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Q8WYA1 (BMAL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aryl hydrocarbon receptor nuclear translocator-like protein 2
Alternative name(s):
Basic-helix-loop-helix-PAS protein MOP9
Brain and muscle ARNT-like 2
CYCLE-like factor
Short name=CLIF
Class E basic helix-loop-helix protein 6
Short name=bHLHe6
Member of PAS protein 9
PAS domain-containing protein 9
Gene names
Name:ARNTL2
Synonyms:BHLHE6, BMAL2, CLIF, MOP9, PASD9
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length636 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. The CLOCK-ARNTL2/BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. Ref.2 Ref.8 Ref.9

Subunit structure

Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, ARNTL/BMAL1 or ARNTL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts directly with CLOCK to form the ARNTL2/BMAL2-CLOCK transactivator. Can form heterodimers or homodimers which interact directly with CLOCK to form the transcription activator. Also interacts with NPAS2 and HIF1A. Interacts with PER2. Ref.2 Ref.3

Subcellular location

Nucleus Ref.1.

Tissue specificity

Expressed in fetal brain. Highly expressed in brain and placenta. Lower levels in heart, liver, thymus, kidney and lung. Located to endothelial cells and neuronal cells of the suprachiasmatic nucleus (SCN). Also detected in endothelial cells of the heart, lung and kidney. In the brain, specifically expressed in the thalamus, hippocampus and amygdala. Ref.1 Ref.2 Ref.3

Induction

Constitutively expressed. Has no circadian rhythm expression pattern. Ref.2

Sequence similarities

Contains 1 bHLH (basic helix-loop-helix) domain.

Contains 1 PAC (PAS-associated C-terminal) domain.

Contains 2 PAS (PER-ARNT-SIM) domains.

Ontologies

Keywords
   Biological processBiological rhythms
Transcription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
   LigandDNA-binding
   Molecular functionActivator
   PTMIsopeptide bond
Ubl conjugation
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcircadian rhythm

Inferred from direct assay Ref.3. Source: MGI

entrainment of circadian clock

Non-traceable author statement Ref.2. Source: UniProtKB

positive regulation of circadian rhythm

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 15147242. Source: BHF-UCL

positive regulation of transcription, DNA-templated

Inferred from direct assay Ref.8. Source: UniProtKB

regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 12055078. Source: MGI

regulation of transcription, DNA-templated

Non-traceable author statement Ref.2. Source: UniProtKB

transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 15147242. Source: GOC

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: InterPro

nucleolus

Inferred from direct assay. Source: HPA

nucleus

Non-traceable author statement Ref.2. Source: UniProtKB

transcription factor complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionE-box binding

Inferred from direct assay Ref.8. Source: UniProtKB

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 15147242. Source: BHF-UCL

sequence-specific DNA binding transcription factor activity

Non-traceable author statement Ref.2. Source: UniProtKB

signal transducer activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 9 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8WYA1-1)

Also known as: BMAL2a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8WYA1-2)

Also known as: BMAL2b;

The sequence of this isoform differs from the canonical sequence as follows:
     96-109: Missing.
Isoform 3 (identifier: Q8WYA1-3)

Also known as: BMAL2c;

The sequence of this isoform differs from the canonical sequence as follows:
     11-11: G → GEVAGGEATAPG
     62-95: Missing.
     96-109: Missing.
Isoform 4 (identifier: Q8WYA1-4)

Also known as: BMAL2d;

The sequence of this isoform differs from the canonical sequence as follows:
     62-95: Missing.
     96-109: Missing.
Isoform 5 (identifier: Q8WYA1-5)

Also known as: CLIF;

The sequence of this isoform differs from the canonical sequence as follows:
     62-95: Missing.
Isoform 6 (identifier: Q8WYA1-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: Missing.
     62-95: Missing.
     96-109: Missing.
Isoform 7 (identifier: Q8WYA1-7)

Also known as: MOP9 long form;

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: Missing.
     96-109: Missing.
Isoform 8 (identifier: Q8WYA1-8)

Also known as: MOP9 short form;

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: Missing.
     61-61: Q → H
     62-74: Missing.
     96-109: Missing.
Note: No experimental confirmation available.
Isoform 9 (identifier: Q8WYA1-9)

The sequence of this isoform differs from the canonical sequence as follows:
     11-11: G → GEVAGGEATAPG
     62-95: Missing.
     96-109: Missing.
     556-635: MSNKELFPPS...PGDFSDIQWT → VMVHSWISMPYVTMMTQPWLH
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 636636Aryl hydrocarbon receptor nuclear translocator-like protein 2
PRO_0000273631

Regions

Domain107 – 16054bHLH
Domain178 – 25073PAS 1
Domain357 – 42771PAS 2
Domain432 – 47544PAC
Region46 – 258213Interaction with PER2 By similarity
Motif49 – 546Nuclear localization signal By similarity
Motif177 – 18711Nuclear export signal 1 By similarity
Motif392 – 4009Nuclear export signal 2 By similarity

Amino acid modifications

Cross-link287Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2 and SUMO3) By similarity

Natural variations

Alternative sequence1 – 3737Missing in isoform 6, isoform 7 and isoform 8.
VSP_022580
Alternative sequence111G → GEVAGGEATAPG in isoform 3 and isoform 9.
VSP_022585
Alternative sequence611Q → H in isoform 8.
VSP_022582
Alternative sequence62 – 9534Missing in isoform 3, isoform 4, isoform 5, isoform 6 and isoform 9.
VSP_022581
Alternative sequence62 – 7413Missing in isoform 8.
VSP_022583
Alternative sequence96 – 10914Missing in isoform 2, isoform 3, isoform 4, isoform 6, isoform 7, isoform 8 and isoform 9.
VSP_022584
Alternative sequence556 – 63580MSNKE…DIQWT → VMVHSWISMPYVTMMTQPWL H in isoform 9.
VSP_044773
Natural variant3401N → S.
Corresponds to variant rs1037921 [ dbSNP | Ensembl ].
VAR_030158
Natural variant5741A → V.
Corresponds to variant rs11049005 [ dbSNP | Ensembl ].
VAR_030159

Experimental info

Sequence conflict411F → S Ref.1
Sequence conflict1731R → G in BAH12415. Ref.5
Sequence conflict2571A → T Ref.3
Sequence conflict2761S → F Ref.3
Sequence conflict3041K → R in BAH12415. Ref.5
Sequence conflict3241P → R Ref.1
Sequence conflict5271L → I Ref.1

Secondary structure

.......................... 636
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (BMAL2a) [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 972CE2BC5B05B1F3

FASTA63670,887
        10         20         30         40         50         60 
MAAEEEAAAG GKVLREENQC IAPVVSSRVS PGTRPTAMGS FSSHMTEFPR KRKGSDSDPS 

        70         80         90        100        110        120 
QSGIMTEKVV EKLSQNPLTY LLSTRIEISA SSGSRVEDGE HQVKMKAFRE AHSQTEKRRR 

       130        140        150        160        170        180 
DKMNNLIEEL SAMIPQCNPM ARKLDKLTVL RMAVQHLRSL KGLTNSYVGS NYRPSFLQDN 

       190        200        210        220        230        240 
ELRHLILKTA EGFLFVVGCE RGKILFVSKS VSKILNYDQA SLTGQSLFDF LHPKDVAKVK 

       250        260        270        280        290        300 
EQLSSFDISP REKLIDAKTG LQVHSNLHAG RTRVYSGSRR SFFCRIKSCK ISVKEEHGCL 

       310        320        330        340        350        360 
PNSKKKEHRK FYTIHCTGYL RSWPPNIVGM EEERNSKKDN SNFTCLVAIG RLQPYIVPQN 

       370        380        390        400        410        420 
SGEINVKPTE FITRFAVNGK FVYVDQRATA ILGYLPQELL GTSCYEYFHQ DDHNNLTDKH 

       430        440        450        460        470        480 
KAVLQSKEKI LTDSYKFRAK DGSFVTLKSQ WFSFTNPWTK ELEYIVSVNT LVLGHSEPGE 

       490        500        510        520        530        540 
ASFLPCSSQS SEESSRQSCM SVPGMSTGTV LGAGSIGTDI ANEILDLQRL QSSSYLDDSS 

       550        560        570        580        590        600 
PTGLMKDTHT VNCRSMSNKE LFPPSPSEMG ELEATRQNQS TVAVHSHEPL LSDGAQLDFD 

       610        620        630 
ALCDNDDTAM AAFMNYLEAE GGLGDPGDFS DIQWTL 

« Hide

Isoform 2 (BMAL2b) [UniParc].

Checksum: EE042DBFFB87BC63
Show »

FASTA62269,231
Isoform 3 (BMAL2c) [UniParc].

Checksum: A5B1B84DBC4B5B40
Show »

FASTA59966,493
Isoform 4 (BMAL2d) [UniParc].

Checksum: 3D49ACC111064FD8
Show »

FASTA58865,553
Isoform 5 (CLIF) [UniParc].

Checksum: AD8937DD526D8B45
Show »

FASTA60267,209
Isoform 6 [UniParc].

Checksum: F845E3F54FFA39B0
Show »

FASTA55161,788
Isoform 7 (MOP9 long form) [UniParc].

Checksum: EE2E576065881B01
Show »

FASTA58565,466
Isoform 8 (MOP9 short form) [UniParc].

Checksum: FDDF781F6E2FDBC5
Show »

FASTA57264,072
Isoform 9 [UniParc].

Checksum: 9C6DF2CB4CE1BB8A
Show »

FASTA54060,390

References

« Hide 'large scale' references
[1]"cDNA cloning of a novel bHLH-PAS transcription factor superfamily gene, BMAL2; Its mRNA expression, subcellular distribution, and chromosomal localization."
Ikeda M., Yu W., Hirai M., Ebisawa T., Honma S., Yoshimura K., Honma K., Nomura M.
Biochem. Biophys. Res. Commun. 275:493-502(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Brain.
[2]"CLIF, a novel cycle-like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression."
Maemura K., de La Monte S.M., Chin M.T., Layne M.D., Hsieh C.-M., Yet S.-F., Perrella M.A., Lee M.-E.
J. Biol. Chem. 275:36847-36851(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), FUNCTION, INDUCTION, TISSUE SPECIFICITY, INTERACTION WITH CLOCK.
Tissue: Umbilical vein endothelial cell.
[3]"The basic helix-loop-helix-PAS protein MOP9 is a brain-specific heterodimeric partner of circadian and hypoxia factors."
Hogenesch J.B., Gu Y.-Z., Moran S.M., Shimomura K., Radcliffe L.A., Takahashi J.S., Bradfield C.A.
J. Neurosci. 20:RC83-RC83(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 7 AND 8), TISSUE SPECIFICITY, INTERACTION WITH CLOCK; NPAS2 AND HIF1A.
Tissue: Brain.
[4]"Chicken pineal clock genes: implication of BMAL2 as a bidirectional regulator in circadian clock oscillation."
Okano T., Yamamoto K., Okano K., Hirota T., Kasahara T., Sasaki M., Takanaka Y., Fukada Y.
Genes Cells 6:825-836(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4).
Tissue: Embryonic kidney.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 9).
Tissue: Tongue.
[6]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 5).
Tissue: Placenta.
[8]"Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2."
Schoenhard J.A., Smith L.H., Painter C.A., Eren M., Johnson C.H., Vaughan D.E.
J. Mol. Cell. Cardiol. 35:473-481(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[9]"A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation."
Kawamoto T., Noshiro M., Sato F., Maemura K., Takeda N., Nagai R., Iwata T., Fujimoto K., Furukawa M., Miyazaki K., Honma S., Honma K.I., Kato Y.
Biochem. Biophys. Res. Commun. 313:117-124(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB039921 mRNA. Translation: BAB01485.1.
AF256215 mRNA. Translation: AAG34652.1.
AF231338 mRNA. Translation: AAF71306.1.
AF231339 mRNA. Translation: AAF71307.1.
AF246960 mRNA. Translation: AAL50339.1.
AF246961 mRNA. Translation: AAL50340.1.
AF246962 mRNA. Translation: AAL50341.1.
AF246963 mRNA. Translation: AAL50342.1.
AK296706 mRNA. Translation: BAH12415.1.
AC068794 Genomic DNA. No translation available.
AC092829 Genomic DNA. No translation available.
BC000172 mRNA. Translation: AAH00172.3.
BC125061 mRNA. Translation: AAI25062.1.
BC125062 mRNA. Translation: AAI25063.1.
CCDSCCDS58219.1. [Q8WYA1-2]
CCDS58220.1. [Q8WYA1-4]
CCDS58221.1. [Q8WYA1-3]
CCDS58222.1. [Q8WYA1-9]
CCDS8712.1. [Q8WYA1-1]
RefSeqNP_001234931.1. NM_001248002.1. [Q8WYA1-2]
NP_001234932.1. NM_001248003.1. [Q8WYA1-3]
NP_001234933.1. NM_001248004.1. [Q8WYA1-4]
NP_001234934.1. NM_001248005.1. [Q8WYA1-9]
NP_064568.3. NM_020183.4. [Q8WYA1-1]
UniGeneHs.445447.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2KDKNMR-A360-477[»]
ProteinModelPortalQ8WYA1.
SMRQ8WYA1. Positions 104-477.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121263. 2 interactions.
IntActQ8WYA1. 3 interactions.

PTM databases

PhosphoSiteQ8WYA1.

Polymorphism databases

DMDM124007121.

Proteomic databases

MaxQBQ8WYA1.
PaxDbQ8WYA1.
PRIDEQ8WYA1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000261178; ENSP00000261178; ENSG00000029153. [Q8WYA1-4]
ENST00000266503; ENSP00000266503; ENSG00000029153. [Q8WYA1-1]
ENST00000311001; ENSP00000312247; ENSG00000029153. [Q8WYA1-2]
ENST00000395901; ENSP00000379238; ENSG00000029153. [Q8WYA1-3]
ENST00000542388; ENSP00000445836; ENSG00000029153. [Q8WYA1-6]
ENST00000544915; ENSP00000442438; ENSG00000029153. [Q8WYA1-5]
ENST00000546179; ENSP00000438545; ENSG00000029153. [Q8WYA1-9]
GeneID56938.
KEGGhsa:56938.
UCSCuc001rht.2. human. [Q8WYA1-1]
uc001rhu.2. human. [Q8WYA1-2]
uc001rhv.2. human. [Q8WYA1-4]
uc001rhw.3. human. [Q8WYA1-3]
uc009zji.2. human. [Q8WYA1-5]

Organism-specific databases

CTD56938.
GeneCardsGC12P027485.
H-InvDBHIX0037110.
HGNCHGNC:18984. ARNTL2.
HPAHPA059074.
MIM614517. gene.
neXtProtNX_Q8WYA1.
PharmGKBPA134896555.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG288887.
HOVERGENHBG107503.
InParanoidQ8WYA1.
KOK09099.
OMASAMIPQC.
OrthoDBEOG7V1FQ8.
PhylomeDBQ8WYA1.
TreeFamTF319983.

Gene expression databases

BgeeQ8WYA1.
CleanExHS_ARNTL2.
GenevestigatorQ8WYA1.

Family and domain databases

Gene3D4.10.280.10. 1 hit.
InterProIPR011598. bHLH_dom.
IPR001067. Nuc_translocat.
IPR001610. PAC.
IPR000014. PAS.
IPR013767. PAS_fold.
[Graphical view]
PfamPF00010. HLH. 1 hit.
PF00989. PAS. 1 hit.
[Graphical view]
PRINTSPR00785. NCTRNSLOCATR.
SMARTSM00353. HLH. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 3 hits.
TIGRFAMsTIGR00229. sensory_box. 1 hit.
PROSITEPS50888. BHLH. 1 hit.
PS50112. PAS. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiARNTL2.
GenomeRNAi56938.
NextBio62501.
PROQ8WYA1.
SOURCESearch...

Entry information

Entry nameBMAL2_HUMAN
AccessionPrimary (citable) accession number: Q8WYA1
Secondary accession number(s): B7Z429 expand/collapse secondary AC list , F5H402, Q8WYA2, Q8WYA3, Q8WYA4, Q96J63, Q9H2M4, Q9NS70, Q9NYQ4, Q9NYQ5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM