Q8WYK1 (CNTP5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Contactin-associated protein-like 5

Alternative name(s):
Cell recognition molecule Caspr5

Gene names

Name:	CNTNAP5
Synonyms:	CASPR5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1306 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication.
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Sequence similarities	Belongs to the neurexin family. Contains 2 EGF-like domains. Contains 1 F5/8 type C domain. Contains 1 fibrinogen C-terminal domain. Contains 4 laminin G-like domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	EGF-like domain Repeat Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 1306	1282	Contactin-associated protein-like 5		PRO_0000317377
Regions
	Topological domain	25 – 1237	1213	Extracellular Potential
	Transmembrane	1238 – 1258	21	Helical; Potential
	Topological domain	1259 – 1306	48	Cytoplasmic Potential
	Domain	30 – 174	145	F5/8 type C
	Domain	180 – 360	181	Laminin G-like 1
	Domain	367 – 544	178	Laminin G-like 2
	Domain	546 – 583	38	EGF-like 1
	Domain	584 – 790	207	Fibrinogen C-terminal
	Domain	791 – 956	166	Laminin G-like 3
	Domain	957 – 995	39	EGF-like 2
	Domain	1013 – 1199	187	Laminin G-like 4
	Compositional bias	44 – 47	4	Poly-Ser
Amino acid modifications
	Glycosylation	282	1	N-linked (GlcNAc...) Potential
	Glycosylation	355	1	N-linked (GlcNAc...) Potential
	Glycosylation	496	1	N-linked (GlcNAc...) Potential
	Glycosylation	571	1	N-linked (GlcNAc...) Potential
	Glycosylation	622	1	N-linked (GlcNAc...) Potential
	Disulfide bond	30 ↔ 174		By similarity
	Disulfide bond	329 ↔ 360		By similarity
	Disulfide bond	512 ↔ 544		By similarity
	Disulfide bond	550 ↔ 561		By similarity
	Disulfide bond	555 ↔ 570		By similarity
	Disulfide bond	572 ↔ 582		By similarity
	Disulfide bond	929 ↔ 956		By similarity
	Disulfide bond	960 ↔ 973		By similarity
	Disulfide bond	967 ↔ 982		By similarity
	Disulfide bond	984 ↔ 994		By similarity
	Disulfide bond	1164 ↔ 1199		By similarity
Natural variations
	Natural variant	452	1	S → L. Corresponds to variant rs17727261 [ dbSNP | Ensembl ].		VAR_038518
	Natural variant	1195	1	T → M. Corresponds to variant rs34165507 [ dbSNP | Ensembl ].		VAR_038519
Experimental info
	Sequence conflict	353	1	T → TV in BAB71205. Ref.4
	Sequence conflict	449	1	L → P in BAB71205. Ref.4
	Sequence conflict	957 – 962	6	PGHCSS → SIKKLK in BAB71205. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q8WYK1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 132F8B1D9200C68E	FASTA	1,306	145,623
	10 20 30 40 50 60 MDSLPRLTSV LTLLFSGLWH LGLTATNYNC DDPLASLLSP MAFSSSSDLT GTHSPAQLNW 70 80 90 100 110 120 RVGTGGWSPA DSNAQQWLQM DLGNRVEITA VATQGRYGSS DWVTSYSLMF SDTGRNWKQY 130 140 150 160 170 180 KQEDSIWTFA GNMNADSVVH HKLLHSVRAR FVRFVPLEWN PSGKIGMRVE VYGCSYKSDV 190 200 210 220 230 240 ADFDGRSSLL YRFNQKLMST LKDVISLKFK SMQGDGVLFH GEGQRGDHIT LELQKGRLAL 250 260 270 280 290 300 HLNLGDSKAR LSSSLPSATL GSLLDDQHWH SVLIERVGKQ VNFTVDKHTQ HFRTKGETDA 310 320 330 340 350 360 LDIDYELSFG GIPVPGKPGT FLKKNFHGCI ENLYYNGVNI IDLAKRRKHQ IYTGNVTFSC 370 380 390 400 410 420 SEPQIVPITF VNSSGSYLLL PGTPQIDGLS VSFQFRTWNK DGLLLSTELS EGSGTLLLSL 430 440 450 460 470 480 EGGILRLVIQ KMTERVAEIL TGSNLNDGLW HSVSINARRN RITLTLDDEA APPAPDSTWV 490 500 510 520 530 540 QIYSGNSYYF GGCPDNLTDS QCLNPIKAFQ GCMRLIFIDN QPKDLISVQQ GSLGNFSDLH 550 560 570 580 590 600 IDLCSIKDRC LPNYCEHGGS CSQSWTTFYC NCSDTSYTGA TCHNSIYEQS CEVYRHQGNT 610 620 630 640 650 660 AGFFYIDSDG SGPLGPLQVY CNITEDKIWT SVQHNNTELT RVRGANPEKP YAMALDYGGS 670 680 690 700 710 720 MEQLEAVIDG SEHCEQEVAY HCRRSRLLNT PDGTPFTWWI GRSNERHPYW GGSPPGVQQC 730 740 750 760 770 780 ECGLDESCLD IQHFCNCDAD KDEWTNDTGF LSFKDHLPVT QIVITDTDRS NSEAAWRIGP 790 800 810 820 830 840 LRCYGDRRFW NAVSFYTEAS YLHFPTFHAE FSADISFFFK TTALSGVFLE NLGIKDFIRL 850 860 870 880 890 900 EISSPSEITF AIDVGNGPVE LVVQSPSLLN DNQWHYVRAE RNLKETSLQV DNLPRSTRET 910 920 930 940 950 960 SEEGHFRLQL NSQLFVGGTS SRQKGFLGCI RSLHLNGQKM DLEERAKVTS GVRPGCPGHC 970 980 990 1000 1010 1020 SSYGSICHNG GKCVEKHNGY LCDCTNSPYE GPFCKKEVSA VFEAGTSVTY MFQEPYPVTK 1030 1040 1050 1060 1070 1080 NISLSSSAIY TDSAPSKENI ALSFVTTQAP SLLLFINSSS QDFVVVLLCK NGSLQVRYHL 1090 1100 1110 1120 1130 1140 NKEETHVFTI DADNFANRRM HHLKINREGR ELTIQMDQQL RLSYNFSPEV EFRVIRSLTL 1150 1160 1170 1180 1190 1200 GKVTENLGLD SEVAKANAMG FAGCMSSVQY NHIAPLKAAL RHATVAPVTV HGTLTESSCG 1210 1220 1230 1240 1250 1260 FMVDSDVNAV TTVHSSSDPF GKTDEREPLT NAVRSDSAVI GGVIAVVIFI IFCIIGIMTR 1270 1280 1290 1300 FLYQHKQSHR TSQMKEKEYP ENLDSSFRNE IDLQNTVSEC KREYFI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"In vitro and in vivo studies on the involvement of neural cell adhesion molecules and chondroitin sulfate proteoglycans in defining discrete axonal pathways of the rat cerebral cortex." Takeuchi K., Watanabe N., Kawano T., Kawamura K. Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-962.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB077881 mRNA. Translation: BAB83897.1. AC019105 Genomic DNA. Translation: AAY14716.1. AC019159 Genomic DNA. Translation: AAX88894.1. AC074362 Genomic DNA. Translation: AAX81997.1. AC079154 Genomic DNA. Translation: AAY15042.1. AC097715 Genomic DNA. Translation: AAY24250.1. AC104648 Genomic DNA. Translation: AAX88904.1. CH471103 Genomic DNA. Translation: EAW95266.1. AK056528 mRNA. Translation: BAB71205.1.
IPI	IPI00292300.
RefSeq	NP_570129.1. NM_130773.2.
UniGene	Hs.660653.
3D structure databases
HSSP	HSSP built from PDB template 1GK5 based on UniProtKB P01132.
ProteinModelPortal	Q8WYK1.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000399013.
PTM databases
PhosphoSite	Q8WYK1.
Polymorphism databases
DMDM	74716461.
Proteomic databases
PaxDb	Q8WYK1.
PRIDE	Q8WYK1.
Protocols and materials databases
DNASU	129684.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000431078; ENSP00000399013; ENSG00000155052.
GeneID	129684.
KEGG	hsa:129684.
UCSC	uc002tno.3. human.
Organism-specific databases
CTD	129684.
GeneCards	GC02P124879.
HGNC	HGNC:18748. CNTNAP5.
MIM	610519. gene.
neXtProt	NX_Q8WYK1.
PharmGKB	PA134898715.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG291100.
HOVERGEN	HBG057718.
InParanoid	Q8WYK1.
OMA	FANRRMH.
Gene expression databases
Bgee	Q8WYK1.
CleanEx	HS_CNTNAP5.
Genevestigator	Q8WYK1.
Family and domain databases
Gene3D	2.60.120.200. 5 hits.
InterPro	IPR000421. Coagulation_fac_5/8-C_type_dom. IPR008985. ConA-like_lec_gl_sf. IPR013320. ConA-like_subgrp. IPR000742. EG-like_dom. IPR002181. Fibrinogen_a/b/g_C_dom. IPR008979. Galactose-bd-like. IPR001791. Laminin_G. [Graphical view]
Pfam	PF00754. F5_F8_type_C. 1 hit. PF02210. Laminin_G_2. 4 hits. [Graphical view]
SMART	SM00181. EGF. 2 hits. SM00231. FA58C. 1 hit. SM00282. LamG. 4 hits. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 4 hits. SSF56496. Fibrinogen_a/b/g_C. 1 hit. SSF49785. Gal_bind_like. 1 hit.
PROSITE	PS00022. EGF_1. False negative. PS01186. EGF_2. False negative. PS50026. EGF_3. 2 hits. PS01285. FA58C_1. False negative. PS01286. FA58C_2. 1 hit. PS50022. FA58C_3. 1 hit. PS00514. FIBRINOGEN_C_1. False negative. PS51406. FIBRINOGEN_C_2. 1 hit. PS50025. LAM_G_DOMAIN. 4 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	129684.
NextBio	82625.
SOURCE	Search...

Entry information

Entry name

CNTP5_HUMAN

Accession

Primary (citable) accession number: Q8WYK1
Secondary accession number(s): Q4ZFW2 , Q4ZG21, Q53R09, Q53RX1, Q53SG3, Q584P3, Q96MS7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.