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Protein

Protein phosphatase Slingshot homolog 1

Gene

SSH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.10 Publications

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei393Phosphocysteine intermediateCurated1

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • DNA binding Source: InterPro
  • phosphoprotein phosphatase activity Source: UniProtKB
  • protein tyrosine/serine/threonine phosphatase activity Source: InterPro
  • protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  • actin cytoskeleton organization Source: UniProtKB
  • cell morphogenesis Source: UniProtKB
  • cellular response to ATP Source: MGI
  • protein dephosphorylation Source: UniProtKB
  • regulation of actin polymerization or depolymerization Source: GO_Central
  • regulation of axonogenesis Source: GO_Central
  • regulation of cellular protein metabolic process Source: MGI
  • regulation of lamellipodium assembly Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

BioCyciZFISH:HS01467-MONOMER.
SIGNORiQ8WYL5.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase Slingshot homolog 1 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
SSH-like protein 1
Short name:
SSH-1L
Short name:
hSSH-1L
Gene namesi
Name:SSH1
Synonyms:KIAA1298, SSH1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:30579. SSH1.

Subcellular locationi

GO - Cellular componenti

  • cleavage furrow Source: UniProtKB-SubCell
  • cytoplasm Source: UniProtKB
  • cytoskeleton Source: UniProtKB-SubCell
  • lamellipodium Source: UniProtKB-SubCell
  • midbody Source: UniProtKB-SubCell
  • nucleoplasm Source: HPA
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi393C → S: Abrogates phosphatase activity. 8 Publications1
Mutagenesisi458W → A: Impairs stimulation of phosphatase activity by actin but does not affect basal activity. 1 Publication1
Mutagenesisi937S → A: Reduces binding to YWHAB, YWHAG, YWHAQ and YWHAZ. Abolishes binding to YWHAB, YWHAG, YWHAQ and YWHAZ and increases association with F-actin; when associated with A-978. 1 Publication1
Mutagenesisi978S → A: Reduces binding to YWHAB, YWHAG, YWHAQ and YWHAZ. Abolishes binding to YWHAB, YWHAG, YWHAQ and YWHAZ and increases association with F-actin; when associated with A-937. 1 Publication1

Organism-specific databases

DisGeNETi54434.
OpenTargetsiENSG00000084112.
PharmGKBiPA134941788.

Polymorphism and mutation databases

BioMutaiSSH1.
DMDMi82582267.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000948412 – 1049Protein phosphatase Slingshot homolog 1Add BLAST1048

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei37PhosphoserineCombined sources1
Modified residuei57PhosphoserineCombined sources1
Modified residuei515PhosphoserineBy similarity1
Modified residuei576PhosphoserineCombined sources1
Modified residuei897PhosphoserineCombined sources1
Modified residuei978Phosphoserine1 Publication1

Post-translational modificationi

Phosphorylated. Inhibitory phosphorylation by PAK4 promotes binding to YWHAZ. Phosphorylation at Ser-978 is decreased by stimuli which promote actin reorganization and lamellipodia formation. Can be dephosphorylated and activated by PPP3CA/calcineurin A. Phosphorylation decreases immediately prior to telophase.4 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8WYL5.
MaxQBiQ8WYL5.
PaxDbiQ8WYL5.
PeptideAtlasiQ8WYL5.
PRIDEiQ8WYL5.

PTM databases

DEPODiQ8WYL5.
iPTMnetiQ8WYL5.
PhosphoSitePlusiQ8WYL5.

Expressioni

Gene expression databases

BgeeiENSG00000084112.
CleanExiHS_SSH1.
ExpressionAtlasiQ8WYL5. baseline and differential.
GenevisibleiQ8WYL5. HS.

Organism-specific databases

HPAiHPA019845.

Interactioni

Subunit structurei

Interacts with actin and this stimulates phosphatase activity. Also interacts with LIMK1 and with the 14-3-3 proteins YWHAB, YWHAG, YWHAQ, and YWHAZ. Interaction with 14-3-3 proteins inhibits phosphatase activity and also blocks recruitment to lamellipodia and stimulation by actin.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CFL1P235282EBI-1222387,EBI-352733
CORO1BQ9BR763EBI-1222387,EBI-351152
LIMK1P536677EBI-1222387,EBI-444403
YWHABP319463EBI-1222387,EBI-359815
YWHAQP273482EBI-1222387,EBI-359854

GO - Molecular functioni

  • actin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi119950. 14 interactors.
IntActiQ8WYL5. 13 interactors.
MINTiMINT-1788740.
STRINGi9606.ENSP00000315713.

Structurei

3D structure databases

ProteinModelPortaliQ8WYL5.
SMRiQ8WYL5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini308 – 448Tyrosine-protein phosphataseAdd BLAST141

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni897 – 1049Interaction with YWHAG1 PublicationAdd BLAST153

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1716. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00760000118902.
HOGENOMiHOG000154427.
HOVERGENiHBG094001.
InParanoidiQ8WYL5.
KOiK05766.
OMAiNSHCDKN.
OrthoDBiEOG091G0249.
PhylomeDBiQ8WYL5.
TreeFamiTF319444.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di1.10.10.60. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR014876. DEK_C.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR009057. Homeodomain-like.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR027233. SSH1.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PTHR10159:SF138. PTHR10159:SF138. 1 hit.
PfamiPF08766. DEK_C. 1 hit.
PF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WYL5-1) [UniParc]FASTAAdd to basket
Also known as: L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALVTLQRSP TPSAASSSAS NSELEAGSEE DRKLNLSLSE SFFMVKGAAL
60 70 80 90 100
FLQQGSSPQG QRSLQHPHKH AGDLPQHLQV MINLLRCEDR IKLAVRLESA
110 120 130 140 150
WADRVRYMVV VYSSGRQDTE ENILLGVDFS SKESKSCTIG MVLRLWSDTK
160 170 180 190 200
IHLDGDGGFS VSTAGRMHIF KPVSVQAMWS ALQVLHKACE VARRHNYFPG
210 220 230 240 250
GVALIWATYY ESCISSEQSC INEWNAMQDL ESTRPDSPAL FVDKPTEGER
260 270 280 290 300
TERLIKAKLR SIMMSQDLEN VTSKEIRNEL EKQMNCNLKE LKEFIDNEML
310 320 330 340 350
LILGQMDKPS LIFDHLYLGS EWNASNLEEL QGSGVDYILN VTREIDNFFP
360 370 380 390 400
GLFAYHNIRV YDEETTDLLA HWNEAYHFIN KAKRNHSKCL VHCKMGVSRS
410 420 430 440 450
ASTVIAYAMK EFGWPLEKAY NYVKQKRSIT RPNAGFMRQL SEYEGILDAS
460 470 480 490 500
KQRHNKLWRQ QTDSSLQQPV DDPAGPGDFL PETPDGTPES QLPFLDDAAQ
510 520 530 540 550
PGLGPPLPCC FRRLSDPLLP SPEDETGSLV HLEDPEREAL LEEAAPPAEV
560 570 580 590 600
HRPARQPQQG SGLCEKDVKK KLEFGSPKGR SGSLLQVEET EREEGLGAGR
610 620 630 640 650
WGQLPTQLDQ NLLNSENLNN NSKRSCPNGM EDDAIFGILN KVKPSYKSCA
660 670 680 690 700
DCMYPTASGA PEASRERCED PNAPAICTQP AFLPHITSSP VAHLASRSRV
710 720 730 740 750
PEKPASGPTE PPPFLPPAGS RRADTSGPGA GAALEPPASL LEPSRETPKV
760 770 780 790 800
LPKSLLLKNS HCDKNPPSTE VVIKEESSPK KDMKPAKDLR LLFSNESEKP
810 820 830 840 850
TTNSYLMQHQ ESIIQLQKAG LVRKHTKELE RLKSVPADPA PPSRDGPASR
860 870 880 890 900
LEASIPEESQ DPAALHELGP LVMPSQAGSD EKSEAAPASL EGGSLKSPPP
910 920 930 940 950
FFYRLDHTSS FSKDFLKTIC YTPTSSSMSS NLTRSSSSDS IHSVRGKPGL
960 970 980 990 1000
VKQRTQEIET RLRLAGLTVS SPLKRSHSLA KLGSLTFSTE DLSSEADPST
1010 1020 1030 1040
VADSQDTTLS ESSFLHEPQG TPRDPAATSK PSGKPAPENL KSPSWMSKS
Length:1,049
Mass (Da):115,511
Last modified:November 22, 2005 - v2
Checksum:i0600B9690F0E6F9C
GO
Isoform 2 (identifier: Q8WYL5-2) [UniParc]FASTAAdd to basket
Also known as: S

The sequence of this isoform differs from the canonical sequence as follows:
     632-692: DDAIFGILNK...LPHITSSPVA → VGRARPAGWH...LQGPEGSFTG
     693-1049: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:692
Mass (Da):77,430
Checksum:i9DC1FF2FC8984384
GO
Isoform 3 (identifier: Q8WYL5-3) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.
     74-93: LPQHLQVMINLLRCEDRIKL → MGGRHHLQRQVSESMSALFQ
     135-157: Missing.
     245-1049: Missing.

Note: Due to intron retention. No experimental confirmation available.
Show »
Length:148
Mass (Da):16,695
Checksum:i3EF171D933E3424D
GO
Isoform 4 (identifier: Q8WYL5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-312: Missing.
     313-334: FDHLYLGSEWNASNLEELQGSG → MRCYLSWDRWTSPPLSSIIFIS

Show »
Length:737
Mass (Da):80,684
Checksum:iE3825E2328B088D2
GO
Isoform 5 (identifier: Q8WYL5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: MALVTLQRSP...SEEDRKLNLS → MARARRAVVG...CCPEVSSSNY
     632-692: DDAIFGILNK...LPHITSSPVA → VGRARPAGWH...LQGPEGSFTG
     693-1049: Missing.

Note: No experimental confirmation available.
Show »
Length:703
Mass (Da):78,978
Checksum:i3ACFAB4B97CBDF7A
GO

Sequence cautioni

The sequence BAA92536 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2A → V in AAH62341 (PubMed:15489334).Curated1
Sequence conflicti230L → P in BAB84116 (PubMed:11832213).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0163111 – 312Missing in isoform 4. 1 PublicationAdd BLAST312
Alternative sequenceiVSP_0163121 – 73Missing in isoform 3. 1 PublicationAdd BLAST73
Alternative sequenceiVSP_0163131 – 37MALVT…KLNLS → MARARRAVVGSVRDVSTAAT NLFYFTDFCIFLQPTHCFCC PEVSSSNY in isoform 5. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_01631474 – 93LPQHL…DRIKL → MGGRHHLQRQVSESMSALFQ in isoform 3. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_016315135 – 157Missing in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_016316245 – 1049Missing in isoform 3. 1 PublicationAdd BLAST805
Alternative sequenceiVSP_016317313 – 334FDHLY…LQGSG → MRCYLSWDRWTSPPLSSIIF IS in isoform 4. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_016318632 – 692DDAIF…SSPVA → VGRARPAGWHTPSLPSHSNW PTSASVVGTTGTRHHTQLIF FYCLLWAPSSHLQGPEGSFT G in isoform 2 and isoform 5. 2 PublicationsAdd BLAST61
Alternative sequenceiVSP_016319693 – 1049Missing in isoform 2 and isoform 5. 2 PublicationsAdd BLAST357

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072355 mRNA. Translation: BAB84114.1.
AB072356 mRNA. Translation: BAB84115.1.
AB072357 mRNA. Translation: BAB84116.1.
AB037719 mRNA. Translation: BAA92536.1. Different initiation.
AK095421 mRNA. Translation: BAC04546.1.
BC062341 mRNA. Translation: AAH62341.1.
CCDSiCCDS53825.1. [Q8WYL5-5]
CCDS55882.1. [Q8WYL5-2]
CCDS9121.1. [Q8WYL5-1]
RefSeqiNP_001154802.1. NM_001161330.1. [Q8WYL5-2]
NP_001154803.1. NM_001161331.1. [Q8WYL5-5]
NP_061857.3. NM_018984.3. [Q8WYL5-1]
XP_016874982.1. XM_017019493.1. [Q8WYL5-4]
XP_016874983.1. XM_017019494.1. [Q8WYL5-4]
UniGeneiHs.199763.

Genome annotation databases

EnsembliENST00000326470; ENSP00000326107; ENSG00000084112. [Q8WYL5-5]
ENST00000326495; ENSP00000315713; ENSG00000084112. [Q8WYL5-1]
ENST00000551165; ENSP00000448824; ENSG00000084112. [Q8WYL5-2]
GeneIDi54434.
KEGGihsa:54434.
UCSCiuc001tnm.4. human. [Q8WYL5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072355 mRNA. Translation: BAB84114.1.
AB072356 mRNA. Translation: BAB84115.1.
AB072357 mRNA. Translation: BAB84116.1.
AB037719 mRNA. Translation: BAA92536.1. Different initiation.
AK095421 mRNA. Translation: BAC04546.1.
BC062341 mRNA. Translation: AAH62341.1.
CCDSiCCDS53825.1. [Q8WYL5-5]
CCDS55882.1. [Q8WYL5-2]
CCDS9121.1. [Q8WYL5-1]
RefSeqiNP_001154802.1. NM_001161330.1. [Q8WYL5-2]
NP_001154803.1. NM_001161331.1. [Q8WYL5-5]
NP_061857.3. NM_018984.3. [Q8WYL5-1]
XP_016874982.1. XM_017019493.1. [Q8WYL5-4]
XP_016874983.1. XM_017019494.1. [Q8WYL5-4]
UniGeneiHs.199763.

3D structure databases

ProteinModelPortaliQ8WYL5.
SMRiQ8WYL5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119950. 14 interactors.
IntActiQ8WYL5. 13 interactors.
MINTiMINT-1788740.
STRINGi9606.ENSP00000315713.

PTM databases

DEPODiQ8WYL5.
iPTMnetiQ8WYL5.
PhosphoSitePlusiQ8WYL5.

Polymorphism and mutation databases

BioMutaiSSH1.
DMDMi82582267.

Proteomic databases

EPDiQ8WYL5.
MaxQBiQ8WYL5.
PaxDbiQ8WYL5.
PeptideAtlasiQ8WYL5.
PRIDEiQ8WYL5.

Protocols and materials databases

DNASUi54434.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326470; ENSP00000326107; ENSG00000084112. [Q8WYL5-5]
ENST00000326495; ENSP00000315713; ENSG00000084112. [Q8WYL5-1]
ENST00000551165; ENSP00000448824; ENSG00000084112. [Q8WYL5-2]
GeneIDi54434.
KEGGihsa:54434.
UCSCiuc001tnm.4. human. [Q8WYL5-1]

Organism-specific databases

CTDi54434.
DisGeNETi54434.
GeneCardsiSSH1.
HGNCiHGNC:30579. SSH1.
HPAiHPA019845.
MIMi606778. gene.
neXtProtiNX_Q8WYL5.
OpenTargetsiENSG00000084112.
PharmGKBiPA134941788.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1716. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00760000118902.
HOGENOMiHOG000154427.
HOVERGENiHBG094001.
InParanoidiQ8WYL5.
KOiK05766.
OMAiNSHCDKN.
OrthoDBiEOG091G0249.
PhylomeDBiQ8WYL5.
TreeFamiTF319444.

Enzyme and pathway databases

BioCyciZFISH:HS01467-MONOMER.
SIGNORiQ8WYL5.

Miscellaneous databases

ChiTaRSiSSH1. human.
GeneWikiiSSH1.
GenomeRNAii54434.
PROiQ8WYL5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000084112.
CleanExiHS_SSH1.
ExpressionAtlasiQ8WYL5. baseline and differential.
GenevisibleiQ8WYL5. HS.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di1.10.10.60. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR014876. DEK_C.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR009057. Homeodomain-like.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR027233. SSH1.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PTHR10159:SF138. PTHR10159:SF138. 1 hit.
PfamiPF08766. DEK_C. 1 hit.
PF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSSH1_HUMAN
AccessioniPrimary (citable) accession number: Q8WYL5
Secondary accession number(s): Q6P6C0
, Q8N9A7, Q8WYL3, Q8WYL4, Q9P2P8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: November 30, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Tyrosine phosphatase activity has not been demonstrated for this protein to date.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.