SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8WYK1

- CNTP5_HUMAN

UniProt

Q8WYK1 - CNTP5_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Contactin-associated protein-like 5

Gene
CNTNAP5, CASPR5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication.

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-associated protein-like 5
Alternative name(s):
Cell recognition molecule Caspr5
Gene namesi
Name:CNTNAP5
Synonyms:CASPR5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:18748. CNTNAP5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 12371213Extracellular Reviewed predictionAdd
BLAST
Transmembranei1238 – 125821Helical; Reviewed predictionAdd
BLAST
Topological domaini1259 – 130648Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134898715.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed predictionAdd
BLAST
Chaini25 – 13061282Contactin-associated protein-like 5PRO_0000317377Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 174 By similarity
Glycosylationi282 – 2821N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi329 ↔ 360 By similarity
Glycosylationi355 – 3551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi496 – 4961N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi512 ↔ 544 By similarity
Disulfide bondi550 ↔ 561 By similarity
Disulfide bondi555 ↔ 570 By similarity
Glycosylationi571 – 5711N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi572 ↔ 582 By similarity
Glycosylationi622 – 6221N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi929 ↔ 956 By similarity
Disulfide bondi960 ↔ 973 By similarity
Disulfide bondi967 ↔ 982 By similarity
Disulfide bondi984 ↔ 994 By similarity
Disulfide bondi1164 ↔ 1199 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8WYK1.
PRIDEiQ8WYK1.

PTM databases

PhosphoSiteiQ8WYK1.

Expressioni

Gene expression databases

BgeeiQ8WYK1.
CleanExiHS_CNTNAP5.
GenevestigatoriQ8WYK1.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000399013.

Structurei

3D structure databases

ProteinModelPortaliQ8WYK1.
SMRiQ8WYK1. Positions 8-174, 180-582, 791-1188.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 174145F5/8 type CAdd
BLAST
Domaini180 – 360181Laminin G-like 1Add
BLAST
Domaini367 – 544178Laminin G-like 2Add
BLAST
Domaini546 – 58338EGF-like 1Add
BLAST
Domaini584 – 790207Fibrinogen C-terminalAdd
BLAST
Domaini791 – 956166Laminin G-like 3Add
BLAST
Domaini957 – 99539EGF-like 2Add
BLAST
Domaini1013 – 1199187Laminin G-like 4Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi44 – 474Poly-Ser

Sequence similaritiesi

Belongs to the neurexin family.
Contains 2 EGF-like domains.
Contains 1 F5/8 type C domain.

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG291100.
HOVERGENiHBG057718.
InParanoidiQ8WYK1.
OMAiNFANRRM.
OrthoDBiEOG7GXP9N.
PhylomeDBiQ8WYK1.
TreeFamiTF321823.

Family and domain databases

Gene3Di2.60.120.200. 5 hits.
2.60.120.260. 1 hit.
InterProiIPR028874. Caspr5.
IPR000421. Coagulation_fac_5/8-C_type_dom.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR008979. Galactose-bd-like.
IPR001791. Laminin_G.
[Graphical view]
PANTHERiPTHR10127:SF605. PTHR10127:SF605. 1 hit.
PfamiPF00754. F5_F8_type_C. 1 hit.
PF02210. Laminin_G_2. 4 hits.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00231. FA58C. 1 hit.
SM00282. LamG. 4 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF49899. SSF49899. 5 hits.
SSF56496. SSF56496. 1 hit.
PROSITEiPS50026. EGF_3. 2 hits.
PS01286. FA58C_2. 1 hit.
PS50022. FA58C_3. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50025. LAM_G_DOMAIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WYK1-1 [UniParc]FASTAAdd to Basket

« Hide

MDSLPRLTSV LTLLFSGLWH LGLTATNYNC DDPLASLLSP MAFSSSSDLT     50
GTHSPAQLNW RVGTGGWSPA DSNAQQWLQM DLGNRVEITA VATQGRYGSS 100
DWVTSYSLMF SDTGRNWKQY KQEDSIWTFA GNMNADSVVH HKLLHSVRAR 150
FVRFVPLEWN PSGKIGMRVE VYGCSYKSDV ADFDGRSSLL YRFNQKLMST 200
LKDVISLKFK SMQGDGVLFH GEGQRGDHIT LELQKGRLAL HLNLGDSKAR 250
LSSSLPSATL GSLLDDQHWH SVLIERVGKQ VNFTVDKHTQ HFRTKGETDA 300
LDIDYELSFG GIPVPGKPGT FLKKNFHGCI ENLYYNGVNI IDLAKRRKHQ 350
IYTGNVTFSC SEPQIVPITF VNSSGSYLLL PGTPQIDGLS VSFQFRTWNK 400
DGLLLSTELS EGSGTLLLSL EGGILRLVIQ KMTERVAEIL TGSNLNDGLW 450
HSVSINARRN RITLTLDDEA APPAPDSTWV QIYSGNSYYF GGCPDNLTDS 500
QCLNPIKAFQ GCMRLIFIDN QPKDLISVQQ GSLGNFSDLH IDLCSIKDRC 550
LPNYCEHGGS CSQSWTTFYC NCSDTSYTGA TCHNSIYEQS CEVYRHQGNT 600
AGFFYIDSDG SGPLGPLQVY CNITEDKIWT SVQHNNTELT RVRGANPEKP 650
YAMALDYGGS MEQLEAVIDG SEHCEQEVAY HCRRSRLLNT PDGTPFTWWI 700
GRSNERHPYW GGSPPGVQQC ECGLDESCLD IQHFCNCDAD KDEWTNDTGF 750
LSFKDHLPVT QIVITDTDRS NSEAAWRIGP LRCYGDRRFW NAVSFYTEAS 800
YLHFPTFHAE FSADISFFFK TTALSGVFLE NLGIKDFIRL EISSPSEITF 850
AIDVGNGPVE LVVQSPSLLN DNQWHYVRAE RNLKETSLQV DNLPRSTRET 900
SEEGHFRLQL NSQLFVGGTS SRQKGFLGCI RSLHLNGQKM DLEERAKVTS 950
GVRPGCPGHC SSYGSICHNG GKCVEKHNGY LCDCTNSPYE GPFCKKEVSA 1000
VFEAGTSVTY MFQEPYPVTK NISLSSSAIY TDSAPSKENI ALSFVTTQAP 1050
SLLLFINSSS QDFVVVLLCK NGSLQVRYHL NKEETHVFTI DADNFANRRM 1100
HHLKINREGR ELTIQMDQQL RLSYNFSPEV EFRVIRSLTL GKVTENLGLD 1150
SEVAKANAMG FAGCMSSVQY NHIAPLKAAL RHATVAPVTV HGTLTESSCG 1200
FMVDSDVNAV TTVHSSSDPF GKTDEREPLT NAVRSDSAVI GGVIAVVIFI 1250
IFCIIGIMTR FLYQHKQSHR TSQMKEKEYP ENLDSSFRNE IDLQNTVSEC 1300
KREYFI 1306
Length:1,306
Mass (Da):145,623
Last modified:March 1, 2002 - v1
Checksum:i132F8B1D9200C68E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti452 – 4521S → L.
Corresponds to variant rs17727261 [ dbSNP | Ensembl ].
VAR_038518
Natural varianti1195 – 11951T → M.
Corresponds to variant rs34165507 [ dbSNP | Ensembl ].
VAR_038519

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti353 – 3531T → TV in BAB71205. 1 Publication
Sequence conflicti449 – 4491L → P in BAB71205. 1 Publication
Sequence conflicti957 – 9626PGHCSS → SIKKLK in BAB71205. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB077881 mRNA. Translation: BAB83897.1.
AC019105 Genomic DNA. Translation: AAY14716.1.
AC019159 Genomic DNA. Translation: AAX88894.1.
AC074362 Genomic DNA. Translation: AAX81997.1.
AC079154 Genomic DNA. Translation: AAY15042.1.
AC097715 Genomic DNA. Translation: AAY24250.1.
AC104648 Genomic DNA. Translation: AAX88904.1.
CH471103 Genomic DNA. Translation: EAW95266.1.
AK056528 mRNA. Translation: BAB71205.1.
CCDSiCCDS46401.1.
RefSeqiNP_570129.1. NM_130773.3.
UniGeneiHs.660653.

Genome annotation databases

EnsembliENST00000431078; ENSP00000399013; ENSG00000155052.
GeneIDi129684.
KEGGihsa:129684.
UCSCiuc002tno.3. human.

Polymorphism databases

DMDMi74716461.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB077881 mRNA. Translation: BAB83897.1 .
AC019105 Genomic DNA. Translation: AAY14716.1 .
AC019159 Genomic DNA. Translation: AAX88894.1 .
AC074362 Genomic DNA. Translation: AAX81997.1 .
AC079154 Genomic DNA. Translation: AAY15042.1 .
AC097715 Genomic DNA. Translation: AAY24250.1 .
AC104648 Genomic DNA. Translation: AAX88904.1 .
CH471103 Genomic DNA. Translation: EAW95266.1 .
AK056528 mRNA. Translation: BAB71205.1 .
CCDSi CCDS46401.1.
RefSeqi NP_570129.1. NM_130773.3.
UniGenei Hs.660653.

3D structure databases

ProteinModelPortali Q8WYK1.
SMRi Q8WYK1. Positions 8-174, 180-582, 791-1188.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000399013.

PTM databases

PhosphoSitei Q8WYK1.

Polymorphism databases

DMDMi 74716461.

Proteomic databases

PaxDbi Q8WYK1.
PRIDEi Q8WYK1.

Protocols and materials databases

DNASUi 129684.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000431078 ; ENSP00000399013 ; ENSG00000155052 .
GeneIDi 129684.
KEGGi hsa:129684.
UCSCi uc002tno.3. human.

Organism-specific databases

CTDi 129684.
GeneCardsi GC02P124879.
HGNCi HGNC:18748. CNTNAP5.
MIMi 610519. gene.
neXtProti NX_Q8WYK1.
PharmGKBi PA134898715.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG291100.
HOVERGENi HBG057718.
InParanoidi Q8WYK1.
OMAi NFANRRM.
OrthoDBi EOG7GXP9N.
PhylomeDBi Q8WYK1.
TreeFami TF321823.

Miscellaneous databases

GenomeRNAii 129684.
NextBioi 82625.
PROi Q8WYK1.
SOURCEi Search...

Gene expression databases

Bgeei Q8WYK1.
CleanExi HS_CNTNAP5.
Genevestigatori Q8WYK1.

Family and domain databases

Gene3Di 2.60.120.200. 5 hits.
2.60.120.260. 1 hit.
InterProi IPR028874. Caspr5.
IPR000421. Coagulation_fac_5/8-C_type_dom.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR008979. Galactose-bd-like.
IPR001791. Laminin_G.
[Graphical view ]
PANTHERi PTHR10127:SF605. PTHR10127:SF605. 1 hit.
Pfami PF00754. F5_F8_type_C. 1 hit.
PF02210. Laminin_G_2. 4 hits.
[Graphical view ]
SMARTi SM00181. EGF. 2 hits.
SM00231. FA58C. 1 hit.
SM00282. LamG. 4 hits.
[Graphical view ]
SUPFAMi SSF49785. SSF49785. 1 hit.
SSF49899. SSF49899. 5 hits.
SSF56496. SSF56496. 1 hit.
PROSITEi PS50026. EGF_3. 2 hits.
PS01286. FA58C_2. 1 hit.
PS50022. FA58C_3. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50025. LAM_G_DOMAIN. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "In vitro and in vivo studies on the involvement of neural cell adhesion molecules and chondroitin sulfate proteoglycans in defining discrete axonal pathways of the rat cerebral cortex."
    Takeuchi K., Watanabe N., Kawano T., Kawamura K.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-962.

Entry informationi

Entry nameiCNTP5_HUMAN
AccessioniPrimary (citable) accession number: Q8WYK1
Secondary accession number(s): Q4ZFW2
, Q4ZG21, Q53R09, Q53RX1, Q53SG3, Q584P3, Q96MS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi