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Protein

THAP domain-containing protein 4

Gene

THAP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi567Iron (heme axial ligand)1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 85THAP-typePROSITE-ProRule annotationAdd BLAST85

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • heme binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • protein homodimerization activity Source: UniProtKB
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB

Keywordsi

Molecular functionDNA-binding
LigandHeme, Iron, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
THAP domain-containing protein 4
Gene namesi
Name:THAP4
ORF Names:CGI-36, PP238
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000176946.11
HGNCiHGNC:23187 THAP4
MIMi612533 gene
neXtProtiNX_Q8WY91

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176946
PharmGKBiPA134864723

Polymorphism and mutation databases

BioMutaiTHAP4
DMDMi29839589

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000686461 – 577THAP domain-containing protein 4Add BLAST577

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei163PhosphoserineCombined sources1
Modified residuei239PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WY91
MaxQBiQ8WY91
PaxDbiQ8WY91
PeptideAtlasiQ8WY91
PRIDEiQ8WY91

PTM databases

iPTMnetiQ8WY91
PhosphoSitePlusiQ8WY91

Expressioni

Gene expression databases

BgeeiENSG00000176946
CleanExiHS_THAP4
ExpressionAtlasiQ8WY91 baseline and differential
GenevisibleiQ8WY91 HS

Organism-specific databases

HPAiHPA044982
HPA053448

Interactioni

Subunit structurei

Homodimer.1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi119269, 12 interactors
IntActiQ8WY91, 11 interactors
MINTiQ8WY91
STRINGi9606.ENSP00000385006

Structurei

Secondary structure

1577
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi420 – 428Combined sources9
Beta strandi430 – 436Combined sources7
Beta strandi438 – 442Combined sources5
Beta strandi445 – 457Combined sources13
Beta strandi459 – 471Combined sources13
Turni473 – 475Combined sources3
Beta strandi478 – 488Combined sources11
Beta strandi494 – 501Combined sources8
Turni502 – 504Combined sources3
Beta strandi505 – 514Combined sources10
Beta strandi517 – 527Combined sources11
Beta strandi536 – 545Combined sources10
Beta strandi551 – 559Combined sources9
Beta strandi562 – 576Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IA8X-ray1.79A/B415-577[»]
ProteinModelPortaliQ8WY91
SMRiQ8WY91
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WY91

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi235 – 238HCFC1-binding motif (HBM)By similarity4

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 85THAP-typePROSITE-ProRule annotationAdd BLAST85

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3371 Eukaryota
ENOG4111TBC LUCA
GeneTreeiENSGT00840000129785
HOGENOMiHOG000154563
HOVERGENiHBG054106
InParanoidiQ8WY91
OrthoDBiEOG091G0OXH
PhylomeDBiQ8WY91
TreeFamiTF315956

Family and domain databases

CDDicd07828 nitrobindin, 1 hit
Gene3Di2.40.128.20, 1 hit
3.30.40.180, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR014878 DUF1794
IPR006612 THAP_Znf
IPR038441 THAP_Znf_sf
PfamiView protein in Pfam
PF08768 DUF1794, 1 hit
PF05485 THAP, 1 hit
SMARTiView protein in SMART
SM00692 DM3, 1 hit
SM00980 THAP, 1 hit
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS50950 ZF_THAP, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WY91-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVICCAAVNC SNRQGKGEKR AVSFHRFPLK DSKRLIQWLK AVQRDNWTPT
60 70 80 90 100
KYSFLCSEHF TKDSFSKRLE DQHRLLKPTA VPSIFHLTEK KRGAGGHGRT
110 120 130 140 150
RRKDASKATG GVRGHSSAAT SRGAAGWSPS SSGNPMAKPE SRRLKQAALQ
160 170 180 190 200
GEATPRAAQE AASQEQAQQA LERTPGDGLA TMVAGSQGKA EASATDAGDE
210 220 230 240 250
SATSSIEGGV TDKSGISMDD FTPPGSGACK FIGSLHSYSF SSKHTRERPS
260 270 280 290 300
VPREPIDRKR LKKDVEPSCS GSSLGPDKGL AQSPPSSSLT ATPQKPSQSP
310 320 330 340 350
SAPPADVTPK PATEAVQSEH SDASPMSINE VILSASGACK LIDSLHSYCF
360 370 380 390 400
SSRQNKSQVC CLREQVEKKN GELKSLRQRV SRSDSQVRKL QEKLDELRRV
410 420 430 440 450
SVPYPSSLLS PSREPPKMNP VVEPLSWMLG TWLSDPPGAG TYPTLQPFQY
460 470 480 490 500
LEEVHISHVG QPMLNFSFNS FHPDTRKPMH RECGFIRLKP DTNKVAFVSA
510 520 530 540 550
QNTGVVEVEE GEVNGQELCI ASHSIARISF AKEPHVEQIT RKFRLNSEGK
560 570
LEQTVSMATT TQPMTQHLHV TYKKVTP
Length:577
Mass (Da):62,890
Last modified:April 11, 2003 - v2
Checksum:i40660A5ACDD0A7C3
GO
Isoform 2 (identifier: Q8WY91-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-412: Missing.
     413-413: R → M

Show »
Length:165
Mass (Da):18,627
Checksum:i3642E9BCC268162B
GO

Sequence cautioni

The sequence AAH00247 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH09439 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA91560 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti261L → P in BAA91560 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027161121S → G2 PublicationsCorresponds to variant dbSNP:rs7424328Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0200781 – 412Missing in isoform 2. 1 PublicationAdd BLAST412
Alternative sequenceiVSP_020079413R → M in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132970 mRNA Translation: AAD27745.1
AF258556 mRNA Translation: AAG23759.1
AC133528 Genomic DNA Translation: AAY14918.1
BC000247 mRNA Translation: AAH00247.1 Different initiation.
BC009439 mRNA Translation: AAH09439.1 Different initiation.
BC069235 mRNA Translation: AAH69235.1
BC071896 mRNA Translation: AAH71896.1
BC094822 mRNA Translation: AAH94822.1
AK001216 mRNA Translation: BAA91560.1 Different initiation.
CCDSiCCDS2551.1 [Q8WY91-1]
CCDS54440.1 [Q8WY91-2]
RefSeqiNP_001157828.1, NM_001164356.1 [Q8WY91-2]
NP_057047.4, NM_015963.5 [Q8WY91-1]
UniGeneiHs.435759

Genome annotation databases

EnsembliENST00000402136; ENSP00000385931; ENSG00000176946 [Q8WY91-2]
ENST00000407315; ENSP00000385006; ENSG00000176946 [Q8WY91-1]
GeneIDi51078
KEGGihsa:51078
UCSCiuc002wbs.3 human [Q8WY91-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTHAP4_HUMAN
AccessioniPrimary (citable) accession number: Q8WY91
Secondary accession number(s): Q53NU7
, Q6GRN0, Q6IPJ3, Q9NW26, Q9Y325
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: April 11, 2003
Last modified: March 28, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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