Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8WYA6

- CTBL1_HUMAN

UniProt

Q8WYA6 - CTBL1_HUMAN

Protein

Beta-catenin-like protein 1

Gene

CTNNBL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.

    GO - Molecular functioni

    1. enzyme binding Source: UniProtKB
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. mRNA processing Source: UniProtKB-KW
    3. positive regulation of apoptotic process Source: UniProtKB
    4. RNA splicing Source: UniProtKB-KW
    5. somatic diversification of immunoglobulins Source: UniProtKB

    Keywords - Biological processi

    Apoptosis, mRNA processing, mRNA splicing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-catenin-like protein 1
    Alternative name(s):
    Nuclear-associated protein
    Short name:
    NAP
    Testis development protein NYD-SP19
    Gene namesi
    Name:CTNNBL1
    Synonyms:C20orf33
    ORF Names:PP8304
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:15879. CTNNBL1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. membrane Source: UniProtKB
    3. nucleus Source: UniProtKB
    4. Prp19 complex Source: UniProtKB
    5. spliceosomal complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Spliceosome

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi16 – 3318Missing: Nuclear and cytoplasmic localization. Add
    BLAST
    Mutagenesisi521 – 56343Missing: No change in NLS binding nor folding. Add
    BLAST

    Organism-specific databases

    PharmGKBiPA27015.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 563563Beta-catenin-like protein 1PRO_0000079490Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine2 Publications
    Modified residuei91 – 911N6-acetyllysine1 Publication
    Modified residuei389 – 3891Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ8WYA6.
    PaxDbiQ8WYA6.
    PRIDEiQ8WYA6.

    PTM databases

    PhosphoSiteiQ8WYA6.

    Expressioni

    Tissue specificityi

    Widely expressed with highest levels in skeletal muscle, placenta, heart, spleen, testis and thyroid.1 Publication

    Gene expression databases

    ArrayExpressiQ8WYA6.
    BgeeiQ8WYA6.
    GenevestigatoriQ8WYA6.

    Organism-specific databases

    HPAiHPA004742.
    HPA027907.

    Interactioni

    Subunit structurei

    Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts directly with CWC15 and CDC5L in the complex. Interacts with AICDA; the interaction is important for the antibody diversification activity of AICDA. Interacts with PRPF31 (via its NLS). Interacts (via its N-terminal NLS) with KPNA1 and KPNA2.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CDC5LQ994592EBI-748128,EBI-374880
    SNW1Q135732EBI-748128,EBI-632715

    Protein-protein interaction databases

    BioGridi121123. 39 interactions.
    IntActiQ8WYA6. 17 interactions.
    MINTiMINT-1444671.

    Structurei

    Secondary structure

    1
    563
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni54 – 563
    Helixi57 – 637
    Helixi81 – 10222
    Beta strandi105 – 1073
    Helixi111 – 12515
    Turni126 – 1294
    Helixi131 – 1344
    Helixi135 – 1395
    Helixi142 – 1498
    Helixi155 – 17016
    Helixi171 – 1733
    Beta strandi174 – 1763
    Helixi179 – 19012
    Helixi193 – 20311
    Helixi209 – 22820
    Helixi232 – 2398
    Helixi241 – 25010
    Helixi257 – 27014
    Helixi274 – 2829
    Helixi285 – 29410
    Beta strandi297 – 2993
    Helixi304 – 32219
    Helixi325 – 3328
    Helixi335 – 34410
    Helixi350 – 36112
    Helixi364 – 3663
    Helixi367 – 3759
    Helixi378 – 38710
    Helixi393 – 3964
    Helixi401 – 41717
    Helixi420 – 42910
    Helixi432 – 46938
    Helixi475 – 48713
    Helixi490 – 50415
    Helixi509 – 52012
    Turni521 – 5233
    Helixi526 – 53914
    Beta strandi542 – 5443
    Helixi546 – 55914
    Turni560 – 5623

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4CB8X-ray2.90A77-563[»]
    4CB9X-ray3.00A1-563[»]
    4CBAX-ray3.10A77-563[»]
    4HM9X-ray3.10A1-563[»]
    4HNMX-ray2.90A75-563[»]
    4MFUX-ray2.74A77-563[»]
    4MFVX-ray2.92A/B33-563[»]
    ProteinModelPortaliQ8WYA6.
    SMRiQ8WYA6. Positions 77-563.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati79 – 12951HEAT 1Add
    BLAST
    Repeati134 – 17643HEAT 2Add
    BLAST
    Repeati178 – 22851ARM 1Add
    BLAST
    Repeati229 – 27345ARM 2Add
    BLAST
    Repeati274 – 32350ARM 3Add
    BLAST
    Repeati325 – 36339ARM 4Add
    BLAST
    Repeati364 – 41754ARM 5Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni130 – 14011Nuclear export signal (NES)CuratedAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili476 – 540651 PublicationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi16 – 3318Nuclear localization signalAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi22 – 254Poly-Glu
    Compositional biasi68 – 758Poly-Glu

    Domaini

    The surface residues of the concave side of the superhelical ARM repeat region contribute to, but are not essential for NLS binding.1 Publication

    Sequence similaritiesi

    Contains 5 ARM repeats.Curated
    Contains 2 HEAT repeats.Curated

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiNOG283719.
    HOVERGENiHBG051212.
    InParanoidiQ8WYA6.
    KOiK12864.
    OMAiMREYAGN.
    OrthoDBiEOG7353WH.
    PhylomeDBiQ8WYA6.
    TreeFamiTF314294.

    Family and domain databases

    Gene3Di1.25.10.10. 2 hits.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR013180. CTNNBL1_N.
    [Graphical view]
    PfamiPF08216. CTNNBL. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 2 hits.

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WYA6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDVGELLSYQ PNRGTKRPRD DEEEEQKMRR KQTGTRERGR YREEEMTVVE    50
    EADDDKKRLL QIIDRDGEEE EEEEEPLDES SVKKMILTFE KRSYKNQELR 100
    IKFPDNPEKF MESELDLNDI IQEMHVVATM PDLYHLLVEL NAVQSLLGLL 150
    GHDNTDVSIA VVDLLQELTD IDTLHESEEG AEVLIDALVD GQVVALLVQN 200
    LERLDESVKE EADGVHNTLA IVENMAEFRP EMCTEGAQQG LLQWLLKRLK 250
    AKMPFDANKL YCSEVLAILL QDNDENRELL GELDGIDVLL QQLSVFKRHN 300
    PSTAEEQEMM ENLFDSLCSC LMLSSNRERF LKGEGLQLMN LMLREKKISR 350
    SSALKVLDHA MIGPEGTDNC HKFVDILGLR TIFPLFMKSP RKIKKVGTTE 400
    KEHEEHVCSI LASLLRNLRG QQRTRLLNKF TENDSEKVDR LMELHFKYLG 450
    AMQVADKKIE GEKHDMVRRG EIIDNDTEEE FYLRRLDAGL FVLQHICYIM 500
    AEICNANVPQ IRQRVHQILN MRGSSIKIVR HIIKEYAENI GDGRSPEFRE 550
    NEQKRILGLL ENF 563
    Length:563
    Mass (Da):65,173
    Last modified:March 1, 2002 - v1
    Checksum:i791BAFCEC5916B5A
    GO
    Isoform 2 (identifier: Q8WYA6-2) [UniParc]FASTAAdd to Basket

    Also known as: NYD-SP19

    The sequence of this isoform differs from the canonical sequence as follows:
         1-187: Missing.
         188-188: L → M

    Show »
    Length:376
    Mass (Da):43,392
    Checksum:i54E26219D2AA8496
    GO
    Isoform 3 (identifier: Q8WYA6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-252: Missing.

    Note: Gene prediction based on EST data.

    Show »
    Length:311
    Mass (Da):36,103
    Checksum:iBEF11FF9CAF56C86
    GO
    Isoform 4 (identifier: Q8WYA6-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-27: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:536
    Mass (Da):61,971
    Checksum:i6508EC207D3688FB
    GO

    Sequence cautioni

    The sequence AAQ15267.1 differs from that shown. Reason: Frameshift at position 96.
    The sequence BAB14992.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti222 – 2221V → A in AAI21006. (PubMed:15489334)Curated
    Sequence conflicti329 – 3291R → L in BAB14992. (PubMed:14702039)Curated
    Sequence conflicti340 – 3401N → Y in BAC11121. (PubMed:14702039)Curated
    Sequence conflicti439 – 4391D → N in BAB14992. (PubMed:14702039)Curated
    Sequence conflicti439 – 4391D → N in BAD96312. 1 PublicationCurated
    Sequence conflicti445 – 4451H → Q in BAB14992. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti507 – 5071N → D.
    Corresponds to variant rs4811236 [ dbSNP | Ensembl ].
    VAR_059638

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 252252Missing in isoform 3. CuratedVSP_015182Add
    BLAST
    Alternative sequencei1 – 187187Missing in isoform 2. 1 PublicationVSP_004058Add
    BLAST
    Alternative sequencei1 – 2727Missing in isoform 4. 1 PublicationVSP_055261Add
    BLAST
    Alternative sequencei188 – 1881L → M in isoform 2. 1 PublicationVSP_004059

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF239607 mRNA. Translation: AAL69567.1.
    AF367471 mRNA. Translation: AAK53407.1.
    AF370431 mRNA. Translation: AAQ15267.1. Frameshift.
    AK074663 mRNA. Translation: BAC11121.1.
    AK293420 mRNA. Translation: BAG56927.1.
    AK024761 mRNA. Translation: BAB14992.1. Different initiation.
    AL118499, AL023804, AL109964 Genomic DNA. Translation: CAI19331.1.
    AL118499, AL023804, AL109964 Genomic DNA. Translation: CAI19332.1.
    AL109964, AL023804, AL118499 Genomic DNA. Translation: CAI42203.1.
    AL109964, AL023804 Genomic DNA. Translation: CAI42204.1.
    AL109964, AL023804, AL118499 Genomic DNA. Translation: CAI42208.1.
    AL023804, AL109964, AL118499 Genomic DNA. Translation: CAI42984.1.
    AL023804, AL109964 Genomic DNA. Translation: CAI42985.1.
    AL023804, AL109964, AL118499 Genomic DNA. Translation: CAI42986.1.
    BC022802 mRNA. Translation: AAH22802.1.
    BC121005 mRNA. Translation: AAI21006.1.
    BC121006 mRNA. Translation: AAI21007.1.
    AK222592 mRNA. Translation: BAD96312.1.
    CCDSiCCDS13298.1. [Q8WYA6-1]
    CCDS63269.1. [Q8WYA6-4]
    RefSeqiNP_001268424.1. NM_001281495.1.
    NP_110517.2. NM_030877.4. [Q8WYA6-1]
    UniGeneiHs.472667.

    Genome annotation databases

    EnsembliENST00000361383; ENSP00000355050; ENSG00000132792. [Q8WYA6-1]
    ENST00000373469; ENSP00000362568; ENSG00000132792. [Q8WYA6-3]
    ENST00000373473; ENSP00000362572; ENSG00000132792. [Q8WYA6-2]
    ENST00000405275; ENSP00000384355; ENSG00000132792. [Q8WYA6-4]
    GeneIDi56259.
    KEGGihsa:56259.
    UCSCiuc002xhh.3. human. [Q8WYA6-2]
    uc002xhj.3. human. [Q8WYA6-1]

    Polymorphism databases

    DMDMi29840792.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF239607 mRNA. Translation: AAL69567.1 .
    AF367471 mRNA. Translation: AAK53407.1 .
    AF370431 mRNA. Translation: AAQ15267.1 . Frameshift.
    AK074663 mRNA. Translation: BAC11121.1 .
    AK293420 mRNA. Translation: BAG56927.1 .
    AK024761 mRNA. Translation: BAB14992.1 . Different initiation.
    AL118499 , AL023804 , AL109964 Genomic DNA. Translation: CAI19331.1 .
    AL118499 , AL023804 , AL109964 Genomic DNA. Translation: CAI19332.1 .
    AL109964 , AL023804 , AL118499 Genomic DNA. Translation: CAI42203.1 .
    AL109964 , AL023804 Genomic DNA. Translation: CAI42204.1 .
    AL109964 , AL023804 , AL118499 Genomic DNA. Translation: CAI42208.1 .
    AL023804 , AL109964 , AL118499 Genomic DNA. Translation: CAI42984.1 .
    AL023804 , AL109964 Genomic DNA. Translation: CAI42985.1 .
    AL023804 , AL109964 , AL118499 Genomic DNA. Translation: CAI42986.1 .
    BC022802 mRNA. Translation: AAH22802.1 .
    BC121005 mRNA. Translation: AAI21006.1 .
    BC121006 mRNA. Translation: AAI21007.1 .
    AK222592 mRNA. Translation: BAD96312.1 .
    CCDSi CCDS13298.1. [Q8WYA6-1 ]
    CCDS63269.1. [Q8WYA6-4 ]
    RefSeqi NP_001268424.1. NM_001281495.1.
    NP_110517.2. NM_030877.4. [Q8WYA6-1 ]
    UniGenei Hs.472667.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4CB8 X-ray 2.90 A 77-563 [» ]
    4CB9 X-ray 3.00 A 1-563 [» ]
    4CBA X-ray 3.10 A 77-563 [» ]
    4HM9 X-ray 3.10 A 1-563 [» ]
    4HNM X-ray 2.90 A 75-563 [» ]
    4MFU X-ray 2.74 A 77-563 [» ]
    4MFV X-ray 2.92 A/B 33-563 [» ]
    ProteinModelPortali Q8WYA6.
    SMRi Q8WYA6. Positions 77-563.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121123. 39 interactions.
    IntActi Q8WYA6. 17 interactions.
    MINTi MINT-1444671.

    PTM databases

    PhosphoSitei Q8WYA6.

    Polymorphism databases

    DMDMi 29840792.

    Proteomic databases

    MaxQBi Q8WYA6.
    PaxDbi Q8WYA6.
    PRIDEi Q8WYA6.

    Protocols and materials databases

    DNASUi 56259.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361383 ; ENSP00000355050 ; ENSG00000132792 . [Q8WYA6-1 ]
    ENST00000373469 ; ENSP00000362568 ; ENSG00000132792 . [Q8WYA6-3 ]
    ENST00000373473 ; ENSP00000362572 ; ENSG00000132792 . [Q8WYA6-2 ]
    ENST00000405275 ; ENSP00000384355 ; ENSG00000132792 . [Q8WYA6-4 ]
    GeneIDi 56259.
    KEGGi hsa:56259.
    UCSCi uc002xhh.3. human. [Q8WYA6-2 ]
    uc002xhj.3. human. [Q8WYA6-1 ]

    Organism-specific databases

    CTDi 56259.
    GeneCardsi GC20P036322.
    HGNCi HGNC:15879. CTNNBL1.
    HPAi HPA004742.
    HPA027907.
    MIMi 611537. gene.
    neXtProti NX_Q8WYA6.
    PharmGKBi PA27015.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG283719.
    HOVERGENi HBG051212.
    InParanoidi Q8WYA6.
    KOi K12864.
    OMAi MREYAGN.
    OrthoDBi EOG7353WH.
    PhylomeDBi Q8WYA6.
    TreeFami TF314294.

    Miscellaneous databases

    GeneWikii CTNNBL1.
    GenomeRNAii 56259.
    NextBioi 35471085.
    PROi Q8WYA6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8WYA6.
    Bgeei Q8WYA6.
    Genevestigatori Q8WYA6.

    Family and domain databases

    Gene3Di 1.25.10.10. 2 hits.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR013180. CTNNBL1_N.
    [Graphical view ]
    Pfami PF08216. CTNNBL. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence, gene structure, and expression pattern of CTNNBL1, a minor-class intron-containing gene - evidence for a role in apoptosis."
      Jabbour L.S., Welter J.F., Kollar J., Hering T.M.
      Genomics 81:292-303(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, POSSIBLE FUNCTION.
    2. "A new testis development gene NYD-SP19 from human testes."
      Sha J.H., Li J.M., Zhou Z.M.
      Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Testis.
    3. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
      Tissue: Aortic smooth muscle and Mammary gland.
    5. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skin.
    7. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 327-563.
      Tissue: Coronary artery.
    8. "Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1."
      Conticello S.G., Ganesh K., Xue K., Lu M., Rada C., Neuberger M.S.
      Mol. Cell 31:474-484(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH AICDA, SUBCELLULAR LOCATION, POSSIBLE FUNCTION, MUTAGENESIS OF 16-LYS--LYS-33.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-389, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-91, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. Cited for: IDENTIFICATION AS A COMPONENT OF THE PRP19-CDC5L COMPLEX, SUBCELLULAR LOCATION, INTERACTION WITH CWC15 AND CDC5L.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31."
      Ganesh K., Adam S., Taylor B., Simpson P., Rada C., Neuberger M.
      J. Biol. Chem. 286:17091-17102(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH AICDA; CDC5L; PRPF31; KPNA1 AND KPNA2, SUBCELLULAR LOCATION.
    14. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "The structure of full-length human CTNNBL1 reveals a distinct member of the armadillo-repeat protein family."
      Huang X., Wang G., Wu Y., Du Z.
      Acta Crystallogr. D 69:1598-1608(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS), ARM REPEATS.
    17. "Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin alpha."
      Ganesh K., van Maldegem F., Telerman S.B., Simpson P., Johnson C.M., Williams R.L., Neuberger M.S., Rada C.
      FEBS Lett. 588:21-27(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS), NUCLEAR EXPORT SIGNAL, HEAT REPEATS, MUTAGENESIS OF 521-MET--PHE-563, COILED-COIL.

    Entry informationi

    Entry nameiCTBL1_HUMAN
    AccessioniPrimary (citable) accession number: Q8WYA6
    Secondary accession number(s): B4DE16
    , Q0VAL9, Q0VAM0, Q53HI8, Q5JWZ2, Q5JWZ3, Q5JWZ7, Q5JWZ8, Q8N454, Q8NCL2, Q8TBD6, Q96KD2, Q9H7A5, Q9NQF9, Q9NTX0, Q9Y3M7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 28, 2003
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3