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Protein

Transmembrane protein 234

Gene

TMEM234

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Protein family/group databases

TCDBi2.A.7.32.1. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 234
Gene namesi
Name:TMEM234
Synonyms:C1orf91
ORF Names:PP1065, UNQ548/PRO1105
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28837. TMEM234.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalSequence analysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence analysisAdd
BLAST
Transmembranei112 – 13221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672475.

Polymorphism and mutation databases

BioMutaiTMEM234.
DMDMi74760615.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 164164Transmembrane protein 234PRO_0000304697Add
BLAST

Proteomic databases

MaxQBiQ8WY98.
PaxDbiQ8WY98.
PeptideAtlasiQ8WY98.
PRIDEiQ8WY98.

Expressioni

Gene expression databases

BgeeiQ8WY98.
CleanExiHS_C1orf91.
ExpressionAtlasiQ8WY98. baseline and differential.
GenevisibleiQ8WY98. HS.

Organism-specific databases

HPAiHPA015049.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CREB3L1Q96BA83EBI-8642211,EBI-6942903

Protein-protein interaction databases

BioGridi121036. 2 interactions.
IntActiQ8WY98. 2 interactions.
STRINGi9606.ENSP00000309792.

Structurei

3D structure databases

ProteinModelPortaliQ8WY98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM234 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4831. Eukaryota.
ENOG4111XD9. LUCA.
GeneTreeiENSGT00390000013398.
HOVERGENiHBG057419.
InParanoidiQ8WY98.
OMAiCGSILMI.
OrthoDBiEOG7SN8FH.
PhylomeDBiQ8WY98.
TreeFamiTF300180.

Family and domain databases

InterProiIPR018908. TMEM234.
[Graphical view]
PfamiPF10639. TMEM234. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WY98-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASLGQVLA LVLVAALWGG TQPLLKRASA GLQRVHEPTW AQQLLQEMKT
60 70 80 90 100
LFLNTEYLMP FLLNQCGSLL YYLTLASTDL TLAVPICNSL AIIFTLIVGK
110 120 130 140 150
ALGEDIGGKR AVAGMVLTVI GISLCITSSV PWTAELQLHG KGQLQTLSQK
160
CKREASGTQS ERFG
Length:164
Mass (Da):17,601
Last modified:March 1, 2002 - v1
Checksum:i40EEF55C8FC80777
GO
Isoform 2 (identifier: Q8WY98-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-164: AVAGMVLTVI...ASGTQSERFG → KLDYCECGTQ...WRKTEAGVWD

Show »
Length:180
Mass (Da):20,040
Checksum:i472DF01C914919B0
GO
Isoform 3 (identifier: Q8WY98-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     131-140: PWTAELQLHG → SKTQGQQSTL
     141-164: Missing.

Show »
Length:140
Mass (Da):14,877
Checksum:iA099583CDABA03B9
GO
Isoform 4 (identifier: Q8WY98-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-96: DLTLAVPICNSLAIIFTL → GWSQTSEFRSSCWNPGKH
     97-164: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:96
Mass (Da):10,683
Checksum:i46A13265EB6E55E0
GO

Sequence cautioni

The sequence BAC11504.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti66 – 661C → R in BAC11504 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei79 – 9618DLTLA…IIFTL → GWSQTSEFRSSCWNPGKH in isoform 4. 1 PublicationVSP_028105Add
BLAST
Alternative sequencei97 – 16468Missing in isoform 4. 1 PublicationVSP_028106Add
BLAST
Alternative sequencei111 – 16454AVAGM…SERFG → KLDYCECGTQLCGSRHTCVS SFPEPISPEWVRTRPFPILP FPLQLFCFLVAIRVPFPWTV WRKTEAGVWD in isoform 2. 2 PublicationsVSP_028107Add
BLAST
Alternative sequencei131 – 14010PWTAELQLHG → SKTQGQQSTL in isoform 3. 1 PublicationVSP_028108
Alternative sequencei141 – 16424Missing in isoform 3. 1 PublicationVSP_028109Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358586 mRNA. Translation: AAQ88949.1.
AK075260 mRNA. Translation: BAC11504.1. Different initiation.
AK312046 mRNA. Translation: BAG34982.1.
AF258548 mRNA. Translation: AAG23751.1.
AL049795 Genomic DNA. Translation: CAI22059.1.
AL049795 Genomic DNA. Translation: CAI22060.1.
AL049795 Genomic DNA. Translation: CAM12880.1.
CH471059 Genomic DNA. Translation: EAX07556.1.
CH471059 Genomic DNA. Translation: EAX07559.1.
BC001256 mRNA. No translation available.
CH471059 Genomic DNA. Translation: EAX07557.1.
BC004885 mRNA. Translation: AAH04885.1.
BC038842 mRNA. Translation: AAH38842.1.
CCDSiCCDS356.2. [Q8WY98-3]
RefSeqiNP_061991.3. NM_019118.4. [Q8WY98-3]
XP_005271101.1. XM_005271044.3. [Q8WY98-2]
XP_006710839.1. XM_006710776.2. [Q8WY98-1]
XP_011540096.1. XM_011541794.1. [Q8WY98-1]
UniGeneiHs.272299.

Genome annotation databases

EnsembliENST00000309777; ENSP00000309792; ENSG00000160055. [Q8WY98-3]
ENST00000344461; ENSP00000344021; ENSG00000160055. [Q8WY98-1]
ENST00000373593; ENSP00000362695; ENSG00000160055. [Q8WY98-2]
ENST00000461402; ENSP00000433020; ENSG00000160055. [Q8WY98-1]
ENST00000483001; ENSP00000434295; ENSG00000160055. [Q8WY98-1]
ENST00000489170; ENSP00000436631; ENSG00000160055. [Q8WY98-1]
ENST00000491434; ENSP00000435588; ENSG00000160055. [Q8WY98-4]
GeneIDi56063.
KEGGihsa:56063.
UCSCiuc001buo.4. human. [Q8WY98-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358586 mRNA. Translation: AAQ88949.1.
AK075260 mRNA. Translation: BAC11504.1. Different initiation.
AK312046 mRNA. Translation: BAG34982.1.
AF258548 mRNA. Translation: AAG23751.1.
AL049795 Genomic DNA. Translation: CAI22059.1.
AL049795 Genomic DNA. Translation: CAI22060.1.
AL049795 Genomic DNA. Translation: CAM12880.1.
CH471059 Genomic DNA. Translation: EAX07556.1.
CH471059 Genomic DNA. Translation: EAX07559.1.
BC001256 mRNA. No translation available.
CH471059 Genomic DNA. Translation: EAX07557.1.
BC004885 mRNA. Translation: AAH04885.1.
BC038842 mRNA. Translation: AAH38842.1.
CCDSiCCDS356.2. [Q8WY98-3]
RefSeqiNP_061991.3. NM_019118.4. [Q8WY98-3]
XP_005271101.1. XM_005271044.3. [Q8WY98-2]
XP_006710839.1. XM_006710776.2. [Q8WY98-1]
XP_011540096.1. XM_011541794.1. [Q8WY98-1]
UniGeneiHs.272299.

3D structure databases

ProteinModelPortaliQ8WY98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121036. 2 interactions.
IntActiQ8WY98. 2 interactions.
STRINGi9606.ENSP00000309792.

Protein family/group databases

TCDBi2.A.7.32.1. the drug/metabolite transporter (dmt) superfamily.

Polymorphism and mutation databases

BioMutaiTMEM234.
DMDMi74760615.

Proteomic databases

MaxQBiQ8WY98.
PaxDbiQ8WY98.
PeptideAtlasiQ8WY98.
PRIDEiQ8WY98.

Protocols and materials databases

DNASUi56063.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309777; ENSP00000309792; ENSG00000160055. [Q8WY98-3]
ENST00000344461; ENSP00000344021; ENSG00000160055. [Q8WY98-1]
ENST00000373593; ENSP00000362695; ENSG00000160055. [Q8WY98-2]
ENST00000461402; ENSP00000433020; ENSG00000160055. [Q8WY98-1]
ENST00000483001; ENSP00000434295; ENSG00000160055. [Q8WY98-1]
ENST00000489170; ENSP00000436631; ENSG00000160055. [Q8WY98-1]
ENST00000491434; ENSP00000435588; ENSG00000160055. [Q8WY98-4]
GeneIDi56063.
KEGGihsa:56063.
UCSCiuc001buo.4. human. [Q8WY98-1]

Organism-specific databases

CTDi56063.
GeneCardsiTMEM234.
HGNCiHGNC:28837. TMEM234.
HPAiHPA015049.
neXtProtiNX_Q8WY98.
PharmGKBiPA142672475.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4831. Eukaryota.
ENOG4111XD9. LUCA.
GeneTreeiENSGT00390000013398.
HOVERGENiHBG057419.
InParanoidiQ8WY98.
OMAiCGSILMI.
OrthoDBiEOG7SN8FH.
PhylomeDBiQ8WY98.
TreeFamiTF300180.

Miscellaneous databases

GenomeRNAii56063.
PROiQ8WY98.

Gene expression databases

BgeeiQ8WY98.
CleanExiHS_C1orf91.
ExpressionAtlasiQ8WY98. baseline and differential.
GenevisibleiQ8WY98. HS.

Family and domain databases

InterProiIPR018908. TMEM234.
[Graphical view]
PfamiPF10639. TMEM234. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 58-164 (ISOFORM 2).
    Tissue: Testis and Thyroid.
  3. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
    Tissue: Brain, Cervix and Ovary.

Entry informationi

Entry nameiTM234_HUMAN
AccessioniPrimary (citable) accession number: Q8WY98
Secondary accession number(s): B2R535
, D3DPP7, Q6UWY9, Q8N2H6, Q9BSR2, Q9NU76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2002
Last modified: July 6, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.