Q8WYA1 (BMAL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aryl hydrocarbon receptor nuclear translocator-like protein 2

Alternative name(s):
Basic-helix-loop-helix-PAS protein MOP9
Brain and muscle ARNT-like 2
CYCLE-like factor
Short name=CLIF
Class E basic helix-loop-helix protein 6
Short name=bHLHe6
Member of PAS protein 9
PAS domain-containing protein 9

Gene names

Name:	ARNTL2
Synonyms:	BHLHE6, BMAL2, CLIF, MOP9, PASD9

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	636 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	ARNTL2-CLOCK heterodimers activate E-box element (5'-CACGTG-5') transcription. Also, in umbilical vein endothelial cells, activates SERPINE1 through E-box sites. This transactivation is inhibited by PER2 and CRY1. Ref.2
Subunit structure	Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, ARNTL or ARNTL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts directly with CLOCK to form the ARNTL2-CLOCK transactivator. Can form heterodimers or homodimers which interact directly with CLOCK to form the transcription activator. Also interacts with NPAS2 and HIF1A. Ref.2 Ref.3
Subcellular location	Nucleus Ref.1.
Tissue specificity	Expressed in fetal brain. Highly expressed in brain and placenta. Lower levels in heart, liver, thymus, kidney and lung. Located to endothelial cells and neuronal cells of the suprachiasmatic nucleus (SCN). Also detected in endothelial cells of the heart, lung and kidney. In the brain, specifically expressed in the thalamus, hippocampus and amygdala. Ref.1 Ref.2 Ref.3
Induction	Constitutively expressed. Has no circadian rhythm expression pattern. Ref.2
Sequence similarities	Contains 1 bHLH (basic helix-loop-helix) domain. Contains 1 PAC (PAS-associated C-terminal) domain. Contains 2 PAS (PER-ARNT-SIM) domains.

Ontologies

Keywords
Biological process	Biological rhythms Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Ligand	DNA-binding
Molecular function	Activator
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	circadian rhythm Inferred from direct assay Ref.3. Source: MGI entrainment of circadian clock Non-traceable author statement Ref.2. Source: UniProtKB positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 15147242. Source: BHF-UCL
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro nucleus Non-traceable author statement Ref.2. Source: UniProtKB transcription factor complex Inferred from electronic annotation. Source: InterPro
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity Inferred from direct assay PubMed 15147242. Source: BHF-UCL signal transducer activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 9 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8WYA1-1)

Also known as: BMAL2a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8WYA1-2)

Also known as: BMAL2b;

The sequence of this isoform differs from the canonical sequence as follows:
     96-109: Missing.

Isoform 3 (identifier: Q8WYA1-3)

Also known as: BMAL2c;

The sequence of this isoform differs from the canonical sequence as follows:
     11-11: G → GEVAGGEATAPG
     62-95: Missing.
     96-109: Missing.

Isoform 4 (identifier: Q8WYA1-4)

Also known as: BMAL2d;

The sequence of this isoform differs from the canonical sequence as follows:
     62-95: Missing.
     96-109: Missing.

Isoform 5 (identifier: Q8WYA1-5)

Also known as: CLIF;

The sequence of this isoform differs from the canonical sequence as follows:
     62-95: Missing.

Isoform 6 (identifier: Q8WYA1-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: Missing.
     62-95: Missing.
     96-109: Missing.

Isoform 7 (identifier: Q8WYA1-7)

Also known as: MOP9 long form;

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: Missing.
     96-109: Missing.

Isoform 8 (identifier: Q8WYA1-8)

Also known as: MOP9 short form;

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: Missing.
     61-61: Q → H
     62-74: Missing.
     96-109: Missing.

Note: No experimental confirmation available.

Isoform 9 (identifier: Q8WYA1-9)

The sequence of this isoform differs from the canonical sequence as follows:
     11-11: G → GEVAGGEATAPG
     62-95: Missing.
     96-109: Missing.
     556-635: MSNKELFPPS...PGDFSDIQWT → VMVHSWISMPYVTMMTQPWLH

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 636

636

Aryl hydrocarbon receptor nuclear translocator-like protein 2

PRO_0000273631

Regions

Domain

107 – 160

54

bHLH

Domain

178 – 250

73

PAS 1

Domain

357 – 427

71

PAS 2

Domain

432 – 475

44

PAC

Natural variations

Alternative sequence

1 – 37

37

Missing in isoform 6, isoform 7 and isoform 8.

VSP_022580

Alternative sequence

11

1

G → GEVAGGEATAPG in isoform 3 and isoform 9.

VSP_022585

Alternative sequence

61

1

Q → H in isoform 8.

VSP_022582

Alternative sequence

62 – 95

34

Missing in isoform 3, isoform 4, isoform 5, isoform 6 and isoform 9.

VSP_022581

Alternative sequence

62 – 74

13

Missing in isoform 8.

VSP_022583

Alternative sequence

96 – 109

14

Missing in isoform 2, isoform 3, isoform 4, isoform 6, isoform 7, isoform 8 and isoform 9.

VSP_022584

Alternative sequence

556 – 635

80

MSNKE…DIQWT → VMVHSWISMPYVTMMTQPWL H in isoform 9.

VSP_044773

Natural variant

340

1

N → S.
Corresponds to variant rs1037921 [ dbSNP | Ensembl ].

VAR_030158

Natural variant

574

1

A → V.
Corresponds to variant rs11049005 [ dbSNP | Ensembl ].

VAR_030159

Experimental info

Sequence conflict

41

1

F → S Ref.1

Sequence conflict

173

1

R → G in BAH12415. Ref.5

Sequence conflict

257

1

A → T Ref.3

Sequence conflict

276

1

S → F Ref.3

Sequence conflict

304

1

K → R in BAH12415. Ref.5

Sequence conflict

324

1

P → R Ref.1

Sequence conflict

527

1

L → I Ref.1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

636

Helix Strand Turn

Details...

Beta strand

368 – 375

8

Beta strand

379 – 384

6

Helix

387 – 391

5

Turn

396 – 398

3

Turn

404 – 407

4

Beta strand

410 – 412

3

Helix

413 – 424

12

Beta strand

426 – 428

3

Beta strand

430 – 438

9

Beta strand

440 – 442

3

Beta strand

444 – 455

12

Beta strand

458 – 460

3

Beta strand

462 – 470

9

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (BMAL2a) [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 972CE2BC5B05B1F3	FASTA	636	70,887
	10 20 30 40 50 60 MAAEEEAAAG GKVLREENQC IAPVVSSRVS PGTRPTAMGS FSSHMTEFPR KRKGSDSDPS 70 80 90 100 110 120 QSGIMTEKVV EKLSQNPLTY LLSTRIEISA SSGSRVEDGE HQVKMKAFRE AHSQTEKRRR 130 140 150 160 170 180 DKMNNLIEEL SAMIPQCNPM ARKLDKLTVL RMAVQHLRSL KGLTNSYVGS NYRPSFLQDN 190 200 210 220 230 240 ELRHLILKTA EGFLFVVGCE RGKILFVSKS VSKILNYDQA SLTGQSLFDF LHPKDVAKVK 250 260 270 280 290 300 EQLSSFDISP REKLIDAKTG LQVHSNLHAG RTRVYSGSRR SFFCRIKSCK ISVKEEHGCL 310 320 330 340 350 360 PNSKKKEHRK FYTIHCTGYL RSWPPNIVGM EEERNSKKDN SNFTCLVAIG RLQPYIVPQN 370 380 390 400 410 420 SGEINVKPTE FITRFAVNGK FVYVDQRATA ILGYLPQELL GTSCYEYFHQ DDHNNLTDKH 430 440 450 460 470 480 KAVLQSKEKI LTDSYKFRAK DGSFVTLKSQ WFSFTNPWTK ELEYIVSVNT LVLGHSEPGE 490 500 510 520 530 540 ASFLPCSSQS SEESSRQSCM SVPGMSTGTV LGAGSIGTDI ANEILDLQRL QSSSYLDDSS 550 560 570 580 590 600 PTGLMKDTHT VNCRSMSNKE LFPPSPSEMG ELEATRQNQS TVAVHSHEPL LSDGAQLDFD 610 620 630 ALCDNDDTAM AAFMNYLEAE GGLGDPGDFS DIQWTL
	Isoform 2 (BMAL2b) [UniParc]. Checksum: EE042DBFFB87BC63	FASTA	622	69,231
	10 20 30 40 50 60 MAAEEEAAAG GKVLREENQC IAPVVSSRVS PGTRPTAMGS FSSHMTEFPR KRKGSDSDPS 70 80 90 100 110 120 QSGIMTEKVV EKLSQNPLTY LLSTRIEISA SSGSREAHSQ TEKRRRDKMN NLIEELSAMI 130 140 150 160 170 180 PQCNPMARKL DKLTVLRMAV QHLRSLKGLT NSYVGSNYRP SFLQDNELRH LILKTAEGFL 190 200 210 220 230 240 FVVGCERGKI LFVSKSVSKI LNYDQASLTG QSLFDFLHPK DVAKVKEQLS SFDISPREKL 250 260 270 280 290 300 IDAKTGLQVH SNLHAGRTRV YSGSRRSFFC RIKSCKISVK EEHGCLPNSK KKEHRKFYTI 310 320 330 340 350 360 HCTGYLRSWP PNIVGMEEER NSKKDNSNFT CLVAIGRLQP YIVPQNSGEI NVKPTEFITR 370 380 390 400 410 420 FAVNGKFVYV DQRATAILGY LPQELLGTSC YEYFHQDDHN NLTDKHKAVL QSKEKILTDS 430 440 450 460 470 480 YKFRAKDGSF VTLKSQWFSF TNPWTKELEY IVSVNTLVLG HSEPGEASFL PCSSQSSEES 490 500 510 520 530 540 SRQSCMSVPG MSTGTVLGAG SIGTDIANEI LDLQRLQSSS YLDDSSPTGL MKDTHTVNCR 550 560 570 580 590 600 SMSNKELFPP SPSEMGELEA TRQNQSTVAV HSHEPLLSDG AQLDFDALCD NDDTAMAAFM 610 620 NYLEAEGGLG DPGDFSDIQW TL
	Isoform 3 (BMAL2c) [UniParc]. Checksum: A5B1B84DBC4B5B40	FASTA	599	66,493
	10 20 30 40 50 60 MAAEEEAAAG GEVAGGEATA PGKVLREENQ CIAPVVSSRV SPGTRPTAMG SFSSHMTEFP 70 80 90 100 110 120 RKRKGSDSDP SQEAHSQTEK RRRDKMNNLI EELSAMIPQC NPMARKLDKL TVLRMAVQHL 130 140 150 160 170 180 RSLKGLTNSY VGSNYRPSFL QDNELRHLIL KTAEGFLFVV GCERGKILFV SKSVSKILNY 190 200 210 220 230 240 DQASLTGQSL FDFLHPKDVA KVKEQLSSFD ISPREKLIDA KTGLQVHSNL HAGRTRVYSG 250 260 270 280 290 300 SRRSFFCRIK SCKISVKEEH GCLPNSKKKE HRKFYTIHCT GYLRSWPPNI VGMEEERNSK 310 320 330 340 350 360 KDNSNFTCLV AIGRLQPYIV PQNSGEINVK PTEFITRFAV NGKFVYVDQR ATAILGYLPQ 370 380 390 400 410 420 ELLGTSCYEY FHQDDHNNLT DKHKAVLQSK EKILTDSYKF RAKDGSFVTL KSQWFSFTNP 430 440 450 460 470 480 WTKELEYIVS VNTLVLGHSE PGEASFLPCS SQSSEESSRQ SCMSVPGMST GTVLGAGSIG 490 500 510 520 530 540 TDIANEILDL QRLQSSSYLD DSSPTGLMKD THTVNCRSMS NKELFPPSPS EMGELEATRQ 550 560 570 580 590 NQSTVAVHSH EPLLSDGAQL DFDALCDNDD TAMAAFMNYL EAEGGLGDPG DFSDIQWTL
	Isoform 4 (BMAL2d) [UniParc]. Checksum: 3D49ACC111064FD8	FASTA	588	65,553
	10 20 30 40 50 60 MAAEEEAAAG GKVLREENQC IAPVVSSRVS PGTRPTAMGS FSSHMTEFPR KRKGSDSDPS 70 80 90 100 110 120 QEAHSQTEKR RRDKMNNLIE ELSAMIPQCN PMARKLDKLT VLRMAVQHLR SLKGLTNSYV 130 140 150 160 170 180 GSNYRPSFLQ DNELRHLILK TAEGFLFVVG CERGKILFVS KSVSKILNYD QASLTGQSLF 190 200 210 220 230 240 DFLHPKDVAK VKEQLSSFDI SPREKLIDAK TGLQVHSNLH AGRTRVYSGS RRSFFCRIKS 250 260 270 280 290 300 CKISVKEEHG CLPNSKKKEH RKFYTIHCTG YLRSWPPNIV GMEEERNSKK DNSNFTCLVA 310 320 330 340 350 360 IGRLQPYIVP QNSGEINVKP TEFITRFAVN GKFVYVDQRA TAILGYLPQE LLGTSCYEYF 370 380 390 400 410 420 HQDDHNNLTD KHKAVLQSKE KILTDSYKFR AKDGSFVTLK SQWFSFTNPW TKELEYIVSV 430 440 450 460 470 480 NTLVLGHSEP GEASFLPCSS QSSEESSRQS CMSVPGMSTG TVLGAGSIGT DIANEILDLQ 490 500 510 520 530 540 RLQSSSYLDD SSPTGLMKDT HTVNCRSMSN KELFPPSPSE MGELEATRQN QSTVAVHSHE 550 560 570 580 PLLSDGAQLD FDALCDNDDT AMAAFMNYLE AEGGLGDPGD FSDIQWTL
	Isoform 5 (CLIF) [UniParc]. Checksum: AD8937DD526D8B45	FASTA	602	67,209
	10 20 30 40 50 60 MAAEEEAAAG GKVLREENQC IAPVVSSRVS PGTRPTAMGS FSSHMTEFPR KRKGSDSDPS 70 80 90 100 110 120 QVEDGEHQVK MKAFREAHSQ TEKRRRDKMN NLIEELSAMI PQCNPMARKL DKLTVLRMAV 130 140 150 160 170 180 QHLRSLKGLT NSYVGSNYRP SFLQDNELRH LILKTAEGFL FVVGCERGKI LFVSKSVSKI 190 200 210 220 230 240 LNYDQASLTG QSLFDFLHPK DVAKVKEQLS SFDISPREKL IDAKTGLQVH SNLHAGRTRV 250 260 270 280 290 300 YSGSRRSFFC RIKSCKISVK EEHGCLPNSK KKEHRKFYTI HCTGYLRSWP PNIVGMEEER 310 320 330 340 350 360 NSKKDNSNFT CLVAIGRLQP YIVPQNSGEI NVKPTEFITR FAVNGKFVYV DQRATAILGY 370 380 390 400 410 420 LPQELLGTSC YEYFHQDDHN NLTDKHKAVL QSKEKILTDS YKFRAKDGSF VTLKSQWFSF 430 440 450 460 470 480 TNPWTKELEY IVSVNTLVLG HSEPGEASFL PCSSQSSEES SRQSCMSVPG MSTGTVLGAG 490 500 510 520 530 540 SIGTDIANEI LDLQRLQSSS YLDDSSPTGL MKDTHTVNCR SMSNKELFPP SPSEMGELEA 550 560 570 580 590 600 TRQNQSTVAV HSHEPLLSDG AQLDFDALCD NDDTAMAAFM NYLEAEGGLG DPGDFSDIQW TL
	Isoform 6 [UniParc]. Checksum: F845E3F54FFA39B0	FASTA	551	61,788
	10 20 30 40 50 60 MGSFSSHMTE FPRKRKGSDS DPSQEAHSQT EKRRRDKMNN LIEELSAMIP QCNPMARKLD 70 80 90 100 110 120 KLTVLRMAVQ HLRSLKGLTN SYVGSNYRPS FLQDNELRHL ILKTAEGFLF VVGCERGKIL 130 140 150 160 170 180 FVSKSVSKIL NYDQASLTGQ SLFDFLHPKD VAKVKEQLSS FDISPREKLI DAKTGLQVHS 190 200 210 220 230 240 NLHAGRTRVY SGSRRSFFCR IKSCKISVKE EHGCLPNSKK KEHRKFYTIH CTGYLRSWPP 250 260 270 280 290 300 NIVGMEEERN SKKDNSNFTC LVAIGRLQPY IVPQNSGEIN VKPTEFITRF AVNGKFVYVD 310 320 330 340 350 360 QRATAILGYL PQELLGTSCY EYFHQDDHNN LTDKHKAVLQ SKEKILTDSY KFRAKDGSFV 370 380 390 400 410 420 TLKSQWFSFT NPWTKELEYI VSVNTLVLGH SEPGEASFLP CSSQSSEESS RQSCMSVPGM 430 440 450 460 470 480 STGTVLGAGS IGTDIANEIL DLQRLQSSSY LDDSSPTGLM KDTHTVNCRS MSNKELFPPS 490 500 510 520 530 540 PSEMGELEAT RQNQSTVAVH SHEPLLSDGA QLDFDALCDN DDTAMAAFMN YLEAEGGLGD 550 PGDFSDIQWT L
	Isoform 7 (MOP9 long form) [UniParc]. Checksum: EE2E576065881B01	FASTA	585	65,466
	10 20 30 40 50 60 MGSFSSHMTE FPRKRKGSDS DPSQSGIMTE KVVEKLSQNP LTYLLSTRIE ISASSGSREA 70 80 90 100 110 120 HSQTEKRRRD KMNNLIEELS AMIPQCNPMA RKLDKLTVLR MAVQHLRSLK GLTNSYVGSN 130 140 150 160 170 180 YRPSFLQDNE LRHLILKTAE GFLFVVGCER GKILFVSKSV SKILNYDQAS LTGQSLFDFL 190 200 210 220 230 240 HPKDVAKVKE QLSSFDISPR EKLIDAKTGL QVHSNLHAGR TRVYSGSRRS FFCRIKSCKI 250 260 270 280 290 300 SVKEEHGCLP NSKKKEHRKF YTIHCTGYLR SWPPNIVGME EERNSKKDNS NFTCLVAIGR 310 320 330 340 350 360 LQPYIVPQNS GEINVKPTEF ITRFAVNGKF VYVDQRATAI LGYLPQELLG TSCYEYFHQD 370 380 390 400 410 420 DHNNLTDKHK AVLQSKEKIL TDSYKFRAKD GSFVTLKSQW FSFTNPWTKE LEYIVSVNTL 430 440 450 460 470 480 VLGHSEPGEA SFLPCSSQSS EESSRQSCMS VPGMSTGTVL GAGSIGTDIA NEILDLQRLQ 490 500 510 520 530 540 SSSYLDDSSP TGLMKDTHTV NCRSMSNKEL FPPSPSEMGE LEATRQNQST VAVHSHEPLL 550 560 570 580 SDGAQLDFDA LCDNDDTAMA AFMNYLEAEG GLGDPGDFSD IQWTL
	Isoform 8 (MOP9 short form) [UniParc]. Checksum: FDDF781F6E2FDBC5	FASTA	572	64,072
	10 20 30 40 50 60 MGSFSSHMTE FPRKRKGSDS DPSHQNPLTY LLSTRIEISA SSGSREAHSQ TEKRRRDKMN 70 80 90 100 110 120 NLIEELSAMI PQCNPMARKL DKLTVLRMAV QHLRSLKGLT NSYVGSNYRP SFLQDNELRH 130 140 150 160 170 180 LILKTAEGFL FVVGCERGKI LFVSKSVSKI LNYDQASLTG QSLFDFLHPK DVAKVKEQLS 190 200 210 220 230 240 SFDISPREKL IDAKTGLQVH SNLHAGRTRV YSGSRRSFFC RIKSCKISVK EEHGCLPNSK 250 260 270 280 290 300 KKEHRKFYTI HCTGYLRSWP PNIVGMEEER NSKKDNSNFT CLVAIGRLQP YIVPQNSGEI 310 320 330 340 350 360 NVKPTEFITR FAVNGKFVYV DQRATAILGY LPQELLGTSC YEYFHQDDHN NLTDKHKAVL 370 380 390 400 410 420 QSKEKILTDS YKFRAKDGSF VTLKSQWFSF TNPWTKELEY IVSVNTLVLG HSEPGEASFL 430 440 450 460 470 480 PCSSQSSEES SRQSCMSVPG MSTGTVLGAG SIGTDIANEI LDLQRLQSSS YLDDSSPTGL 490 500 510 520 530 540 MKDTHTVNCR SMSNKELFPP SPSEMGELEA TRQNQSTVAV HSHEPLLSDG AQLDFDALCD 550 560 570 NDDTAMAAFM NYLEAEGGLG DPGDFSDIQW TL
	Isoform 9 [UniParc]. Checksum: 9C6DF2CB4CE1BB8A	FASTA	540	60,390
	10 20 30 40 50 60 MAAEEEAAAG GEVAGGEATA PGKVLREENQ CIAPVVSSRV SPGTRPTAMG SFSSHMTEFP 70 80 90 100 110 120 RKRKGSDSDP SQEAHSQTEK RRRDKMNNLI EELSAMIPQC NPMARKLDKL TVLRMAVQHL 130 140 150 160 170 180 RSLKGLTNSY VGSNYRPSFL QDNELRHLIL KTAEGFLFVV GCERGKILFV SKSVSKILNY 190 200 210 220 230 240 DQASLTGQSL FDFLHPKDVA KVKEQLSSFD ISPREKLIDA KTGLQVHSNL HAGRTRVYSG 250 260 270 280 290 300 SRRSFFCRIK SCKISVKEEH GCLPNSKKKE HRKFYTIHCT GYLRSWPPNI VGMEEERNSK 310 320 330 340 350 360 KDNSNFTCLV AIGRLQPYIV PQNSGEINVK PTEFITRFAV NGKFVYVDQR ATAILGYLPQ 370 380 390 400 410 420 ELLGTSCYEY FHQDDHNNLT DKHKAVLQSK EKILTDSYKF RAKDGSFVTL KSQWFSFTNP 430 440 450 460 470 480 WTKELEYIVS VNTLVLGHSE PGEASFLPCS SQSSEESSRQ SCMSVPGMST GTVLGAGSIG 490 500 510 520 530 540 TDIANEILDL QRLQSSSYLD DSSPTGLMKD THTVNCRSVM VHSWISMPYV TMMTQPWLHL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA cloning of a novel bHLH-PAS transcription factor superfamily gene, BMAL2; Its mRNA expression, subcellular distribution, and chromosomal localization." Ikeda M., Yu W., Hirai M., Ebisawa T., Honma S., Yoshimura K., Honma K., Nomura M. Biochem. Biophys. Res. Commun. 275:493-502(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6), SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Brain.
[2]	"CLIF, a novel cycle-like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression." Maemura K., de La Monte S.M., Chin M.T., Layne M.D., Hsieh C.-M., Yet S.-F., Perrella M.A., Lee M.-E. J. Biol. Chem. 275:36847-36851(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), FUNCTION, INDUCTION, TISSUE SPECIFICITY, INTERACTION WITH CLOCK. Tissue: Umbilical vein endothelial cell.
[3]	"The basic helix-loop-helix-PAS protein MOP9 is a brain-specific heterodimeric partner of circadian and hypoxia factors." Hogenesch J.B., Gu Y.-Z., Moran S.M., Shimomura K., Radcliffe L.A., Takahashi J.S., Bradfield C.A. J. Neurosci. 20:RC83-RC83(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 7 AND 8), TISSUE SPECIFICITY, INTERACTION WITH CLOCK; NPAS2 AND HIF1A. Tissue: Brain.
[4]	"Chicken pineal clock genes: implication of BMAL2 as a bidirectional regulator in circadian clock oscillation." Okano T., Yamamoto K., Okano K., Hirota T., Kasahara T., Sasaki M., Takanaka Y., Fukada Y. Genes Cells 6:825-836(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4). Tissue: Embryonic kidney.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 9). Tissue: Tongue.
[6]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 5). Tissue: Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB039921 mRNA. Translation: BAB01485.1.
AF256215 mRNA. Translation: AAG34652.1.
AF231338 mRNA. Translation: AAF71306.1.
AF231339 mRNA. Translation: AAF71307.1.
AF246960 mRNA. Translation: AAL50339.1.
AF246961 mRNA. Translation: AAL50340.1.
AF246962 mRNA. Translation: AAL50341.1.
AF246963 mRNA. Translation: AAL50342.1.
AK296706 mRNA. Translation: BAH12415.1.
AC068794 Genomic DNA. No translation available.
AC092829 Genomic DNA. No translation available.
BC000172 mRNA. Translation: AAH00172.3.
BC125061 mRNA. Translation: AAI25062.1.
BC125062 mRNA. Translation: AAI25063.1.

IPI

IPI00142781.
IPI00163662.
IPI00465306.
IPI00788724.
IPI00789255.
IPI00795339.
IPI00827866.
IPI00827897.
IPI01009213.

RefSeq

NP_001234931.1. NM_001248002.1.
NP_001234932.1. NM_001248003.1.
NP_001234933.1. NM_001248004.1.
NP_001234934.1. NM_001248005.1.
NP_064568.3. NM_020183.4.

UniGene

Hs.434269.
Hs.445447.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2KDK	NMR	-	A	360-477	[»]

ProteinModelPortal

Q8WYA1.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q8WYA1. 3 interactions.

PTM databases

PhosphoSite

Q8WYA1.

Polymorphism databases

DMDM

124007121.

Proteomic databases

PaxDb

Q8WYA1.

PRIDE

Q8WYA1.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000261178; ENSP00000261178; ENSG00000029153.
ENST00000266503; ENSP00000266503; ENSG00000029153.
ENST00000311001; ENSP00000312247; ENSG00000029153.
ENST00000395901; ENSP00000379238; ENSG00000029153.
ENST00000542388; ENSP00000445836; ENSG00000029153.
ENST00000544915; ENSP00000442438; ENSG00000029153.
ENST00000546179; ENSP00000438545; ENSG00000029153.

GeneID

56938.

KEGG

hsa:56938.

UCSC

uc001rht.2. human.
uc001rhu.2. human.
uc001rhv.2. human.
uc001rhw.3. human.
uc009zji.2. human.
uc010sjp.2. human.

Organism-specific databases

CTD

56938.

GeneCards

GC12P027485.

H-InvDB

HIX0037110.

HGNC

HGNC:18984. ARNTL2.

MIM

614517. gene.

neXtProt

NX_Q8WYA1.

PharmGKB

PA134896555.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG288887.

HOVERGEN

HBG107503.

InParanoid

Q8WYA1.

KO

K09099.

OMA

IPQCNPM.

PhylomeDB

Q8WYA1.

Gene expression databases

ArrayExpress

Q8WYA1.

Bgee

Q8WYA1.

CleanEx

HS_ARNTL2.

Genevestigator

Q8WYA1.

Family and domain databases

Gene3D

4.10.280.10. 1 hit.

InterPro

IPR011598. bHLH_dom.
IPR001067. Nuc_translocat.
IPR001610. PAC.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR013655. PAS_fold_3.
[Graphical view]

Pfam

PF00010. HLH. 1 hit.
PF00989. PAS. 1 hit.
PF08447. PAS_3. 1 hit.
[Graphical view]

PRINTS

PR00785. NCTRNSLOCATR.

SMART

SM00353. HLH. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]

SUPFAM

SSF47459. HLH_basic. 1 hit.
SSF55785. SSF55785. 2 hits.

TIGRFAMs

TIGR00229. sensory_box. 1 hit.

PROSITE

PS50888. BHLH. 1 hit.
PS50113. PAC. False negative.
PS50112. PAS. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

GenomeRNAi

56938.

NextBio

62501.

SOURCE

Search...

Entry information

Entry name

BMAL2_HUMAN

Accession

Primary (citable) accession number: Q8WYA1
Secondary accession number(s): B7Z429 , F5H402, Q8WYA2, Q8WYA3, Q8WYA4, Q96J63, Q9H2M4, Q9NS70, Q9NYQ4, Q9NYQ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	January 23, 2007
Last modified:	May 29, 2013
This is version 100 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.