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Q8WY36 (BBX_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
HMG box transcription factor BBX
Alternative name(s):
Bobby sox homolog
HMG box-containing protein 2
Gene names
Name:BBX
Synonyms:HBP2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length941 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcription factor that is necessary for cell cycle progression from G1 to S phase. Ref.1

Subcellular location

Nucleus Probable.

Sequence similarities

Contains 1 HMG box DNA-binding domain.

Sequence caution

The sequence AAI10904.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
   LigandDNA-binding
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbone development

Inferred from electronic annotation. Source: Ensembl

regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from direct assay. Source: HPA

nucleus

Inferred from direct assay. Source: HPA

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8WY36-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8WY36-2)

Also known as: BBXa;

The sequence of this isoform differs from the canonical sequence as follows:
     735-764: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 941941HMG box transcription factor BBX
PRO_0000232885

Regions

DNA binding80 – 14869HMG box
Coiled coil326 – 37045 Potential
Compositional bias41 – 5010Poly-Glu
Compositional bias446 – 54297Lys-rich
Compositional bias671 – 773103Lys-rich

Amino acid modifications

Modified residue2431Phosphoserine Ref.8
Modified residue4851Phosphoserine Ref.5
Modified residue7041Phosphoserine Ref.8
Modified residue8221Phosphoserine Ref.5 Ref.8
Modified residue8441Phosphoserine Ref.7

Natural variations

Alternative sequence735 – 76430Missing in isoform 2.
VSP_018006
Natural variant5761P → S.
Corresponds to variant rs59781647 [ dbSNP | Ensembl ].
VAR_061264

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: E45B359A602B5D8D

FASTA941105,130
        10         20         30         40         50         60 
MKGSNRNKDH SAEGEGVGKR PKRKCLQWHP LLAKKLLDFS EEEEEEDEEE DIDKVQLLGA 

        70         80         90        100        110        120 
DGLEQDVGET EDDESPEQRA RRPMNAFLLF CKRHRSLVRQ EHPRLDNRGA TKILADWWAV 

       130        140        150        160        170        180 
LDPKEKQKYT DMAKEYKDAF MKANPGYKWC PTTNKPVKSP TPTVNPRKKL WAFPSDSSRD 

       190        200        210        220        230        240 
LPSPKKAKTE EMPQLNFGMA DPTQMGGLSM LLLAGEHALG TPEVSSGTCR PDVSESPELR 

       250        260        270        280        290        300 
QKSPLFQFAE ISSSTSHSDA STKQCQTSAL FQFAEISSNT SQLGGAEPVK RCGKSALFQL 

       310        320        330        340        350        360 
AEMCLASEGM KMEESKLIKA KESDGGRIKE LEKGKEEKEI KMEKTDETRL QKEAEFEKSA 

       370        380        390        400        410        420 
KENLRDSKEL RNFEALQIDD IMAIKMEDPK EIRKEELEED HKCSHFPDFS YSASSKIIIS 

       430        440        450        460        470        480 
DVPSRKDHMC HPHGIMIIED PAALNKPEKL KKKKKKSKMD RHGNDKSTPK KTCKKRQSSE 

       490        500        510        520        530        540 
SDIESVIYTI EAVAKGDWGI EKLGDTPRKK VRTSSSGKGS ILDAKPPKKK VKSREKKMSK 

       550        560        570        580        590        600 
EKSSDTTKES RPPDFISISA SKNISGETPE GIKAEPLTPM EDALPPSLSG QAKPEDSDCH 

       610        620        630        640        650        660 
RKIETCGSRK SERSCKGALY KTLVSEGMLT SLRANVDRGK RSSGKGNSSD HEGCWNEESW 

       670        680        690        700        710        720 
TFSQSGTSGS KKFKKTKPKE DCLLGSAKLD EEFEKKFNSL PQYSPVTFDR KCVPVPRKKK 

       730        740        750        760        770        780 
KTGNVSSEPT KTSKGPFQSQ KKNLFHKIVS KYKHKKEKPN VPEKGSGDKW SNKQLFLDAI 

       790        800        810        820        830        840 
HPTEAIFSED RNTMEPVHKV KNIPSIFNTP EPTTTQEPLV GSQKRKARKT KITHLVRTAD 

       850        860        870        880        890        900 
GRVSPAGGTL DDKPKEQLQR SLPKATETDC NDKCSHNTEV GETRSSTPEM PAVSAFFSLA 

       910        920        930        940 
ALAEVAAMEN VHRGQRSTPL THDGQPKEMP QAPVLISCAD Q 

« Hide

Isoform 2 (BBXa) [UniParc].

Checksum: 3D048BF5C0076D37
Show »

FASTA911101,555

References

« Hide 'large scale' references
[1]"HBP2: a new mammalian protein that complements the fission yeast MBF transcription complex."
Sanchez-Diaz A., Blanco M.A., Jones N., Moreno S.
Curr. Genet. 40:110-118(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
Tissue: Bone marrow.
[2]"BBX is expressed in developing CNS and in neuronal tumours."
Lee C.-J., Chan W.-I., Appleby V.J., Orme A.T., Scotting P.J.
Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Testis.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Ovary and Skin.
[5]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-485 AND SER-822, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-844, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[8]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-243; SER-704 AND SER-822, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF276948 mRNA. Translation: AAL68984.1.
AF276949 mRNA. Translation: AAL68985.1.
AF454941 mRNA. Translation: AAL58870.1.
AF454942 mRNA. Translation: AAL58871.1.
AL136769 mRNA. Translation: CAB66703.1.
AL834307 mRNA. Translation: CAD38977.1.
BC012837 mRNA. Translation: AAH12837.2.
BC110903 mRNA. Translation: AAI10904.1. Sequence problems.
RefSeqNP_001136040.1. NM_001142568.2.
NP_064620.2. NM_020235.6.
XP_005247699.1. XM_005247642.2.
XP_005247700.1. XM_005247643.2.
XP_005247701.1. XM_005247644.2.
XP_005247702.1. XM_005247645.2.
XP_005247703.1. XM_005247646.2.
UniGeneHs.124366.
Hs.736885.

3D structure databases

ProteinModelPortalQ8WY36.
SMRQ8WY36. Positions 80-153.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121304. 6 interactions.
IntActQ8WY36. 2 interactions.
STRING9606.ENSP00000319974.

PTM databases

PhosphoSiteQ8WY36.

Polymorphism databases

DMDM74724044.

Proteomic databases

PaxDbQ8WY36.
PRIDEQ8WY36.

Protocols and materials databases

DNASU56987.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000325805; ENSP00000319974; ENSG00000114439. [Q8WY36-1]
ENST00000406780; ENSP00000385530; ENSG00000114439. [Q8WY36-2]
ENST00000415149; ENSP00000408358; ENSG00000114439. [Q8WY36-2]
GeneID56987.
KEGGhsa:56987.
UCSCuc003dwk.5. human. [Q8WY36-2]
uc010hpr.4. human. [Q8WY36-1]

Organism-specific databases

CTD56987.
GeneCardsGC03P107241.
HGNCHGNC:14422. BBX.
HPAHPA006049.
HPA050646.
neXtProtNX_Q8WY36.
PharmGKBPA25280.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG305473.
HOVERGENHBG079777.
InParanoidQ8WY36.
OMAFQFAEIS.
OrthoDBEOG77DJ8X.
PhylomeDBQ8WY36.
TreeFamTF106402.

Gene expression databases

ArrayExpressQ8WY36.
BgeeQ8WY36.
CleanExHS_BBX.
GenevestigatorQ8WY36.

Family and domain databases

Gene3D1.10.30.10. 1 hit.
InterProIPR009071. HMG_box_dom.
IPR019102. TF_HMG_box_BBX_DUF2028.
[Graphical view]
PfamPF09667. DUF2028. 1 hit.
PF00505. HMG_box. 1 hit.
[Graphical view]
SMARTSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMSSF47095. SSF47095. 1 hit.
PROSITEPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSBBX. human.
GeneWikiBBX_(gene).
GenomeRNAi56987.
NextBio62675.
PROQ8WY36.

Entry information

Entry nameBBX_HUMAN
AccessionPrimary (citable) accession number: Q8WY36
Secondary accession number(s): Q2TAJ1 expand/collapse secondary AC list , Q7L3J8, Q7LBY8, Q8NDB0, Q8WY35, Q9H0J6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: March 1, 2002
Last modified: April 16, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM