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Protein

Contactin-associated protein-like 5

Gene

CNTNAP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-associated protein-like 5
Alternative name(s):
Cell recognition molecule Caspr5
Gene namesi
Name:CNTNAP5
Synonyms:CASPR5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:18748. CNTNAP5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 1237ExtracellularSequence analysisAdd BLAST1213
Transmembranei1238 – 1258HelicalSequence analysisAdd BLAST21
Topological domaini1259 – 1306CytoplasmicSequence analysisAdd BLAST48

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi129684.
OpenTargetsiENSG00000155052.
PharmGKBiPA134898715.

Polymorphism and mutation databases

DMDMi74716461.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000031737725 – 1306Contactin-associated protein-like 5Add BLAST1282

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 174By similarity
Glycosylationi282N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi329 ↔ 360By similarity
Glycosylationi355N-linked (GlcNAc...)Sequence analysis1
Glycosylationi496N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi512 ↔ 544By similarity
Disulfide bondi550 ↔ 561By similarity
Disulfide bondi555 ↔ 570By similarity
Glycosylationi571N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi572 ↔ 582By similarity
Glycosylationi622N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi929 ↔ 956By similarity
Disulfide bondi960 ↔ 973By similarity
Disulfide bondi967 ↔ 982By similarity
Disulfide bondi984 ↔ 994By similarity
Disulfide bondi1164 ↔ 1199By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ8WYK1.
PaxDbiQ8WYK1.
PeptideAtlasiQ8WYK1.
PRIDEiQ8WYK1.

PTM databases

iPTMnetiQ8WYK1.
PhosphoSitePlusiQ8WYK1.

Expressioni

Gene expression databases

BgeeiENSG00000155052.
CleanExiHS_CNTNAP5.
GenevisibleiQ8WYK1. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000399013.

Structurei

3D structure databases

ProteinModelPortaliQ8WYK1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 174F5/8 type CPROSITE-ProRule annotationAdd BLAST145
Domaini180 – 360Laminin G-like 1PROSITE-ProRule annotationAdd BLAST181
Domaini367 – 544Laminin G-like 2PROSITE-ProRule annotationAdd BLAST178
Domaini546 – 583EGF-like 1PROSITE-ProRule annotationAdd BLAST38
Domaini584 – 790Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST207
Domaini791 – 956Laminin G-like 3PROSITE-ProRule annotationAdd BLAST166
Domaini957 – 995EGF-like 2PROSITE-ProRule annotationAdd BLAST39
Domaini1013 – 1199Laminin G-like 4PROSITE-ProRule annotationAdd BLAST187

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi44 – 47Poly-Ser4

Sequence similaritiesi

Belongs to the neurexin family.Curated
Contains 2 EGF-like domains.PROSITE-ProRule annotation
Contains 1 F5/8 type C domain.PROSITE-ProRule annotation
Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation
Contains 4 laminin G-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3516. Eukaryota.
ENOG410XPHG. LUCA.
GeneTreeiENSGT00760000118991.
HOVERGENiHBG057718.
InParanoidiQ8WYK1.
OMAiFANRRMH.
OrthoDBiEOG091G00LF.
PhylomeDBiQ8WYK1.
TreeFamiTF321823.

Family and domain databases

Gene3Di2.60.120.200. 5 hits.
2.60.120.260. 1 hit.
InterProiIPR028874. Caspr5.
IPR013320. ConA-like_dom.
IPR000742. EGF-like_dom.
IPR000421. FA58C.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR008979. Galactose-bd-like.
IPR001791. Laminin_G.
[Graphical view]
PANTHERiPTHR10127:SF665. PTHR10127:SF665. 1 hit.
PfamiPF00754. F5_F8_type_C. 1 hit.
PF02210. Laminin_G_2. 4 hits.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00231. FA58C. 1 hit.
SM00282. LamG. 4 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF49899. SSF49899. 5 hits.
SSF56496. SSF56496. 1 hit.
PROSITEiPS50026. EGF_3. 2 hits.
PS01286. FA58C_2. 1 hit.
PS50022. FA58C_3. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50025. LAM_G_DOMAIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WYK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSLPRLTSV LTLLFSGLWH LGLTATNYNC DDPLASLLSP MAFSSSSDLT
60 70 80 90 100
GTHSPAQLNW RVGTGGWSPA DSNAQQWLQM DLGNRVEITA VATQGRYGSS
110 120 130 140 150
DWVTSYSLMF SDTGRNWKQY KQEDSIWTFA GNMNADSVVH HKLLHSVRAR
160 170 180 190 200
FVRFVPLEWN PSGKIGMRVE VYGCSYKSDV ADFDGRSSLL YRFNQKLMST
210 220 230 240 250
LKDVISLKFK SMQGDGVLFH GEGQRGDHIT LELQKGRLAL HLNLGDSKAR
260 270 280 290 300
LSSSLPSATL GSLLDDQHWH SVLIERVGKQ VNFTVDKHTQ HFRTKGETDA
310 320 330 340 350
LDIDYELSFG GIPVPGKPGT FLKKNFHGCI ENLYYNGVNI IDLAKRRKHQ
360 370 380 390 400
IYTGNVTFSC SEPQIVPITF VNSSGSYLLL PGTPQIDGLS VSFQFRTWNK
410 420 430 440 450
DGLLLSTELS EGSGTLLLSL EGGILRLVIQ KMTERVAEIL TGSNLNDGLW
460 470 480 490 500
HSVSINARRN RITLTLDDEA APPAPDSTWV QIYSGNSYYF GGCPDNLTDS
510 520 530 540 550
QCLNPIKAFQ GCMRLIFIDN QPKDLISVQQ GSLGNFSDLH IDLCSIKDRC
560 570 580 590 600
LPNYCEHGGS CSQSWTTFYC NCSDTSYTGA TCHNSIYEQS CEVYRHQGNT
610 620 630 640 650
AGFFYIDSDG SGPLGPLQVY CNITEDKIWT SVQHNNTELT RVRGANPEKP
660 670 680 690 700
YAMALDYGGS MEQLEAVIDG SEHCEQEVAY HCRRSRLLNT PDGTPFTWWI
710 720 730 740 750
GRSNERHPYW GGSPPGVQQC ECGLDESCLD IQHFCNCDAD KDEWTNDTGF
760 770 780 790 800
LSFKDHLPVT QIVITDTDRS NSEAAWRIGP LRCYGDRRFW NAVSFYTEAS
810 820 830 840 850
YLHFPTFHAE FSADISFFFK TTALSGVFLE NLGIKDFIRL EISSPSEITF
860 870 880 890 900
AIDVGNGPVE LVVQSPSLLN DNQWHYVRAE RNLKETSLQV DNLPRSTRET
910 920 930 940 950
SEEGHFRLQL NSQLFVGGTS SRQKGFLGCI RSLHLNGQKM DLEERAKVTS
960 970 980 990 1000
GVRPGCPGHC SSYGSICHNG GKCVEKHNGY LCDCTNSPYE GPFCKKEVSA
1010 1020 1030 1040 1050
VFEAGTSVTY MFQEPYPVTK NISLSSSAIY TDSAPSKENI ALSFVTTQAP
1060 1070 1080 1090 1100
SLLLFINSSS QDFVVVLLCK NGSLQVRYHL NKEETHVFTI DADNFANRRM
1110 1120 1130 1140 1150
HHLKINREGR ELTIQMDQQL RLSYNFSPEV EFRVIRSLTL GKVTENLGLD
1160 1170 1180 1190 1200
SEVAKANAMG FAGCMSSVQY NHIAPLKAAL RHATVAPVTV HGTLTESSCG
1210 1220 1230 1240 1250
FMVDSDVNAV TTVHSSSDPF GKTDEREPLT NAVRSDSAVI GGVIAVVIFI
1260 1270 1280 1290 1300
IFCIIGIMTR FLYQHKQSHR TSQMKEKEYP ENLDSSFRNE IDLQNTVSEC

KREYFI
Length:1,306
Mass (Da):145,623
Last modified:March 1, 2002 - v1
Checksum:i132F8B1D9200C68E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti353T → TV in BAB71205 (PubMed:14702039).Curated1
Sequence conflicti449L → P in BAB71205 (PubMed:14702039).Curated1
Sequence conflicti957 – 962PGHCSS → SIKKLK in BAB71205 (PubMed:14702039).Curated6

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038518452S → L.Corresponds to variant rs17727261dbSNPEnsembl.1
Natural variantiVAR_0385191195T → M.Corresponds to variant rs34165507dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB077881 mRNA. Translation: BAB83897.1.
AC019105 Genomic DNA. Translation: AAY14716.1.
AC019159 Genomic DNA. Translation: AAX88894.1.
AC074362 Genomic DNA. Translation: AAX81997.1.
AC079154 Genomic DNA. Translation: AAY15042.1.
AC097715 Genomic DNA. Translation: AAY24250.1.
AC104648 Genomic DNA. Translation: AAX88904.1.
CH471103 Genomic DNA. Translation: EAW95266.1.
AK056528 mRNA. Translation: BAB71205.1.
CCDSiCCDS46401.1.
RefSeqiNP_570129.1. NM_130773.3.
UniGeneiHs.660653.

Genome annotation databases

EnsembliENST00000431078; ENSP00000399013; ENSG00000155052.
GeneIDi129684.
KEGGihsa:129684.
UCSCiuc002tno.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB077881 mRNA. Translation: BAB83897.1.
AC019105 Genomic DNA. Translation: AAY14716.1.
AC019159 Genomic DNA. Translation: AAX88894.1.
AC074362 Genomic DNA. Translation: AAX81997.1.
AC079154 Genomic DNA. Translation: AAY15042.1.
AC097715 Genomic DNA. Translation: AAY24250.1.
AC104648 Genomic DNA. Translation: AAX88904.1.
CH471103 Genomic DNA. Translation: EAW95266.1.
AK056528 mRNA. Translation: BAB71205.1.
CCDSiCCDS46401.1.
RefSeqiNP_570129.1. NM_130773.3.
UniGeneiHs.660653.

3D structure databases

ProteinModelPortaliQ8WYK1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000399013.

PTM databases

iPTMnetiQ8WYK1.
PhosphoSitePlusiQ8WYK1.

Polymorphism and mutation databases

DMDMi74716461.

Proteomic databases

EPDiQ8WYK1.
PaxDbiQ8WYK1.
PeptideAtlasiQ8WYK1.
PRIDEiQ8WYK1.

Protocols and materials databases

DNASUi129684.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000431078; ENSP00000399013; ENSG00000155052.
GeneIDi129684.
KEGGihsa:129684.
UCSCiuc002tno.5. human.

Organism-specific databases

CTDi129684.
DisGeNETi129684.
GeneCardsiCNTNAP5.
HGNCiHGNC:18748. CNTNAP5.
MIMi610519. gene.
neXtProtiNX_Q8WYK1.
OpenTargetsiENSG00000155052.
PharmGKBiPA134898715.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3516. Eukaryota.
ENOG410XPHG. LUCA.
GeneTreeiENSGT00760000118991.
HOVERGENiHBG057718.
InParanoidiQ8WYK1.
OMAiFANRRMH.
OrthoDBiEOG091G00LF.
PhylomeDBiQ8WYK1.
TreeFamiTF321823.

Miscellaneous databases

GenomeRNAii129684.
PROiQ8WYK1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000155052.
CleanExiHS_CNTNAP5.
GenevisibleiQ8WYK1. HS.

Family and domain databases

Gene3Di2.60.120.200. 5 hits.
2.60.120.260. 1 hit.
InterProiIPR028874. Caspr5.
IPR013320. ConA-like_dom.
IPR000742. EGF-like_dom.
IPR000421. FA58C.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR008979. Galactose-bd-like.
IPR001791. Laminin_G.
[Graphical view]
PANTHERiPTHR10127:SF665. PTHR10127:SF665. 1 hit.
PfamiPF00754. F5_F8_type_C. 1 hit.
PF02210. Laminin_G_2. 4 hits.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00231. FA58C. 1 hit.
SM00282. LamG. 4 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF49899. SSF49899. 5 hits.
SSF56496. SSF56496. 1 hit.
PROSITEiPS50026. EGF_3. 2 hits.
PS01286. FA58C_2. 1 hit.
PS50022. FA58C_3. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50025. LAM_G_DOMAIN. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNTP5_HUMAN
AccessioniPrimary (citable) accession number: Q8WYK1
Secondary accession number(s): Q4ZFW2
, Q4ZG21, Q53R09, Q53RX1, Q53SG3, Q584P3, Q96MS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.