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Q8WYK1

- CNTP5_HUMAN

UniProt

Q8WYK1 - CNTP5_HUMAN

Protein

Contactin-associated protein-like 5

Gene

CNTNAP5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication.

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Contactin-associated protein-like 5
    Alternative name(s):
    Cell recognition molecule Caspr5
    Gene namesi
    Name:CNTNAP5
    Synonyms:CASPR5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:18748. CNTNAP5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134898715.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 13061282Contactin-associated protein-like 5PRO_0000317377Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi30 ↔ 174By similarity
    Glycosylationi282 – 2821N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi329 ↔ 360By similarity
    Glycosylationi355 – 3551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi496 – 4961N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi512 ↔ 544By similarity
    Disulfide bondi550 ↔ 561By similarity
    Disulfide bondi555 ↔ 570By similarity
    Glycosylationi571 – 5711N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi572 ↔ 582By similarity
    Glycosylationi622 – 6221N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi929 ↔ 956By similarity
    Disulfide bondi960 ↔ 973By similarity
    Disulfide bondi967 ↔ 982By similarity
    Disulfide bondi984 ↔ 994By similarity
    Disulfide bondi1164 ↔ 1199By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8WYK1.
    PRIDEiQ8WYK1.

    PTM databases

    PhosphoSiteiQ8WYK1.

    Expressioni

    Gene expression databases

    BgeeiQ8WYK1.
    CleanExiHS_CNTNAP5.
    GenevestigatoriQ8WYK1.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000399013.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WYK1.
    SMRiQ8WYK1. Positions 8-174, 180-582, 791-1188.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 12371213ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1259 – 130648CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1238 – 125821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 174145F5/8 type CPROSITE-ProRule annotationAdd
    BLAST
    Domaini180 – 360181Laminin G-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini367 – 544178Laminin G-like 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini546 – 58338EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini584 – 790207Fibrinogen C-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini791 – 956166Laminin G-like 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini957 – 99539EGF-like 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1013 – 1199187Laminin G-like 4PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi44 – 474Poly-Ser

    Sequence similaritiesi

    Belongs to the neurexin family.Curated
    Contains 2 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 F5/8 type C domain.PROSITE-ProRule annotation
    Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation
    Contains 4 laminin G-like domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG291100.
    HOVERGENiHBG057718.
    InParanoidiQ8WYK1.
    OMAiNFANRRM.
    OrthoDBiEOG7GXP9N.
    PhylomeDBiQ8WYK1.
    TreeFamiTF321823.

    Family and domain databases

    Gene3Di2.60.120.200. 5 hits.
    2.60.120.260. 1 hit.
    InterProiIPR028874. Caspr5.
    IPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR002181. Fibrinogen_a/b/g_C_dom.
    IPR008979. Galactose-bd-like.
    IPR001791. Laminin_G.
    [Graphical view]
    PANTHERiPTHR10127:SF605. PTHR10127:SF605. 1 hit.
    PfamiPF00754. F5_F8_type_C. 1 hit.
    PF02210. Laminin_G_2. 4 hits.
    [Graphical view]
    SMARTiSM00181. EGF. 2 hits.
    SM00231. FA58C. 1 hit.
    SM00282. LamG. 4 hits.
    [Graphical view]
    SUPFAMiSSF49785. SSF49785. 1 hit.
    SSF49899. SSF49899. 5 hits.
    SSF56496. SSF56496. 1 hit.
    PROSITEiPS50026. EGF_3. 2 hits.
    PS01286. FA58C_2. 1 hit.
    PS50022. FA58C_3. 1 hit.
    PS51406. FIBRINOGEN_C_2. 1 hit.
    PS50025. LAM_G_DOMAIN. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8WYK1-1 [UniParc]FASTAAdd to Basket

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    MDSLPRLTSV LTLLFSGLWH LGLTATNYNC DDPLASLLSP MAFSSSSDLT     50
    GTHSPAQLNW RVGTGGWSPA DSNAQQWLQM DLGNRVEITA VATQGRYGSS 100
    DWVTSYSLMF SDTGRNWKQY KQEDSIWTFA GNMNADSVVH HKLLHSVRAR 150
    FVRFVPLEWN PSGKIGMRVE VYGCSYKSDV ADFDGRSSLL YRFNQKLMST 200
    LKDVISLKFK SMQGDGVLFH GEGQRGDHIT LELQKGRLAL HLNLGDSKAR 250
    LSSSLPSATL GSLLDDQHWH SVLIERVGKQ VNFTVDKHTQ HFRTKGETDA 300
    LDIDYELSFG GIPVPGKPGT FLKKNFHGCI ENLYYNGVNI IDLAKRRKHQ 350
    IYTGNVTFSC SEPQIVPITF VNSSGSYLLL PGTPQIDGLS VSFQFRTWNK 400
    DGLLLSTELS EGSGTLLLSL EGGILRLVIQ KMTERVAEIL TGSNLNDGLW 450
    HSVSINARRN RITLTLDDEA APPAPDSTWV QIYSGNSYYF GGCPDNLTDS 500
    QCLNPIKAFQ GCMRLIFIDN QPKDLISVQQ GSLGNFSDLH IDLCSIKDRC 550
    LPNYCEHGGS CSQSWTTFYC NCSDTSYTGA TCHNSIYEQS CEVYRHQGNT 600
    AGFFYIDSDG SGPLGPLQVY CNITEDKIWT SVQHNNTELT RVRGANPEKP 650
    YAMALDYGGS MEQLEAVIDG SEHCEQEVAY HCRRSRLLNT PDGTPFTWWI 700
    GRSNERHPYW GGSPPGVQQC ECGLDESCLD IQHFCNCDAD KDEWTNDTGF 750
    LSFKDHLPVT QIVITDTDRS NSEAAWRIGP LRCYGDRRFW NAVSFYTEAS 800
    YLHFPTFHAE FSADISFFFK TTALSGVFLE NLGIKDFIRL EISSPSEITF 850
    AIDVGNGPVE LVVQSPSLLN DNQWHYVRAE RNLKETSLQV DNLPRSTRET 900
    SEEGHFRLQL NSQLFVGGTS SRQKGFLGCI RSLHLNGQKM DLEERAKVTS 950
    GVRPGCPGHC SSYGSICHNG GKCVEKHNGY LCDCTNSPYE GPFCKKEVSA 1000
    VFEAGTSVTY MFQEPYPVTK NISLSSSAIY TDSAPSKENI ALSFVTTQAP 1050
    SLLLFINSSS QDFVVVLLCK NGSLQVRYHL NKEETHVFTI DADNFANRRM 1100
    HHLKINREGR ELTIQMDQQL RLSYNFSPEV EFRVIRSLTL GKVTENLGLD 1150
    SEVAKANAMG FAGCMSSVQY NHIAPLKAAL RHATVAPVTV HGTLTESSCG 1200
    FMVDSDVNAV TTVHSSSDPF GKTDEREPLT NAVRSDSAVI GGVIAVVIFI 1250
    IFCIIGIMTR FLYQHKQSHR TSQMKEKEYP ENLDSSFRNE IDLQNTVSEC 1300
    KREYFI 1306
    Length:1,306
    Mass (Da):145,623
    Last modified:March 1, 2002 - v1
    Checksum:i132F8B1D9200C68E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti353 – 3531T → TV in BAB71205. (PubMed:14702039)Curated
    Sequence conflicti449 – 4491L → P in BAB71205. (PubMed:14702039)Curated
    Sequence conflicti957 – 9626PGHCSS → SIKKLK in BAB71205. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti452 – 4521S → L.
    Corresponds to variant rs17727261 [ dbSNP | Ensembl ].
    VAR_038518
    Natural varianti1195 – 11951T → M.
    Corresponds to variant rs34165507 [ dbSNP | Ensembl ].
    VAR_038519

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB077881 mRNA. Translation: BAB83897.1.
    AC019105 Genomic DNA. Translation: AAY14716.1.
    AC019159 Genomic DNA. Translation: AAX88894.1.
    AC074362 Genomic DNA. Translation: AAX81997.1.
    AC079154 Genomic DNA. Translation: AAY15042.1.
    AC097715 Genomic DNA. Translation: AAY24250.1.
    AC104648 Genomic DNA. Translation: AAX88904.1.
    CH471103 Genomic DNA. Translation: EAW95266.1.
    AK056528 mRNA. Translation: BAB71205.1.
    CCDSiCCDS46401.1.
    RefSeqiNP_570129.1. NM_130773.3.
    UniGeneiHs.660653.

    Genome annotation databases

    EnsembliENST00000431078; ENSP00000399013; ENSG00000155052.
    GeneIDi129684.
    KEGGihsa:129684.
    UCSCiuc002tno.3. human.

    Polymorphism databases

    DMDMi74716461.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB077881 mRNA. Translation: BAB83897.1 .
    AC019105 Genomic DNA. Translation: AAY14716.1 .
    AC019159 Genomic DNA. Translation: AAX88894.1 .
    AC074362 Genomic DNA. Translation: AAX81997.1 .
    AC079154 Genomic DNA. Translation: AAY15042.1 .
    AC097715 Genomic DNA. Translation: AAY24250.1 .
    AC104648 Genomic DNA. Translation: AAX88904.1 .
    CH471103 Genomic DNA. Translation: EAW95266.1 .
    AK056528 mRNA. Translation: BAB71205.1 .
    CCDSi CCDS46401.1.
    RefSeqi NP_570129.1. NM_130773.3.
    UniGenei Hs.660653.

    3D structure databases

    ProteinModelPortali Q8WYK1.
    SMRi Q8WYK1. Positions 8-174, 180-582, 791-1188.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000399013.

    PTM databases

    PhosphoSitei Q8WYK1.

    Polymorphism databases

    DMDMi 74716461.

    Proteomic databases

    PaxDbi Q8WYK1.
    PRIDEi Q8WYK1.

    Protocols and materials databases

    DNASUi 129684.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000431078 ; ENSP00000399013 ; ENSG00000155052 .
    GeneIDi 129684.
    KEGGi hsa:129684.
    UCSCi uc002tno.3. human.

    Organism-specific databases

    CTDi 129684.
    GeneCardsi GC02P124879.
    HGNCi HGNC:18748. CNTNAP5.
    MIMi 610519. gene.
    neXtProti NX_Q8WYK1.
    PharmGKBi PA134898715.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG291100.
    HOVERGENi HBG057718.
    InParanoidi Q8WYK1.
    OMAi NFANRRM.
    OrthoDBi EOG7GXP9N.
    PhylomeDBi Q8WYK1.
    TreeFami TF321823.

    Miscellaneous databases

    GenomeRNAii 129684.
    NextBioi 82625.
    PROi Q8WYK1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8WYK1.
    CleanExi HS_CNTNAP5.
    Genevestigatori Q8WYK1.

    Family and domain databases

    Gene3Di 2.60.120.200. 5 hits.
    2.60.120.260. 1 hit.
    InterProi IPR028874. Caspr5.
    IPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR002181. Fibrinogen_a/b/g_C_dom.
    IPR008979. Galactose-bd-like.
    IPR001791. Laminin_G.
    [Graphical view ]
    PANTHERi PTHR10127:SF605. PTHR10127:SF605. 1 hit.
    Pfami PF00754. F5_F8_type_C. 1 hit.
    PF02210. Laminin_G_2. 4 hits.
    [Graphical view ]
    SMARTi SM00181. EGF. 2 hits.
    SM00231. FA58C. 1 hit.
    SM00282. LamG. 4 hits.
    [Graphical view ]
    SUPFAMi SSF49785. SSF49785. 1 hit.
    SSF49899. SSF49899. 5 hits.
    SSF56496. SSF56496. 1 hit.
    PROSITEi PS50026. EGF_3. 2 hits.
    PS01286. FA58C_2. 1 hit.
    PS50022. FA58C_3. 1 hit.
    PS51406. FIBRINOGEN_C_2. 1 hit.
    PS50025. LAM_G_DOMAIN. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "In vitro and in vivo studies on the involvement of neural cell adhesion molecules and chondroitin sulfate proteoglycans in defining discrete axonal pathways of the rat cerebral cortex."
      Takeuchi K., Watanabe N., Kawano T., Kawamura K.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-962.

    Entry informationi

    Entry nameiCNTP5_HUMAN
    AccessioniPrimary (citable) accession number: Q8WYK1
    Secondary accession number(s): Q4ZFW2
    , Q4ZG21, Q53R09, Q53RX1, Q53SG3, Q584P3, Q96MS7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3