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Q8WYK2

- JDP2_HUMAN

UniProt

Q8WYK2 - JDP2_HUMAN

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Protein
Jun dimerization protein 2
Gene
JDP2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin.4 Publications

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. double-stranded DNA binding Source: Ensembl
  3. protein binding Source: IntAct
  4. sequence-specific DNA binding Source: InterPro
  5. sequence-specific DNA binding transcription factor activity Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. negative regulation of fat cell differentiation Source: Ensembl
  2. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  3. positive regulation of histone deacetylation Source: Ensembl
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Jun dimerization protein 2
Gene namesi
Name:JDP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:17546. JDP2.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162392499.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 163163Jun dimerization protein 2
PRO_0000331130Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei148 – 1481Phosphothreonine; by MAPK81 Publication

Post-translational modificationi

Phosphorylation of Thr-148 by MAPK8 in response to different stress conditions such as, UV irradiation, oxidatives stress and anisomycin treatments.
Polyubiquitinated; probably by IRF2BP1.

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ8WYK2.
PaxDbiQ8WYK2.
PRIDEiQ8WYK2.

PTM databases

PhosphoSiteiQ8WYK2.

Expressioni

Gene expression databases

ArrayExpressiQ8WYK2.
BgeeiQ8WYK2.
CleanExiHS_JDP2.
GenevestigatoriQ8WYK2.

Organism-specific databases

HPAiHPA051651.
HPA059511.

Interactioni

Subunit structurei

Forms a homodimer or heterodimer with JUN, JUNB, JUND, CEBPG and ATF2 thereby inhibiting transactivation by JUN, ATF2 and CEBPG By similarity. Binds multiple DNA elements such as cAMP-response element (CRE) and TPA response element (TRE) either as homodimer or heterodimer By similarity. Interacts with IRF2BP1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
IRF2BP1Q8IU814EBI-1248415,EBI-6115514

Protein-protein interaction databases

BioGridi125807. 15 interactions.
IntActiQ8WYK2. 12 interactions.
MINTiMINT-189454.
STRINGi9606.ENSP00000267569.

Structurei

3D structure databases

ProteinModelPortaliQ8WYK2.
SMRiQ8WYK2. Positions 73-135.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini72 – 13564bZIP
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni74 – 9623Basic motif By similarity
Add
BLAST
Regioni100 – 12829Leucine-zipper By similarity
Add
BLAST

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.

Phylogenomic databases

eggNOGiNOG280450.
HOGENOMiHOG000034126.
HOVERGENiHBG057870.
InParanoidiQ8WYK2.
KOiK09033.
OMAiPLQFLEV.
OrthoDBiEOG70S777.
PhylomeDBiQ8WYK2.
TreeFamiTF326301.

Family and domain databases

InterProiIPR004827. bZIP.
IPR000837. Leuzip_Fos.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8WYK2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MMPGQIPDPS VTTGSLPGLG PLTGLPSSAL TVEELKYADI RNLGAMIAPL    50
HFLEVKLGKR PQPVKSELDE EEERRKRRRE KNKVAAARCR NKKKERTEFL 100
QRESERLELM NAELKTQIEE LKQERQQLIL MLNRHRPTCI VRTDSVKTPE 150
SEGNPLLEQL EKK 163
Length:163
Mass (Da):18,704
Last modified:March 1, 2002 - v1
Checksum:i29C576AF2C574BA8
GO
Isoform 2 (identifier: Q8WYK2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVAGWPATPPAM

Note: Gene prediction based on EST data.

Show »
Length:174
Mass (Da):19,783
Checksum:i4E073AA3A46F0B7C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti13 – 131T → A.
Corresponds to variant rs3625 [ dbSNP | Ensembl ].
VAR_042738

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MVAGWPATPPAM in isoform 2.
VSP_047128

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB077880 mRNA. Translation: BAB83896.1.
AF111167 Genomic DNA. Translation: AAC98313.1.
AC009363 Genomic DNA. Translation: AAF21148.1.
CH471061 Genomic DNA. Translation: EAW81231.1.
BC051303 mRNA. Translation: AAH51303.1.
CCDSiCCDS45139.1. [Q8WYK2-2]
CCDS9842.1. [Q8WYK2-1]
RefSeqiNP_001128519.1. NM_001135047.1. [Q8WYK2-1]
NP_001128520.1. NM_001135048.1. [Q8WYK2-1]
NP_001128521.1. NM_001135049.1. [Q8WYK2-2]
NP_569736.1. NM_130469.3. [Q8WYK2-1]
XP_005267389.1. XM_005267332.2. [Q8WYK2-1]
XP_006720095.1. XM_006720032.1. [Q8WYK2-2]
UniGeneiHs.196482.

Genome annotation databases

EnsembliENST00000267569; ENSP00000267569; ENSG00000140044. [Q8WYK2-2]
ENST00000419727; ENSP00000415558; ENSG00000140044. [Q8WYK2-1]
ENST00000435893; ENSP00000399587; ENSG00000140044. [Q8WYK2-1]
ENST00000437176; ENSP00000409787; ENSG00000140044. [Q8WYK2-1]
GeneIDi122953.
KEGGihsa:122953.
UCSCiuc010asj.3. human. [Q8WYK2-1]

Polymorphism databases

DMDMi74751626.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB077880 mRNA. Translation: BAB83896.1 .
AF111167 Genomic DNA. Translation: AAC98313.1 .
AC009363 Genomic DNA. Translation: AAF21148.1 .
CH471061 Genomic DNA. Translation: EAW81231.1 .
BC051303 mRNA. Translation: AAH51303.1 .
CCDSi CCDS45139.1. [Q8WYK2-2 ]
CCDS9842.1. [Q8WYK2-1 ]
RefSeqi NP_001128519.1. NM_001135047.1. [Q8WYK2-1 ]
NP_001128520.1. NM_001135048.1. [Q8WYK2-1 ]
NP_001128521.1. NM_001135049.1. [Q8WYK2-2 ]
NP_569736.1. NM_130469.3. [Q8WYK2-1 ]
XP_005267389.1. XM_005267332.2. [Q8WYK2-1 ]
XP_006720095.1. XM_006720032.1. [Q8WYK2-2 ]
UniGenei Hs.196482.

3D structure databases

ProteinModelPortali Q8WYK2.
SMRi Q8WYK2. Positions 73-135.
ModBasei Search...

Protein-protein interaction databases

BioGridi 125807. 15 interactions.
IntActi Q8WYK2. 12 interactions.
MINTi MINT-189454.
STRINGi 9606.ENSP00000267569.

PTM databases

PhosphoSitei Q8WYK2.

Polymorphism databases

DMDMi 74751626.

Proteomic databases

MaxQBi Q8WYK2.
PaxDbi Q8WYK2.
PRIDEi Q8WYK2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000267569 ; ENSP00000267569 ; ENSG00000140044 . [Q8WYK2-2 ]
ENST00000419727 ; ENSP00000415558 ; ENSG00000140044 . [Q8WYK2-1 ]
ENST00000435893 ; ENSP00000399587 ; ENSG00000140044 . [Q8WYK2-1 ]
ENST00000437176 ; ENSP00000409787 ; ENSG00000140044 . [Q8WYK2-1 ]
GeneIDi 122953.
KEGGi hsa:122953.
UCSCi uc010asj.3. human. [Q8WYK2-1 ]

Organism-specific databases

CTDi 122953.
GeneCardsi GC14P075894.
H-InvDB HIX0026627.
HGNCi HGNC:17546. JDP2.
HPAi HPA051651.
HPA059511.
MIMi 608657. gene.
neXtProti NX_Q8WYK2.
PharmGKBi PA162392499.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG280450.
HOGENOMi HOG000034126.
HOVERGENi HBG057870.
InParanoidi Q8WYK2.
KOi K09033.
OMAi PLQFLEV.
OrthoDBi EOG70S777.
PhylomeDBi Q8WYK2.
TreeFami TF326301.

Miscellaneous databases

GeneWikii JDP2_(gene).
Jun_dimerization_protein.
GenomeRNAii 122953.
NextBioi 35534825.
PROi Q8WYK2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8WYK2.
Bgeei Q8WYK2.
CleanExi HS_JDP2.
Genevestigatori Q8WYK2.

Family and domain databases

InterProi IPR004827. bZIP.
IPR000837. Leuzip_Fos.
[Graphical view ]
Pfami PF00170. bZIP_1. 1 hit.
[Graphical view ]
PRINTSi PR00042. LEUZIPPRFOS.
SMARTi SM00338. BRLZ. 1 hit.
[Graphical view ]
PROSITEi PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Jun dimerization protein 2 (JDP2), a member of the AP-1 family of transcription factor, mediates osteoclast differentiation induced by RANKL."
    Kawaida R., Ohtsuka T., Okutsu J., Takahashi T., Kadono Y., Oda H., Hikita A., Nakamura K., Tanaka S., Furukawa H.
    J. Exp. Med. 197:1029-1035(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  2. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  5. "Transcriptional regulation of the c-jun gene by AP-1 repressor protein JDP2 during the differentiation of F9 cells."
    Jin C., Li H., Ugai H., Murata T., Yokoyama K.K.
    Nucleic Acids Res. Suppl. 2:97-98(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Regulation of histone acetylation and nucleosome assembly by transcription factor JDP2."
    Jin C., Kato K., Chimura T., Yamasaki T., Nakade K., Murata T., Li H., Pan J., Zhao M., Sun K., Chiu R., Ito T., Nagata K., Horikoshi M., Yokoyama K.K.
    Nat. Struct. Mol. Biol. 13:331-338(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Depletion of the AP-1 repressor JDP2 induces cell death similar to apoptosis."
    Lerdrup M., Holmberg C., Dietrich N., Shaulian E., Herdegen T., Jaeaettelae M., Kallunki T.
    Biochim. Biophys. Acta 1745:29-37(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Phosphorylation of two eukaryotic transcription factors, Jun dimerization protein 2 and activation transcription factor 2, in Escherichia coli by Jun N-terminal kinase 1."
    Murata T., Shinozuka Y., Obata Y., Yokoyama K.K.
    Anal. Biochem. 376:115-121(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT THR-148 BY MAPK8, IDENTIFICATION BY MASS SPECTROMETRY.
  9. "IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor of ATF2-dependent transcription."
    Kimura M.
    FEBS Lett. 582:2833-2837(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION, INTERACTION WITH IRF2BP1.

Entry informationi

Entry nameiJDP2_HUMAN
AccessioniPrimary (citable) accession number: Q8WYK2
Secondary accession number(s): J3KN58, O95430, Q9UIE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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