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Q8WYJ6

- SEPT1_HUMAN

UniProt

Q8WYJ6 - SEPT1_HUMAN

Protein

Septin-1

Gene

SEPT1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (16 Apr 2002)
      Previous versions | rss
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    Functioni

    Filament-forming cytoskeletal GTPase By similarity. May play a role in cytokinesis Potential.By similarityCurated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei66 – 661GTPBy similarity
    Binding sitei92 – 921GTP; via amide nitrogenBy similarity
    Binding sitei229 – 2291GTP; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei245 – 2451GTPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi32 – 398GTPBy similarity
    Nucleotide bindingi171 – 1799GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW

    Keywords - Biological processi

    Cell cycle, Cell division

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Septin-1
    Alternative name(s):
    LARP
    Peanut-like protein 3
    Serologically defined breast cancer antigen NY-BR-24
    Gene namesi
    Name:SEPT1
    Synonyms:DIFF6, PNUTL3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:2879. SEPT1.

    Subcellular locationi

    Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome. Midbody
    Note: Remains at the centrosomes and the nearby microtubules throughout mitosis. Localizes to the midbody during cytokinesis.

    GO - Cellular componenti

    1. microtubule organizing center Source: UniProtKB-SubCell
    2. midbody Source: UniProtKB-SubCell
    3. septin complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi19 – 191S → A: No effect on phosphorylation. 1 Publication
    Mutagenesisi206 – 2061S → A: No effect on phosphorylation. 1 Publication
    Mutagenesisi248 – 2481S → A: Great reduction in phosphorylation. 1 Publication
    Mutagenesisi307 – 3071S → A: Great reduction in phosphorylation. 1 Publication
    Mutagenesisi312 – 3121S → A: No effect on phosphorylation. 1 Publication
    Mutagenesisi315 – 3151S → A: Great reduction in phosphorylation. 1 Publication

    Organism-specific databases

    PharmGKBiPA24354.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 367367Septin-1PRO_0000173513Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei248 – 2481Phosphoserine; by AURKB1 Publication
    Modified residuei307 – 3071Phosphoserine; by AURKB1 Publication
    Modified residuei315 – 3151Phosphoserine; by AURKB1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8WYJ6.
    PaxDbiQ8WYJ6.
    PRIDEiQ8WYJ6.

    PTM databases

    PhosphoSiteiQ8WYJ6.

    Expressioni

    Tissue specificityi

    Expressed at high levels in lymphoid and hematopoietic tissues.1 Publication

    Gene expression databases

    BgeeiQ8WYJ6.
    CleanExiHS_SEPT1.
    GenevestigatoriQ8WYJ6.

    Organism-specific databases

    HPAiHPA041566.

    Interactioni

    Subunit structurei

    Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation By similarity. Interacts with AURKB.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AURKBQ96GD46EBI-693002,EBI-624291

    Protein-protein interaction databases

    IntActiQ8WYJ6. 5 interactions.
    MINTiMINT-1435466.
    STRINGi9606.ENSP00000324511.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WYJ6.
    SMRiQ8WYJ6. Positions 22-295.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 296275Septin-type GAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG5019.
    HOGENOMiHOG000233586.
    HOVERGENiHBG065093.
    InParanoidiQ8WYJ6.
    KOiK13737.
    PhylomeDBiQ8WYJ6.
    TreeFamiTF101079.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR000038. Cell_div_GTP-bd.
    IPR027417. P-loop_NTPase.
    IPR016491. Septin.
    [Graphical view]
    PANTHERiPTHR18884. PTHR18884. 1 hit.
    PfamiPF00735. Septin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006698. Septin. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS51719. G_SEPTIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WYJ6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDKEYVGFAA LPNQLHRKSV KKGFDFTLMV AGESGLGKST LINSLFLTNL    50
    YEDRQVPEAS ARLTQTLAIE RRGVEIEEGG VKVKLTLVDT PGFGDSVDCS 100
    DCWLPVVKFI EEQFEQYLRD ESGLNRKNIQ DSRVHCCLYF ISPFGRGLRP 150
    LDVAFLRAVH EKVNIIPVIG KADALMPQET QALKQKIRDQ LKEEEIHIYQ 200
    FPECDSDEDE DFKRQDAEMK ESIPFAVVGS CEVVRDGGNR PVRGRRYSWG 250
    TVEVENPHHC DFLNLRRMLV QTHLQDLKEV THDLLYEGYR ARCLQSLARP 300
    GARDRASRSK LSRQSATEIP LPMLPLADTE KLIREKDEEL RRMQEMLEKM 350
    QAQMQQSQAQ GEQSDAL 367
    Length:367
    Mass (Da):41,971
    Last modified:April 16, 2002 - v2
    Checksum:iE9C6BEF373CB0FC4
    GO
    Isoform 2 (identifier: Q8WYJ6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         148-167: LRPLDVAFLRAVHEKVNIIP → SGGGILGAGAFREGWGVSAP
         168-367: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:167
    Mass (Da):18,354
    Checksum:i2C7A515F1236AAC4
    GO

    Sequence cautioni

    The sequence AAK61491.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti60 – 601S → G in AAL40393. 1 PublicationCurated
    Sequence conflicti148 – 1503LRP → SR in AAL40393. 1 PublicationCurated
    Sequence conflicti240 – 2412RP → GL in AAL40393. 1 PublicationCurated
    Sequence conflicti324 – 3241L → P in AAL40393. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti80 – 801G → V.
    Corresponds to variant rs34518080 [ dbSNP | Ensembl ].
    VAR_051934

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei148 – 16720LRPLD…VNIIP → SGGGILGAGAFREGWGVSAP in isoform 2. 1 PublicationVSP_038269Add
    BLAST
    Alternative sequencei168 – 367200Missing in isoform 2. 1 PublicationVSP_038270Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF085235 mRNA. Translation: AAL40393.1.
    AY034176 mRNA. Translation: AAK61491.1. Different initiation.
    AK301045 mRNA. Translation: BAG62658.1.
    BC012161 mRNA. Translation: AAH12161.1.
    AL833004 mRNA. Translation: CAH56484.1.
    AF308288 Genomic DNA. Translation: AAG48256.1.
    RefSeqiNP_443070.5. NM_052838.4.
    UniGeneiHs.632176.

    Genome annotation databases

    EnsembliENST00000571393; ENSP00000460441; ENSG00000180096. [Q8WYJ6-1]
    GeneIDi1731.
    KEGGihsa:1731.

    Polymorphism databases

    DMDMi20178107.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF085235 mRNA. Translation: AAL40393.1 .
    AY034176 mRNA. Translation: AAK61491.1 . Different initiation.
    AK301045 mRNA. Translation: BAG62658.1 .
    BC012161 mRNA. Translation: AAH12161.1 .
    AL833004 mRNA. Translation: CAH56484.1 .
    AF308288 Genomic DNA. Translation: AAG48256.1 .
    RefSeqi NP_443070.5. NM_052838.4.
    UniGenei Hs.632176.

    3D structure databases

    ProteinModelPortali Q8WYJ6.
    SMRi Q8WYJ6. Positions 22-295.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8WYJ6. 5 interactions.
    MINTi MINT-1435466.
    STRINGi 9606.ENSP00000324511.

    PTM databases

    PhosphoSitei Q8WYJ6.

    Polymorphism databases

    DMDMi 20178107.

    Proteomic databases

    MaxQBi Q8WYJ6.
    PaxDbi Q8WYJ6.
    PRIDEi Q8WYJ6.

    Protocols and materials databases

    DNASUi 1731.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000571393 ; ENSP00000460441 ; ENSG00000180096 . [Q8WYJ6-1 ]
    GeneIDi 1731.
    KEGGi hsa:1731.

    Organism-specific databases

    CTDi 1731.
    GeneCardsi GC16M030389.
    HGNCi HGNC:2879. SEPT1.
    HPAi HPA041566.
    MIMi 612897. gene.
    neXtProti NX_Q8WYJ6.
    PharmGKBi PA24354.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5019.
    HOGENOMi HOG000233586.
    HOVERGENi HBG065093.
    InParanoidi Q8WYJ6.
    KOi K13737.
    PhylomeDBi Q8WYJ6.
    TreeFami TF101079.

    Miscellaneous databases

    ChiTaRSi SEPT1. human.
    GeneWikii SEPT1.
    GenomeRNAii 1731.
    NextBioi 7009.
    PROi Q8WYJ6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8WYJ6.
    CleanExi HS_SEPT1.
    Genevestigatori Q8WYJ6.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR000038. Cell_div_GTP-bd.
    IPR027417. P-loop_NTPase.
    IPR016491. Septin.
    [Graphical view ]
    PANTHERi PTHR18884. PTHR18884. 1 hit.
    Pfami PF00735. Septin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006698. Septin. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS51719. G_SEPTIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of a novel human gene, HSLARP."
      Tu Q., Yu L., Bi A., Zhang H., Zhao Y., Zhao S.
      Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Molecular cloning and characterization of human septins which are expressed in liver."
      Peng J., Yu L.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Spleen.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: B-cell.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 79-367.
      Tissue: Stomach.
    6. "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression."
      Scanlan M.J., Gout I., Gordon C.M., Williamson B., Stockert E., Gure A.O., Jaeger D., Chen Y.-T., Mackay A., O'Hare M.J., Old L.J.
      Cancer Immun. 1:4-4(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 93-367.
      Tissue: Mammary gland.
    7. "Septin1, a new interaction partner for human serine/threonine kinase aurora-B."
      Qi M., Yu W., Liu S., Jia H., Tang L., Shen M., Yan X., Saiyin H., Lang Q., Wan B., Zhao S., Yu L.
      Biochem. Biophys. Res. Commun. 336:994-1000(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH AURKB, PHOSPHORYLATION AT SER-248; SER-307 AND SER-315, MUTAGENESIS OF SER-19; SER-206; SER-248; SER-307; SER-312 AND SER-315.
    8. "Expression profiling the human septin gene family."
      Hall P.A., Jung K., Hillan K.J., Russell S.E.H.
      J. Pathol. 206:269-278(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    9. "From midbody protein-protein interaction network construction to novel regulators in cytokinesis."
      Chen T.C., Lee S.A., Hong T.M., Shih J.Y., Lai J.M., Chiou H.Y., Yang S.C., Chan C.H., Kao C.Y., Yang P.C., Huang C.Y.
      J. Proteome Res. 8:4943-4953(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiSEPT1_HUMAN
    AccessioniPrimary (citable) accession number: Q8WYJ6
    Secondary accession number(s): B4DVE6
    , Q658T1, Q8NEZ1, Q96EL4, Q9H285
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 16, 2002
    Last sequence update: April 16, 2002
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3