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Protein

THAP domain-containing protein 4

Gene

THAP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi567 – 5671Iron (heme axial ligand)

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1 – 8585THAP-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding, Heme, Iron, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
THAP domain-containing protein 4
Gene namesi
Name:THAP4
ORF Names:CGI-36, PP238
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:23187. THAP4.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134864723.

Polymorphism and mutation databases

BioMutaiTHAP4.
DMDMi29839589.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 577577THAP domain-containing protein 4PRO_0000068646Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei163 – 1631PhosphoserineCombined sources
Modified residuei239 – 2391PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WY91.
MaxQBiQ8WY91.
PaxDbiQ8WY91.
PeptideAtlasiQ8WY91.
PRIDEiQ8WY91.

PTM databases

iPTMnetiQ8WY91.
PhosphoSiteiQ8WY91.

Expressioni

Gene expression databases

BgeeiQ8WY91.
CleanExiHS_THAP4.
ExpressionAtlasiQ8WY91. baseline and differential.
GenevisibleiQ8WY91. HS.

Organism-specific databases

HPAiHPA044982.
HPA053448.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi119269. 10 interactions.
IntActiQ8WY91. 3 interactions.
MINTiMINT-1402478.
STRINGi9606.ENSP00000385006.

Structurei

Secondary structure

1
577
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi420 – 4289Combined sources
Beta strandi430 – 4367Combined sources
Beta strandi438 – 4425Combined sources
Beta strandi445 – 45713Combined sources
Beta strandi459 – 47113Combined sources
Turni473 – 4753Combined sources
Beta strandi478 – 48811Combined sources
Beta strandi494 – 5018Combined sources
Turni502 – 5043Combined sources
Beta strandi505 – 51410Combined sources
Beta strandi517 – 52711Combined sources
Beta strandi536 – 54510Combined sources
Beta strandi551 – 5599Combined sources
Beta strandi562 – 57615Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3IA8X-ray1.79A/B415-577[»]
ProteinModelPortaliQ8WY91.
SMRiQ8WY91. Positions 1-85, 415-576.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WY91.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi235 – 2384HCFC1-binding motif (HBM)By similarity

Sequence similaritiesi

Contains 1 THAP-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1 – 8585THAP-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3371. Eukaryota.
ENOG4111TBC. LUCA.
GeneTreeiENSGT00840000129949.
HOGENOMiHOG000154563.
HOVERGENiHBG054106.
InParanoidiQ8WY91.
OrthoDBiEOG789CC0.
PhylomeDBiQ8WY91.
TreeFamiTF315956.

Family and domain databases

InterProiIPR011038. Calycin-like.
IPR014878. DUF1794.
IPR006612. Znf_C2CH.
[Graphical view]
PfamiPF08768. DUF1794. 1 hit.
PF05485. THAP. 1 hit.
[Graphical view]
SMARTiSM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view]
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS50950. ZF_THAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WY91-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVICCAAVNC SNRQGKGEKR AVSFHRFPLK DSKRLIQWLK AVQRDNWTPT
60 70 80 90 100
KYSFLCSEHF TKDSFSKRLE DQHRLLKPTA VPSIFHLTEK KRGAGGHGRT
110 120 130 140 150
RRKDASKATG GVRGHSSAAT SRGAAGWSPS SSGNPMAKPE SRRLKQAALQ
160 170 180 190 200
GEATPRAAQE AASQEQAQQA LERTPGDGLA TMVAGSQGKA EASATDAGDE
210 220 230 240 250
SATSSIEGGV TDKSGISMDD FTPPGSGACK FIGSLHSYSF SSKHTRERPS
260 270 280 290 300
VPREPIDRKR LKKDVEPSCS GSSLGPDKGL AQSPPSSSLT ATPQKPSQSP
310 320 330 340 350
SAPPADVTPK PATEAVQSEH SDASPMSINE VILSASGACK LIDSLHSYCF
360 370 380 390 400
SSRQNKSQVC CLREQVEKKN GELKSLRQRV SRSDSQVRKL QEKLDELRRV
410 420 430 440 450
SVPYPSSLLS PSREPPKMNP VVEPLSWMLG TWLSDPPGAG TYPTLQPFQY
460 470 480 490 500
LEEVHISHVG QPMLNFSFNS FHPDTRKPMH RECGFIRLKP DTNKVAFVSA
510 520 530 540 550
QNTGVVEVEE GEVNGQELCI ASHSIARISF AKEPHVEQIT RKFRLNSEGK
560 570
LEQTVSMATT TQPMTQHLHV TYKKVTP
Length:577
Mass (Da):62,890
Last modified:April 11, 2003 - v2
Checksum:i40660A5ACDD0A7C3
GO
Isoform 2 (identifier: Q8WY91-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-412: Missing.
     413-413: R → M

Show »
Length:165
Mass (Da):18,627
Checksum:i3642E9BCC268162B
GO

Sequence cautioni

The sequence AAH00247.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH09439.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA91560.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti261 – 2611L → P in BAA91560 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti121 – 1211S → G.2 Publications
Corresponds to variant rs7424328 [ dbSNP | Ensembl ].
VAR_027161

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 412412Missing in isoform 2. 1 PublicationVSP_020078Add
BLAST
Alternative sequencei413 – 4131R → M in isoform 2. 1 PublicationVSP_020079

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132970 mRNA. Translation: AAD27745.1.
AF258556 mRNA. Translation: AAG23759.1.
AC133528 Genomic DNA. Translation: AAY14918.1.
BC000247 mRNA. Translation: AAH00247.1. Different initiation.
BC009439 mRNA. Translation: AAH09439.1. Different initiation.
BC069235 mRNA. Translation: AAH69235.1.
BC071896 mRNA. Translation: AAH71896.1.
BC094822 mRNA. Translation: AAH94822.1.
AK001216 mRNA. Translation: BAA91560.1. Different initiation.
CCDSiCCDS2551.1. [Q8WY91-1]
CCDS54440.1. [Q8WY91-2]
RefSeqiNP_001157828.1. NM_001164356.1. [Q8WY91-2]
NP_057047.4. NM_015963.5. [Q8WY91-1]
UniGeneiHs.435759.

Genome annotation databases

EnsembliENST00000402136; ENSP00000385931; ENSG00000176946. [Q8WY91-2]
ENST00000407315; ENSP00000385006; ENSG00000176946. [Q8WY91-1]
GeneIDi51078.
KEGGihsa:51078.
UCSCiuc002wbs.3. human. [Q8WY91-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132970 mRNA. Translation: AAD27745.1.
AF258556 mRNA. Translation: AAG23759.1.
AC133528 Genomic DNA. Translation: AAY14918.1.
BC000247 mRNA. Translation: AAH00247.1. Different initiation.
BC009439 mRNA. Translation: AAH09439.1. Different initiation.
BC069235 mRNA. Translation: AAH69235.1.
BC071896 mRNA. Translation: AAH71896.1.
BC094822 mRNA. Translation: AAH94822.1.
AK001216 mRNA. Translation: BAA91560.1. Different initiation.
CCDSiCCDS2551.1. [Q8WY91-1]
CCDS54440.1. [Q8WY91-2]
RefSeqiNP_001157828.1. NM_001164356.1. [Q8WY91-2]
NP_057047.4. NM_015963.5. [Q8WY91-1]
UniGeneiHs.435759.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3IA8X-ray1.79A/B415-577[»]
ProteinModelPortaliQ8WY91.
SMRiQ8WY91. Positions 1-85, 415-576.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119269. 10 interactions.
IntActiQ8WY91. 3 interactions.
MINTiMINT-1402478.
STRINGi9606.ENSP00000385006.

PTM databases

iPTMnetiQ8WY91.
PhosphoSiteiQ8WY91.

Polymorphism and mutation databases

BioMutaiTHAP4.
DMDMi29839589.

Proteomic databases

EPDiQ8WY91.
MaxQBiQ8WY91.
PaxDbiQ8WY91.
PeptideAtlasiQ8WY91.
PRIDEiQ8WY91.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000402136; ENSP00000385931; ENSG00000176946. [Q8WY91-2]
ENST00000407315; ENSP00000385006; ENSG00000176946. [Q8WY91-1]
GeneIDi51078.
KEGGihsa:51078.
UCSCiuc002wbs.3. human. [Q8WY91-1]

Organism-specific databases

CTDi51078.
GeneCardsiTHAP4.
HGNCiHGNC:23187. THAP4.
HPAiHPA044982.
HPA053448.
MIMi612533. gene.
neXtProtiNX_Q8WY91.
PharmGKBiPA134864723.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3371. Eukaryota.
ENOG4111TBC. LUCA.
GeneTreeiENSGT00840000129949.
HOGENOMiHOG000154563.
HOVERGENiHBG054106.
InParanoidiQ8WY91.
OrthoDBiEOG789CC0.
PhylomeDBiQ8WY91.
TreeFamiTF315956.

Miscellaneous databases

ChiTaRSiTHAP4. human.
EvolutionaryTraceiQ8WY91.
GeneWikiiTHAP4.
GenomeRNAii51078.
PROiQ8WY91.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WY91.
CleanExiHS_THAP4.
ExpressionAtlasiQ8WY91. baseline and differential.
GenevisibleiQ8WY91. HS.

Family and domain databases

InterProiIPR011038. Calycin-like.
IPR014878. DUF1794.
IPR006612. Znf_C2CH.
[Graphical view]
PfamiPF08768. DUF1794. 1 hit.
PF05485. THAP. 1 hit.
[Graphical view]
SMARTiSM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view]
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS50950. ZF_THAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLY-121.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLY-121.
    Tissue: Brain, Eye, Melanoma and Ovarian carcinoma.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 221-577 (ISOFORM 1).
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-163, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  7. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-239, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Erythroleukemia.
  8. "Structure of the C-terminal heme-binding domain of THAP domain containing protein 4 from Homo sapiens."
    Bianchetti C.M., Bingman C.A., Phillips G.N. Jr.
    Proteins 79:1337-1341(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.79 ANGSTROMS) OF 415-577 IN COMPLEX WITH HEME, SUBUNIT.

Entry informationi

Entry nameiTHAP4_HUMAN
AccessioniPrimary (citable) accession number: Q8WY91
Secondary accession number(s): Q53NU7
, Q6GRN0, Q6IPJ3, Q9NW26, Q9Y325
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: April 11, 2003
Last modified: July 6, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.