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Protein

Jun dimerization protein 2

Gene

JDP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin.4 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000140044-MONOMER.
SIGNORiQ8WYK2.

Names & Taxonomyi

Protein namesi
Recommended name:
Jun dimerization protein 2
Gene namesi
Name:JDP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:17546. JDP2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi122953.
OpenTargetsiENSG00000140044.
PharmGKBiPA162392499.

Chemistry databases

DrugBankiDB00852. Pseudoephedrine.

Polymorphism and mutation databases

BioMutaiJDP2.
DMDMi74751626.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003311301 – 163Jun dimerization protein 2Add BLAST163

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki65Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei148Phosphothreonine; by MAPK8Combined sources1 Publication1

Post-translational modificationi

Phosphorylation of Thr-148 by MAPK8 in response to different stress conditions such as, UV irradiation, oxidatives stress and anisomycin treatments.1 Publication
Polyubiquitinated; probably by IRF2BP1.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8WYK2.
MaxQBiQ8WYK2.
PaxDbiQ8WYK2.
PeptideAtlasiQ8WYK2.
PRIDEiQ8WYK2.

PTM databases

iPTMnetiQ8WYK2.
PhosphoSitePlusiQ8WYK2.

Expressioni

Gene expression databases

BgeeiENSG00000140044.
CleanExiHS_JDP2.
ExpressionAtlasiQ8WYK2. baseline and differential.
GenevisibleiQ8WYK2. HS.

Organism-specific databases

HPAiHPA059511.

Interactioni

Subunit structurei

Forms a homodimer or heterodimer with JUN, JUNB, JUND, CEBPG and ATF2 thereby inhibiting transactivation by JUN, ATF2 and CEBPG (By similarity). Binds multiple DNA elements such as cAMP-response element (CRE) and TPA response element (TRE) either as homodimer or heterodimer (By similarity). Interacts with IRF2BP1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
IRF2BP1Q8IU814EBI-1248415,EBI-6115514

Protein-protein interaction databases

BioGridi125807. 14 interactors.
IntActiQ8WYK2. 14 interactors.
MINTiMINT-189454.
STRINGi9606.ENSP00000267569.

Structurei

3D structure databases

ProteinModelPortaliQ8WYK2.
SMRiQ8WYK2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 135bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni74 – 96Basic motifPROSITE-ProRule annotationAdd BLAST23
Regioni100 – 128Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
GeneTreeiENSGT00730000110847.
HOGENOMiHOG000034126.
HOVERGENiHBG057870.
InParanoidiQ8WYK2.
KOiK09033.
OMAiXESERLE.
OrthoDBiEOG091G0M4N.
PhylomeDBiQ8WYK2.
TreeFamiTF326301.

Family and domain databases

InterProiIPR000837. AP-1.
IPR004827. bZIP.
IPR029819. JDP2.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF10. PTHR23351:SF10. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WYK2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMPGQIPDPS VTTGSLPGLG PLTGLPSSAL TVEELKYADI RNLGAMIAPL
60 70 80 90 100
HFLEVKLGKR PQPVKSELDE EEERRKRRRE KNKVAAARCR NKKKERTEFL
110 120 130 140 150
QRESERLELM NAELKTQIEE LKQERQQLIL MLNRHRPTCI VRTDSVKTPE
160
SEGNPLLEQL EKK
Length:163
Mass (Da):18,704
Last modified:March 1, 2002 - v1
Checksum:i29C576AF2C574BA8
GO
Isoform 2 (identifier: Q8WYK2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVAGWPATPPAM

Note: Gene prediction based on EST data.
Show »
Length:174
Mass (Da):19,783
Checksum:i4E073AA3A46F0B7C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04273813T → A.Corresponds to variant rs3625dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0471281M → MVAGWPATPPAM in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB077880 mRNA. Translation: BAB83896.1.
AF111167 Genomic DNA. Translation: AAC98313.1.
AC009363 Genomic DNA. Translation: AAF21148.1.
CH471061 Genomic DNA. Translation: EAW81231.1.
BC051303 mRNA. Translation: AAH51303.1.
CCDSiCCDS45139.1. [Q8WYK2-2]
CCDS9842.1. [Q8WYK2-1]
RefSeqiNP_001128519.1. NM_001135047.1. [Q8WYK2-1]
NP_001128520.1. NM_001135048.1. [Q8WYK2-1]
NP_001128521.1. NM_001135049.1. [Q8WYK2-2]
NP_569736.1. NM_130469.3. [Q8WYK2-1]
XP_005267389.1. XM_005267332.4. [Q8WYK2-1]
XP_016876461.1. XM_017020972.1. [Q8WYK2-2]
XP_016876462.1. XM_017020973.1. [Q8WYK2-1]
XP_016876463.1. XM_017020974.1. [Q8WYK2-1]
XP_016876464.1. XM_017020975.1. [Q8WYK2-1]
UniGeneiHs.196482.

Genome annotation databases

EnsembliENST00000267569; ENSP00000267569; ENSG00000140044. [Q8WYK2-2]
ENST00000419727; ENSP00000415558; ENSG00000140044. [Q8WYK2-1]
ENST00000435893; ENSP00000399587; ENSG00000140044. [Q8WYK2-1]
ENST00000437176; ENSP00000409787; ENSG00000140044. [Q8WYK2-1]
GeneIDi122953.
KEGGihsa:122953.
UCSCiuc001xrq.4. human. [Q8WYK2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB077880 mRNA. Translation: BAB83896.1.
AF111167 Genomic DNA. Translation: AAC98313.1.
AC009363 Genomic DNA. Translation: AAF21148.1.
CH471061 Genomic DNA. Translation: EAW81231.1.
BC051303 mRNA. Translation: AAH51303.1.
CCDSiCCDS45139.1. [Q8WYK2-2]
CCDS9842.1. [Q8WYK2-1]
RefSeqiNP_001128519.1. NM_001135047.1. [Q8WYK2-1]
NP_001128520.1. NM_001135048.1. [Q8WYK2-1]
NP_001128521.1. NM_001135049.1. [Q8WYK2-2]
NP_569736.1. NM_130469.3. [Q8WYK2-1]
XP_005267389.1. XM_005267332.4. [Q8WYK2-1]
XP_016876461.1. XM_017020972.1. [Q8WYK2-2]
XP_016876462.1. XM_017020973.1. [Q8WYK2-1]
XP_016876463.1. XM_017020974.1. [Q8WYK2-1]
XP_016876464.1. XM_017020975.1. [Q8WYK2-1]
UniGeneiHs.196482.

3D structure databases

ProteinModelPortaliQ8WYK2.
SMRiQ8WYK2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125807. 14 interactors.
IntActiQ8WYK2. 14 interactors.
MINTiMINT-189454.
STRINGi9606.ENSP00000267569.

Chemistry databases

DrugBankiDB00852. Pseudoephedrine.

PTM databases

iPTMnetiQ8WYK2.
PhosphoSitePlusiQ8WYK2.

Polymorphism and mutation databases

BioMutaiJDP2.
DMDMi74751626.

Proteomic databases

EPDiQ8WYK2.
MaxQBiQ8WYK2.
PaxDbiQ8WYK2.
PeptideAtlasiQ8WYK2.
PRIDEiQ8WYK2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267569; ENSP00000267569; ENSG00000140044. [Q8WYK2-2]
ENST00000419727; ENSP00000415558; ENSG00000140044. [Q8WYK2-1]
ENST00000435893; ENSP00000399587; ENSG00000140044. [Q8WYK2-1]
ENST00000437176; ENSP00000409787; ENSG00000140044. [Q8WYK2-1]
GeneIDi122953.
KEGGihsa:122953.
UCSCiuc001xrq.4. human. [Q8WYK2-1]

Organism-specific databases

CTDi122953.
DisGeNETi122953.
GeneCardsiJDP2.
H-InvDBHIX0026627.
HGNCiHGNC:17546. JDP2.
HPAiHPA059511.
MIMi608657. gene.
neXtProtiNX_Q8WYK2.
OpenTargetsiENSG00000140044.
PharmGKBiPA162392499.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
GeneTreeiENSGT00730000110847.
HOGENOMiHOG000034126.
HOVERGENiHBG057870.
InParanoidiQ8WYK2.
KOiK09033.
OMAiXESERLE.
OrthoDBiEOG091G0M4N.
PhylomeDBiQ8WYK2.
TreeFamiTF326301.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000140044-MONOMER.
SIGNORiQ8WYK2.

Miscellaneous databases

GeneWikiiJDP2_(gene).
Jun_dimerization_protein.
GenomeRNAii122953.
PROiQ8WYK2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140044.
CleanExiHS_JDP2.
ExpressionAtlasiQ8WYK2. baseline and differential.
GenevisibleiQ8WYK2. HS.

Family and domain databases

InterProiIPR000837. AP-1.
IPR004827. bZIP.
IPR029819. JDP2.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF10. PTHR23351:SF10. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiJDP2_HUMAN
AccessioniPrimary (citable) accession number: Q8WYK2
Secondary accession number(s): J3KN58, O95430, Q9UIE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.