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Protein

HMG box transcription factor BBX

Gene

BBX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that is necessary for cell cycle progression from G1 to S phase.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi80 – 14869HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. bone development Source: Ensembl
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HMG box transcription factor BBX
Alternative name(s):
Bobby sox homolog
HMG box-containing protein 2
Gene namesi
Name:BBX
Synonyms:HBP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:14422. BBX.

Subcellular locationi

  1. Nucleus Curated

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25280.

Polymorphism and mutation databases

DMDMi74724044.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 941941HMG box transcription factor BBXPRO_0000232885Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei243 – 2431Phosphoserine1 Publication
Modified residuei485 – 4851Phosphoserine1 Publication
Modified residuei704 – 7041Phosphoserine1 Publication
Modified residuei822 – 8221Phosphoserine2 Publications
Modified residuei844 – 8441Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8WY36.
PaxDbiQ8WY36.
PRIDEiQ8WY36.

PTM databases

PhosphoSiteiQ8WY36.

Expressioni

Gene expression databases

BgeeiQ8WY36.
CleanExiHS_BBX.
ExpressionAtlasiQ8WY36. baseline and differential.
GenevestigatoriQ8WY36.

Organism-specific databases

HPAiHPA006049.
HPA050646.

Interactioni

Protein-protein interaction databases

BioGridi121304. 22 interactions.
IntActiQ8WY36. 2 interactions.
STRINGi9606.ENSP00000319974.

Structurei

3D structure databases

ProteinModelPortaliQ8WY36.
SMRiQ8WY36. Positions 80-153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili326 – 37045Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi41 – 5010Poly-Glu
Compositional biasi446 – 54297Lys-richAdd
BLAST
Compositional biasi671 – 773103Lys-richAdd
BLAST

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG305473.
GeneTreeiENSGT00530000063757.
HOGENOMiHOG000236273.
HOVERGENiHBG079777.
InParanoidiQ8WY36.
OMAiFQFAEIS.
OrthoDBiEOG77DJ8X.
PhylomeDBiQ8WY36.
TreeFamiTF106402.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR019102. TF_HMG_box_BBX_DUF2028.
[Graphical view]
PfamiPF09667. DUF2028. 1 hit.
PF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WY36-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKGSNRNKDH SAEGEGVGKR PKRKCLQWHP LLAKKLLDFS EEEEEEDEEE
60 70 80 90 100
DIDKVQLLGA DGLEQDVGET EDDESPEQRA RRPMNAFLLF CKRHRSLVRQ
110 120 130 140 150
EHPRLDNRGA TKILADWWAV LDPKEKQKYT DMAKEYKDAF MKANPGYKWC
160 170 180 190 200
PTTNKPVKSP TPTVNPRKKL WAFPSDSSRD LPSPKKAKTE EMPQLNFGMA
210 220 230 240 250
DPTQMGGLSM LLLAGEHALG TPEVSSGTCR PDVSESPELR QKSPLFQFAE
260 270 280 290 300
ISSSTSHSDA STKQCQTSAL FQFAEISSNT SQLGGAEPVK RCGKSALFQL
310 320 330 340 350
AEMCLASEGM KMEESKLIKA KESDGGRIKE LEKGKEEKEI KMEKTDETRL
360 370 380 390 400
QKEAEFEKSA KENLRDSKEL RNFEALQIDD IMAIKMEDPK EIRKEELEED
410 420 430 440 450
HKCSHFPDFS YSASSKIIIS DVPSRKDHMC HPHGIMIIED PAALNKPEKL
460 470 480 490 500
KKKKKKSKMD RHGNDKSTPK KTCKKRQSSE SDIESVIYTI EAVAKGDWGI
510 520 530 540 550
EKLGDTPRKK VRTSSSGKGS ILDAKPPKKK VKSREKKMSK EKSSDTTKES
560 570 580 590 600
RPPDFISISA SKNISGETPE GIKAEPLTPM EDALPPSLSG QAKPEDSDCH
610 620 630 640 650
RKIETCGSRK SERSCKGALY KTLVSEGMLT SLRANVDRGK RSSGKGNSSD
660 670 680 690 700
HEGCWNEESW TFSQSGTSGS KKFKKTKPKE DCLLGSAKLD EEFEKKFNSL
710 720 730 740 750
PQYSPVTFDR KCVPVPRKKK KTGNVSSEPT KTSKGPFQSQ KKNLFHKIVS
760 770 780 790 800
KYKHKKEKPN VPEKGSGDKW SNKQLFLDAI HPTEAIFSED RNTMEPVHKV
810 820 830 840 850
KNIPSIFNTP EPTTTQEPLV GSQKRKARKT KITHLVRTAD GRVSPAGGTL
860 870 880 890 900
DDKPKEQLQR SLPKATETDC NDKCSHNTEV GETRSSTPEM PAVSAFFSLA
910 920 930 940
ALAEVAAMEN VHRGQRSTPL THDGQPKEMP QAPVLISCAD Q
Length:941
Mass (Da):105,130
Last modified:March 1, 2002 - v1
Checksum:iE45B359A602B5D8D
GO
Isoform 2 (identifier: Q8WY36-2) [UniParc]FASTAAdd to basket

Also known as: BBXa

The sequence of this isoform differs from the canonical sequence as follows:
     735-764: Missing.

Show »
Length:911
Mass (Da):101,555
Checksum:i3D048BF5C0076D37
GO
Isoform 3 (identifier: Q8WY36-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     303-628: MCLASEGMKM...LYKTLVSEGM → ENEAQEKETP...YPSLVFTEGC
     629-941: Missing.

Note: No experimental confirmation available.

Show »
Length:628
Mass (Da):71,487
Checksum:i5635A9387F0EBD10
GO

Sequence cautioni

The sequence AAI10904.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti576 – 5761P → S.
Corresponds to variant rs59781647 [ dbSNP | Ensembl ].
VAR_061264

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei303 – 628326MCLAS…VSEGM → ENEAQEKETPLIMKGVGMKK AGHLVRVGPVGARSSRRQSQ KKTVSLAPQSWMKNLKKNST ASLNIVLLHLTGNVYLSQEK RRRLEMCPQNRLKPAKVLSS LRKRTYSTKLSANISTKRRS PMFRKKEVGINGQTSNSSWM PFTLQKPYFQKTETPWSLFI RLKISHPFSTLQSQQQRKNL WWAAKREKQGKPRLHTLSGQ QMAGYHQQEVLWMTNQRNNC RGVSLKQLRQTAMTNAHTTP RSGRRGAVLQKCLPCLRSLA SLRWLKWQPWKMCTEVRGQL RSPMMDSQKKCRRLLYLFPA LTSEAPFHCKTLCFTYYPSL VFTEGC in isoform 3. 1 PublicationVSP_054880Add
BLAST
Alternative sequencei629 – 941313Missing in isoform 3. 1 PublicationVSP_054881Add
BLAST
Alternative sequencei735 – 76430Missing in isoform 2. 2 PublicationsVSP_018006Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF276948 mRNA. Translation: AAL68984.1.
AF276949 mRNA. Translation: AAL68985.1.
AF454941 mRNA. Translation: AAL58870.1.
AF454942 mRNA. Translation: AAL58871.1.
AL136769 mRNA. Translation: CAB66703.1.
AL834307 mRNA. Translation: CAD38977.1.
AC068765 Genomic DNA. No translation available.
AC072044 Genomic DNA. No translation available.
AC117477 Genomic DNA. No translation available.
BC012837 mRNA. Translation: AAH12837.2.
BC110903 mRNA. Translation: AAI10904.1. Sequence problems.
BC131718 mRNA. Translation: AAI31719.1.
CCDSiCCDS2950.1. [Q8WY36-2]
CCDS46881.1. [Q8WY36-1]
CCDS63712.1. [Q8WY36-3]
RefSeqiNP_001136040.1. NM_001142568.2. [Q8WY36-1]
NP_001263215.1. NM_001276286.1. [Q8WY36-3]
NP_064620.2. NM_020235.6. [Q8WY36-2]
XP_005247699.1. XM_005247642.3. [Q8WY36-1]
XP_005247700.1. XM_005247643.3. [Q8WY36-1]
XP_005247701.1. XM_005247644.3. [Q8WY36-1]
UniGeneiHs.124366.
Hs.736885.

Genome annotation databases

EnsembliENST00000325805; ENSP00000319974; ENSG00000114439. [Q8WY36-1]
ENST00000406780; ENSP00000385530; ENSG00000114439. [Q8WY36-2]
ENST00000415149; ENSP00000408358; ENSG00000114439. [Q8WY36-2]
ENST00000416476; ENSP00000403860; ENSG00000114439. [Q8WY36-3]
GeneIDi56987.
KEGGihsa:56987.
UCSCiuc003dwk.5. human. [Q8WY36-2]
uc003dwl.5. human.
uc010hpr.4. human. [Q8WY36-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF276948 mRNA. Translation: AAL68984.1.
AF276949 mRNA. Translation: AAL68985.1.
AF454941 mRNA. Translation: AAL58870.1.
AF454942 mRNA. Translation: AAL58871.1.
AL136769 mRNA. Translation: CAB66703.1.
AL834307 mRNA. Translation: CAD38977.1.
AC068765 Genomic DNA. No translation available.
AC072044 Genomic DNA. No translation available.
AC117477 Genomic DNA. No translation available.
BC012837 mRNA. Translation: AAH12837.2.
BC110903 mRNA. Translation: AAI10904.1. Sequence problems.
BC131718 mRNA. Translation: AAI31719.1.
CCDSiCCDS2950.1. [Q8WY36-2]
CCDS46881.1. [Q8WY36-1]
CCDS63712.1. [Q8WY36-3]
RefSeqiNP_001136040.1. NM_001142568.2. [Q8WY36-1]
NP_001263215.1. NM_001276286.1. [Q8WY36-3]
NP_064620.2. NM_020235.6. [Q8WY36-2]
XP_005247699.1. XM_005247642.3. [Q8WY36-1]
XP_005247700.1. XM_005247643.3. [Q8WY36-1]
XP_005247701.1. XM_005247644.3. [Q8WY36-1]
UniGeneiHs.124366.
Hs.736885.

3D structure databases

ProteinModelPortaliQ8WY36.
SMRiQ8WY36. Positions 80-153.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121304. 22 interactions.
IntActiQ8WY36. 2 interactions.
STRINGi9606.ENSP00000319974.

PTM databases

PhosphoSiteiQ8WY36.

Polymorphism and mutation databases

DMDMi74724044.

Proteomic databases

MaxQBiQ8WY36.
PaxDbiQ8WY36.
PRIDEiQ8WY36.

Protocols and materials databases

DNASUi56987.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325805; ENSP00000319974; ENSG00000114439. [Q8WY36-1]
ENST00000406780; ENSP00000385530; ENSG00000114439. [Q8WY36-2]
ENST00000415149; ENSP00000408358; ENSG00000114439. [Q8WY36-2]
ENST00000416476; ENSP00000403860; ENSG00000114439. [Q8WY36-3]
GeneIDi56987.
KEGGihsa:56987.
UCSCiuc003dwk.5. human. [Q8WY36-2]
uc003dwl.5. human.
uc010hpr.4. human. [Q8WY36-1]

Organism-specific databases

CTDi56987.
GeneCardsiGC03P107241.
HGNCiHGNC:14422. BBX.
HPAiHPA006049.
HPA050646.
neXtProtiNX_Q8WY36.
PharmGKBiPA25280.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG305473.
GeneTreeiENSGT00530000063757.
HOGENOMiHOG000236273.
HOVERGENiHBG079777.
InParanoidiQ8WY36.
OMAiFQFAEIS.
OrthoDBiEOG77DJ8X.
PhylomeDBiQ8WY36.
TreeFamiTF106402.

Miscellaneous databases

ChiTaRSiBBX. human.
GeneWikiiBBX_(gene).
GenomeRNAii56987.
NextBioi35461285.
PROiQ8WY36.

Gene expression databases

BgeeiQ8WY36.
CleanExiHS_BBX.
ExpressionAtlasiQ8WY36. baseline and differential.
GenevestigatoriQ8WY36.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR019102. TF_HMG_box_BBX_DUF2028.
[Graphical view]
PfamiPF09667. DUF2028. 1 hit.
PF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "HBP2: a new mammalian protein that complements the fission yeast MBF transcription complex."
    Sanchez-Diaz A., Blanco M.A., Jones N., Moreno S.
    Curr. Genet. 40:110-118(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
    Tissue: Bone marrow.
  2. "BBX is expressed in developing CNS and in neuronal tumours."
    Lee C.-J., Chan W.-I., Appleby V.J., Orme A.T., Scotting P.J.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  4. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Ovary and Skin.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-485 AND SER-822, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-844, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-243; SER-704 AND SER-822, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-844, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiBBX_HUMAN
AccessioniPrimary (citable) accession number: Q8WY36
Secondary accession number(s): A2RRM7
, Q2TAJ1, Q7L3J8, Q7LBY8, Q8NDB0, Q8WY35, Q9H0J6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: March 1, 2002
Last modified: April 29, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.