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Protein

Septin-1

Gene

SEPT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).By similarityCurated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei66GTPBy similarity1
Binding sitei92GTP; via amide nitrogenBy similarity1
Binding sitei229GTP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei245GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32 – 39GTPBy similarity8
Nucleotide bindingi171 – 179GTPBy similarity9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180096-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-1
Alternative name(s):
LARP
Peanut-like protein 3
Serologically defined breast cancer antigen NY-BR-24
Gene namesi
Name:SEPT1
Synonyms:DIFF6, PNUTL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:2879. SEPT1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi19S → A: No effect on phosphorylation. 1 Publication1
Mutagenesisi206S → A: No effect on phosphorylation. 1 Publication1
Mutagenesisi248S → A: Great reduction in phosphorylation. 1 Publication1
Mutagenesisi307S → A: Great reduction in phosphorylation. 1 Publication1
Mutagenesisi312S → A: No effect on phosphorylation. 1 Publication1
Mutagenesisi315S → A: Great reduction in phosphorylation. 1 Publication1

Organism-specific databases

DisGeNETi1731.
PharmGKBiPA24354.

Polymorphism and mutation databases

DMDMi20178107.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001735131 – 367Septin-1Add BLAST367

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei206PhosphoserineCombined sources1
Modified residuei248Phosphoserine; by AURKBCombined sources1 Publication1
Modified residuei251PhosphothreonineBy similarity1
Modified residuei307Phosphoserine; by AURKB1 Publication1
Modified residuei315Phosphoserine; by AURKBCombined sources1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WYJ6.
MaxQBiQ8WYJ6.
PaxDbiQ8WYJ6.
PeptideAtlasiQ8WYJ6.
PRIDEiQ8WYJ6.

PTM databases

iPTMnetiQ8WYJ6.
PhosphoSitePlusiQ8WYJ6.

Expressioni

Tissue specificityi

Expressed at high levels in lymphoid and hematopoietic tissues.1 Publication

Gene expression databases

BgeeiENSG00000180096.
CleanExiHS_SEPT1.

Organism-specific databases

HPAiHPA041566.

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Interacts with AURKB.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-693002,EBI-693002
AMOTQ4VCS5-23EBI-693002,EBI-3891843
AURKBQ96GD46EBI-693002,EBI-624291
SEPT11Q9NVA24EBI-693002,EBI-957999
SEPT12Q8IYM15EBI-693002,EBI-2585067
SEPT5Q997197EBI-693002,EBI-373345
SEPT6Q141416EBI-693002,EBI-745901
TEX11Q8IYF33EBI-693002,EBI-742397

Protein-protein interaction databases

BioGridi108075. 22 interactors.
IntActiQ8WYJ6. 17 interactors.
MINTiMINT-1435466.
STRINGi9606.ENSP00000460441.

Structurei

3D structure databases

ProteinModelPortaliQ8WYJ6.
SMRiQ8WYJ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 296Septin-type GAdd BLAST275

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2655. Eukaryota.
COG5019. LUCA.
HOGENOMiHOG000233586.
HOVERGENiHBG065093.
InParanoidiQ8WYJ6.
KOiK13737.
PhylomeDBiQ8WYJ6.
TreeFamiTF101079.

Family and domain databases

CDDicd01850. CDC_Septin. 1 hit.
Gene3Di3.40.50.300. 1 hit.
InterProiIPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WYJ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDKEYVGFAA LPNQLHRKSV KKGFDFTLMV AGESGLGKST LINSLFLTNL
60 70 80 90 100
YEDRQVPEAS ARLTQTLAIE RRGVEIEEGG VKVKLTLVDT PGFGDSVDCS
110 120 130 140 150
DCWLPVVKFI EEQFEQYLRD ESGLNRKNIQ DSRVHCCLYF ISPFGRGLRP
160 170 180 190 200
LDVAFLRAVH EKVNIIPVIG KADALMPQET QALKQKIRDQ LKEEEIHIYQ
210 220 230 240 250
FPECDSDEDE DFKRQDAEMK ESIPFAVVGS CEVVRDGGNR PVRGRRYSWG
260 270 280 290 300
TVEVENPHHC DFLNLRRMLV QTHLQDLKEV THDLLYEGYR ARCLQSLARP
310 320 330 340 350
GARDRASRSK LSRQSATEIP LPMLPLADTE KLIREKDEEL RRMQEMLEKM
360
QAQMQQSQAQ GEQSDAL
Length:367
Mass (Da):41,971
Last modified:April 16, 2002 - v2
Checksum:iE9C6BEF373CB0FC4
GO
Isoform 2 (identifier: Q8WYJ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     148-167: LRPLDVAFLRAVHEKVNIIP → SGGGILGAGAFREGWGVSAP
     168-367: Missing.

Note: No experimental confirmation available.
Show »
Length:167
Mass (Da):18,354
Checksum:i2C7A515F1236AAC4
GO

Sequence cautioni

The sequence AAK61491 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60S → G in AAL40393 (Ref. 1) Curated1
Sequence conflicti148 – 150LRP → SR in AAL40393 (Ref. 1) Curated3
Sequence conflicti240 – 241RP → GL in AAL40393 (Ref. 1) Curated2
Sequence conflicti324L → P in AAL40393 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05193480G → V.Corresponds to variant rs34518080dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_038269148 – 167LRPLD…VNIIP → SGGGILGAGAFREGWGVSAP in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_038270168 – 367Missing in isoform 2. 1 PublicationAdd BLAST200

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085235 mRNA. Translation: AAL40393.1.
AY034176 mRNA. Translation: AAK61491.1. Different initiation.
AK301045 mRNA. Translation: BAG62658.1.
BC012161 mRNA. Translation: AAH12161.1.
AL833004 mRNA. Translation: CAH56484.1.
AF308288 Genomic DNA. Translation: AAG48256.1.
RefSeqiNP_443070.5. NM_052838.4.
UniGeneiHs.632176.

Genome annotation databases

EnsembliENST00000571393; ENSP00000460441; ENSG00000180096.
GeneIDi1731.
KEGGihsa:1731.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085235 mRNA. Translation: AAL40393.1.
AY034176 mRNA. Translation: AAK61491.1. Different initiation.
AK301045 mRNA. Translation: BAG62658.1.
BC012161 mRNA. Translation: AAH12161.1.
AL833004 mRNA. Translation: CAH56484.1.
AF308288 Genomic DNA. Translation: AAG48256.1.
RefSeqiNP_443070.5. NM_052838.4.
UniGeneiHs.632176.

3D structure databases

ProteinModelPortaliQ8WYJ6.
SMRiQ8WYJ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108075. 22 interactors.
IntActiQ8WYJ6. 17 interactors.
MINTiMINT-1435466.
STRINGi9606.ENSP00000460441.

PTM databases

iPTMnetiQ8WYJ6.
PhosphoSitePlusiQ8WYJ6.

Polymorphism and mutation databases

DMDMi20178107.

Proteomic databases

EPDiQ8WYJ6.
MaxQBiQ8WYJ6.
PaxDbiQ8WYJ6.
PeptideAtlasiQ8WYJ6.
PRIDEiQ8WYJ6.

Protocols and materials databases

DNASUi1731.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000571393; ENSP00000460441; ENSG00000180096.
GeneIDi1731.
KEGGihsa:1731.

Organism-specific databases

CTDi1731.
DisGeNETi1731.
GeneCardsiSEPT1.
HGNCiHGNC:2879. SEPT1.
HPAiHPA041566.
MIMi612897. gene.
neXtProtiNX_Q8WYJ6.
PharmGKBiPA24354.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2655. Eukaryota.
COG5019. LUCA.
HOGENOMiHOG000233586.
HOVERGENiHBG065093.
InParanoidiQ8WYJ6.
KOiK13737.
PhylomeDBiQ8WYJ6.
TreeFamiTF101079.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180096-MONOMER.

Miscellaneous databases

ChiTaRSiSEPT1. human.
GeneWikiiSEPT1.
GenomeRNAii1731.
PROiQ8WYJ6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000180096.
CleanExiHS_SEPT1.

Family and domain databases

CDDicd01850. CDC_Septin. 1 hit.
Gene3Di3.40.50.300. 1 hit.
InterProiIPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSEPT1_HUMAN
AccessioniPrimary (citable) accession number: Q8WYJ6
Secondary accession number(s): B4DVE6
, Q658T1, Q8NEZ1, Q96EL4, Q9H285
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: April 16, 2002
Last modified: November 30, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.