRLSGLSSV 130 140 GHNWRKRMGT RRGRHEQSPT SRPRKGPD
	Isoform 2 [UniParc]. Checksum: 746D8A957B1B95A3	FASTA	142	15,418
	10 20 30 40 50 60 MFIKVMFGAG CSVLVNTSCR LVNLTAHLRQ KAGLPPDATI ALLAEDGNLV SLEEDLKEGA 70 80 90 100 110 120 SRAQTMGNSL LKERAIYVLV RIISKVAQEG EDMASTRYES LLENLDDHYP ELAGANRQQP 130 140 SRTPLAESGI AEKLHQQEGQ GP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of N27C7-3 gene." Shimizu N., Minosima S., Kawasaki K., Sasaki T., Hosono K. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[2]	"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:R84.1-R84.11(2004) [PubMed: 15461802] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed: 10591208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB050773 Genomic DNA. Translation: BAB83035.1. CR456371 mRNA. Translation: CAG30257.1. AP000348 Genomic DNA. No translation available. AP000349 Genomic DNA. No translation available.
IPI	IPI00103766. IPI00607803.
RefSeq	NP_872326.2. NM_182520.2.
UniGene	Hs.116254.
3D structure databases
ProteinModelPortal	Q8WYQ4.
ModBase	Search...
Polymorphism databases
DMDM	68565600.
Proteomic databases
PRIDE	Q8WYQ4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000402217; ENSP00000384965; ENSG00000169314.
GeneID	150248.
KEGG	hsa:150248.
UCSC	uc002zxu.1. human.
Organism-specific databases
CTD	150248.
GeneCards	GC22P024105.
HGNC	HGNC:15558. C22orf15.
HPA	HPA018006. HPA019494.
neXtProt	NX_Q8WYQ4.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000015147.
HOVERGEN	HBG081379.
OMA	EQGPPSR.
OrthoDB	EOG4B2SZP.
PhylomeDB	Q8WYQ4.
Gene expression databases
ArrayExpress	Q8WYQ4.
Bgee	Q8WYQ4.
CleanEx	HS_C22orf15.
Genevestigator	Q8WYQ4.
GermOnline	ENSG00000169314. Homo sapiens.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

CV015_HUMAN

Accession

Primary (citable) accession number: Q8WYQ4
Secondary accession number(s): Q6ICJ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.