Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8WYK2 (JDP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Jun dimerization protein 2
Gene names
Name:JDP2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length163 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin. Ref.1 Ref.5 Ref.6 Ref.7

Subunit structure

Forms a homodimer or heterodimer with JUN, JUNB, JUND, CEBPG and ATF2 thereby inhibiting transactivation by JUN, ATF2 and CEBPG By similarity. Binds multiple DNA elements such as cAMP-response element (CRE) and TPA response element (TRE) either as homodimer or heterodimer By similarity. Interacts with IRF2BP1. Ref.9

Subcellular location

Nucleus Probable.

Post-translational modification

Phosphorylation of Thr-148 by MAPK8 in response to different stress conditions such as, UV irradiation, oxidatives stress and anisomycin treatments.

Polyubiquitinated; probably by IRF2BP1.

Sequence similarities

Belongs to the bZIP family. ATF subfamily.

Contains 1 bZIP (basic-leucine zipper) domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

IRF2BP1Q8IU814EBI-1248415,EBI-6115514

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8WYK2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8WYK2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVAGWPATPPAM
Note: Gene prediction based on EST data.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 163163Jun dimerization protein 2
PRO_0000331130

Regions

Domain72 – 13564bZIP
Region74 – 9623Basic motif By similarity
Region100 – 12829Leucine-zipper By similarity

Amino acid modifications

Modified residue1481Phosphothreonine; by MAPK8 Ref.8

Natural variations

Alternative sequence11M → MVAGWPATPPAM in isoform 2.
VSP_047128
Natural variant131T → A.
Corresponds to variant rs3625 [ dbSNP | Ensembl ].
VAR_042738

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 29C576AF2C574BA8

FASTA16318,704
        10         20         30         40         50         60 
MMPGQIPDPS VTTGSLPGLG PLTGLPSSAL TVEELKYADI RNLGAMIAPL HFLEVKLGKR 

        70         80         90        100        110        120 
PQPVKSELDE EEERRKRRRE KNKVAAARCR NKKKERTEFL QRESERLELM NAELKTQIEE 

       130        140        150        160 
LKQERQQLIL MLNRHRPTCI VRTDSVKTPE SEGNPLLEQL EKK 

« Hide

Isoform 2 [UniParc].

Checksum: 4E073AA3A46F0B7C
Show »

FASTA17419,783

References

« Hide 'large scale' references
[1]"Jun dimerization protein 2 (JDP2), a member of the AP-1 family of transcription factor, mediates osteoclast differentiation induced by RANKL."
Kawaida R., Ohtsuka T., Okutsu J., Takahashi T., Kadono Y., Oda H., Hikita A., Nakamura K., Tanaka S., Furukawa H.
J. Exp. Med. 197:1029-1035(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
[2]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon.
[5]"Transcriptional regulation of the c-jun gene by AP-1 repressor protein JDP2 during the differentiation of F9 cells."
Jin C., Li H., Ugai H., Murata T., Yokoyama K.K.
Nucleic Acids Res. Suppl. 2:97-98(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"Regulation of histone acetylation and nucleosome assembly by transcription factor JDP2."
Jin C., Kato K., Chimura T., Yamasaki T., Nakade K., Murata T., Li H., Pan J., Zhao M., Sun K., Chiu R., Ito T., Nagata K., Horikoshi M., Yokoyama K.K.
Nat. Struct. Mol. Biol. 13:331-338(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"Depletion of the AP-1 repressor JDP2 induces cell death similar to apoptosis."
Lerdrup M., Holmberg C., Dietrich N., Shaulian E., Herdegen T., Jaeaettelae M., Kallunki T.
Biochim. Biophys. Acta 1745:29-37(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[8]"Phosphorylation of two eukaryotic transcription factors, Jun dimerization protein 2 and activation transcription factor 2, in Escherichia coli by Jun N-terminal kinase 1."
Murata T., Shinozuka Y., Obata Y., Yokoyama K.K.
Anal. Biochem. 376:115-121(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT THR-148 BY MAPK8, IDENTIFICATION BY MASS SPECTROMETRY.
[9]"IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor of ATF2-dependent transcription."
Kimura M.
FEBS Lett. 582:2833-2837(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: UBIQUITINATION, INTERACTION WITH IRF2BP1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB077880 mRNA. Translation: BAB83896.1.
AF111167 Genomic DNA. Translation: AAC98313.1.
AC009363 Genomic DNA. Translation: AAF21148.1.
CH471061 Genomic DNA. Translation: EAW81231.1.
BC051303 mRNA. Translation: AAH51303.1.
RefSeqNP_001128519.1. NM_001135047.1.
NP_001128520.1. NM_001135048.1.
NP_001128521.1. NM_001135049.1.
NP_569736.1. NM_130469.3.
XP_005267389.1. XM_005267332.2.
UniGeneHs.196482.

3D structure databases

ProteinModelPortalQ8WYK2.
SMRQ8WYK2. Positions 73-135.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125807. 15 interactions.
IntActQ8WYK2. 12 interactions.
MINTMINT-189454.
STRING9606.ENSP00000267569.

PTM databases

PhosphoSiteQ8WYK2.

Polymorphism databases

DMDM74751626.

Proteomic databases

PaxDbQ8WYK2.
PRIDEQ8WYK2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000267569; ENSP00000267569; ENSG00000140044. [Q8WYK2-2]
ENST00000419727; ENSP00000415558; ENSG00000140044. [Q8WYK2-1]
ENST00000435893; ENSP00000399587; ENSG00000140044. [Q8WYK2-1]
ENST00000437176; ENSP00000409787; ENSG00000140044. [Q8WYK2-1]
GeneID122953.
KEGGhsa:122953.
UCSCuc010asj.3. human. [Q8WYK2-1]

Organism-specific databases

CTD122953.
GeneCardsGC14P075894.
H-InvDBHIX0026627.
HGNCHGNC:17546. JDP2.
HPAHPA051651.
HPA059511.
MIM608657. gene.
neXtProtNX_Q8WYK2.
PharmGKBPA162392499.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG280450.
HOGENOMHOG000034126.
HOVERGENHBG057870.
InParanoidQ8WYK2.
KOK09033.
OMAQEFGTML.
OrthoDBEOG70S777.
PhylomeDBQ8WYK2.
TreeFamTF326301.

Gene expression databases

ArrayExpressQ8WYK2.
BgeeQ8WYK2.
CleanExHS_JDP2.
GenevestigatorQ8WYK2.

Family and domain databases

InterProIPR004827. bZIP.
IPR000837. Leuzip_Fos.
[Graphical view]
PfamPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSPR00042. LEUZIPPRFOS.
SMARTSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiJDP2_(gene).
Jun_dimerization_protein.
GenomeRNAi122953.
NextBio35534825.
PROQ8WYK2.
SOURCESearch...

Entry information

Entry nameJDP2_HUMAN
AccessionPrimary (citable) accession number: Q8WYK2
Secondary accession number(s): J3KN58, O95430, Q9UIE4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2002
Last modified: April 16, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM