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Protein

Cysteine/serine-rich nuclear protein 3

Gene

CSRNP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity. Plays a role in apoptosis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine/serine-rich nuclear protein 3
Short name:
CSRNP-3
Alternative name(s):
Protein FAM130A2
TGF-beta-induced apoptosis protein 2
Short name:
TAIP-2
Gene namesi
Name:CSRNP3
Synonyms:FAM130A2, TAIP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:30729. CSRNP3.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164718184.

Polymorphism and mutation databases

BioMutaiCSRNP3.
DMDMi24418715.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 585585Cysteine/serine-rich nuclear protein 3PRO_0000114788Add
BLAST

Proteomic databases

PaxDbiQ8WYN3.
PeptideAtlasiQ8WYN3.
PRIDEiQ8WYN3.

PTM databases

iPTMnetiQ8WYN3.
PhosphoSiteiQ8WYN3.

Expressioni

Gene expression databases

BgeeiQ8WYN3.
ExpressionAtlasiQ8WYN3. baseline and differential.
GenevisibleiQ8WYN3. HS.

Organism-specific databases

HPAiHPA017905.

Interactioni

Protein-protein interaction databases

BioGridi123083. 1 interaction.
IntActiQ8WYN3. 1 interaction.
STRINGi9606.ENSP00000318258.

Structurei

3D structure databases

ProteinModelPortaliQ8WYN3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi15 – 5238Ser-richAdd
BLAST
Compositional biasi212 – 25039Cys-richAdd
BLAST
Compositional biasi318 – 38366Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the AXUD1 family.Curated

Phylogenomic databases

eggNOGiKOG3813. Eukaryota.
ENOG410XREB. LUCA.
GeneTreeiENSGT00390000015510.
HOGENOMiHOG000039987.
HOVERGENiHBG067792.
InParanoidiQ8WYN3.
KOiK17494.
OrthoDBiEOG7W6WM4.
PhylomeDBiQ8WYN3.
TreeFamiTF323969.

Family and domain databases

InterProiIPR031972. CSRNP_N.
IPR023260. Cys/Ser-rich_nuc_prot.
[Graphical view]
PANTHERiPTHR13580. PTHR13580. 1 hit.
PfamiPF16019. CSRNP_N. 1 hit.
[Graphical view]
PRINTSiPR02031. CYSSERRICHNP.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WYN3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGILKRKFE EVDGSSPCSS VRESDDEVSS SESADSGDSV NPSTSSHFTP
60 70 80 90 100
SSILKREKRL RTKNVHFSCV TVYYFTRRQG FTSVPSQGGS TLGMSSRHNS
110 120 130 140 150
VRQYTLGEFA REQERLHREM LREHLREEKL NSLKLKMTKN GTVESEEAST
160 170 180 190 200
LTLDDISDDD IDLDNTEVDE YFFLQPLPTK KRRALLRASG VKKIDVEEKH
210 220 230 240 250
ELRAIRLSRE DCGCDCRVFC DPDTCTCSLA GIKCQVDRMS FPCGCTKEGC
260 270 280 290 300
SNTAGRIEFN PIRVRTHFLH TIMKLELEKN REQQIPTLNG CHSEISAHSS
310 320 330 340 350
SMGPVAHSVE YSIADSFEIE TEPQAAVLHL QSAEELDCQG EEEEEEEDGS
360 370 380 390 400
SFCSGVTDSS TQSLAPSESD EEEEEEEEEE EEEDDDDDKG DGFVEGLGTH
410 420 430 440 450
AEVVPLPSVL CYSDGTAVHE SHAKNASFYA NSSTLYYQID SHIPGTPNQI
460 470 480 490 500
SENYSERDTV KNGTLSLVPY TMTPEQFVDY ARQAEEAYGA SHYPAANPSV
510 520 530 540 550
IVCCSSSEND SGVPCNSLYP EHRSNHPQVE FHSYLKGPSQ EGFVSALNGD
560 570 580
SHISEHPAEN SLSLAEKSIL HEECIKSPVV ETVPV
Length:585
Mass (Da):64,900
Last modified:March 1, 2002 - v1
Checksum:i3CA2E6A0CCFD01CB
GO
Isoform 2 (identifier: Q8WYN3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRSQGTCDSTAA
     439-508: Missing.

Note: No experimental confirmation available.
Show »
Length:526
Mass (Da):58,358
Checksum:i75810212B3DE1A8E
GO

Sequence cautioni

The sequence BAB13890.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC86454.1 differs from that shown.Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.Curated
The sequence BAC86454.1 differs from that shown. Reason: Frameshift at position 180. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti474 – 4741P → L in a colorectal cancer sample; somatic mutation. 1 Publication
Corresponds to variant rs766623860 [ dbSNP | Ensembl ].
VAR_035993

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MRSQGTCDSTAA in isoform 2. 1 PublicationVSP_034258
Alternative sequencei439 – 50870Missing in isoform 2. 1 PublicationVSP_034259Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB063300 mRNA. Translation: BAB79449.1.
AK021765 mRNA. Translation: BAB13890.1. Different initiation.
AK056655 mRNA. Translation: BAG51776.1.
AK126129 mRNA. Translation: BAC86454.1. Frameshift.
AC019140 Genomic DNA. Translation: AAY24139.1.
CH471058 Genomic DNA. Translation: EAX11326.1.
CCDSiCCDS2225.1. [Q8WYN3-1]
RefSeqiNP_001165644.1. NM_001172173.1. [Q8WYN3-1]
NP_079245.2. NM_024969.3. [Q8WYN3-1]
UniGeneiHs.470479.

Genome annotation databases

EnsembliENST00000314499; ENSP00000318258; ENSG00000178662. [Q8WYN3-1]
ENST00000342316; ENSP00000344042; ENSG00000178662. [Q8WYN3-1]
GeneIDi80034.
KEGGihsa:80034.
UCSCiuc002udf.3. human. [Q8WYN3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB063300 mRNA. Translation: BAB79449.1.
AK021765 mRNA. Translation: BAB13890.1. Different initiation.
AK056655 mRNA. Translation: BAG51776.1.
AK126129 mRNA. Translation: BAC86454.1. Frameshift.
AC019140 Genomic DNA. Translation: AAY24139.1.
CH471058 Genomic DNA. Translation: EAX11326.1.
CCDSiCCDS2225.1. [Q8WYN3-1]
RefSeqiNP_001165644.1. NM_001172173.1. [Q8WYN3-1]
NP_079245.2. NM_024969.3. [Q8WYN3-1]
UniGeneiHs.470479.

3D structure databases

ProteinModelPortaliQ8WYN3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123083. 1 interaction.
IntActiQ8WYN3. 1 interaction.
STRINGi9606.ENSP00000318258.

PTM databases

iPTMnetiQ8WYN3.
PhosphoSiteiQ8WYN3.

Polymorphism and mutation databases

BioMutaiCSRNP3.
DMDMi24418715.

Proteomic databases

PaxDbiQ8WYN3.
PeptideAtlasiQ8WYN3.
PRIDEiQ8WYN3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314499; ENSP00000318258; ENSG00000178662. [Q8WYN3-1]
ENST00000342316; ENSP00000344042; ENSG00000178662. [Q8WYN3-1]
GeneIDi80034.
KEGGihsa:80034.
UCSCiuc002udf.3. human. [Q8WYN3-1]

Organism-specific databases

CTDi80034.
GeneCardsiCSRNP3.
HGNCiHGNC:30729. CSRNP3.
HPAiHPA017905.
neXtProtiNX_Q8WYN3.
PharmGKBiPA164718184.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3813. Eukaryota.
ENOG410XREB. LUCA.
GeneTreeiENSGT00390000015510.
HOGENOMiHOG000039987.
HOVERGENiHBG067792.
InParanoidiQ8WYN3.
KOiK17494.
OrthoDBiEOG7W6WM4.
PhylomeDBiQ8WYN3.
TreeFamiTF323969.

Miscellaneous databases

ChiTaRSiCSRNP3. human.
GenomeRNAii80034.
PROiQ8WYN3.

Gene expression databases

BgeeiQ8WYN3.
ExpressionAtlasiQ8WYN3. baseline and differential.
GenevisibleiQ8WYN3. HS.

Family and domain databases

InterProiIPR031972. CSRNP_N.
IPR023260. Cys/Ser-rich_nuc_prot.
[Graphical view]
PANTHERiPTHR13580. PTHR13580. 1 hit.
PfamiPF16019. CSRNP_N. 1 hit.
[Graphical view]
PRINTSiPR02031. CYSSERRICHNP.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "TGF-beta induced apoptosis protein 2 (TAIP-2)."
    Akiyama N., Kondoh S.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain, Embryo and Thymus.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-474.

Entry informationi

Entry nameiCSRN3_HUMAN
AccessioniPrimary (citable) accession number: Q8WYN3
Secondary accession number(s): B3KPR4
, Q53SG0, Q6ZTX3, Q9HAF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: March 1, 2002
Last modified: July 6, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.