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Q8WYK2

- JDP2_HUMAN

UniProt

Q8WYK2 - JDP2_HUMAN

Protein

Jun dimerization protein 2

Gene

JDP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin.4 Publications

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. double-stranded DNA binding Source: Ensembl
    3. protein binding Source: IntAct
    4. sequence-specific DNA binding Source: InterPro
    5. sequence-specific DNA binding transcription factor activity Source: Ensembl

    GO - Biological processi

    1. negative regulation of fat cell differentiation Source: Ensembl
    2. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    3. positive regulation of histone deacetylation Source: Ensembl
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Jun dimerization protein 2
    Gene namesi
    Name:JDP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:17546. JDP2.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162392499.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 163163Jun dimerization protein 2PRO_0000331130Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei148 – 1481Phosphothreonine; by MAPK81 Publication

    Post-translational modificationi

    Phosphorylation of Thr-148 by MAPK8 in response to different stress conditions such as, UV irradiation, oxidatives stress and anisomycin treatments.1 Publication
    Polyubiquitinated; probably by IRF2BP1.1 Publication

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ8WYK2.
    PaxDbiQ8WYK2.
    PRIDEiQ8WYK2.

    PTM databases

    PhosphoSiteiQ8WYK2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8WYK2.
    BgeeiQ8WYK2.
    CleanExiHS_JDP2.
    GenevestigatoriQ8WYK2.

    Organism-specific databases

    HPAiHPA051651.
    HPA059511.

    Interactioni

    Subunit structurei

    Forms a homodimer or heterodimer with JUN, JUNB, JUND, CEBPG and ATF2 thereby inhibiting transactivation by JUN, ATF2 and CEBPG By similarity. Binds multiple DNA elements such as cAMP-response element (CRE) and TPA response element (TRE) either as homodimer or heterodimer By similarity. Interacts with IRF2BP1.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    IRF2BP1Q8IU814EBI-1248415,EBI-6115514

    Protein-protein interaction databases

    BioGridi125807. 15 interactions.
    IntActiQ8WYK2. 12 interactions.
    MINTiMINT-189454.
    STRINGi9606.ENSP00000267569.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WYK2.
    SMRiQ8WYK2. Positions 73-135.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini72 – 13564bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni74 – 9623Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni100 – 12829Leucine-zipperPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the bZIP family. ATF subfamily.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG280450.
    HOGENOMiHOG000034126.
    HOVERGENiHBG057870.
    InParanoidiQ8WYK2.
    KOiK09033.
    OMAiPLQFLEV.
    OrthoDBiEOG70S777.
    PhylomeDBiQ8WYK2.
    TreeFamiTF326301.

    Family and domain databases

    InterProiIPR004827. bZIP.
    IPR000837. Leuzip_Fos.
    [Graphical view]
    PfamiPF00170. bZIP_1. 1 hit.
    [Graphical view]
    PRINTSiPR00042. LEUZIPPRFOS.
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    PROSITEiPS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WYK2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMPGQIPDPS VTTGSLPGLG PLTGLPSSAL TVEELKYADI RNLGAMIAPL    50
    HFLEVKLGKR PQPVKSELDE EEERRKRRRE KNKVAAARCR NKKKERTEFL 100
    QRESERLELM NAELKTQIEE LKQERQQLIL MLNRHRPTCI VRTDSVKTPE 150
    SEGNPLLEQL EKK 163
    Length:163
    Mass (Da):18,704
    Last modified:March 1, 2002 - v1
    Checksum:i29C576AF2C574BA8
    GO
    Isoform 2 (identifier: Q8WYK2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MVAGWPATPPAM

    Note: Gene prediction based on EST data.

    Show »
    Length:174
    Mass (Da):19,783
    Checksum:i4E073AA3A46F0B7C
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti13 – 131T → A.
    Corresponds to variant rs3625 [ dbSNP | Ensembl ].
    VAR_042738

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MVAGWPATPPAM in isoform 2. CuratedVSP_047128

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB077880 mRNA. Translation: BAB83896.1.
    AF111167 Genomic DNA. Translation: AAC98313.1.
    AC009363 Genomic DNA. Translation: AAF21148.1.
    CH471061 Genomic DNA. Translation: EAW81231.1.
    BC051303 mRNA. Translation: AAH51303.1.
    CCDSiCCDS45139.1. [Q8WYK2-2]
    CCDS9842.1. [Q8WYK2-1]
    RefSeqiNP_001128519.1. NM_001135047.1. [Q8WYK2-1]
    NP_001128520.1. NM_001135048.1. [Q8WYK2-1]
    NP_001128521.1. NM_001135049.1. [Q8WYK2-2]
    NP_569736.1. NM_130469.3. [Q8WYK2-1]
    XP_005267389.1. XM_005267332.2. [Q8WYK2-1]
    XP_006720095.1. XM_006720032.1. [Q8WYK2-2]
    UniGeneiHs.196482.

    Genome annotation databases

    EnsembliENST00000267569; ENSP00000267569; ENSG00000140044. [Q8WYK2-2]
    ENST00000419727; ENSP00000415558; ENSG00000140044. [Q8WYK2-1]
    ENST00000435893; ENSP00000399587; ENSG00000140044. [Q8WYK2-1]
    ENST00000437176; ENSP00000409787; ENSG00000140044. [Q8WYK2-1]
    GeneIDi122953.
    KEGGihsa:122953.
    UCSCiuc010asj.3. human. [Q8WYK2-1]

    Polymorphism databases

    DMDMi74751626.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB077880 mRNA. Translation: BAB83896.1 .
    AF111167 Genomic DNA. Translation: AAC98313.1 .
    AC009363 Genomic DNA. Translation: AAF21148.1 .
    CH471061 Genomic DNA. Translation: EAW81231.1 .
    BC051303 mRNA. Translation: AAH51303.1 .
    CCDSi CCDS45139.1. [Q8WYK2-2 ]
    CCDS9842.1. [Q8WYK2-1 ]
    RefSeqi NP_001128519.1. NM_001135047.1. [Q8WYK2-1 ]
    NP_001128520.1. NM_001135048.1. [Q8WYK2-1 ]
    NP_001128521.1. NM_001135049.1. [Q8WYK2-2 ]
    NP_569736.1. NM_130469.3. [Q8WYK2-1 ]
    XP_005267389.1. XM_005267332.2. [Q8WYK2-1 ]
    XP_006720095.1. XM_006720032.1. [Q8WYK2-2 ]
    UniGenei Hs.196482.

    3D structure databases

    ProteinModelPortali Q8WYK2.
    SMRi Q8WYK2. Positions 73-135.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125807. 15 interactions.
    IntActi Q8WYK2. 12 interactions.
    MINTi MINT-189454.
    STRINGi 9606.ENSP00000267569.

    Chemistry

    DrugBanki DB00852. Pseudoephedrine.

    PTM databases

    PhosphoSitei Q8WYK2.

    Polymorphism databases

    DMDMi 74751626.

    Proteomic databases

    MaxQBi Q8WYK2.
    PaxDbi Q8WYK2.
    PRIDEi Q8WYK2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000267569 ; ENSP00000267569 ; ENSG00000140044 . [Q8WYK2-2 ]
    ENST00000419727 ; ENSP00000415558 ; ENSG00000140044 . [Q8WYK2-1 ]
    ENST00000435893 ; ENSP00000399587 ; ENSG00000140044 . [Q8WYK2-1 ]
    ENST00000437176 ; ENSP00000409787 ; ENSG00000140044 . [Q8WYK2-1 ]
    GeneIDi 122953.
    KEGGi hsa:122953.
    UCSCi uc010asj.3. human. [Q8WYK2-1 ]

    Organism-specific databases

    CTDi 122953.
    GeneCardsi GC14P075894.
    H-InvDB HIX0026627.
    HGNCi HGNC:17546. JDP2.
    HPAi HPA051651.
    HPA059511.
    MIMi 608657. gene.
    neXtProti NX_Q8WYK2.
    PharmGKBi PA162392499.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG280450.
    HOGENOMi HOG000034126.
    HOVERGENi HBG057870.
    InParanoidi Q8WYK2.
    KOi K09033.
    OMAi PLQFLEV.
    OrthoDBi EOG70S777.
    PhylomeDBi Q8WYK2.
    TreeFami TF326301.

    Miscellaneous databases

    GeneWikii JDP2_(gene).
    Jun_dimerization_protein.
    GenomeRNAii 122953.
    NextBioi 35534825.
    PROi Q8WYK2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8WYK2.
    Bgeei Q8WYK2.
    CleanExi HS_JDP2.
    Genevestigatori Q8WYK2.

    Family and domain databases

    InterProi IPR004827. bZIP.
    IPR000837. Leuzip_Fos.
    [Graphical view ]
    Pfami PF00170. bZIP_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00042. LEUZIPPRFOS.
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    PROSITEi PS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Jun dimerization protein 2 (JDP2), a member of the AP-1 family of transcription factor, mediates osteoclast differentiation induced by RANKL."
      Kawaida R., Ohtsuka T., Okutsu J., Takahashi T., Kadono Y., Oda H., Hikita A., Nakamura K., Tanaka S., Furukawa H.
      J. Exp. Med. 197:1029-1035(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    2. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.
    5. "Transcriptional regulation of the c-jun gene by AP-1 repressor protein JDP2 during the differentiation of F9 cells."
      Jin C., Li H., Ugai H., Murata T., Yokoyama K.K.
      Nucleic Acids Res. Suppl. 2:97-98(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "Regulation of histone acetylation and nucleosome assembly by transcription factor JDP2."
      Jin C., Kato K., Chimura T., Yamasaki T., Nakade K., Murata T., Li H., Pan J., Zhao M., Sun K., Chiu R., Ito T., Nagata K., Horikoshi M., Yokoyama K.K.
      Nat. Struct. Mol. Biol. 13:331-338(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Depletion of the AP-1 repressor JDP2 induces cell death similar to apoptosis."
      Lerdrup M., Holmberg C., Dietrich N., Shaulian E., Herdegen T., Jaeaettelae M., Kallunki T.
      Biochim. Biophys. Acta 1745:29-37(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "Phosphorylation of two eukaryotic transcription factors, Jun dimerization protein 2 and activation transcription factor 2, in Escherichia coli by Jun N-terminal kinase 1."
      Murata T., Shinozuka Y., Obata Y., Yokoyama K.K.
      Anal. Biochem. 376:115-121(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT THR-148 BY MAPK8, IDENTIFICATION BY MASS SPECTROMETRY.
    9. "IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor of ATF2-dependent transcription."
      Kimura M.
      FEBS Lett. 582:2833-2837(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION, INTERACTION WITH IRF2BP1.

    Entry informationi

    Entry nameiJDP2_HUMAN
    AccessioniPrimary (citable) accession number: Q8WYK2
    Secondary accession number(s): J3KN58, O95430, Q9UIE4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3