Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Inhibitor of growth protein 5

Gene

ING5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei188Histone H3K4me3Combined sources1 Publication1
Metal bindingi189Zinc 1Combined sources1 Publication1
Metal bindingi191Zinc 1Combined sources1 Publication1
Binding sitei199Histone H3K4me3Combined sources1 Publication1
Metal bindingi202Zinc 2Combined sources1 Publication1
Binding sitei203Histone H3K4me3Combined sources1 Publication1
Metal bindingi207Zinc 2Combined sources1 Publication1
Binding sitei211Histone H3K4me3Combined sources1 Publication1
Metal bindingi213Zinc 1; via pros nitrogenCombined sources1 Publication1
Metal bindingi216Zinc 1Combined sources1 Publication1
Metal bindingi229Zinc 2Combined sources1 Publication1
Metal bindingi232Zinc 2Combined sources1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri186 – 235PHD-typePROSITE-ProRule annotationAdd BLAST50

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • methylated histone binding Source: UniProtKB

GO - Biological processi

  • DNA replication Source: UniProtKB
  • histone H3 acetylation Source: UniProtKB
  • negative regulation of cell proliferation Source: UniProtKB
  • negative regulation of growth Source: UniProtKB
  • positive regulation of apoptotic process Source: MGI
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • protein acetylation Source: UniProtKB
  • regulation of signal transduction by p53 class mediator Source: Reactome
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, Chromatin regulator
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-3214847 HATs acetylate histones
R-HSA-6804758 Regulation of TP53 Activity through Acetylation

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibitor of growth protein 5
Alternative name(s):
p28ING5
Gene namesi
Name:ING5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000168395.14
HGNCiHGNC:19421 ING5
MIMi608525 gene
neXtProtiNX_Q8WYH8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi84289
OpenTargetsiENSG00000168395
PharmGKBiPA134935441

Polymorphism and mutation databases

BioMutaiING5
DMDMi57012960

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002126711 – 240Inhibitor of growth protein 5Add BLAST240

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei114N6-acetyllysineCombined sources1
Modified residuei118PhosphoserineCombined sources1
Modified residuei126Omega-N-methylarginineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ8WYH8
MaxQBiQ8WYH8
PaxDbiQ8WYH8
PeptideAtlasiQ8WYH8
PRIDEiQ8WYH8

PTM databases

iPTMnetiQ8WYH8
PhosphoSitePlusiQ8WYH8

Expressioni

Gene expression databases

BgeeiENSG00000168395
CleanExiHS_ING5
ExpressionAtlasiQ8WYH8 baseline and differential
GenevisibleiQ8WYH8 HS

Organism-specific databases

HPAiHPA042685

Interactioni

Subunit structurei

Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. Interacts with EP300 and TP53.5 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • methylated histone binding Source: UniProtKB

Protein-protein interaction databases

BioGridi124016, 58 interactors
CORUMiQ8WYH8
DIPiDIP-32511N
IntActiQ8WYH8, 43 interactors
MINTiQ8WYH8
STRINGi9606.ENSP00000322142

Structurei

Secondary structure

1240
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1 – 9Combined sources9
Helixi10 – 13Combined sources4
Helixi14 – 16Combined sources3
Helixi19 – 52Combined sources34
Helixi53 – 55Combined sources3
Helixi58 – 100Combined sources43
Turni189 – 192Combined sources4
Beta strandi197 – 201Combined sources5
Beta strandi211 – 213Combined sources3
Helixi215 – 217Combined sources3
Helixi230 – 233Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3C6WX-ray1.75A/C184-236[»]
5ME8X-ray3.20A/B1-105[»]
5MTOX-ray3.10A/B1-105[»]
ProteinModelPortaliQ8WYH8
SMRiQ8WYH8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WYH8

Family & Domainsi

Domaini

The PHD-type zinc finger mediates the binding to H3K4me3.1 Publication

Sequence similaritiesi

Belongs to the ING family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri186 – 235PHD-typePROSITE-ProRule annotationAdd BLAST50

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1973 Eukaryota
COG5034 LUCA
GeneTreeiENSGT00550000074538
HOGENOMiHOG000239724
HOVERGENiHBG006607
InParanoidiQ8WYH8
KOiK11345
OMAiFCPRCTQ
OrthoDBiEOG091G0J8Y
PhylomeDBiQ8WYH8
TreeFamiTF352014

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR028638 ING5
IPR024610 ING_N_histone_binding
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR10333:SF41 PTHR10333:SF41, 1 hit
PfamiView protein in Pfam
PF12998 ING, 1 hit
SMARTiView protein in SMART
SM01408 ING, 1 hit
SM00249 PHD, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WYH8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATAMYLEHY LDSIENLPCE LQRNFQLMRE LDQRTEDKKA EIDILAAEYI
60 70 80 90 100
STVKTLSPDQ RVERLQKIQN AYSKCKEYSD DKVQLAMQTY EMVDKHIRRL
110 120 130 140 150
DADLARFEAD LKDKMEGSDF ESSGGRGLKK GRGQKEKRGS RGRGRRTSEE
160 170 180 190 200
DTPKKKKHKG GSEFTDTILS VHPSDVLDMP VDPNEPTYCL CHQVSYGEMI
210 220 230 240
GCDNPDCPIE WFHFACVDLT TKPKGKWFCP RCVQEKRKKK
Length:240
Mass (Da):27,751
Last modified:March 1, 2002 - v1
Checksum:iB66DA23209EE9B9E
GO
Isoform 2 (identifier: Q8WYH8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-240: Missing.

Note: No experimental confirmation available.
Show »
Length:226
Mass (Da):25,932
Checksum:i56BF8A921005AAF4
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012528227 – 240Missing in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF189286 mRNA Translation: AAL68979.1
AK074422 mRNA Translation: BAB85078.1
AK289958 mRNA Translation: BAF82647.1
AC114730 Genomic DNA Translation: AAX82019.1
AC133528 Genomic DNA Translation: AAY14921.1
BC005370 mRNA Translation: AAH05370.1
BC071899 mRNA Translation: AAH71899.1
CCDSiCCDS33425.1 [Q8WYH8-1]
CCDS82586.1 [Q8WYH8-2]
RefSeqiNP_001317091.1, NM_001330162.1 [Q8WYH8-2]
NP_115705.2, NM_032329.5 [Q8WYH8-1]
UniGeneiHs.529172

Genome annotation databases

EnsembliENST00000313552; ENSP00000322142; ENSG00000168395 [Q8WYH8-1]
ENST00000406941; ENSP00000385937; ENSG00000168395 [Q8WYH8-2]
GeneIDi84289
KEGGihsa:84289
UCSCiuc002wcd.4 human [Q8WYH8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiING5_HUMAN
AccessioniPrimary (citable) accession number: Q8WYH8
Secondary accession number(s): A8K1P3
, Q53NU6, Q57Z54, Q9BS30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health