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Protein
Submitted name:

Dystrophin

Gene

DMD

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein predictedi

Functioni

GO - Biological processi

  1. cardiac muscle cell action potential Source: Ensembl
  2. cellular protein complex assembly Source: Ensembl
  3. cellular protein localization Source: Ensembl
  4. establishment of blood-nerve barrier Source: Ensembl
  5. establishment of glial blood-brain barrier Source: Ensembl
  6. muscle cell cellular homeostasis Source: Ensembl
  7. muscle fiber development Source: Ensembl
  8. myotube cell development Source: Ensembl
  9. negative regulation of peptidyl-cysteine S-nitrosylation Source: Ensembl
  10. negative regulation of peptidyl-serine phosphorylation Source: Ensembl
  11. neurotransmitter receptor metabolic process Source: Ensembl
  12. nucleus localization Source: Ensembl
  13. olfactory nerve structural organization Source: Ensembl
  14. positive regulation of cell-matrix adhesion Source: Ensembl
  15. positive regulation of sodium ion transmembrane transporter activity Source: Ensembl
  16. regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: Ensembl
  17. regulation of heart rate Source: Ensembl
  18. regulation of ryanodine-sensitive calcium-release channel activity Source: Ensembl
  19. regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion Source: Ensembl
  20. regulation of transcription, DNA-templated Source: Ensembl
  21. regulation of voltage-gated calcium channel activity Source: Ensembl
  22. skeletal muscle tissue development Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
DystrophinImported
Gene namesi
Name:DMDImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cell-substrate junction Source: Ensembl
  2. dystrophin-associated glycoprotein complex Source: Ensembl
  3. membrane raft Source: Ensembl
  4. neuron projection terminus Source: Ensembl
  5. sarcolemma Source: Ensembl
  6. synapse Source: Ensembl
  7. Z disc Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ8WYD4.
ExpressionAtlasiQ8WYD4. baseline and differential.

Family & Domainsi

Family and domain databases

InterProiIPR002017. Spectrin_repeat.
[Graphical view]
PfamiPF00435. Spectrin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8WYD4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
ATQKEIEKQK VHLKSITEVG EALKTVLGKK ETLVEDKLSL LNSNWIAVTS
60
RAEEWLNLLL
Length:60
Mass (Da):6,788
Last modified:March 1, 2002 - v1
Checksum:iCFA756DDF0C490AB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei60 – 601Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF213425 Genomic DNA. Translation: AAL61572.1.
UniGeneiHs.495912.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF213425 Genomic DNA. Translation: AAL61572.1.
UniGeneiHs.495912.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

ChiTaRSiDMD. human.

Gene expression databases

BgeeiQ8WYD4.
ExpressionAtlasiQ8WYD4. baseline and differential.

Family and domain databases

InterProiIPR002017. Spectrin_repeat.
[Graphical view]
PfamiPF00435. Spectrin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Beggs A.H., Koenig M., Kunkel L.M.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. den Dunnen J.T.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ8WYD4_HUMAN
AccessioniPrimary (citable) accession number: Q8WYD4
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.