SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8WYA6

- CTBL1_HUMAN

UniProt

Q8WYA6 - CTBL1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Beta-catenin-like protein 1
Gene
CTNNBL1, C20orf33, PP8304
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.2 Publications

GO - Molecular functioni

  1. enzyme binding Source: UniProtKB
  2. protein binding Source: UniProtKB

GO - Biological processi

  1. RNA splicing Source: UniProtKB-KW
  2. apoptotic process Source: UniProtKB-KW
  3. mRNA processing Source: UniProtKB-KW
  4. positive regulation of apoptotic process Source: UniProtKB
  5. somatic diversification of immunoglobulins Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis, mRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-catenin-like protein 1
Alternative name(s):
Nuclear-associated protein
Short name:
NAP
Testis development protein NYD-SP19
Gene namesi
Name:CTNNBL1
Synonyms:C20orf33
ORF Names:PP8304
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:15879. CTNNBL1.

Subcellular locationi

Isoform 1 : Nucleus 4 Publications
Isoform 2 : Cytoplasm Inferred 4 Publications

GO - Cellular componenti

  1. Prp19 complex Source: UniProtKB
  2. nucleus Source: HPA
  3. spliceosomal complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi16 – 3318Missing: Nuclear and cytoplasmic localization. 1 Publication
Add
BLAST
Mutagenesisi521 – 56343Missing: No change in NLS binding nor folding. 1 Publication
Add
BLAST

Organism-specific databases

PharmGKBiPA27015.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 563563Beta-catenin-like protein 1
PRO_0000079490Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine2 Publications
Modified residuei91 – 911N6-acetyllysine1 Publication
Modified residuei389 – 3891Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8WYA6.
PaxDbiQ8WYA6.
PRIDEiQ8WYA6.

PTM databases

PhosphoSiteiQ8WYA6.

Expressioni

Tissue specificityi

Widely expressed with highest levels in skeletal muscle, placenta, heart, spleen, testis and thyroid.1 Publication

Gene expression databases

ArrayExpressiQ8WYA6.
BgeeiQ8WYA6.
GenevestigatoriQ8WYA6.

Organism-specific databases

HPAiHPA004742.
HPA027907.

Interactioni

Subunit structurei

Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts directly with CWC15 and CDC5L in the complex. Interacts with AICDA; the interaction is important for the antibody diversification activity of AICDA. Interacts with PRPF31 (via its NLS). Interacts (via its N-terminal NLS) with KPNA1 and KPNA2.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CDC5LQ994592EBI-748128,EBI-374880
SNW1Q135732EBI-748128,EBI-632715

Protein-protein interaction databases

BioGridi121123. 39 interactions.
IntActiQ8WYA6. 17 interactions.
MINTiMINT-1444671.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni54 – 563
Helixi57 – 637
Helixi81 – 10222
Beta strandi105 – 1073
Helixi111 – 12515
Turni126 – 1294
Helixi131 – 1344
Helixi135 – 1395
Helixi142 – 1498
Helixi155 – 17016
Helixi171 – 1733
Beta strandi174 – 1763
Helixi179 – 19012
Helixi193 – 20311
Helixi209 – 22820
Helixi232 – 2398
Helixi241 – 25010
Helixi257 – 27014
Helixi274 – 2829
Helixi285 – 29410
Beta strandi297 – 2993
Helixi304 – 32219
Helixi325 – 3328
Helixi335 – 34410
Helixi350 – 36112
Helixi364 – 3663
Helixi367 – 3759
Helixi378 – 38710
Helixi393 – 3964
Helixi401 – 41717
Helixi420 – 42910
Helixi432 – 46938
Helixi475 – 48713
Helixi490 – 50415
Helixi509 – 52012
Turni521 – 5233
Helixi526 – 53914
Beta strandi542 – 5443
Helixi546 – 55914
Turni560 – 5623

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4CB8X-ray2.90A77-563[»]
4CB9X-ray3.00A1-563[»]
4CBAX-ray3.10A77-563[»]
4HM9X-ray3.10A1-563[»]
4HNMX-ray2.90A75-563[»]
4MFUX-ray2.74A77-563[»]
4MFVX-ray2.92A/B33-563[»]
ProteinModelPortaliQ8WYA6.
SMRiQ8WYA6. Positions 77-563.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati79 – 12951HEAT 1
Add
BLAST
Repeati134 – 17643HEAT 2
Add
BLAST
Repeati178 – 22851ARM 1
Add
BLAST
Repeati229 – 27345ARM 2
Add
BLAST
Repeati274 – 32350ARM 3
Add
BLAST
Repeati325 – 36339ARM 4
Add
BLAST
Repeati364 – 41754ARM 5
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni130 – 14011Nuclear export signal (NES) Inferred
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili476 – 540651 Publication
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi16 – 3318Nuclear localization signal
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi22 – 254Poly-Glu
Compositional biasi68 – 758Poly-Glu

Domaini

The surface residues of the concave side of the superhelical ARM repeat region contribute to, but are not essential for NLS binding (1 Publication).

Sequence similaritiesi

Contains 5 ARM repeats.
Contains 2 HEAT repeats.

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG283719.
HOVERGENiHBG051212.
InParanoidiQ8WYA6.
KOiK12864.
OMAiMREYAGN.
OrthoDBiEOG7353WH.
PhylomeDBiQ8WYA6.
TreeFamiTF314294.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013180. CTNNBL1_N.
[Graphical view]
PfamiPF08216. CTNNBL. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8WYA6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDVGELLSYQ PNRGTKRPRD DEEEEQKMRR KQTGTRERGR YREEEMTVVE    50
EADDDKKRLL QIIDRDGEEE EEEEEPLDES SVKKMILTFE KRSYKNQELR 100
IKFPDNPEKF MESELDLNDI IQEMHVVATM PDLYHLLVEL NAVQSLLGLL 150
GHDNTDVSIA VVDLLQELTD IDTLHESEEG AEVLIDALVD GQVVALLVQN 200
LERLDESVKE EADGVHNTLA IVENMAEFRP EMCTEGAQQG LLQWLLKRLK 250
AKMPFDANKL YCSEVLAILL QDNDENRELL GELDGIDVLL QQLSVFKRHN 300
PSTAEEQEMM ENLFDSLCSC LMLSSNRERF LKGEGLQLMN LMLREKKISR 350
SSALKVLDHA MIGPEGTDNC HKFVDILGLR TIFPLFMKSP RKIKKVGTTE 400
KEHEEHVCSI LASLLRNLRG QQRTRLLNKF TENDSEKVDR LMELHFKYLG 450
AMQVADKKIE GEKHDMVRRG EIIDNDTEEE FYLRRLDAGL FVLQHICYIM 500
AEICNANVPQ IRQRVHQILN MRGSSIKIVR HIIKEYAENI GDGRSPEFRE 550
NEQKRILGLL ENF 563
Length:563
Mass (Da):65,173
Last modified:March 1, 2002 - v1
Checksum:i791BAFCEC5916B5A
GO
Isoform 2 (identifier: Q8WYA6-2) [UniParc]FASTAAdd to Basket

Also known as: NYD-SP19

The sequence of this isoform differs from the canonical sequence as follows:
     1-187: Missing.
     188-188: L → M

Show »
Length:376
Mass (Da):43,392
Checksum:i54E26219D2AA8496
GO
Isoform 3 (identifier: Q8WYA6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-252: Missing.

Note: Gene prediction based on EST data.

Show »
Length:311
Mass (Da):36,103
Checksum:iBEF11FF9CAF56C86
GO
Isoform 4 (identifier: Q8WYA6-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: Missing.

Note: No experimental confirmation available.

Show »
Length:536
Mass (Da):61,971
Checksum:i6508EC207D3688FB
GO

Sequence cautioni

The sequence AAQ15267.1 differs from that shown. Reason: Frameshift at position 96.
The sequence BAB14992.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti507 – 5071N → D.
Corresponds to variant rs4811236 [ dbSNP | Ensembl ].
VAR_059638

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 252252Missing in isoform 3.
VSP_015182Add
BLAST
Alternative sequencei1 – 187187Missing in isoform 2.
VSP_004058Add
BLAST
Alternative sequencei1 – 2727Missing in isoform 4.
VSP_055261Add
BLAST
Alternative sequencei188 – 1881L → M in isoform 2.
VSP_004059

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti222 – 2221V → A in AAI21006. 1 Publication
Sequence conflicti329 – 3291R → L in BAB14992. 1 Publication
Sequence conflicti340 – 3401N → Y in BAC11121. 1 Publication
Sequence conflicti439 – 4391D → N in BAB14992. 1 Publication
Sequence conflicti439 – 4391D → N in BAD96312. 1 Publication
Sequence conflicti445 – 4451H → Q in BAB14992. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF239607 mRNA. Translation: AAL69567.1.
AF367471 mRNA. Translation: AAK53407.1.
AF370431 mRNA. Translation: AAQ15267.1. Frameshift.
AK074663 mRNA. Translation: BAC11121.1.
AK293420 mRNA. Translation: BAG56927.1.
AK024761 mRNA. Translation: BAB14992.1. Different initiation.
AL118499, AL023804, AL109964 Genomic DNA. Translation: CAI19331.1.
AL118499, AL023804, AL109964 Genomic DNA. Translation: CAI19332.1.
AL109964, AL023804, AL118499 Genomic DNA. Translation: CAI42203.1.
AL109964, AL023804 Genomic DNA. Translation: CAI42204.1.
AL109964, AL023804, AL118499 Genomic DNA. Translation: CAI42208.1.
AL023804, AL109964, AL118499 Genomic DNA. Translation: CAI42984.1.
AL023804, AL109964 Genomic DNA. Translation: CAI42985.1.
AL023804, AL109964, AL118499 Genomic DNA. Translation: CAI42986.1.
BC022802 mRNA. Translation: AAH22802.1.
BC121005 mRNA. Translation: AAI21006.1.
BC121006 mRNA. Translation: AAI21007.1.
AK222592 mRNA. Translation: BAD96312.1.
CCDSiCCDS13298.1. [Q8WYA6-1]
RefSeqiNP_001268424.1. NM_001281495.1.
NP_110517.2. NM_030877.4. [Q8WYA6-1]
UniGeneiHs.472667.

Genome annotation databases

EnsembliENST00000361383; ENSP00000355050; ENSG00000132792. [Q8WYA6-1]
ENST00000373469; ENSP00000362568; ENSG00000132792. [Q8WYA6-3]
ENST00000373473; ENSP00000362572; ENSG00000132792. [Q8WYA6-2]
ENST00000405275; ENSP00000384355; ENSG00000132792.
GeneIDi56259.
KEGGihsa:56259.
UCSCiuc002xhh.3. human. [Q8WYA6-2]
uc002xhj.3. human. [Q8WYA6-1]

Polymorphism databases

DMDMi29840792.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF239607 mRNA. Translation: AAL69567.1 .
AF367471 mRNA. Translation: AAK53407.1 .
AF370431 mRNA. Translation: AAQ15267.1 . Frameshift.
AK074663 mRNA. Translation: BAC11121.1 .
AK293420 mRNA. Translation: BAG56927.1 .
AK024761 mRNA. Translation: BAB14992.1 . Different initiation.
AL118499 , AL023804 , AL109964 Genomic DNA. Translation: CAI19331.1 .
AL118499 , AL023804 , AL109964 Genomic DNA. Translation: CAI19332.1 .
AL109964 , AL023804 , AL118499 Genomic DNA. Translation: CAI42203.1 .
AL109964 , AL023804 Genomic DNA. Translation: CAI42204.1 .
AL109964 , AL023804 , AL118499 Genomic DNA. Translation: CAI42208.1 .
AL023804 , AL109964 , AL118499 Genomic DNA. Translation: CAI42984.1 .
AL023804 , AL109964 Genomic DNA. Translation: CAI42985.1 .
AL023804 , AL109964 , AL118499 Genomic DNA. Translation: CAI42986.1 .
BC022802 mRNA. Translation: AAH22802.1 .
BC121005 mRNA. Translation: AAI21006.1 .
BC121006 mRNA. Translation: AAI21007.1 .
AK222592 mRNA. Translation: BAD96312.1 .
CCDSi CCDS13298.1. [Q8WYA6-1 ]
RefSeqi NP_001268424.1. NM_001281495.1.
NP_110517.2. NM_030877.4. [Q8WYA6-1 ]
UniGenei Hs.472667.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4CB8 X-ray 2.90 A 77-563 [» ]
4CB9 X-ray 3.00 A 1-563 [» ]
4CBA X-ray 3.10 A 77-563 [» ]
4HM9 X-ray 3.10 A 1-563 [» ]
4HNM X-ray 2.90 A 75-563 [» ]
4MFU X-ray 2.74 A 77-563 [» ]
4MFV X-ray 2.92 A/B 33-563 [» ]
ProteinModelPortali Q8WYA6.
SMRi Q8WYA6. Positions 77-563.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121123. 39 interactions.
IntActi Q8WYA6. 17 interactions.
MINTi MINT-1444671.

PTM databases

PhosphoSitei Q8WYA6.

Polymorphism databases

DMDMi 29840792.

Proteomic databases

MaxQBi Q8WYA6.
PaxDbi Q8WYA6.
PRIDEi Q8WYA6.

Protocols and materials databases

DNASUi 56259.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000361383 ; ENSP00000355050 ; ENSG00000132792 . [Q8WYA6-1 ]
ENST00000373469 ; ENSP00000362568 ; ENSG00000132792 . [Q8WYA6-3 ]
ENST00000373473 ; ENSP00000362572 ; ENSG00000132792 . [Q8WYA6-2 ]
ENST00000405275 ; ENSP00000384355 ; ENSG00000132792 .
GeneIDi 56259.
KEGGi hsa:56259.
UCSCi uc002xhh.3. human. [Q8WYA6-2 ]
uc002xhj.3. human. [Q8WYA6-1 ]

Organism-specific databases

CTDi 56259.
GeneCardsi GC20P036322.
HGNCi HGNC:15879. CTNNBL1.
HPAi HPA004742.
HPA027907.
MIMi 611537. gene.
neXtProti NX_Q8WYA6.
PharmGKBi PA27015.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG283719.
HOVERGENi HBG051212.
InParanoidi Q8WYA6.
KOi K12864.
OMAi MREYAGN.
OrthoDBi EOG7353WH.
PhylomeDBi Q8WYA6.
TreeFami TF314294.

Miscellaneous databases

GeneWikii CTNNBL1.
GenomeRNAii 56259.
NextBioi 35471085.
PROi Q8WYA6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8WYA6.
Bgeei Q8WYA6.
Genevestigatori Q8WYA6.

Family and domain databases

Gene3Di 1.25.10.10. 2 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013180. CTNNBL1_N.
[Graphical view ]
Pfami PF08216. CTNNBL. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence, gene structure, and expression pattern of CTNNBL1, a minor-class intron-containing gene - evidence for a role in apoptosis."
    Jabbour L.S., Welter J.F., Kollar J., Hering T.M.
    Genomics 81:292-303(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, POSSIBLE FUNCTION.
  2. "A new testis development gene NYD-SP19 from human testes."
    Sha J.H., Li J.M., Zhou Z.M.
    Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Testis.
  3. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
    Tissue: Aortic smooth muscle and Mammary gland.
  5. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skin.
  7. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 327-563.
    Tissue: Coronary artery.
  8. "Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1."
    Conticello S.G., Ganesh K., Xue K., Lu M., Rada C., Neuberger M.S.
    Mol. Cell 31:474-484(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH AICDA, SUBCELLULAR LOCATION, POSSIBLE FUNCTION, MUTAGENESIS OF 16-LYS--LYS-33.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-389, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-91, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: IDENTIFICATION AS A COMPONENT OF THE PRP19-CDC5L COMPLEX, SUBCELLULAR LOCATION, INTERACTION WITH CWC15 AND CDC5L.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31."
    Ganesh K., Adam S., Taylor B., Simpson P., Rada C., Neuberger M.
    J. Biol. Chem. 286:17091-17102(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH AICDA; CDC5L; PRPF31; KPNA1 AND KPNA2, SUBCELLULAR LOCATION.
  14. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "The structure of full-length human CTNNBL1 reveals a distinct member of the armadillo-repeat protein family."
    Huang X., Wang G., Wu Y., Du Z.
    Acta Crystallogr. D 69:1598-1608(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS), ARM REPEATS.
  17. "Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin alpha."
    Ganesh K., van Maldegem F., Telerman S.B., Simpson P., Johnson C.M., Williams R.L., Neuberger M.S., Rada C.
    FEBS Lett. 588:21-27(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS), NUCLEAR EXPORT SIGNAL, HEAT REPEATS, MUTAGENESIS OF 521-MET--PHE-563, COILED-COIL.

Entry informationi

Entry nameiCTBL1_HUMAN
AccessioniPrimary (citable) accession number: Q8WYA6
Secondary accession number(s): B4DE16
, Q0VAL9, Q0VAM0, Q53HI8, Q5JWZ2, Q5JWZ3, Q5JWZ7, Q5JWZ8, Q8N454, Q8NCL2, Q8TBD6, Q96KD2, Q9H7A5, Q9NQF9, Q9NTX0, Q9Y3M7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: March 1, 2002
Last modified: September 3, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi