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Q8WY36

- BBX_HUMAN

UniProt

Q8WY36 - BBX_HUMAN

Protein

HMG box transcription factor BBX

Gene

BBX

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Transcription factor that is necessary for cell cycle progression from G1 to S phase.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi80 – 14869HMG boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. bone development Source: Ensembl
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HMG box transcription factor BBX
    Alternative name(s):
    Bobby sox homolog
    HMG box-containing protein 2
    Gene namesi
    Name:BBX
    Synonyms:HBP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:14422. BBX.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25280.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 941941HMG box transcription factor BBXPRO_0000232885Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei243 – 2431Phosphoserine1 Publication
    Modified residuei485 – 4851Phosphoserine1 Publication
    Modified residuei704 – 7041Phosphoserine1 Publication
    Modified residuei822 – 8221Phosphoserine2 Publications
    Modified residuei844 – 8441Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8WY36.
    PaxDbiQ8WY36.
    PRIDEiQ8WY36.

    PTM databases

    PhosphoSiteiQ8WY36.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8WY36.
    BgeeiQ8WY36.
    CleanExiHS_BBX.
    GenevestigatoriQ8WY36.

    Organism-specific databases

    HPAiHPA006049.
    HPA050646.

    Interactioni

    Protein-protein interaction databases

    BioGridi121304. 10 interactions.
    IntActiQ8WY36. 2 interactions.
    STRINGi9606.ENSP00000319974.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WY36.
    SMRiQ8WY36. Positions 80-153.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili326 – 37045Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi41 – 5010Poly-Glu
    Compositional biasi446 – 54297Lys-richAdd
    BLAST
    Compositional biasi671 – 773103Lys-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG305473.
    HOVERGENiHBG079777.
    InParanoidiQ8WY36.
    OMAiFQFAEIS.
    OrthoDBiEOG77DJ8X.
    PhylomeDBiQ8WY36.
    TreeFamiTF106402.

    Family and domain databases

    Gene3Di1.10.30.10. 1 hit.
    InterProiIPR009071. HMG_box_dom.
    IPR019102. TF_HMG_box_BBX_DUF2028.
    [Graphical view]
    PfamiPF09667. DUF2028. 1 hit.
    PF00505. HMG_box. 1 hit.
    [Graphical view]
    SMARTiSM00398. HMG. 1 hit.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 1 hit.
    PROSITEiPS50118. HMG_BOX_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WY36-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKGSNRNKDH SAEGEGVGKR PKRKCLQWHP LLAKKLLDFS EEEEEEDEEE    50
    DIDKVQLLGA DGLEQDVGET EDDESPEQRA RRPMNAFLLF CKRHRSLVRQ 100
    EHPRLDNRGA TKILADWWAV LDPKEKQKYT DMAKEYKDAF MKANPGYKWC 150
    PTTNKPVKSP TPTVNPRKKL WAFPSDSSRD LPSPKKAKTE EMPQLNFGMA 200
    DPTQMGGLSM LLLAGEHALG TPEVSSGTCR PDVSESPELR QKSPLFQFAE 250
    ISSSTSHSDA STKQCQTSAL FQFAEISSNT SQLGGAEPVK RCGKSALFQL 300
    AEMCLASEGM KMEESKLIKA KESDGGRIKE LEKGKEEKEI KMEKTDETRL 350
    QKEAEFEKSA KENLRDSKEL RNFEALQIDD IMAIKMEDPK EIRKEELEED 400
    HKCSHFPDFS YSASSKIIIS DVPSRKDHMC HPHGIMIIED PAALNKPEKL 450
    KKKKKKSKMD RHGNDKSTPK KTCKKRQSSE SDIESVIYTI EAVAKGDWGI 500
    EKLGDTPRKK VRTSSSGKGS ILDAKPPKKK VKSREKKMSK EKSSDTTKES 550
    RPPDFISISA SKNISGETPE GIKAEPLTPM EDALPPSLSG QAKPEDSDCH 600
    RKIETCGSRK SERSCKGALY KTLVSEGMLT SLRANVDRGK RSSGKGNSSD 650
    HEGCWNEESW TFSQSGTSGS KKFKKTKPKE DCLLGSAKLD EEFEKKFNSL 700
    PQYSPVTFDR KCVPVPRKKK KTGNVSSEPT KTSKGPFQSQ KKNLFHKIVS 750
    KYKHKKEKPN VPEKGSGDKW SNKQLFLDAI HPTEAIFSED RNTMEPVHKV 800
    KNIPSIFNTP EPTTTQEPLV GSQKRKARKT KITHLVRTAD GRVSPAGGTL 850
    DDKPKEQLQR SLPKATETDC NDKCSHNTEV GETRSSTPEM PAVSAFFSLA 900
    ALAEVAAMEN VHRGQRSTPL THDGQPKEMP QAPVLISCAD Q 941
    Length:941
    Mass (Da):105,130
    Last modified:March 1, 2002 - v1
    Checksum:iE45B359A602B5D8D
    GO
    Isoform 2 (identifier: Q8WY36-2) [UniParc]FASTAAdd to Basket

    Also known as: BBXa

    The sequence of this isoform differs from the canonical sequence as follows:
         735-764: Missing.

    Show »
    Length:911
    Mass (Da):101,555
    Checksum:i3D048BF5C0076D37
    GO
    Isoform 3 (identifier: Q8WY36-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         303-628: MCLASEGMKM...LYKTLVSEGM → ENEAQEKETP...YPSLVFTEGC
         629-941: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:628
    Mass (Da):71,487
    Checksum:i5635A9387F0EBD10
    GO

    Sequence cautioni

    The sequence AAI10904.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti576 – 5761P → S.
    Corresponds to variant rs59781647 [ dbSNP | Ensembl ].
    VAR_061264

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei303 – 628326MCLAS…VSEGM → ENEAQEKETPLIMKGVGMKK AGHLVRVGPVGARSSRRQSQ KKTVSLAPQSWMKNLKKNST ASLNIVLLHLTGNVYLSQEK RRRLEMCPQNRLKPAKVLSS LRKRTYSTKLSANISTKRRS PMFRKKEVGINGQTSNSSWM PFTLQKPYFQKTETPWSLFI RLKISHPFSTLQSQQQRKNL WWAAKREKQGKPRLHTLSGQ QMAGYHQQEVLWMTNQRNNC RGVSLKQLRQTAMTNAHTTP RSGRRGAVLQKCLPCLRSLA SLRWLKWQPWKMCTEVRGQL RSPMMDSQKKCRRLLYLFPA LTSEAPFHCKTLCFTYYPSL VFTEGC in isoform 3. 1 PublicationVSP_054880Add
    BLAST
    Alternative sequencei629 – 941313Missing in isoform 3. 1 PublicationVSP_054881Add
    BLAST
    Alternative sequencei735 – 76430Missing in isoform 2. 2 PublicationsVSP_018006Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF276948 mRNA. Translation: AAL68984.1.
    AF276949 mRNA. Translation: AAL68985.1.
    AF454941 mRNA. Translation: AAL58870.1.
    AF454942 mRNA. Translation: AAL58871.1.
    AL136769 mRNA. Translation: CAB66703.1.
    AL834307 mRNA. Translation: CAD38977.1.
    AC068765 Genomic DNA. No translation available.
    AC072044 Genomic DNA. No translation available.
    AC117477 Genomic DNA. No translation available.
    BC012837 mRNA. Translation: AAH12837.2.
    BC110903 mRNA. Translation: AAI10904.1. Sequence problems.
    BC131718 mRNA. Translation: AAI31719.1.
    CCDSiCCDS2950.1. [Q8WY36-2]
    CCDS46881.1. [Q8WY36-1]
    CCDS63712.1. [Q8WY36-3]
    RefSeqiNP_001136040.1. NM_001142568.2. [Q8WY36-1]
    NP_001263215.1. NM_001276286.1. [Q8WY36-3]
    NP_064620.2. NM_020235.6. [Q8WY36-2]
    XP_005247699.1. XM_005247642.2. [Q8WY36-1]
    XP_005247700.1. XM_005247643.2. [Q8WY36-1]
    XP_005247701.1. XM_005247644.2. [Q8WY36-1]
    XP_005247702.1. XM_005247645.2. [Q8WY36-1]
    XP_005247703.1. XM_005247646.2. [Q8WY36-2]
    UniGeneiHs.124366.
    Hs.736885.

    Genome annotation databases

    EnsembliENST00000325805; ENSP00000319974; ENSG00000114439. [Q8WY36-1]
    ENST00000406780; ENSP00000385530; ENSG00000114439. [Q8WY36-2]
    ENST00000415149; ENSP00000408358; ENSG00000114439. [Q8WY36-2]
    ENST00000416476; ENSP00000403860; ENSG00000114439. [Q8WY36-3]
    GeneIDi56987.
    KEGGihsa:56987.
    UCSCiuc003dwk.5. human. [Q8WY36-2]
    uc010hpr.4. human. [Q8WY36-1]

    Polymorphism databases

    DMDMi74724044.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF276948 mRNA. Translation: AAL68984.1 .
    AF276949 mRNA. Translation: AAL68985.1 .
    AF454941 mRNA. Translation: AAL58870.1 .
    AF454942 mRNA. Translation: AAL58871.1 .
    AL136769 mRNA. Translation: CAB66703.1 .
    AL834307 mRNA. Translation: CAD38977.1 .
    AC068765 Genomic DNA. No translation available.
    AC072044 Genomic DNA. No translation available.
    AC117477 Genomic DNA. No translation available.
    BC012837 mRNA. Translation: AAH12837.2 .
    BC110903 mRNA. Translation: AAI10904.1 . Sequence problems.
    BC131718 mRNA. Translation: AAI31719.1 .
    CCDSi CCDS2950.1. [Q8WY36-2 ]
    CCDS46881.1. [Q8WY36-1 ]
    CCDS63712.1. [Q8WY36-3 ]
    RefSeqi NP_001136040.1. NM_001142568.2. [Q8WY36-1 ]
    NP_001263215.1. NM_001276286.1. [Q8WY36-3 ]
    NP_064620.2. NM_020235.6. [Q8WY36-2 ]
    XP_005247699.1. XM_005247642.2. [Q8WY36-1 ]
    XP_005247700.1. XM_005247643.2. [Q8WY36-1 ]
    XP_005247701.1. XM_005247644.2. [Q8WY36-1 ]
    XP_005247702.1. XM_005247645.2. [Q8WY36-1 ]
    XP_005247703.1. XM_005247646.2. [Q8WY36-2 ]
    UniGenei Hs.124366.
    Hs.736885.

    3D structure databases

    ProteinModelPortali Q8WY36.
    SMRi Q8WY36. Positions 80-153.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121304. 10 interactions.
    IntActi Q8WY36. 2 interactions.
    STRINGi 9606.ENSP00000319974.

    PTM databases

    PhosphoSitei Q8WY36.

    Polymorphism databases

    DMDMi 74724044.

    Proteomic databases

    MaxQBi Q8WY36.
    PaxDbi Q8WY36.
    PRIDEi Q8WY36.

    Protocols and materials databases

    DNASUi 56987.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000325805 ; ENSP00000319974 ; ENSG00000114439 . [Q8WY36-1 ]
    ENST00000406780 ; ENSP00000385530 ; ENSG00000114439 . [Q8WY36-2 ]
    ENST00000415149 ; ENSP00000408358 ; ENSG00000114439 . [Q8WY36-2 ]
    ENST00000416476 ; ENSP00000403860 ; ENSG00000114439 . [Q8WY36-3 ]
    GeneIDi 56987.
    KEGGi hsa:56987.
    UCSCi uc003dwk.5. human. [Q8WY36-2 ]
    uc010hpr.4. human. [Q8WY36-1 ]

    Organism-specific databases

    CTDi 56987.
    GeneCardsi GC03P107241.
    HGNCi HGNC:14422. BBX.
    HPAi HPA006049.
    HPA050646.
    neXtProti NX_Q8WY36.
    PharmGKBi PA25280.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG305473.
    HOVERGENi HBG079777.
    InParanoidi Q8WY36.
    OMAi FQFAEIS.
    OrthoDBi EOG77DJ8X.
    PhylomeDBi Q8WY36.
    TreeFami TF106402.

    Miscellaneous databases

    ChiTaRSi BBX. human.
    GeneWikii BBX_(gene).
    GenomeRNAii 56987.
    NextBioi 35461285.
    PROi Q8WY36.

    Gene expression databases

    ArrayExpressi Q8WY36.
    Bgeei Q8WY36.
    CleanExi HS_BBX.
    Genevestigatori Q8WY36.

    Family and domain databases

    Gene3Di 1.10.30.10. 1 hit.
    InterProi IPR009071. HMG_box_dom.
    IPR019102. TF_HMG_box_BBX_DUF2028.
    [Graphical view ]
    Pfami PF09667. DUF2028. 1 hit.
    PF00505. HMG_box. 1 hit.
    [Graphical view ]
    SMARTi SM00398. HMG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 1 hit.
    PROSITEi PS50118. HMG_BOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "HBP2: a new mammalian protein that complements the fission yeast MBF transcription complex."
      Sanchez-Diaz A., Blanco M.A., Jones N., Moreno S.
      Curr. Genet. 40:110-118(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
      Tissue: Bone marrow.
    2. "BBX is expressed in developing CNS and in neuronal tumours."
      Lee C.-J., Chan W.-I., Appleby V.J., Orme A.T., Scotting P.J.
      Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    4. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Ovary and Skin.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-485 AND SER-822, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-844, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-243; SER-704 AND SER-822, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiBBX_HUMAN
    AccessioniPrimary (citable) accession number: Q8WY36
    Secondary accession number(s): A2RRM7
    , Q2TAJ1, Q7L3J8, Q7LBY8, Q8NDB0, Q8WY35, Q9H0J6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 18, 2006
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3